Medical principles and practice : international journal of the Kuwait University, Health Science Centre最新文献_第10页

Letter to the Editor regarding the Article 'Association between D-Dimer and Long-Term Major Adverse Cardiovascular Outcomes in Patients with Masked Hypertension'. d -二聚体和隐蔽性高血压：走向实用的风险分层。

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-01-01 Epub Date: 2026-01-09 DOI: 10.1159/000550379

Faisal A Shaikh, Terrence Curran, Laura E Nemeth, Zoltan H Nemeth

引用次数: 0

The Value of Baseline Intact Parathyroid Hormone in Vitamin D Supplementation for Early Multiple Sclerosis. 基线iPTH在早期多发性硬化症补充维生素D中的价值。

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-01-01 Epub Date: 2025-10-24 DOI: 10.1159/000548988

Faisal A Shaikh, Laura E Nemeth, Christian R Schmidhauser, Zoltan H Nemeth

引用次数: 0

Amalgamation of Biofilms and Synthetic Biology: A Paradigm Shift in Biotechnology. 生物膜与合成生物学的融合：生物技术的范式转变。

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-01-01 Epub Date: 2026-02-17 DOI: 10.1159/000550994

Durgananda Lahari Bhamidipaty, Veenadhari Bhamidipaty, Fayaz M Shaikh, Kanaka Durga Prasad Bhamidipaty, Rajesh Botchu

{"title":"Amalgamation of Biofilms and Synthetic Biology: A Paradigm Shift in Biotechnology.","authors":"Durgananda Lahari Bhamidipaty, Veenadhari Bhamidipaty, Fayaz M Shaikh, Kanaka Durga Prasad Bhamidipaty, Rajesh Botchu","doi":"10.1159/000550994","DOIUrl":"10.1159/000550994","url":null,"abstract":"Biofilms are intricately organized microbial communities enveloped in self-produced extracellular polymeric substances. They display remarkable resilience to environmental and antimicrobial stresses and adhere to various surfaces. Synthetic biology, which combines molecular biology with engineering principles, offers tools to modulate biofilm behavior for biotechnological applications and to address associated challenges. This review examines recent developments at the intersection of biofilm engineering and synthetic biology, highlighting strategies such as phage therapy, electrogenetic systems, microbial consortia design, quorum sensing regulation, genetic circuits, extracellular polymeric substances modification, and antimicrobial peptide-coated surfaces. These tools allow precise manipulation of biofilm structure, composition, and metabolic output. Biofilms are increasingly optimized for applications such as wastewater treatment, bioremediation, bioenergy, and diagnostics. Enhancements in stability and function are achieved via engineered circuits and extracellular polymeric substances adjustments, while antimicrobial approaches help control pathogenic biofilms. Despite these innovations, challenges remain, including biosafety, heterogeneity, scalability, and regulatory compliance. Continued interdisciplinary efforts are essential for translating these systems into viable technologies. .","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"201-209"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interpreting Low Alkaline Phosphatase in Fibromyalgia: The Importance of Comprehensive Clinical and Biochemical Assessment. 解读纤维肌痛低碱性磷酸酶：综合临床和生化评估的重要性。

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-01-01 Epub Date: 2026-02-12 DOI: 10.1159/000550852

Tamara Rodríguez Araya, Pilar Peris

引用次数: 0

Blending Artificial Intelligence with Expertise: A Comparative Study of Concept Maps in Anatomy Education. 人工智能与专业知识的融合：解剖学教育中概念图的比较研究。

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-01-01 Epub Date: 2026-05-08 DOI: 10.1159/000552430

Salem Albuainain, Yousif Alkubaisi, Sami Zaqout

{"title":"Blending Artificial Intelligence with Expertise: A Comparative Study of Concept Maps in Anatomy Education.","authors":"Salem Albuainain, Yousif Alkubaisi, Sami Zaqout","doi":"10.1159/000552430","DOIUrl":"10.1159/000552430","url":null,"abstract":"Objective: Concept maps are valuable tools in anatomy education, helping students organize complex information visually. With the rise of generative artificial intelligence (AI), tools like large language models (LLMs) and large action models (LAMs) offer new opportunities to automate concept map creation. However, their effectiveness compared with human-generated maps remains unclear.Methods: In this cross-sectional study, 74 medical students at Qatar University evaluated three concept maps - one generated by a LLM, one by a LAM, and one by a human expert. Students rated each map on clarity, structure, and scientific accuracy using Likert-scale items and selected their preferred map based on explanation, engagement, and future use. Data were analyzed using non-parametric and categorical tests.Results: Human-generated maps demonstrated the highest ratings for contribution to understanding, while clarity ratings were comparable between the human-generated and LLM maps. Maps generated by the action-based model received lower ratings overall. Students consistently preferred the human-generated map across all categories, including explanation, engagement, and future use. While overall differences in categorical preferences were not statistically significant consistently, the selected pairwise comparisons showed significant differences favoring the human-generated map.Conclusions: Human-generated concept maps remain the most effective and preferred learning tool in anatomy education. AI models, particularly LLMs, show promising potential as supportive tools but do not yet surpass expert-designed materials. .","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"487-495"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13341128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and Impact of Lower Urinary Tract Symptoms among Women with Rheumatoid Arthritis: A Multicenter Cross-Sectional Study. 类风湿性关节炎女性患者下尿路症状的患病率及其影响：一项多中心横断面研究

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-01-01 Epub Date: 2026-02-17 DOI: 10.1159/000549991

Ghadeer Alshaikh, Baydaa Alsannan, Dana Aldabeeb, Ibrahim I Almaghlouth, Raed M Almannie, Antonio Simone Laganà, Mohammed A Omair

{"title":"Prevalence and Impact of Lower Urinary Tract Symptoms among Women with Rheumatoid Arthritis: A Multicenter Cross-Sectional Study.","authors":"Ghadeer Alshaikh, Baydaa Alsannan, Dana Aldabeeb, Ibrahim I Almaghlouth, Raed M Almannie, Antonio Simone Laganà, Mohammed A Omair","doi":"10.1159/000549991","DOIUrl":"10.1159/000549991","url":null,"abstract":"Objectives: This study aimed to determine the prevalence of voiding dysfunction and its impact on quality of life among women diagnosed with rheumatoid arthritis, a chronic autoimmune condition known for joint inflammation and systemic manifestations.Methods: A cross-sectional observational design was employed at two tertiary care centers in Saudi Arabia. Over an 8-week period, 144 female patients with rheumatoid arthritis completed a self-administered online survey. The questionnaire included demographic data and the International Prostate Symptom Score (IPSS), a validated tool used to assess urinary symptoms and their effect on quality of life. Patients under 18 or with known urological disorders were excluded.Results: Participants had a mean age of 47.2 years, and 72.9% were married. The average IPSS was 11.2, with 41.7% classified as moderately symptomatic, 40.4% mildly symptomatic, and 17.9% severely symptomatic. Only 16.7% discussed urinary issues with family or partners, and 15.3% with physicians. Notably, 35.4% planned to consult a specialist, and this intent was significantly associated with higher IPSS scores (p < 0.03).Conclusions: Voiding dysfunction is highly prevalent among women with rheumatoid arthritis and significantly affects quality of life. Despite moderate to severe symptoms, many patients do not seek medical help. Routine screening and increased awareness are recommended to improve management and outcomes for this population. Further research is needed to explore regional differences and incorporate objective diagnostic tools. .","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"227-234"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12912796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Selective Serotonin Reuptake Inhibitors and Risk of Serotonin Syndrome as a Consequence of Drug-Drug Interactions". 对“选择性血清素再摄取抑制剂和血清素综合征的风险作为药物-药物相互作用的结果”的评论。

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-01-01 Epub Date: 2026-02-03 DOI: 10.1159/000550853

Abdullah Faisal Albukhari

引用次数: 0

New Aspects of Understanding Individual Magnetosensitivity to Geomagnetic Storms. 对地磁暴个体磁敏感性认识的新方面。

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-01-01 Epub Date: 2026-03-16 DOI: 10.1159/000551471

Oleg Gaisenok

{"title":"New Aspects of Understanding Individual Magnetosensitivity to Geomagnetic Storms.","authors":"Oleg Gaisenok","doi":"10.1159/000551471","DOIUrl":"10.1159/000551471","url":null,"abstract":"Objective(s): The influence of geomagnetic storms (GMSs) on humans has long been questioned. The aim of this study was to assess GMS influence on the functional cardiovascular parameters and human well-being depending on the presence of arterial hypertension, drug therapy, and smoking status.Methods: The study participants (n = 31) were analyzed for systolic blood pressure (SBP), vascular stiffness index (VSI), Baevsky stress index (BI) and other indicеs during quiet day and GMS day (K-index >5). Well-being was assessed using a validated \"САН\" questionnaire (SAN).Results: During GMS, significant SBP decrease was noted among \"not taking medications\" (108.0 [100.0; 110.0] vs. 103.5 [98.0; 110.0], p = 0.03); SBP increase was noted among \"smokers\" (120.0 [120.0; 130.0] vs. 130.0 [122.0; 145.0], p = 0.06). VSI decrease was noted during GMS, but significant differences in VSI were obtained among persons without hypertension (2.5 [-11.2; 14.6] vs. -5.3 [-17.6; 6.2], p = 0.04) and \"non-smokers\" (6.05 [-8.85; 13.5] vs. 0.3 [-10.2; 6.9], p = 0.01). BI increase during GMS was obtained among hypertensive patients and \"smokers.\" The total SAN questionnaire score decreased during GMS, especially among persons without hypertension (173.0 [159.0; 178.0] vs. 158.0 [125.0; 168.0], p = 0.03) and \"not taking medications\" (175.5 [173.0; 189.0] vs. 157.5 [156.0; 162.0], p = 0.04). β-Blockers and combined drug therapy had a protective effect on the prevention of SAN score decrease (RR 0.31 [0.12; 0.84] and RR 0.54 [0.33; 0.88]).Conclusion: This study confirmed GMS influence on functional cardiovascular parameters and human well-being depending on the presence of arterial hypertension, drug therapy, and smoking status. A protective effect of some drugs was noted on the manifestation of \"magnetosensitivity\" symptoms. .","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"385-394"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13175578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated Intra-Abdominal Pressure as a Prognostic Marker of Enteral Nutrition Intolerance and Adverse Outcomes in Neurocritical Care: A Retrospective Cohort Study. 腹内压升高作为神经危重症患者肠内营养不耐受和不良结局的预后标志：一项回顾性队列研究

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-01-01 Epub Date: 2026-03-23 DOI: 10.1159/000551687

Jiangyan Ren, Shufang Shi, Zhenyang Liu, Junhong Cui, Hu Su, Jingjing Wang, Xiaojia Ren, Yanafeng Pei, Yu Liu, Xiaoqin Sun

{"title":"Elevated Intra-Abdominal Pressure as a Prognostic Marker of Enteral Nutrition Intolerance and Adverse Outcomes in Neurocritical Care: A Retrospective Cohort Study.","authors":"Jiangyan Ren, Shufang Shi, Zhenyang Liu, Junhong Cui, Hu Su, Jingjing Wang, Xiaojia Ren, Yanafeng Pei, Yu Liu, Xiaoqin Sun","doi":"10.1159/000551687","DOIUrl":"10.1159/000551687","url":null,"abstract":"Objective: This study investigated the association between intra-abdominal pressure (IAP), enteral nutrition tolerance, and the clinical outcomes.Methods: In this retrospective cohort study, 120 patients admitted to a neurological critical care unit between 2021 and 2024 were evaluated. Only the patients receiving enteral nutrition for five or more days were included. IAP was measured every 6 h via bladder catheterization. Data regarding gastrointestinal complications, nutritional adequacy (volume ratio), and hospital outcomes were analyzed using multivariate logistic regression and random-effects modeling.Results: Elevated IAP (exceeding 14 mm Hg) was present in 92% of the cohort. Patients with gastrointestinal complications 54 (45%) exhibited significantly higher IAP (16.1 vs. 15.45 mm Hg; p = 0.0212), significantly longer stays in the neurocritical care unit (p = 0.0002) and longer total hospitalizations (p = 0.0002) compared to those without complications 66 (55%). Diarrhea (33%) and constipation (31%) were the most frequent complications. Multivariate analysis identified IAP as an independent predictor of prolonged intensive care stay (RR = 2.209), extended total hospitalization (RR = 2.203), and mortality (RR = 2.062). Furthermore, high IAP was significantly associated with a failure to achieve ninety percent of nutritional goals (p < 0.0001).Conclusion: IAP is a reliable indicator of enteral nutrition intolerance and systemic deterioration in neurocritical care. Routine monitoring of abdominal pressure should be integrated into clinical practice to enhance risk stratification and optimize nutritional delivery in patients with acute neurological injury. .","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"332-339"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147506058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Overview of Beriberi. 脚气病概述。

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-01-01 Epub Date: 2025-08-01 DOI: 10.1159/000547719

Amanda Gomes Pereira, Letycia Netto de Paula Cunha, Sergio Alberto Rupp Paiva, Paula Schmidt Azevedo, Leonardo Antônio Mamede Zornoff, Bertha Furlan Polegato, Nara Aline Costa, Marcos Ferreira Minicucci

{"title":"An Overview of Beriberi.","authors":"Amanda Gomes Pereira, Letycia Netto de Paula Cunha, Sergio Alberto Rupp Paiva, Paula Schmidt Azevedo, Leonardo Antônio Mamede Zornoff, Bertha Furlan Polegato, Nara Aline Costa, Marcos Ferreira Minicucci","doi":"10.1159/000547719","DOIUrl":"10.1159/000547719","url":null,"abstract":"Beriberi is a nutritional disorder caused by thiamine deficiency. Classically, Beriberi presents in two primary clinical forms: \"wet\" Beriberi, which features heart and circulatory system impairment, and \"dry\" Beriberi, which causes polyneuropathy. Although it is an easily treatable condition, it is often misdiagnosed and can be life-threatening if not promptly recognized and managed. The diagnosis of Beriberi is performed by the signs and symptoms of the disease and can be confirmed by thiamine deficiency identification or by therapeutic testing. However, considering the costs and the limitations of the assays to evaluate thiamine deficiency, the diagnosis based on the evaluation of clinical signs and symptoms and the therapeutic test could eliminate the need for measuring serum thiamine levels. Regarding treatment, immediate thiamine administration in the presence of clinical manifestations of the disease is recommended. Overall, 100-300 mg daily doses are enough to improve symptoms. In this review, we aim to (1) provide a clinical update about how to identify and treat the Beriberi and (2) describe the historical perspective, pathophysiological mechanisms, and other relevant aspects which may have applications in clinical management of Beriberi. .","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"18-24"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0