Neurosciences (Riyadh, Saudi Arabia)最新文献_第8页

A novel primary culture method for rat choroidal epithelial cells. 一种新的大鼠脉络膜上皮细胞原代培养方法。

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Neurosciences (Riyadh, Saudi Arabia) Pub Date : 2013-01-01

Sheng-Li Huang, Xi-Jing He, Zong-Fang Li, Lu Yao, Wei Shi

{"title":"A novel primary culture method for rat choroidal epithelial cells.","authors":"Sheng-Li Huang, Xi-Jing He, Zong-Fang Li, Lu Yao, Wei Shi","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To establish a method for the culture of primary choroidal epithelial cells.Methods: This descriptive experimental study was carried out in Xi`an Jiaotong University, Xi`an, China from September 2009 to August 2012. Choroidal epithelial cells were isolated from the choroid plexus tissues of the lateral ventricles from neonatal rats (n=36). The tissues were dissociated into small cell aggregates by a mechanical method, and cultured on plastic culture dishes containing Dulbecco`s modified Eagle`s medium with 10% fetal bovine serum and 10 ng/ml epidermal growth factor at 37 degrees C in an incubator with 5% humidified carbon dioxide. The cultured cells were examined by phase contrast microscope, electron microscopy, and immunocytochemistry.Results: The cells showed typical morphologic characteristics of epithelial phenotypes with a cobblestone appearance in monolayer 7-9 days post-seeding. The electron microscopy spotted typical choroidal epithelial cells with microvilli on the cytomembrane, organelles in the cytoplasm, and tight junctions welding 2 adjacent cells. They were positive against anti-transthyretin immunostaining.Conclusion: This culture technique, which does not require complex equipment and operation skills, might be a simple and efficient method for obtaining choroidal epithelial cells in sufficient number and purity from mixed primary cultures of rat tissue.","PeriodicalId":520723,"journal":{"name":"Neurosciences (Riyadh, Saudi Arabia)","volume":" ","pages":"27-32"},"PeriodicalIF":0.9,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40212065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal magnetic resonance imaging in the diagnosis and therapeutical follow-up of brain tumors. 多模态磁共振成像在脑肿瘤诊断及治疗随访中的应用。

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Neurosciences (Riyadh, Saudi Arabia) Pub Date : 2013-01-01

Abdelkhalek Housni, Saïd Boujraf

引用次数: 0

Dravet syndrome, what is new? 德拉韦综合征，有什么新发现吗?

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Neurosciences (Riyadh, Saudi Arabia) Pub Date : 2013-01-01

Raidah S Al-Baradie

引用次数: 0

Magnetic resonance imaging mesencephalic tectum dimensions according to age and gender. 根据年龄和性别磁共振成像中脑顶盖尺寸。

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Neurosciences (Riyadh, Saudi Arabia) Pub Date : 2013-01-01

Vedat Sabanciogullari, Ismail Salk, Hatice Balaban, Ibrahim Oztoprak, Seref Kelkit, Mehmet Cimen

{"title":"Magnetic resonance imaging mesencephalic tectum dimensions according to age and gender.","authors":"Vedat Sabanciogullari, Ismail Salk, Hatice Balaban, Ibrahim Oztoprak, Seref Kelkit, Mehmet Cimen","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To analyze and classify normal MRI tectum length and colliculus dimensions according to age and gender.Methods: Tectum length and colliculus diameters were measured on the T1 midsagittal and axial cranial MR images in the radiology archive of 532 (344 women, 188 men) patients aged 37.36+/-21.49 (range: 4-91) years old on average, and with no disorders affecting the mesencephalic tectum. All 532 patients underwent clinical MR imaging of the cranium at the MRI Unit of Sivas Numune Hospital and Sivas Cumhuriyet University Hospital, Sivas, Turkey between February and December 2011.Results: Although there was a positive linear correlation between tectum length and age, there was a negative correlation between the anteroposterior diameter of the colliculus superior and colliculus inferior and age (p<0.01). While tectum length (M3) increases with age, the anteroposterior diameter of the colliculus superior and inferior (M1 and M2) decreased (p<0.01). The colliculi were larger, and the tectum was longer in men. Although there was no difference in size between right and left superior colliculi, the left colliculus inferior was larger than the right one.Conclusion: In addition to the fact that normal mesencephalic tectum dimensions provide information on the brain development of individuals, they may also be beneficial for the detection and treatment of related pathologies.","PeriodicalId":520723,"journal":{"name":"Neurosciences (Riyadh, Saudi Arabia)","volume":" ","pages":"33-9"},"PeriodicalIF":0.9,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40214054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Depression and anxiety among parents and caregivers of autistic spectral disorder children. 自闭症谱系障碍儿童家长和照顾者的抑郁和焦虑。

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Neurosciences (Riyadh, Saudi Arabia) Pub Date : 2013-01-01

Mohammed A Almansour, Mohammed A Alateeq, Mansour K Alzahrani, Metab A Algeffari, Homaidan T Alhomaidan

{"title":"Depression and anxiety among parents and caregivers of autistic spectral disorder children.","authors":"Mohammed A Almansour, Mohammed A Alateeq, Mansour K Alzahrani, Metab A Algeffari, Homaidan T Alhomaidan","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To evaluate the presence of depression and anxiety in parents/caregivers of autistic spectral disorder (ASD) children, and to identify associated factors.Methods: In this retrospective cohort study carried out between July and December 2011, parents/caregivers of at least one child diagnosed with an ASD (cases group), were recruited through the Saudi Charitable Society of Autism Families and the Autism Clinic in the Pediatric out-patient clinic in King Fahad National Guard Hospital, King Abdulaziz Medical City (KAMC), Riyadh, Kingdom of Saudi Arabia. The parents/caregivers of a normally developed child (control group) were recruited from the Well Child Clinic at King Abdulaziz Medical City, Riyadh. We used a self-reported questionnaire containing questions on demographic data, as well as the Arabic version of the hospital anxiety and depression scale.Results: The study included 100 parents/caregivers, 50 cases and 50 controls. More than 50% of the control group was in the age group 26-30 years (56%), while 42% of cases were in the age group 31-35 years. Time lapsed since autism diagnosis was over 3 years in one-third of cases. Twenty-two percent of cases, and only 2% of control parents/caregivers had a history of psychiatric problems (p=0.002). Both the mean depression score, and the mean anxiety score was significantly higher among cases when compared with controls, p<0.001.Conclusion: Autism is associated with burden and stress for parents/caregivers of the affected child. The demands placed by the disability contribute to a higher overall incidence of depression and anxiety among parents/caregivers.","PeriodicalId":520723,"journal":{"name":"Neurosciences (Riyadh, Saudi Arabia)","volume":" ","pages":"58-63"},"PeriodicalIF":0.9,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40214058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of paradoxical insomnia with atypical antipsychotic drugs. A comparison of olanzapine and risperidone. 非典型抗精神病药物治疗悖论性失眠症。奥氮平与利培酮的比较。

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Neurosciences (Riyadh, Saudi Arabia) Pub Date : 2013-01-01

Habibolah Khazaie, Leeba Rezaie, Freshteh Darvishi, Farid Najafi, Kristin Avis

{"title":"Treatment of paradoxical insomnia with atypical antipsychotic drugs. A comparison of olanzapine and risperidone.","authors":"Habibolah Khazaie, Leeba Rezaie, Freshteh Darvishi, Farid Najafi, Kristin Avis","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To compare the efficacy of 2 atypical anti-psychotic drugs, olanzapine and risperidone, in the treatment of paradoxical insomnia.Methods: In this cross-sectional study over a 2-year period (September 2008 to September 2010), 29 patients with paradoxical insomnia, diagnosed in Kermanshah, Iran by both psychiatric interview and actigraphy, were randomly assigned to 2 groups. For 8 weeks, the first group (n=14) was treated with 10 mg olanzapine daily, and the second group (n=15) was treated with 4 mg risperidone daily. All participants completed the Pittsburgh Sleep Quality Inventory (PSQI) at baseline and at the end of the study.Results: As expected, a baseline actigraphy analysis showed that total sleep time was not significantly different between the 2 treatment groups (p<0.3). In both groups, sleep quality was improved (p<0.001) with treatment. When comparing the 2 treatments directions, a significant difference emerged (9.21+/-2.35, 6.07+/-4.46) among the 2 treatment groups based on data from the PSQI. Patients who were treated with olanzapine showed greater improvement than patients who were treated by risperidone (p<0.04).Conclusion: Atypical anti-psychotic drugs such as olanzapine and risperidone may be beneficial options for treatment of paradoxical insomnia. Larger clinical trials with longer periods of follow-up are needed for further investigation.","PeriodicalId":520723,"journal":{"name":"Neurosciences (Riyadh, Saudi Arabia)","volume":" ","pages":"64-9"},"PeriodicalIF":0.9,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40214059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seizure and skin lesions. 癫痫和皮肤损伤。

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Neurosciences (Riyadh, Saudi Arabia) Pub Date : 2013-01-01

Ramachandiran Nandhagopal

引用次数: 0

Induced hypothermia to treat neonatal hypoxic-ischemic encephalopathy. Review of literature with meta-analysis and development of national protocol. 诱导低温治疗新生儿缺氧缺血性脑病。文献综述与荟萃分析和国家方案的发展。

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Neurosciences (Riyadh, Saudi Arabia) Pub Date : 2013-01-01

Turki M Alkharfy

引用次数: 0

Effects of exposure to lead on the peripheral motor system of the rat. An ultrastructural study. 铅暴露对大鼠外周运动系统的影响。超微结构研究。