Medical principles and practice : international journal of the Kuwait University, Health Science Centre最新文献

Clinical efficacy of silver fluoride pretreatment on hypersensitivity relief and success of glass hybrid restorations in MIH-affected molars: A randomized controlled split-mouth clinical trial. 氟化银预处理对mih牙磨牙超敏反应缓解及玻璃杂化修复成功的临床疗效：一项随机对照裂口临床试验

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-10-17 DOI: 10.1159/mpp/adpag036

Betul Sen Yavuz, Afra Nur Savas, Ceyda Ipek Isseven, Ecem Akbeyaz Sivet, Basak Durmus, Betul Kargul

{"title":"Clinical efficacy of silver fluoride pretreatment on hypersensitivity relief and success of glass hybrid restorations in MIH-affected molars: A randomized controlled split-mouth clinical trial.","authors":"Betul Sen Yavuz, Afra Nur Savas, Ceyda Ipek Isseven, Ecem Akbeyaz Sivet, Basak Durmus, Betul Kargul","doi":"10.1159/mpp/adpag036","DOIUrl":"https://doi.org/10.1159/mpp/adpag036","url":null,"abstract":"Objectives: Managing hypersensitivity in molar incisor hypomineralization (MIH)-affected first permanent molars (FPMs) remains challenging. Silver fluoride (SF) combined with potassium iodide (KI) has been suggested to reduce sensitivity and improve clinical outcomes. This study aimed to evaluate whether the application of SF+KI prior to glass hybrid (GH) restorations provides additional benefit in reducing hypersensitivity and improving clinical performance in MIH-affected FPMs.Methods: This randomized split-mouth clinical trial included 34 children (8-13 years) with MIH-affected FPMs. A total of 82 FPMs were allocated to SF+KI+GH or GH alone. Hypersensitivity was assessed using the \"Schiff Cold Air Sensitivity Scale\" at baseline and at 1, 3, 6, and 12 months. Clinical performance was evaluated using modified USPHS criteria.Results: Hypersensitivity decreased markedly in both groups after treatment and remained minimal throughout follow-up, with no significant differences between groups (p>0.05). At 12 months, 90.6% (29/32) of the SF+KI+GH and 93.9% (31/33) of the GH restorations were clinically acceptable; three restorations in the SF+KI+GH group and two in the GH group were classified as unsatisfactory, with survival probabilities of 89.8% and 93.9%, respectively.Conclusion: Both protocols effectively reduced hypersensitivity and showed acceptable short-term clinical performance. SF+KI pretreatment did not provide additional benefit over GH alone within 12 months.","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"1"},"PeriodicalIF":2.2,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to Letter to the Editor: Evaluating the Predictive Value of the Endothelial Activation and Stress Index in Determining the Severity and Prognosis of Acute Pulmonary Embolism. 对编辑的回复：评估内皮激活和应激指数在确定急性肺栓塞严重程度和预后中的预测价值。

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-10-15 DOI: 10.1159/mpp/adpag023

Orhan Karayigit, Muhammet Cihat Çelik, Murat Gök, Ahmet Balun, Burcunur Karayigit, Funda Basyigit, Zehra Güven Çetin

引用次数: 0

The Role of Probiotics in Primary and Secondary Prevention of Vulvovaginitis during Pregnancy and Preterm Labor: A Systematic Review. 益生菌在妊娠和早产期间外阴阴道炎一级和二级预防中的作用：系统综述。

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-10-15 DOI: 10.1159/mpp/adpag013

Cynthia Klas, Newotn Sergio De Carvalho

{"title":"The Role of Probiotics in Primary and Secondary Prevention of Vulvovaginitis during Pregnancy and Preterm Labor: A Systematic Review.","authors":"Cynthia Klas, Newotn Sergio De Carvalho","doi":"10.1159/mpp/adpag013","DOIUrl":"https://doi.org/10.1159/mpp/adpag013","url":null,"abstract":"Objectives: To evaluate the effectiveness and safety of oral probiotic supplementation for the primary prevention of vulvovaginal infections and preterm birth in pregnant women.Methods: A systematic review (PROSPERO 1129806) of randomized, placebo-controlled studies evaluating oral probiotics in pregnant women was conducted using PubMed, Virtual Health Library, Scopus, Cochrane Library, Web of Science, and Embase databases (2002-2025). The studies published in English assessing probiotics for vulvovaginitis or preterm birth prevention were included.Results: Four primary prevention studies were included, all used oral probiotics containing Lactobacillus rhamnosus, and no severe adverse events were reported. One study demonstrated reduced abundance of Candida albicans and Candida glabrata and increased beneficial lactobacilli following probiotic use after antifungal treatment. However, none of the studies showed a statistically significant effect on vulvovaginitis or preterm birth. The largest study indicated a non-significant trend toward reduced preterm birth among women with asymptomatic intermediate bacterial vaginosis.Conclusions: Oral probiotics appear to be safe during pregnancy but are not effective as standalone therapy for vulvovaginitis. Combined approaches may provide benefit. Vaginal administration and specific species may offer greater efficacy. Further studies are needed, particularly regarding preterm birth prevention.","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"1"},"PeriodicalIF":2.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical CPR - Assisted Percutaneous Coronary Intervention During Cardiac Arrest: Feasibility and Outcomes. 心脏骤停期间机械CPR辅助经皮冠状动脉介入治疗：可行性和结果。

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-10-15 DOI: 10.1159/mpp/adpag012

Andreas Triantafyllis, Sotirios C Kotoulas, Ibraheem Aqeel, Eleni Karapedi, Konstantinos Antoniades, Agoritsa Maria Pervana, Georgios Sotiris, Angeliki Kolyda, Andreas Giannakopoulos, Leonidas E Poulimenos

{"title":"Mechanical CPR - Assisted Percutaneous Coronary Intervention During Cardiac Arrest: Feasibility and Outcomes.","authors":"Andreas Triantafyllis, Sotirios C Kotoulas, Ibraheem Aqeel, Eleni Karapedi, Konstantinos Antoniades, Agoritsa Maria Pervana, Georgios Sotiris, Angeliki Kolyda, Andreas Giannakopoulos, Leonidas E Poulimenos","doi":"10.1159/mpp/adpag012","DOIUrl":"https://doi.org/10.1159/mpp/adpag012","url":null,"abstract":"Cardiac arrest complicating acute coronary syndromes requires immediate coronary reperfusion; however, performing percutaneous coronary intervention (PCI) during active manual cardiopulmonary resuscitation (CPR) presents significant technical challenges. The Lund University Cardiac Arrest System (LUCAS) provides automated mechanical chest compressions and enables uninterrupted CPR during coronary angiography and PCI. Existing evidence is primarily limited to case reports and small observational studies, mechanical CPR has emerged as a practical adjunct in catheterization laboratories where manual compressions are unsafe or logistically challenging. We report two cases from our center in which LUCAS-assisted PCI was performed during ongoing cardiac arrest in the setting of cardiogenic shock and acute coronary syndromes, alongside a structured narrative synthesis of contemporary literature addressing feasibility, procedural considerations, and clinical outcomes. Mechanical chest compressions allowed uninterrupted angiography and successful revascularization in both cases, with return of spontaneous circulation achieved in one patient. Despite procedural success, survival remained poor, reflecting severe global ischemia and metabolic derangement. LUCAS-assisted PCI is a technically feasible strategy that facilitates coronary reperfusion in carefully selected patients. Evidence of survival benefit remains limited and derives predominantly from observational studies and case reports rather than randomized controlled trials. The role of extracorporeal CPR (ECPR) as a complementary or alternative strategy warrants explicit consideration at appropriately resourced centers. Improved patient selection and integration into structured resuscitation pathways may enhance clinical outcomes.","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"1"},"PeriodicalIF":2.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two Anesthetic Strategies for Pediatric Magnetic Resonance Imaging: Face-Mask Sevoflurane versus an Intravenous Propofol-Ketamine Regimen in a Randomized Parallel-Group Trial. 儿童磁共振成像的两种麻醉策略：在一项随机平行组试验中，面罩七氟醚与静脉注射异丙酚-氯胺酮方案。

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-10-12 DOI: 10.1159/mpp/adpag031

Bedirhan Gunel, Ahmet Ergun, Nurseda Dundar, Gozde Gamze Uzun, Mehmet Yilmaz

{"title":"Two Anesthetic Strategies for Pediatric Magnetic Resonance Imaging: Face-Mask Sevoflurane versus an Intravenous Propofol-Ketamine Regimen in a Randomized Parallel-Group Trial.","authors":"Bedirhan Gunel, Ahmet Ergun, Nurseda Dundar, Gozde Gamze Uzun, Mehmet Yilmaz","doi":"10.1159/mpp/adpag031","DOIUrl":"https://doi.org/10.1159/mpp/adpag031","url":null,"abstract":"Objective: To compare recovery time between two complete anesthetic strategies for pediatric magnetic resonance imaging: face-mask sevoflurane maintenance and intravenous ketamine-propofol induction followed by intermittent supplemental propofol boluses.Subjects and methods: In this single-center randomized trial, 230 children aged 3 months to 10 years were assigned to propofol-ketamine (Group P) or sevoflurane (Group S). After 19 post-randomization exclusions, 211 participants were analyzed per protocol (Group P, n = 106; Group S, n = 105). The primary outcome was recovery time; secondary outcomes included protocol-specific anesthetic escalation, discharge time, respiratory and hemodynamic events, image quality, and peak Pediatric Anesthesia Emergence Delirium (PAED) score.Results: Recovery time was shorter in Group P (means, 4.46 vs. 5.31 min; 5% trimmed-mean difference [Group S minus Group P], 1.05 min; 95% CI, 0.17-1.94; p = 0.020). Protocol-specific anesthetic escalation was more frequent in Group P (29.2% vs. 11.4%; risk difference, 17.8 percentage points; 95% CI, 7.0-28.2; p = 0.001), whereas peak PAED scores were lower in Group P (Hodges-Lehmann location-shift estimate, -2; 95% CI, -4 to -1; p < 0.001). No between-group differences were detected in discharge time, image quality, or respiratory and hemodynamic outcomes.Conclusion: Propofol-ketamine was associated with a small, approximately one-minute shorter recovery time and more frequent protocol-specific anesthetic escalation, whereas face-mask sevoflurane was associated with higher peak PAED scores. Because no minimal clinically important differences were prespecified, their clinical and operational importance remains uncertain. Nonsignificant safety findings do not establish equivalent safety.","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"1"},"PeriodicalIF":2.2,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathological and Methodological Considerations in the Prognostic Assessment of Unplanned Excision in Soft Tissue Sarcoma. 软组织肉瘤非计划切除预后评估的病理和方法学考虑。

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-10-12 DOI: 10.1159/mpp/adpag033

Burcu Yilmaz

引用次数: 0

Perceived Stress, Sleep Quality, and Their Impact on Glycemic Control Among Type 2 Diabetes Patients in Riyadh: Cross-Sectional Evidence. 利雅得2型糖尿病患者的感知压力、睡眠质量及其对血糖控制的影响：横断面证据

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-10-12 DOI: 10.1159/mpp/adpag019

Reem Almutairi, Abdullah Mohammad Ali Khattab, Amen Ahmed Bawazir, Meshal Aljarboua, Abdullah Aljarboua, Alshabawi Munays Dhafer

{"title":"Perceived Stress, Sleep Quality, and Their Impact on Glycemic Control Among Type 2 Diabetes Patients in Riyadh: Cross-Sectional Evidence.","authors":"Reem Almutairi, Abdullah Mohammad Ali Khattab, Amen Ahmed Bawazir, Meshal Aljarboua, Abdullah Aljarboua, Alshabawi Munays Dhafer","doi":"10.1159/mpp/adpag019","DOIUrl":"https://doi.org/10.1159/mpp/adpag019","url":null,"abstract":"Objective: To investigate the relation between Perceived Stress and Sleep Quality with glycemic blood levels in T2DM patients in Riyadh.Subject and methods: This cross-sectional study evaluated a total of 309 patients diagnosed with Type 2 Diabetes Mellitus in Riyadh, Saudi Arabia. The study comprised an initial validation and Arabic translation phase involving 160 participants, followed by an analytical phase focusing on 149 adult patients. To investigate impact of psychosocial and metabolic factors on glycemic control (HbA1c), data were collected using the Pittsburgh Sleep Quality Index (PSQI) and the Perceived Stress Scale (PSS-10), alongside clinical metrics such as BMI and dyslipidemia extracted from medical records. A multivariable linear regression model was utilized to identify independent factors associated with glycemic regulation within the local population.Results: The multivariable regression model demonstrated robust explanatory power (Adjusted R2 = 0.726, p < 0.001). Traditional risk factors, specifically elevated BMI (β = 0.448, p < 0.001) and dyslipidemia (β = 0.304, p < 0.001), were significantly associated with higher HbA1c levels. Notably, poor sleep quality emerged as a significant independent factor associated with elevated HbA1c (β = 0.261, p < 0.001), whereas perceived stress did not exhibit a significant correlation. Conversely, physical activity demonstrated a significant protective effect, correlating with lower HbA1c (β = -0.271, p <0.001).Conclusion: Poor sleep quality, rather than perceived psychological stress, is a primary factor independently associated with hyperglycemia in this patient cohort. These findings suggest that standard diabetes care should integrate formal sleep assessments alongside patient care management.","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"1"},"PeriodicalIF":2.2,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Moxibustion for Hyperlipidemia: Methodological Caution is Needed before Clinical Interpretation. 艾灸治疗高脂血症：临床解释前需注意方法学。

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-10-10 DOI: 10.1159/mpp/adpag034

Zheng Han, Qingjie Tian, Hongwei Wang

引用次数: 0

Clinical Significance of Klotho, Fibroblast Growth Factor 23, and their Ratio for Acute Kidney Injury in Sepsis Patients. Klotho、成纤维细胞生长因子23及其比值在脓毒症患者急性肾损伤中的临床意义

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-10-09 DOI: 10.1159/mpp/adpag028

Sumian Dou, Yuchao Shen, Botao Zhao, Ling Wang, Wei Zhang, Jing Wang, Chunxue Wu, Long Yang, Zhanghai Sun, Ying Cui

{"title":"Clinical Significance of Klotho, Fibroblast Growth Factor 23, and their Ratio for Acute Kidney Injury in Sepsis Patients.","authors":"Sumian Dou, Yuchao Shen, Botao Zhao, Ling Wang, Wei Zhang, Jing Wang, Chunxue Wu, Long Yang, Zhanghai Sun, Ying Cui","doi":"10.1159/mpp/adpag028","DOIUrl":"https://doi.org/10.1159/mpp/adpag028","url":null,"abstract":"Objective: The sepsis-associated acute kidney injury (SA-AKI) is common in patients with sepsis and associated with poor outcomes, yet serum creatinine and urine output have limited value for early assessment. We examined whether admission Klotho, fibroblast growth factor 23 (FGF23), and the Klotho/FGF23 ratio were associated with SA-AKI and short-term outcomes and compared their discriminative performance.Methods: We conducted a retrospective cohort study of 320 patients admitted to the intensive care unit (ICU) with Sepsis-3-defined sepsis. SA-AKI (n = 112) was retrospectively identified according to Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Klotho and FGF23 were measured by enzyme-linked immunosorbent assay in stored serum samples collected within 24 h of ICU admission. Discrimination was assessed by receiver operating characteristic analysis, and adjusted associations were evaluated using multivariable logistic and linear regression.Results: Patients with SA-AKI had lower Klotho, higher FGF23, and a reduced Klotho/FGF23 ratio at admission (all p < 0.001). The ratio showed the highest area under the curve biomarkers for SA-AKI (0.84; 95% confidence interval 0.79 - 0.88) and remained associated with SA-AKI after multivariable adjustment (odds ratio 2.25; 95% confidence interval 1.46 - 3.53). The ratio decreased with increasing KDIGO stage. Among patients with SA-AKI, a low ratio remained associated with lower 3-month renal recovery, longer ICU and hospital stays, higher in-hospital mortality, and greater 3-month chronic kidney disease progression after adjustment.Conclusion: The admission Klotho/FGF23 ratio was associated with SA-AKI, higher KDIGO stage, and short-term outcomes and showed the highest observed discrimination among the three biomarkers.","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"1"},"PeriodicalIF":2.2,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complications following Breast Augmentation using Injectable Fillers in Kuwait. 在科威特使用注射填充物隆胸后的并发症。

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-10-08 DOI: 10.1159/mpp/adpag032

Mervat Al-Saleh, Ebtesam Al-Bader, Sarah AlYouha, Fatemah AlOtaibi, Sara Al-Hassani, Carol Dsouza

{"title":"Complications following Breast Augmentation using Injectable Fillers in Kuwait.","authors":"Mervat Al-Saleh, Ebtesam Al-Bader, Sarah AlYouha, Fatemah AlOtaibi, Sara Al-Hassani, Carol Dsouza","doi":"10.1159/mpp/adpag032","DOIUrl":"https://doi.org/10.1159/mpp/adpag032","url":null,"abstract":"Objectives: The study aims to evaluate and present clinical outcomes and complications associated with breast augmentation using injectable fillers and autologous fat transfer.Methods: This is a retrospective case series of patients who presented with complications following breast augmentation via injectable fillers or autologous fat grafting between September 2015 and November 2019 at a private clinic in Kuwait.Results: Amongst the 10 patients, 8 had complications from injectable fillers; co-polyamide (n=4), hyaluronic acid (n=1), collagen (n=1), unknown materials (n=3) and 2 from autologous fat transfer. Common complications included mastalgia (90%), palpable masses (80%), cyst formation (80%), filler migration (30%), and infection (20%). Imaging revealed multiple cystic lesions, filler deposition, and inflammatory changes, with several cases categorized as Breast Imaging Reporting and Data System-4 (BIRADS-4), which required biopsy. Surgical interventions, including mastectomy and drainage, were required in 40% of cases, while others were managed conservatively with imaging follow-up and/or aspiration.Conclusion: Injectable fillers for breast augmentation, particularly unregulated substances, are associated with a high risk of serious complications requiring invasive management. This study emphasizes the need for strict regulation, increased public awareness, and reliance on FDA-approved methods such as silicone implants or autologous fat grafting.","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"1"},"PeriodicalIF":2.2,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149140368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0