诱导低温治疗新生儿缺氧缺血性脑病。文献综述与荟萃分析和国家方案的发展。

Neurosciences (Riyadh, Saudi Arabia) Pub Date : 2013-01-01
Turki M Alkharfy
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引用次数: 0

摘要

6项多中心随机对照试验评价了诱导低温治疗足月婴儿缺氧缺血性脑病(HIE)的疗效。这些试验的荟萃分析显示,中重度HIE后6小时内的低温降低了18个月大时死亡或神经功能损伤的风险;风险比(RR): 0.81(95%可信区间[CI]: 0.71 ~ 0.93, p=0.002);风险差异-0.11 (95% CI: -0.18至-0.04),需要治疗的人数为9 (95% CI: 5-25)。它还表明,低温治疗与完整存活率的增加有关;RR: 1.53 (95% CI: 1.22-1.93, p
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Induced hypothermia to treat neonatal hypoxic-ischemic encephalopathy. Review of literature with meta-analysis and development of national protocol.

The efficacy of induced hypothermia to treat hypoxic-ischemic encephalopathy (HIE) in term infants has been evaluated in 6 multicenter randomized controlled trials. Meta-analysis of these trials shows that hypothermia in the first 6 hours after moderately severe HIE reduced the risk rate of death or neurological impairment at 18 months of age; risk ratio (RR): 0.81 (95% confidence interval [CI]: 0.71 to 0.93, p=0.002); risk difference -0.11 (95% CI: -0.18 to -0.04), with a number needed to treat of 9 (95% CI: 5-25). It also showed that treatment with hypothermia was associated with an increased rate of intact survival; RR: 1.53 (95% CI: 1.22-1.93, p<0.001); risk difference: 0.12 (95% CI: 0.06-0.18), with a number need to treat of 8 (95% CI: 5-17). We developed a national protocol using a simplified method of cooling. This protocol will hopefully lead to a widespread implementation of induced hypothermia in different settings within Saudi Arabia.

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