Utility of [18F]FDG PET/CT in sarcoidosis management: A retrospective case series.

IF 0.7
Mourad Zekri, Majdouline Bel Lakhdar, Dounia Alami, Soumia Kriouile, Leila Achachi, Abdellah Achir, Hicham Harmouche, Ayat Mouaden, Hasnae Guerrouj, Imad Ghfir
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Abstract

Background: Sarcoidosis is a granulomatosis of variable manifestation and evolution. It is crucial to assess the disease's extent, activity, and severity to effectively manage and monitor patients with sarcoidosis. Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) is a nuclear medicine technique that proved to be of great use in oncology. Its role in extra-oncological indications, including sarcoidosis, has been reported.

Material and methods: Twenty-five patients with sarcoidosis were retrospectively included. All patients underwent at least one [18F]FDG PET/CT scan. Five patients underwent a second [18F]FDG PET/CT to assess their response to corticosteroid treatment. Clinical data were gathered from medical records. Radiological and PET data were obtained from reports and digital imaging and communications in medicine (DICOM) archives.

Results: [18F]FDG PET/CT revealed active inflammation in 76% of patients. All had intrathoracic activity, including 76% mediastinal and 44% pulmonary lesions. Additionally, 60% of patients displayed associated extrathoracic activity, mainly in peripheral lymph nodes, spleen, and bone. Cardiac activity was reported in two patients. [18F]FDG PET/CT prompted a diagnostic biopsy in 32% of patients. [18F]FDG PET/CT had an impact on therapeutic decision-making in 60% of patients. Follow-up [18F]FDG PET/CT showed a complete metabolic response in two cases and an incomplete metabolic response in one patient. Disease progression was noted in two patients.

Conclusions: Providing a complete functional map of the extent of inflammatory active disease, [18F]FDG PET/CT proves to be particularly useful in the management of sarcoidosis patients, by explaining persistent disabling symptoms, revealing suitable sites for biopsy, guiding therapeutic decisions and assessing treatment response.

[18F]FDG PET/CT在结节病治疗中的应用:回顾性病例系列。
背景:结节病是一种表现和发展变化多端的肉芽肿病。评估结节病的范围、活动性和严重程度是有效管理和监测结节病患者的关键。氟-18氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描([18F]FDG PET/CT)是一种核医学技术,被证明在肿瘤学中有很大的应用。它在肿瘤外适应症(包括结节病)中的作用已被报道。材料和方法:回顾性分析25例结节病患者。所有患者均接受了至少一次[18F]FDG PET/CT扫描。5例患者接受了第二次[18F]FDG PET/CT检查,以评估他们对皮质类固醇治疗的反应。从医疗记录中收集临床数据。放射学和PET数据来自报告和医学数字成像和通信(DICOM)档案。结果:[18F]FDG PET/CT显示76%的患者有活动性炎症。所有患者均有胸内活动,包括76%的纵隔病变和44%的肺部病变。此外,60%的患者表现出相关的胸外活动,主要表现在周围淋巴结、脾脏和骨骼。2例患者报告心脏活动。[18F] 32%的患者行FDG PET/CT活检诊断。[18F]FDG PET/CT对60%患者的治疗决策有影响。随访[18F]FDG PET/CT显示2例完全代谢缓解,1例不完全代谢缓解。2例患者出现疾病进展。结论:FDG PET/CT提供了炎性活动性疾病范围的完整功能图谱[18F],通过解释持续致残症状,揭示活检的合适部位,指导治疗决策和评估治疗反应,在结节病患者的治疗中被证明特别有用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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