Spectacular effect of [177Lu]Lu-PSMA-617 therapy in a patient with hormone-resistant prostate cancer after failure of other therapeutic options.

IF 0.7
Katarzyna Barańska, Katarzyna Niemas, Marta Wojewódzka-Mirocha, Jacek Kabat, Marek Dedecjus
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Abstract

This research presents the case of a 72-year-old patient with a long history of high-grade prostate cancer (Gleason 8), previously treated with radiotherapy, hormone therapy, and chemotherapy. Due to persistent disease progression and widespread metastases, the patient was enrolled in [177Lu]Lu-PSMA-617 therapy under the Rescue Drug Therapy Access (RDTL) program. Six therapeutic cycles were administered, resulting in marked clinical improvement and a decline in prostate-specific antigen (PSA) levels from 1128.00 ng/mL to 1.68 ng/mL. Positron emission tomography/computed tomography (PET/CT) imaging using [68Ga] Ga-PSMA-11 demonstrated a favorable treatment response, with no significant adverse effects. This case highlights the potential of a theranostic approach in oncology.

[177Lu]Lu-PSMA-617治疗激素抵抗性前列腺癌患者在其他治疗方案失败后的惊人效果。
本研究报告一位72岁的高级别前列腺癌患者(Gleason 8),既往接受放疗、激素治疗和化疗。由于持续的疾病进展和广泛的转移,该患者被纳入救援药物治疗准入(RDTL)计划下的[177Lu]Lu-PSMA-617治疗。6个治疗周期后,患者临床显著改善,前列腺特异性抗原(PSA)水平从1128.00 ng/mL降至1.68 ng/mL。使用[68Ga] Ga-PSMA-11进行正电子发射断层扫描/计算机断层扫描(PET/CT)成像显示出良好的治疗效果,没有明显的不良反应。这个病例强调了肿瘤治疗方法的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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