Nuclear medicine review. Central & Eastern Europe最新文献

{"title":"Hepatic complications of peptide receptor radionuclide therapy with Lutetium-177 and Yttrium-90 in patients with neuroendocrine neoplasm.","authors":"Barbara Bober,&nbsp;Marek Saracyn,&nbsp;Arkadiusz Lubas,&nbsp;Maciej Kolodziej,&nbsp;Dorota Brodowska-Kania,&nbsp;Waldemar Kapusta,&nbsp;Grzegorz Kaminski","doi":"10.5603/NMR.a2022.0016","DOIUrl":"https://doi.org/10.5603/NMR.a2022.0016","url":null,"abstract":"<p><p>Neuroendocrine neoplasms (NENs) are a heterogeneous group of tumors originating from neuroendocrine cells spread throughout the body, forming the so-called diffuse endocrine system. The gold standard in treating unresectable or disseminated, progressive, and well-differentiated NENs is therapy with radiolabeled somatostatin analogs (peptide receptor radionuclide therapy - PRRT). PRRT is a method based on peptides combined with beta-emitting radionuclides. The study aimed to assess the early and long-term liver complications after administration of Lutetium-177 or Lutetium-177 combined with Yttrium-90. We enrolled 27 patients treated with [177Lu]Lu-DOTATATE with an activity of 7.4 GBq (200 mCi) and 9 patients received the tandem treatment [90Y]Y-DOTATATE + [177Lu]Lu-DOTATATE with an activity of 3.7 GBq (50 mCi + 50 mCi). In the assessment of early as well as long-term complications, no significant effect of the applied treatment on the parameters of liver injury was found. Regarding liver function PRRT was a safe treatment for patients with highly or moderately differentiated, unresectable, or diffuse NENs.</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":" ","pages":"54-61"},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39764934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The scintigraphic diagnosis of cardiac amyloidosis. An expert opinion endorsed by the Section of Nuclear Medicine of the Polish Cardiac Society and the Polish Nuclear Medicine Society.","authors":"Katarzyna Holcman,&nbsp;Miroslaw Dziuk,&nbsp;Jacek Grzybowski,&nbsp;Anna Teresinska,&nbsp;Bogdan Malkowski,&nbsp;Diana Jedrzejuk,&nbsp;Bogna Brockhuis,&nbsp;Rafał Czepczynski,&nbsp;Lidia Tomkiewicz-Pajak,&nbsp;Magdalena Kostkiewicz","doi":"10.5603/NMR.a2022.0033","DOIUrl":"https://doi.org/10.5603/NMR.a2022.0033","url":null,"abstract":"<p><p>Amyloid transthyretin cardiomyopathy is a progressive disease that confers significant mortality. While it is relatively rare, the frequency of diagnoses has risen with the increased contribution of novel diagnostic approach over the last decade. Traditionally tissue biopsy was considered to be a gold standard for amyloidosis diagnosis. However, there are significant limitations in the wide application of this approach. A noninvasive imaging-based diagnostic algorithm has been substantially developed in recent years. Establishing radionuclide imaging standards may translate into a further enhancement of disease detection and improving prognosis in the group of patients. Therefore we present in the following document current evidence on the scintigraphic diagnosis of cardiac transthyretin amyloidosis. Moreover, we present standardized protocol for the acquisition and interpretation criteria in the scintigraphic evaluation of cardiac amyloidosis.</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":" ","pages":"142-147"},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40695339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid bone SPECT/CT reveals spleen calcification in sickle cell mutation and beta-thalassemia.","authors":"Konstantinos Sakellariou,&nbsp;Sofia Charalampidou,&nbsp;Andreas Fotopoulos,&nbsp;Chrissa Sioka","doi":"10.5603/NMR.a2021.0015","DOIUrl":"https://doi.org/10.5603/NMR.a2021.0015","url":null,"abstract":"<p><p>We present a case of a 65 years-old male with sickle cell mutation and beta-thalassemia (Hb S/β-Thal), who had whole-body bone scan evaluation for osteomyelitis. The examination revealed high radiopharmaceutical uptake in the left abdomen. Further evaluation with hybrid single photon emission computed tomography/computed tomography (SPECT/CT) showed calcification of approximately the entire spleen, in the context of sickle cell anemia. This report highlights the role of SPECT/CT in such cases.</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":" ","pages":"70-71"},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39764939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased physiological [18F]FDG uptake in the liver and blood pool among patients with impaired renal function.","authors":"Yoichi Otomi,&nbsp;Yuta Arai,&nbsp;Maki Otomo,&nbsp;Saho Irahara,&nbsp;Kaori Terazawa,&nbsp;Michiko Kubo,&nbsp;Takashi Abe,&nbsp;Takayoshi Shinya,&nbsp;Hideki Otsuka,&nbsp;Masafumi Harada","doi":"10.5603/NMR.a2022.0021","DOIUrl":"https://doi.org/10.5603/NMR.a2022.0021","url":null,"abstract":"<p><strong>Background: </strong>In the daily clinical course, the liver uptake may seem to be increased in patients with renal failure. The purpose of this study was to investigate whether or not the FDG uptake of the liver, and the FDG uptake of blood pool which is generally used as a reference site as well as liver, is increased in patients with renal failure.</p><p><strong>Material and methods: </strong>We retrospectively analyzed 233 patients who underwent FDG positron emission tomography/computed tomography (PET/CT). Renal failure is defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2. We compared the FDG uptake in the liver and mediastinal blood pool of 67 patients with impaired renal function to that in 166 patients with a normal renal function (eGFR ≥ 60 mL/min/1.73 m2). Correlations between the liver or mediastinal blood pool FDG uptake and the eGFR were also analyzed by Spearman's correlation test.</p><p><strong>Results: </strong>Maximum and mean standardized uptake values (SUVmax and SUVmean, respectively) of the liver and the SUVmean of the mediastinal blood pool were 3.48 ± 0.57, 2.56 ± 0.37, and 1.90 ± 0.28 in the impaired renal function group, respectively, and 3.13 ± 0.45, 2.29 ± 0.33, and 1.66 ± 0.23, in the normal group, respectively. The SUVmax and SUVmean of the liver and SUVmean of the mediastinal blood pool in the impaired renal function group were significantly higher than those in the normal group (p < 0.001, < 0.001, and < 0.001, respectively). The SUVmax and SUVmean of the liver and SUVmean of the mediastinal blood pool of patients showed a significant negative correlation with the eGFR (Spearman's p = -0.25, -0.30, and -0.40, respectively, each p < 0.001).</p><p><strong>Conclusions: </strong>FDG uptake in both the liver and mediastinal blood pool was higher in patients with impaired renal function.</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":" ","pages":"95-100"},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40515963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal activity of [18F]FDG for Hodgkin lymphoma imaging performed on PET/CT camera with BGO crystals.","authors":"Miroslaw Dziuk,&nbsp;Ewa Witkowska-Patena,&nbsp;Agnieszka Gizewska,&nbsp;Andrzej Mazurek,&nbsp;Anna Pieczonka,&nbsp;Magdalena Koza,&nbsp;Marina Gerszewska,&nbsp;Zbigniew Podgajny,&nbsp;Marta Chojnowska","doi":"10.5603/NMR.a2022.0009","DOIUrl":"https://doi.org/10.5603/NMR.a2022.0009","url":null,"abstract":"<p><strong>Background: </strong>We aimed to find the minimum feasible activity of fluorodeoxyglucose ([18F]FDG) in positron emission tomography/computed tomography (PET/CT) of Hodgkin lymphoma patients performed on a camera with bismuth germanate (BGO) crystals.</p><p><strong>Material and methods: </strong>Ninety-one [18F]FDG PET/CT scans (each in seven Bayesian Penalized Likelihood [BPL] reconstructions with varying acquisition time per bed position - 2 min, 1.5 min, 1 min, 50 s, 40 s, 30 s, and 20 s) were independently assessed by three physicians to evaluate image quality. Mean administered activity was 3.0 ± 0.1 MBq/kg and mean uptake time was 54.0 ± 8.7 min. The series quality was subjectively marked on a 1-10 scale and then ranked 1-7 based on the mean mark. Interobserver rank correlation and intraclass correlation within each series for the three observers were calculated. Phantom studies were also performed to determine if reduced acquisition time can be directly translated into a reduced activity.</p><p><strong>Results: </strong>Time series were marked and ranked unanimously - the longer the time of acquisition the higher the mark and rank. The interobserver agreement in the ranking was excellent (100%) with a kappa coefficient of 1.00 (95% CI [0.83-1.0]). The general intraclass correlation coefficient (agreement between the marks observers gave each time series) was very high (0.945, 95% CI [0.936-0.952]) and was higher the shorter the time per bed. According to all three observers only the series with 2 min and 1.5 min acquisition time were appropriate for assessment (mean mark ≥ 7). In phantom studies there was a linear correlation between time per bed, administered activity, and number of total prompts detected by a scanner. Hence, a reduction of acquisition time of 25% (from 2 min to 1.5 min) could be directly translated into a 25% activity reduction (from 3.0 to 2.25 MBq/kg).</p><p><strong>Conclusions: </strong>In patients with HL, [18F]FDG activity can be reduced by up to 25% when using a BGO crystal camera, without substantial impact on image quality.</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":" ","pages":"47-53"},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39902630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of [18F]FDG PET activity with expressions of Ki-67 in non-small-cell lung cancer.","authors":"Ilknur Kucukosmanoglu,&nbsp;Meryem Ilkay Eren Karanis,&nbsp;Yasar Unlu,&nbsp;Mustafa Erol","doi":"10.5603/NMR.a2022.0017","DOIUrl":"https://doi.org/10.5603/NMR.a2022.0017","url":null,"abstract":"<p><strong>Background: </strong>Lung carcinoma is the most commonly diagnosed cancer throughout the world and is the leading cause of cancer-related deaths. Non-small cell lung cancer (NSCLC) accounts for up to 80% of newly diagnosed lung cancer cases. This study aimed to investigate the relationship between Ki-67 proliferation index (PI) and the maximum standardized uptake value (SUVmax) obtained from [18F]FDG PET/CT in NSCLCs and whether prognosis was predicted with SUVmax values.</p><p><strong>Material and methods: </strong>This retrospective study included biopsy and resection materials of 41 patients, who were examined in the pathology laboratory of Konya Training and Research Hospital between January 2010 and December 2019, and diagnosed with NSCLC, and whose [18F]FDG PET/CT images were present.</p><p><strong>Results: </strong>There was no significant difference between histopathological subtypes in terms of age (p = 0.077), Ki-67 PI (p = 0.454), and SUVmax (p = 0.143). No correlation was observed between Ki-67 PI and SUVmax values obtained from [18F]FDG PET/CT (p = 0.338, r = 0.153). There was no significant correlation between Ki-67 PI and tumor diameter (p = 0.531). The SUVmax value was found to be lower (12.78 ± 6.14) in tumors measuring ≤ 2.5 in diameter and higher (18.46 ± 7.81) in tumors measuring > 2.5 cm (p = 0.027). Metastases not proven histopathologically but detected in [18F]FDG PET/CT were found to have no significant correlation with Ki-67 and SUVmax values (p = 0.881, p = 0.837).</p><p><strong>Conclusions: </strong>This study showed that there was no significant relationship between Ki-67 PI and SUVmax value obtained from [18F]FDG PET/CT in NSCLC tumors.</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":" ","pages":"73-77"},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40335672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 4.000 € way to improve perceived quality and meet expectations of thyroid cancer patients receiving therapeutic dose of Iodine-131.","authors":"Evanthia Giannoula,&nbsp;Christos Melidis,&nbsp;Nikitas Papadopoulos,&nbsp;Panagiotis Bamidis,&nbsp;Vasilios Raftopoulos,&nbsp;Vasiliki Chatzipavlidou,&nbsp;Ioannis Iakovou","doi":"10.5603/NMR.a2022.0031","DOIUrl":"https://doi.org/10.5603/NMR.a2022.0031","url":null,"abstract":"<p><strong>Background: </strong>Thyroid cancer is the most common malignant disease of the endocrine system and radioiodine therapy (RAIT) is still very often used, resulting in patients staying hospitalized for a few days alone and without visitors, augmenting their stress and discomfort. Our objective was to find simple ways of improving RAIT patients' feelings and perceived quality of the nuclear medicine (NM) department services.</p><p><strong>Material and methods: </strong>We designed a two-year study in order to enhance RAIT patients' perceived quality of the nuclear medicine (NM) department services and expectations' fulfillment. A questionnaire was used in order to capture patients' perceived quality and expectations from their RAIT.</p><p><strong>Results: </strong>549 replies were collected. Many intrinsic and extrinsic determinants were found to be positively or negatively related to the perceived quality and fulfillment of patients' expectations of receiving RAIT. A 1% increase could be achieved by spending 110 € per RAIT room.</p><p><strong>Conclusions: </strong>In this article, we present some easily implemented changes in both personnel behavior and room amenities that could, at least in theory and based on our results, offer a 37.9% improvement in RAIT patients' perceived quality and expectations' fulfillment at a cost of 4169 €.</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":" ","pages":"138-140"},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40335673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare osteoarticular complications on [18F]FDG-PET/CT - following intravesical BCG immunotherapy for bladder cancer.","authors":"Jan-Henning Schierz,&nbsp;Anke McLeod,&nbsp;Farzana Ali","doi":"10.5603/NMR.a2022.0014","DOIUrl":"https://doi.org/10.5603/NMR.a2022.0014","url":null,"abstract":"<p><p>This case illustrates rare osteoarticular complications of Bacillus Calmette-Guérin (BCG) immunotherapy in a 55-year-old male with high-risk non-muscle-invasive bladder cancer (NMIBC). The patient was referred for 18F-fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) to rule out bone metastases suspected on prior post-gadolinium magnetic resonance imaging (MRI). Although metastases were excluded, nearly symmetrical uptakes were detected in the costovertebral and costotransverse joints. Medical history revealed that the patient had been receiving intravesical instillations of BCG, the first-line therapy for high-risk NMIBC. The patient was diagnosed with reactive arthritis (ReA), a rare autoimmune complication of BCG, that was successfully treated with a nonsteroidal anti-inflammatory drug (NSAID).</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":" ","pages":"68-69"},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39764938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amino acid extravasation: a rare red flag to keep in mind during peptide receptor radioligand therapy (PRRT) with [177Lu]Lu-DOTATATE.","authors":"Ghasemali Divband,&nbsp;Seyed Hootan Alavi,&nbsp;Zohre Adinehpour,&nbsp;Forough Kalantari,&nbsp;Soroush Zarehparvar Moghadam","doi":"10.5603/NMR.a2022.0030","DOIUrl":"https://doi.org/10.5603/NMR.a2022.0030","url":null,"abstract":"<p><p>A 64 years-old woman with intestinal neuroendocrine tumor (NET) and multiple liver metastases was referred for peptide receptor radioligand therapy (PRRT) with [177Lu]Lu-DOTATATE. A few days after the third cycle of PRRT, erythema and swelling in the injection site is occurred which progressed up to one-month post-therapy. The cutaneous lesion was managed by a plastic surgeon with topical treatment. Amino acid extravasation could have devastating effects and should always be considered in patients who underwent PRRT and who receive amino acids for nephroprotection.</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":" ","pages":"136-137"},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40603833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative detection of sentinel lymph node in patients with endometrial cancer - comparison of planar lymphoscintigraphy, spect and SPECT/CT.","authors":"Anamarija Jankulovska,&nbsp;Bojana Stoilovska Rizova,&nbsp;Nikolina Bozhinovska,&nbsp;Aleksandra Peshevska,&nbsp;Mile Tanturovski,&nbsp;Igor Aluloski,&nbsp;Sasho Stojcevski,&nbsp;Nevena Manevska,&nbsp;Sinisa Stojanoski,&nbsp;Daniela Miladinova","doi":"10.5603/NMR.a2022.0022","DOIUrl":"https://doi.org/10.5603/NMR.a2022.0022","url":null,"abstract":"<p><strong>Background: </strong>Sentinel lymph node (SLN) mapping allows minimal invasive assessment of lymph node status in patients with early-stage endometrial cancer (EC). Intraoperative detection of SLNs is based on the results obtained from preoperative nuclear medical images. The purpose of this study was to compare the data obtained from planar lymphoscintigraphy (PL), single-photon emission computed tomography (SPECT), and SPECT with computed tomography (SPECT/CT) for preoperative SLN detection in patients with EC.</p><p><strong>Material and methods: </strong>A total of 44 images in 22 patients with early-stage EC (22 PL, 9 SPECT and 13 SPECT/CT) were analyzed. The scans were performed in the period 2018-2020 at the Institute of Pathophysiology and Nuclear Medicine in Skopje. Thirteen patients underwent PL and SPECT/CT and nine patients underwent PL and SPECT after cervical injection of 4 mCi 99mTc-SENTI-SCINT on the day of surgery. Descriptive statistics, Wilcoxon Matched Pairs Test, and Spearman rank R coefficient were used for data analyses.</p><p><strong>Results: </strong>Twenty-two patients with mean age of 61.1 ± 7.5 and body mass index (BMI) 34.62 ± 6.4 kg/m2 were included in the study. In four patients (18.2%) SLN was not detected on PL. Detection rate on SPECT and SPECT/CT was 100%. The average number of detected SLN was 1.4 ± 1.05, 2.2 ± 1.1 и 2.15 ± 1.1 on PL, SPECT and SPECT/CT respectively. We found a statistically significant difference in the number of detected SLNs on PL vs SPECT/CT (p = 0.0077). The most common SLN location on SPECT/CT was the right internal iliac followed by the left common iliac region.</p><p><strong>Conclusions: </strong>The results of the presented study indicate a higher diagnostic value of SPECT/CT in terms of SLN detection and exact anatomic localization as compared to planar lymphoscintigraphy (PL).</p>","PeriodicalId":520725,"journal":{"name":"Nuclear medicine review. Central & Eastern Europe","volume":" ","pages":"101-104"},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40672307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}