Medical principles and practice : international journal of the Kuwait University, Health Science Centre最新文献_第5页

Methanol extract of Bauhinia purpurea leaf possesses anti-ulcer activity. 紫荆叶甲醇提取物具有抗溃疡活性。

IF 3.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2012-01-01 Epub Date: 2012-03-07 DOI: 10.1159/000336593

Z A Zakaria, E E Abdul Hisam, M Norhafizah, M S Rofiee, F Othman, A H Hasiah, M Vasudevan

{"title":"Methanol extract of Bauhinia purpurea leaf possesses anti-ulcer activity.","authors":"Z A Zakaria, E E Abdul Hisam, M Norhafizah, M S Rofiee, F Othman, A H Hasiah, M Vasudevan","doi":"10.1159/000336593","DOIUrl":"https://doi.org/10.1159/000336593","url":null,"abstract":"Objective: The aim of the present study was to determine the anti-ulcer activity of a methanol extract of Bauhinia purpurea leaf (MEBP).Materials and methods: MEBP was administered at doses of 100, 500 and 1,000 mg/kg and its effects on acute toxicity, absolute ethanol- and indomethacin-induced gastric ulceration, and pyloric ligation tests in rats were investigated.Results: At a dose of 5,000 mg/kg, MEBP did not cause any signs of toxicity in rats when given orally. Oral administration of MEBP exerted anti-ulcer activity (p < 0.05) in all models tested. However, a dose-dependent protection was observed only in the indomethacin-induced gastric ulceration model. Histological studies supported the observed anti-ulcer activity of MEBP. In the pyloric ligation assay, MEBP significantly increased gastric wall mucus secretion (p < 0.05), but did not affect the acidity of the gastric contents.Conclusion: MEBP exhibited anti-ulcer activity, which could be due to the presence of flavonoids, saponins or other polyphenols, thereby validating the traditional use of B. purpurea in the treatment of ulcers.","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"476-82"},"PeriodicalIF":3.2,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000336593","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40147824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Concomitant drug- and infection-induced antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis with multispecific ANCA. 伴随药物和感染诱导的抗中性粒细胞胞浆自身抗体(ANCA)相关血管炎伴多特异性ANCA。

IF 3.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2012-01-01 Epub Date: 2012-04-25 DOI: 10.1159/000337944

Milica Kontic, Sanja Radovanovic, Milos Nikolic, Branka Bonaci-Nikolic

引用次数: 7

Can ephedrine pretreatment be effective in alleviating rocuronium injection pain? 麻黄碱预处理能否有效缓解罗库溴铵注射疼痛?

IF 3.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2012-01-01 Epub Date: 2012-03-07 DOI: 10.1159/000336582

Zeynep Nur Akcaboy, Erkan Yavuz Akcaboy, Ozlem Balkız Soyal, Guldane Turhan, Nermin Gogus

{"title":"Can ephedrine pretreatment be effective in alleviating rocuronium injection pain?","authors":"Zeynep Nur Akcaboy, Erkan Yavuz Akcaboy, Ozlem Balkız Soyal, Guldane Turhan, Nermin Gogus","doi":"10.1159/000336582","DOIUrl":"https://doi.org/10.1159/000336582","url":null,"abstract":"Objective: The aim of this randomized, double-blind, placebo-controlled study was to evaluate the effect of ephedrine pretreatment on the intensity of rocuronium injection pain when rocuronium was applied by timing principle and also to compare this effect with lidocaine and placebo.Subjects and methods: 120 American Society of Anesthesiology risk score I-II patients scheduled for elective surgery under general anesthesia were randomized into three groups to receive either 70 μg/kg ephedrine (ephedrine group, n = 40) or 0.5 mg/kg lidocaine (lidocaine group, n = 40) or 5 ml NaCl 0.9% (placebo group, n = 40) as pretreatment. Thirty seconds after pretreatment drugs, rocuronium 0.6 mg/kg was administered by the timing principle and rocuronium injection pain scores were recorded. Twenty seconds after rocuronium administration, anesthesia was induced with thiopental and the patient's trachea was intubated. Hemodynamic parameters and adverse effects were recorded.Results: The overall frequency of having pain was 82.5, 52.5 and 22.5% in placebo, ephedrine and lidocaine groups, respectively. Although the frequency of mild and moderate pain scores was higher in the ephedrine group than in the lidocaine group, this difference was not statistically significant (p = 0.032 and p = 0.001, respectively).Conclusion: Although not as effective as lidocaine 0.5 mg/kg, 70 μg/kg ephedrine pretreatment was able to alleviate rocuronium injection pain when rocuronium was applied by timing principle.","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"323-7"},"PeriodicalIF":3.2,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000336582","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40147802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Prevalence of water pipe use and its correlates in Iranian women of reproductive age in Tehran: a population-based study. 德黑兰伊朗育龄妇女水管使用率及其相关因素:一项基于人口的研究。

IF 3.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2012-01-01 Epub Date: 2012-03-09 DOI: 10.1159/000336583

Azam Baheiraei, Mojgan Mirghafourvand, Saharnaz Nedjat, Eesa Mohammadi, Sakineh Mohammad-Alizadeh Charandabi

{"title":"Prevalence of water pipe use and its correlates in Iranian women of reproductive age in Tehran: a population-based study.","authors":"Azam Baheiraei, Mojgan Mirghafourvand, Saharnaz Nedjat, Eesa Mohammadi, Sakineh Mohammad-Alizadeh Charandabi","doi":"10.1159/000336583","DOIUrl":"https://doi.org/10.1159/000336583","url":null,"abstract":"Objective: The objective of this study was to determine the prevalence of water pipe smoking and its associated sociodemographic factors among Iranian women of reproductive age in Tehran.Subjects and methods: This was a population-based cross-sectional study of 1,359 Iranian women aged 15-49 years. The multistage random cluster technique was used to obtain the sample. Questionnaire-based interviews with questions relating to water pipe smoking and sociodemographic variables were used to collect the data. The multivariate logistic regression model was used to analyse the relationships between the dependent variable (water pipe smoking) and the independent variables (sociodemographic characteristics).Results: The prevalence of water pipe smoking was 6.3% among Iranian women. Water pipe smoking was more likely in the age range of 15-24 years [odds ratio (OR) = 4.8, 95% confidence interval (95% CI) = 2.7-8.6] compared to the age range of 35 years or older, in women with a university education (OR = 1.9, 95% CI = 1.3-3.0) compared to women with a high-school diploma or lower, and in women with an average crowding index score (OR = 4.7, 95% CI = 2.1-10.6) compared to women living in small families.Conclusion: The findings of this study show that Iranian women with a university education and the younger age group (15-24 years) were at most risk of water pipe smoking. The findings of this study about associated factors may contribute to the development of efficient health promotion programmes for the prevention and cessation of water pipe smoking.","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"340-4"},"PeriodicalIF":3.2,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000336583","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40160169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

Risk factors in patients with hereditary gallstones in Chinese pedigrees. 中国家系遗传性胆结石患者的危险因素分析。

IF 3.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2012-01-01 Epub Date: 2012-03-31 DOI: 10.1159/000337437

Yunfeng Cui, Zhonglian Li, Erpeng Zhao, Naiqiang Cui

{"title":"Risk factors in patients with hereditary gallstones in Chinese pedigrees.","authors":"Yunfeng Cui, Zhonglian Li, Erpeng Zhao, Naiqiang Cui","doi":"10.1159/000337437","DOIUrl":"https://doi.org/10.1159/000337437","url":null,"abstract":"Objective: We aimed to define the risk factors and to evaluate the impact of family background on the prevalence of gallstones in China.Subjects and methods: Thirty-eight gallstone pedigrees were collected and a case-control study was conducted. This study consisted of 272 first-degree relatives and 201 non-first-degree relatives of index patients. The participants completed a questionnaire and underwent physical and ultrasonographic examinations. The risk factors examined included age, sex, body mass index (BMI), smoking status, alcohol consumption, pregnancy, fat content in dietary meat, history of gastrointestinal surgery, hypertension, hyperlipidemia, fatty liver, coronary heart disease and diabetes.Results: The prevalence of gallstones in first-degree and non-first-degree relatives of index patients was 38.2 and 10.9%, respectively. Age, pregnancy and BMI significantly differed between cases and controls (p < 0.05). The relative risks were: consumption of meat with a high fat content 1.4 (95% CI 1.1-1.8); hyperlipidemia 2.4 (95% CI 1.3-4.6); diabetes 1.9 (95% CI 1.1-3.2); fatty liver 4.9 (95% CI 1.0-24); coronary heart disease 2.5 (95% CI 1.7-3.9).Conclusion: Data showed that age, overweight, more consumption of high-fat food, high frequency of pregnancy, fatty liver, hyperlipidemia, coronary heart disease and diabetes could increase the risk of gallstones in the first-degree relatives of index patients.","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"467-71"},"PeriodicalIF":3.2,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000337437","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39971947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Reversible minimal change nephrotic syndrome and glomerular IgA deposition associated with nonparenteral heroin abuse: a case report. 可逆最小改变肾病综合征和肾小球IgA沉积与非肠外海洛因滥用:1例报告。

IF 3.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2012-01-01 Epub Date: 2012-04-25 DOI: 10.1159/000337941

Kenan Turgutalp, Ahmet Kiykim, Umit Karabulut, Didar Gursoy, Iclal Gurses

引用次数: 3

Significance of Virchow-Robin spaces in patients newly diagnosed with multiple sclerosis: a case-control study in an Arab population. Virchow-Robin间隙在新诊断多发性硬化症患者中的意义:一项阿拉伯人群的病例对照研究。

IF 3.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2012-01-01 Epub Date: 2012-04-25 DOI: 10.1159/000337427

Osama Al-Saeed, Reji Athyal, Mohammed Ismail, Mehraj Sheikh

{"title":"Significance of Virchow-Robin spaces in patients newly diagnosed with multiple sclerosis: a case-control study in an Arab population.","authors":"Osama Al-Saeed, Reji Athyal, Mohammed Ismail, Mehraj Sheikh","doi":"10.1159/000337427","DOIUrl":"https://doi.org/10.1159/000337427","url":null,"abstract":"Objective: To assess the frequency and extent of dilatation of Virchow-Robin (VR) spaces at three levels of the brain in patients of Arab ethnicity in Kuwait recently diagnosed with multiple sclerosis (MS) and compare the results with age- and gender-matched controls. Methods: The magnetic resonance imaging (MRI) scans performed within 3 months of the clinical diagnosis of 80 patients recently diagnosed with active MS were compared to those of 80 age- and gender-matched controls with headache but without any neurological deficits for the frequency and size of VR spaces. MRI was done with noncontrast axial and coronal T1W FSE, axial T2W FSE, axial T2W FLAIR and sagittal FLAIR sequences followed by postcontrast axial and coronal T1W sequences. The frequency of VR spaces in MS patients and controls at midbrain, lenticulostriate vessels and supraventricular levels was analyzed using a two-tailed McNemar test. Results: There was no difference in the frequency of VR spaces at the levels of the midbrain, lenticulostriate vessels and supraventricular white matter between MS patients and controls. In the supraventricular region, however, there were 91 dilated VR spaces in 26 (32%) of the MS patients while in the control group, there were 8 dilated VR spaces in 6 (7.5%) patients and the difference was statistically significant (p < 0.0001). Conclusion: The data showed that dilated VR spaces in the supraventricular region could potentially be used as a marker for MS and as a prognostic tool. However, further studies with a larger population are needed to further evaluate and confirm this observation.","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"447-51"},"PeriodicalIF":3.2,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000337427","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40186377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Is genetic screening necessary for determining the possibility of venous thromboembolism in cancer patients? 基因筛查对于确定癌症患者静脉血栓栓塞的可能性有必要吗?

IF 3.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2012-01-01 Epub Date: 2011-11-05 DOI: 10.1159/000333394

Ece Onur, Adnan Taner Kurdal, Berrin Tugrul, Ihsan Iskesen, Pınar Dundar, Fatma Taneli, Cevval Ulman, Ahmet Var

{"title":"Is genetic screening necessary for determining the possibility of venous thromboembolism in cancer patients?","authors":"Ece Onur, Adnan Taner Kurdal, Berrin Tugrul, Ihsan Iskesen, Pınar Dundar, Fatma Taneli, Cevval Ulman, Ahmet Var","doi":"10.1159/000333394","DOIUrl":"https://doi.org/10.1159/000333394","url":null,"abstract":"Objective: To determine the risk of an association with some genetic polymorphisms involved in venous thromboembolism (VTE) gene variations (FVL, FV H1299R, FII G20210A, MTHFR C677T, MTHFR A1298C, PAI-1 4G/5G, β-ﬁbrinogen -455 G → A, FXIII Val34Leu and GpIIIa HPA-1a) in cancer patients.Subjects and methods: Among 78 cancer patients, 28 who had proven first episode of VTE were selected as the patient group, with 50 control samples selected from age-, sex- and body mass index-matched healthy volunteers (healthy group). The differences in frequency of genetic polymorphisms were found to be statistically insignificant between these two groups.Results: Logistic regression analysis after adjustment for age, sex, smoking and hypertension showed no difference. The screened mutations of these genes were not significantly associated with VTE risk.Conclusion: There is no possible benefit from genetic screening tests regarding VTE in cancer patients.","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"160-3"},"PeriodicalIF":3.2,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000333394","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40139279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Radiation dose features and solid cancer induction in pediatric computed tomography. 儿童计算机断层扫描中的辐射剂量特征和实体癌诱导。

IF 3.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2012-01-01 Epub Date: 2012-03-30 DOI: 10.1159/000337404

Ernest K J Pauwels, Michel H Bourguignon

引用次数: 34