Nuclear medicine review. Central & Eastern Europe最新文献

{"title":"Fibroblast activation protein inhibitor (FAPI)-negative huge renal cell carcinoma demonstrating an intriguing pattern on [99mTc]Tc-FAPI-46 scintigraphy.","authors":"Nasrin Raeisi, Amin Saber Tanha, Salman Soltani, Ali Zare, Atena Aghaee","doi":"10.5603/nmr.106313","DOIUrl":"10.5603/nmr.106313","url":null,"abstract":"<p><p>This report describes a 58-year-old man with right flank pain, hematuria, and dysuria, leading to the discovery of a large renal mass via ultrasonography. A contrast-enhanced computed tomography (CT) scan revealed a huge abdominal mass with areas of necrosis and calcification. [99mTc]Tc-FAPI-46 scintigraphy showed photopenic areas and accumulation in a compressed gallbladder, showing an intriguing pattern. A comprehensive surgical resection of the tumor involving the right kidney, adrenal gland, ascending and a portion of transverse colon and liver was successfully performed, and the pathological evaluation confirmed the diagnosis of clear cell renal cell carcinoma (ccRCC). This case represents the pioneering application of [99mTc]Tc-FAPI-46 scintigraphy in ccRCC with sarcomatoid features, demonstrating a lack of avidity.</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":"28 0","pages":"55-57"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between [68Ga]Ga-PSMA-11 PET/CT-derived skeletal muscle index and sarcopenia parameters in hypogonadal men undergoing androgen deprivation therapy for prostate cancer.","authors":"Stefan Valentinov Radev, Tanya Stoeva, Marina Dyankova, Mira Siderova","doi":"10.5603/nmr.107111","DOIUrl":"10.5603/nmr.107111","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia is an emerging health problem, and its detection in prostate cancer patients undergoing androgen deprivation therapy (ADT) is of rising importance. This study aims to evaluate the relationship between sarcopenia parameters such as estimated skeletal muscle index (SMI) using the gallium-68 labeled prostate-specific membrane antigen-11 positron-emission tomography/computed tomography ([68Ga] Ga-PSMA-11 PET/CT) imaging performed for oncological staging, hand grip strength (HGS) with dynamometer and Strength, Assistance in walking, Rise from a chair, Climb stairs, Falls (SARC-F) questionnaire score in prostate cancer patients, and to assess how these relationships are influenced by androgen deprivation duration.</p><p><strong>Material and methods: </strong>20 patients with prostate cancer without ADT and 39 men on ADT with a mean duration of 34.8 ± 21.8 months in a hypogonadal state were included. SMI using the psoas muscle area on the third lumbar vertebra (L3) level was measured on [68Ga]Ga-PSMA-11 PET/CT images, adjusted to height, HGS, and SARC-F score were also assessed.</p><p><strong>Results: </strong>SMI and HGS demonstrated a strong positive correlation (r = 0.85, p < 0.001) among all participants. SMI and SARC-F scores showed a moderate negative link (r = -0.74, p < 0.001), while HGS and SARC-F scores were strongly negatively associated (r = -0.95, p < 0.001). In hypogonadal men, SMI and HGS were both negatively correlated with ADT duration (r = -0.57, p < 0.001; and r = -0.82, p < 0.001). A strong positive correlation was found between SARC-F score and ADT duration (r = 0.43, p < 0.001).</p><p><strong>Conclusions: </strong>The present results confirm that prolonged ADT in prostate cancer patients is associated with a significant decline in muscle mass and strength, and support the integration of both imaging ([68Ga]Ga-PSMA-11 PET/CT-derived SMI) and simple clinical tools (HGS, SARC-F) in the routine assessment of prostate cancer patients receiving ADT.</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":"28 0","pages":"65-71"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of [18F]FDG PET/CT in sarcoidosis management: A retrospective case series.","authors":"Mourad Zekri, Majdouline Bel Lakhdar, Dounia Alami, Soumia Kriouile, Leila Achachi, Abdellah Achir, Hicham Harmouche, Ayat Mouaden, Hasnae Guerrouj, Imad Ghfir","doi":"10.5603/nmr.104702","DOIUrl":"https://doi.org/10.5603/nmr.104702","url":null,"abstract":"<p><strong>Background: </strong>Sarcoidosis is a granulomatosis of variable manifestation and evolution. It is crucial to assess the disease's extent, activity, and severity to effectively manage and monitor patients with sarcoidosis. Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) is a nuclear medicine technique that proved to be of great use in oncology. Its role in extra-oncological indications, including sarcoidosis, has been reported.</p><p><strong>Material and methods: </strong>Twenty-five patients with sarcoidosis were retrospectively included. All patients underwent at least one [18F]FDG PET/CT scan. Five patients underwent a second [18F]FDG PET/CT to assess their response to corticosteroid treatment. Clinical data were gathered from medical records. Radiological and PET data were obtained from reports and digital imaging and communications in medicine (DICOM) archives.</p><p><strong>Results: </strong>[18F]FDG PET/CT revealed active inflammation in 76% of patients. All had intrathoracic activity, including 76% mediastinal and 44% pulmonary lesions. Additionally, 60% of patients displayed associated extrathoracic activity, mainly in peripheral lymph nodes, spleen, and bone. Cardiac activity was reported in two patients. [18F]FDG PET/CT prompted a diagnostic biopsy in 32% of patients. [18F]FDG PET/CT had an impact on therapeutic decision-making in 60% of patients. Follow-up [18F]FDG PET/CT showed a complete metabolic response in two cases and an incomplete metabolic response in one patient. Disease progression was noted in two patients.</p><p><strong>Conclusions: </strong>Providing a complete functional map of the extent of inflammatory active disease, [18F]FDG PET/CT proves to be particularly useful in the management of sarcoidosis patients, by explaining persistent disabling symptoms, revealing suitable sites for biopsy, guiding therapeutic decisions and assessing treatment response.</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":"28 0","pages":"18-26"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"99mTc/Tricine/HYNIC ubiquicidin 29-41 uptake in a giant cell tumor of the hallux: insights into the importance of time-activity curve analysis for accurate scan interpretation.","authors":"Saeedeh Ataei Nakhaei, Amin Saber Tanha, Kamran Aryana, Nasrin Raeisi, Somaye Barashki","doi":"10.5603/nmr.106527","DOIUrl":"https://doi.org/10.5603/nmr.106527","url":null,"abstract":"<p><p>A 37-year-old man presented with swelling and erythema in the left first toe after a prior trauma, suspicious for osteomyelitis. X-ray and computed tomography (CT) scans revealed a radiolucent lesion with cortical disruption. A 99mTc/tricine/HYNIC ubiquicidin 29-41 (UBI) scintigraphy showed increased uptake but a non-accumulative time-activity curve, indicating a false positive for infection. Surgical excision confirmed a giant cell tumor. This case underscores the importance of integrating time-activity curve analysis with target-to-reference ratios in [99mTc]Tc-UBI scintigraphy for accurate diagnosis.</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":"28 0","pages":"58-60"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Polish radioligand therapy (RLT) Registry: initial real-world evidence in neuroendocrine tumors.","authors":"Maciej Kołodziej, Violetta Rosiek, Jan Musiałkiewicz, Aleksandra Ledwon, Anna Lewczuk-Myślicka, Karol P Sagan, Katarzyna Jóźwik-Plebanek, Beata Kos-Kudła, Marek Ruchała, Daria Handkiewicz-Junak, Renata Świątkowska-Stodulska, Anhelli Syrenicz, Grzegorz Kamiński","doi":"10.5603/nmr.108401","DOIUrl":"10.5603/nmr.108401","url":null,"abstract":"<p><strong>Background: </strong>Radioligand therapy (RLT) with [177Lu]Lu-DOTA-TATE has become a key treatment option for advanced gastroenteropancreatic neuroendocrine tumors (NETs). In Poland, RLT has been reimbursed since March 2023 within the national drug program B.139. In order to monitor real-world data and patient characteristics, the Polish RLT Registry was established under the auspices of the Polish Society of Endocrinology.</p><p><strong>Material and methods: </strong>This first report summarizes two years of data collection in six major clinical centers. The Registry includes retrospective and prospective data on demographics, primary tumor site, hormonal activity, prior therapies, type of progression leading to qualification, as well as the safety of administered RLT.</p><p><strong>Results: </strong>The analyzed cohort reflects the real-world population of Polish patients referred for RLT. Most patients presented with advanced, progressive NETs after multiple treatment lines. Registry data allowed characterization of referral patterns, disease progression leading to qualification, and the patient care pathway from initial diagnosis to RLT. Due to the short observation period, survival outcomes such as progression-free survival (PFS) and overall survival (OS) are not yet available.</p><p><strong>Conclusions: </strong>This is the first national real-world evidence report on RLT for NET in Poland. The Registry provides unique insight into patient characteristics and clinical practice in the early phase of therapy implementation. Collected data will serve as a basis for the development of national recommendations and optimization of NET management.</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":"28 0","pages":"92-98"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of multiple machine learning models predicting the results of hybrid imaging in primary hyperparathyroidism.","authors":"Anna Drynda, Jacek Podlewski, Karolina Kucharczyk, Grzegorz Sokołowski, Anna Sowa-Staszczak, Alicja Hubalewska-Dydejczyk, Małgorzata Trofimiuk-Müldner","doi":"10.5603/nmr.105377","DOIUrl":"https://doi.org/10.5603/nmr.105377","url":null,"abstract":"<p><strong>Background: </strong>Primary hyperparathyroidism (PHP) diagnosis is based on abnormalities in biochemical blood tests. Preoperative localization of the affected gland with imaging may increase the effectiveness of the surgical treatment. The aim of this study is to evaluate predictive strategies for the assessment of radiotracer uptake in pre-operative [99mTc]Tc-sestamibi scintigraphy ([99mTc] Tc-MIBI SPECT-CT) among PHP patients to identify individuals with a high probability of negative results, and to develop clinical decision-making tools.</p><p><strong>Material and methods: </strong>Development and evaluation of logistic regression (LR), classification trees utilizing the classification and regression trees (CART) algorithm, random forest (RF), and boosted trees employing XGBoost (XGB) predictive models. All models were constructed using data obtained from 499 patients diagnosed with PHP who underwent [99mTc]Tc-MIBI SPECT-CT imaging between 2010 and 2022 at the University Hospital in Cracow, Poland.</p><p><strong>Results: </strong>The LR model demonstrated the best out-of-sample performance, achieving a specificity of 81.3% and an accuracy of 69.3%, with a sensitivity of 55.7%. Along with CART and XGB, LR performed well when using only 5 predictors: concentrations of parathormone (PTH), serum calcium, serum phosphates, total serum vitamin D, and maximal lesion diameter measured in ultrasound. Random forest (RF) exhibited higher sensitivity (62.7%), but lower specificity (74.2%) and accuracy (68.6%). Other models demonstrated subpar performance.</p><p><strong>Conclusions: </strong>Logistic regression and RF models were the most effective in predicting radiotracer uptake in pre-operative hybrid imaging of the parathyroids, suggesting their suitability as the foundation for software to be used in clinical settings. However, opting for the CART model, despite its easier interpretation, would come at the expense of performance.</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":"28 0","pages":"47-54"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectacular effect of [177Lu]Lu-PSMA-617 therapy in a patient with hormone-resistant prostate cancer after failure of other therapeutic options.","authors":"Katarzyna Barańska, Katarzyna Niemas, Marta Wojewódzka-Mirocha, Jacek Kabat, Marek Dedecjus","doi":"10.5603/nmr.108217","DOIUrl":"10.5603/nmr.108217","url":null,"abstract":"<p><p>This research presents the case of a 72-year-old patient with a long history of high-grade prostate cancer (Gleason 8), previously treated with radiotherapy, hormone therapy, and chemotherapy. Due to persistent disease progression and widespread metastases, the patient was enrolled in [177Lu]Lu-PSMA-617 therapy under the Rescue Drug Therapy Access (RDTL) program. Six therapeutic cycles were administered, resulting in marked clinical improvement and a decline in prostate-specific antigen (PSA) levels from 1128.00 ng/mL to 1.68 ng/mL. Positron emission tomography/computed tomography (PET/CT) imaging using [68Ga] Ga-PSMA-11 demonstrated a favorable treatment response, with no significant adverse effects. This case highlights the potential of a theranostic approach in oncology.</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":"28 0","pages":"61-64"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic complications of peptide receptor radionuclide therapy with Lutetium-177 and Yttrium-90 in patients with neuroendocrine neoplasm.","authors":"Barbara Bober,&nbsp;Marek Saracyn,&nbsp;Arkadiusz Lubas,&nbsp;Maciej Kolodziej,&nbsp;Dorota Brodowska-Kania,&nbsp;Waldemar Kapusta,&nbsp;Grzegorz Kaminski","doi":"10.5603/NMR.a2022.0016","DOIUrl":"https://doi.org/10.5603/NMR.a2022.0016","url":null,"abstract":"<p><p>Neuroendocrine neoplasms (NENs) are a heterogeneous group of tumors originating from neuroendocrine cells spread throughout the body, forming the so-called diffuse endocrine system. The gold standard in treating unresectable or disseminated, progressive, and well-differentiated NENs is therapy with radiolabeled somatostatin analogs (peptide receptor radionuclide therapy - PRRT). PRRT is a method based on peptides combined with beta-emitting radionuclides. The study aimed to assess the early and long-term liver complications after administration of Lutetium-177 or Lutetium-177 combined with Yttrium-90. We enrolled 27 patients treated with [177Lu]Lu-DOTATATE with an activity of 7.4 GBq (200 mCi) and 9 patients received the tandem treatment [90Y]Y-DOTATATE + [177Lu]Lu-DOTATATE with an activity of 3.7 GBq (50 mCi + 50 mCi). In the assessment of early as well as long-term complications, no significant effect of the applied treatment on the parameters of liver injury was found. Regarding liver function PRRT was a safe treatment for patients with highly or moderately differentiated, unresectable, or diffuse NENs.</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":" ","pages":"54-61"},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39764934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The scintigraphic diagnosis of cardiac amyloidosis. An expert opinion endorsed by the Section of Nuclear Medicine of the Polish Cardiac Society and the Polish Nuclear Medicine Society.","authors":"Katarzyna Holcman,&nbsp;Miroslaw Dziuk,&nbsp;Jacek Grzybowski,&nbsp;Anna Teresinska,&nbsp;Bogdan Malkowski,&nbsp;Diana Jedrzejuk,&nbsp;Bogna Brockhuis,&nbsp;Rafał Czepczynski,&nbsp;Lidia Tomkiewicz-Pajak,&nbsp;Magdalena Kostkiewicz","doi":"10.5603/NMR.a2022.0033","DOIUrl":"https://doi.org/10.5603/NMR.a2022.0033","url":null,"abstract":"<p><p>Amyloid transthyretin cardiomyopathy is a progressive disease that confers significant mortality. While it is relatively rare, the frequency of diagnoses has risen with the increased contribution of novel diagnostic approach over the last decade. Traditionally tissue biopsy was considered to be a gold standard for amyloidosis diagnosis. However, there are significant limitations in the wide application of this approach. A noninvasive imaging-based diagnostic algorithm has been substantially developed in recent years. Establishing radionuclide imaging standards may translate into a further enhancement of disease detection and improving prognosis in the group of patients. Therefore we present in the following document current evidence on the scintigraphic diagnosis of cardiac transthyretin amyloidosis. Moreover, we present standardized protocol for the acquisition and interpretation criteria in the scintigraphic evaluation of cardiac amyloidosis.</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":" ","pages":"142-147"},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40695339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid bone SPECT/CT reveals spleen calcification in sickle cell mutation and beta-thalassemia.","authors":"Konstantinos Sakellariou,&nbsp;Sofia Charalampidou,&nbsp;Andreas Fotopoulos,&nbsp;Chrissa Sioka","doi":"10.5603/NMR.a2021.0015","DOIUrl":"https://doi.org/10.5603/NMR.a2021.0015","url":null,"abstract":"<p><p>We present a case of a 65 years-old male with sickle cell mutation and beta-thalassemia (Hb S/β-Thal), who had whole-body bone scan evaluation for osteomyelitis. The examination revealed high radiopharmaceutical uptake in the left abdomen. Further evaluation with hybrid single photon emission computed tomography/computed tomography (SPECT/CT) showed calcification of approximately the entire spleen, in the context of sickle cell anemia. This report highlights the role of SPECT/CT in such cases.</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":" ","pages":"70-71"},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39764939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}