Medical principles and practice : international journal of the Kuwait University, Health Science Centre最新文献_第9页

Inhaled Aviptadil for Post-COVID Lung Injury: Early Promise, Future Directions. 吸入阿维他地尔治疗covid - 19后肺损伤：早期前景和未来方向。

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-01-01 Epub Date: 2025-09-18 DOI: 10.1159/000547366

Eric J Charles, Faisal A Shaikh, Zoltan H Nemeth

引用次数: 0

Prevalence and Impact of Cardiovascular Comorbidities on Disease Outcomes in a Middle Eastern Chronic Lymphocytic Leukemia Population: A Retrospective Study at Kuwait Cancer Control Center. 中东慢性淋巴细胞白血病人群心血管合并症的患病率及对疾病结局的影响：科威特癌症控制中心的回顾性研究

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-01-01 Epub Date: 2026-04-02 DOI: 10.1159/000551819

Salem H Alshemmari, Ahmed Alsarraf, Abdulaziz Dashti, Yousef Hajji, Habiba Babul, Nourah Almutairi, Anita Kunhikrishnan, Mohmad Yassin

{"title":"Prevalence and Impact of Cardiovascular Comorbidities on Disease Outcomes in a Middle Eastern Chronic Lymphocytic Leukemia Population: A Retrospective Study at Kuwait Cancer Control Center.","authors":"Salem H Alshemmari, Ahmed Alsarraf, Abdulaziz Dashti, Yousef Hajji, Habiba Babul, Nourah Almutairi, Anita Kunhikrishnan, Mohmad Yassin","doi":"10.1159/000551819","DOIUrl":"10.1159/000551819","url":null,"abstract":"Objectives: We aimed to investigate the prevalence of comorbidities including diabetes mellitus (DM), hypertension, dyslipidemia, and cardiovascular disease in the Middle Eastern chronic lymphocytic leukemia (CLL) population and their correlation with disease outcome at the Kuwait Cancer Control Center (KCCC).Methods: We performed a retrospective study of the CLL patients diagnosed in the KCCC between 2008 and 2021. The hazards ratio (HR) of death was calculated using Cox regression analysis. Statistical analysis was performed using SPSS (v27).Results: A total of 316 patients had recorded comorbidities. The mean age at diagnosis was 60 years (SD + 13) with a male-to-female ratio of 3:1. Of these, 140 (44%) had hypertension, 132 (42%) had DM, and 32 (10%) had dyslipidemia. Nineteen CLL patients (6%) had vascular disease at diagnosis and 48 (15%) had a cardiac disease. The HR of death in patients with DM, hypertension, and dyslipidemia was 1.74 (1.04-2.89; p value 0.034), 1.14 (0.68-1.91; p value 0.628), and 1.91 (0.91-3.77; p value 0.063), respectively. The vascular disease and the cardiac disease were associated with HR of death of 3.48 (1.69-7.15; p value <0.001) and 1.39 (0.74-2.61; p value 0.312), respectively. In the multivariate analysis, vascular comorbidities remained as an independent predictor of death with an HR of 2.96 (1.41-6.21; p value = 0.004).Conclusion: The cardiovascular disease and associated risk factors are prevalent in the Kuwaiti CLL patients, and they are also associated with an unfavorable prognosis. .","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"439-449"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13252981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147611683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges and Opportunities in the Application of CRISPR-Cas9: A Review on Genomic Editing and Therapeutic Potentials. CRISPR-Cas9应用的挑战与机遇：基因组编辑及其治疗潜力综述

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-01-01 Epub Date: 2025-07-17 DOI: 10.1159/000547334

Mohammad Ali Karimi, Mahdiesadat Paryan, Ghazaleh Behrouzian Fard, Hamid Sadeghian, Hossein Zarrinfar, Mahdi Hosseini Bafghi

{"title":"Challenges and Opportunities in the Application of CRISPR-Cas9: A Review on Genomic Editing and Therapeutic Potentials.","authors":"Mohammad Ali Karimi, Mahdiesadat Paryan, Ghazaleh Behrouzian Fard, Hamid Sadeghian, Hossein Zarrinfar, Mahdi Hosseini Bafghi","doi":"10.1159/000547334","DOIUrl":"10.1159/000547334","url":null,"abstract":"Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and the CRISPR-associated protein 9 (Cas9) constitute a revolutionary gene-editing technology, allowing precise DNA modifications with vast potential for disease treatment and the creation of genetically modified organisms. This system consists of various components designed to target specific genes, requiring efficient nuclear access within target cells through diverse delivery methods, including physical techniques and carrier-based approaches. Despite its transformative promise, CRISPR faces several challenges, including efficient cellular delivery, off-target effects, immune responses, optimizing editing efficiency, and ethical concerns. Overcoming these hurdles is crucial for fully harnessing its applications. However, CRISPR-Cas9 offers remarkable opportunities for pioneering gene therapies across various disorders, including cancer, and could revolutionize agriculture by engineering disease-resistant crops. A key strength of CRIScPR lies in its adaptability to a broad spectrum of genes, significantly enhancing its versatility. The technology's potential further expands through emerging interdisciplinary integrations, such as artificial intelligence, machine learning, and biological imaging. These advancements can refine CRISPR's precision, improve efficiency, and mitigate existing limitations, positioning it as an indispensable tool in future genetic research. Overall, CRISPR-Cas9 promises transformative progress in healthcare and agriculture, solidifying its role as a cornerstone in the evolution of genetic engineering. .","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"1-17"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Music Exposure on Epileptic Seizures Induced by Pentylenetetrazole in Rats. 音乐暴露对戊四唑致大鼠癫痫发作的影响。

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-01-01 Epub Date: 2026-01-22 DOI: 10.1159/000550550

Hilal Adil, Burcu Çevreli, Güler Öztürk, Erhan Caner Akkaya

{"title":"The Effect of Music Exposure on Epileptic Seizures Induced by Pentylenetetrazole in Rats.","authors":"Hilal Adil, Burcu Çevreli, Güler Öztürk, Erhan Caner Akkaya","doi":"10.1159/000550550","DOIUrl":"10.1159/000550550","url":null,"abstract":"Objective: This study aimed to investigate the effects of Mozart's Sonata K.448 on GABAergic activity using the prepulse inhibition (PPI) paradigm and to evaluate its impact on seizure susceptibility in a pentylenetetrazole (PTZ)-induced epilepsy model.Subject and methods: Thirteen male Wistar albino rats (14 days old) were randomly assigned to control (n = 6) and music (n = 7) groups. The control group was exposed to white noise (65 dB), while the music group was exposed to Mozart's Sonata K.448 (65-75 dB), 12 h/day during the dark cycle for 10 weeks. GABAergic activity was assessed through PPI at 74, 78, and 86 dB intensities. Epileptic seizures were induced by a single intraperitoneal injection of PTZ (60 mg/kg), and seizure latency and severity were recorded.Results: No significant differences were observed between groups in %PPI at 74 dB (p = 0.542), 78 dB (p = 0.889), or 86 dB (p = 0.863). Seizure latency was longer in the control group (903.5 s vs. 80 s), but this difference was not statistically significant (p = 0.098). Seizure severity scores were higher in the music group; however, the difference did not reach significance (p = 0.164).Conclusion: Under the present experimental conditions, Mozart K.448 did not significantly modulate GABAergic activity as measured by PPI. The observed trends toward shorter seizure latency and higher seizure severity in the music group may reflect a possible context-dependent increase in excitability, although these findings remain preliminary due to the small sample size. Given the complex nature of music's effects, further studies employing larger cohorts, and complementary neurophysiological methods are warranted. .","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"340-348"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12975275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Injury Mortality: Global Ascertainment and Prevention. 自伤死亡率：全球确定和预防。

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-01-01 Epub Date: 2026-05-04 DOI: 10.1159/000552292

Franklin White

{"title":"Self-Injury Mortality: Global Ascertainment and Prevention.","authors":"Franklin White","doi":"10.1159/000552292","DOIUrl":"10.1159/000552292","url":null,"abstract":"The aim of this review was to explore self-injury mortality (SIM) for its utility and potential in capturing deaths due to a desire or indifference to ending one's life. Suicide deaths are underreported, and a high percentage of substance use disorder deaths are misclassified as \"accidental\" or \"undetermined.\" The challenge is how to plan interventions when such deaths are inadequately ascertained? Shifting the focus from suicide to SIM unmasks a hidden global crisis. Globally, over 727,000 suicide deaths are reported each year. However, if adjusted for estimated underreporting and substance use disorder deaths, the actual number of people driven by a desire to escape despair by bringing one's life to an end could be more than double this. A case is argued for construction of globally applicable composite measures of SIM. To respond intelligently to suicide and self-injury prevention opportunities requires that the etiology and natural history of underlying mental disorders are understood, so that effective interventions are implemented. This is illustrated for the following disorders: anorexia nervosa, schizophrenia, bipolar disorder, major depressive disorder, gambling disorder, and substance use disorder. The keys to reducing SIM as an outcome of mental and behavioral disorders remain timely clinical intervention by informed health professionals and supportive families and communities. Policy and service interventions to address determinants and risk factors are equally important. The ultimate enabling agent for ensuring conditions for optimal mental health must be society itself and how it prioritizes elements within the political economy. .","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"401-415"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147849276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Anti-Cell Adhesion Molecule 1 Antibody Improves Mite Antigen-Induced Atopic Dermatitis-Like Lesions and Pruritus in NC/Nga Mice. 抗细胞粘附分子1抗体可改善NC/Nga小鼠螨抗原诱导的特应性皮炎样病变和瘙痒。

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-01-01 Epub Date: 2026-04-16 DOI: 10.1159/000552015

Fuka Takeuchi, Azusa Yoneshige, Yuji Shoya, Man Hagiyama, Takao Inoue, Akihiko Ito

{"title":"An Anti-Cell Adhesion Molecule 1 Antibody Improves Mite Antigen-Induced Atopic Dermatitis-Like Lesions and Pruritus in NC/Nga Mice.","authors":"Fuka Takeuchi, Azusa Yoneshige, Yuji Shoya, Man Hagiyama, Takao Inoue, Akihiko Ito","doi":"10.1159/000552015","DOIUrl":"10.1159/000552015","url":null,"abstract":"Objective: In atopic dermatitis, skin scratching leads to worsening of the dermatitis. Cell adhesion molecule 1 (CADM1), an immunoglobulin superfamily member, is highly expressed in peripheral nerve fibers, and the anti-CADM1 antibody 3E1 preferentially localizes to dermal nerve fibers upon subcutaneous injection and exerts analgesic effects. Whether 3E1 improves atopic dermatitis-like lesions and pruritus was examined in NC/Nga mice.Subjects and methods: The systemic distribution of 3E1 after intravenous injection was examined using indocyanine green imaging, immunostaining, and Western blotting techniques. Atopic dermatitis-like lesions were created by repeated application of the mite antigen Biostir. 3E1 was then administered subcutaneously at the lesion sites (30 μg/day; 3 consecutive days) or intravenously via the tail vein (5 mg/kg; 3 times every other day), and macroscopic inflammatory signs of the skin, such as erythema and crust formation, were recorded. Mice were videotaped, and the duration of skin scratching behavior was measured.Results: Intravenously injected 3E1 accumulated in dermal nerve fibers and dorsal root ganglia. By both routes of administration, the 3E1-treated group showed a shorter duration of scratching behavior in the first week and a faster improvement in dermatitis in the second week after the initial injection than the control group.Conclusion: 3E1 has potential as a therapeutic agent for atopic dermatitis owing to its antipruritic effect. .","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"450-459"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13309144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147701993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent Takotsubo: Interpreting the 5.9-Fold 30-Day Cardiovascular Mortality Signal. 复发性Takotsubo：解释5.9倍30天心血管死亡率信号。

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-01-01 Epub Date: 2025-11-21 DOI: 10.1159/000549582

Hakan Tibilli, Veysi Kavalcı

引用次数: 0

Letter to the Editor regarding the Article 'Association between D-Dimer and Long-Term Major Adverse Cardiovascular Outcomes in Patients with Masked Hypertension'. d -二聚体和隐蔽性高血压：走向实用的风险分层。

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-01-01 Epub Date: 2026-01-09 DOI: 10.1159/000550379

Faisal A Shaikh, Terrence Curran, Laura E Nemeth, Zoltan H Nemeth

引用次数: 0

The Value of Baseline Intact Parathyroid Hormone in Vitamin D Supplementation for Early Multiple Sclerosis. 基线iPTH在早期多发性硬化症补充维生素D中的价值。

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-01-01 Epub Date: 2025-10-24 DOI: 10.1159/000548988

Faisal A Shaikh, Laura E Nemeth, Christian R Schmidhauser, Zoltan H Nemeth

引用次数: 0

Amalgamation of Biofilms and Synthetic Biology: A Paradigm Shift in Biotechnology. 生物膜与合成生物学的融合：生物技术的范式转变。

IF 2.2

Medical principles and practice : international journal of the Kuwait University, Health Science Centre Pub Date : 2026-01-01 Epub Date: 2026-02-17 DOI: 10.1159/000550994

Durgananda Lahari Bhamidipaty, Veenadhari Bhamidipaty, Fayaz M Shaikh, Kanaka Durga Prasad Bhamidipaty, Rajesh Botchu

{"title":"Amalgamation of Biofilms and Synthetic Biology: A Paradigm Shift in Biotechnology.","authors":"Durgananda Lahari Bhamidipaty, Veenadhari Bhamidipaty, Fayaz M Shaikh, Kanaka Durga Prasad Bhamidipaty, Rajesh Botchu","doi":"10.1159/000550994","DOIUrl":"10.1159/000550994","url":null,"abstract":"Biofilms are intricately organized microbial communities enveloped in self-produced extracellular polymeric substances. They display remarkable resilience to environmental and antimicrobial stresses and adhere to various surfaces. Synthetic biology, which combines molecular biology with engineering principles, offers tools to modulate biofilm behavior for biotechnological applications and to address associated challenges. This review examines recent developments at the intersection of biofilm engineering and synthetic biology, highlighting strategies such as phage therapy, electrogenetic systems, microbial consortia design, quorum sensing regulation, genetic circuits, extracellular polymeric substances modification, and antimicrobial peptide-coated surfaces. These tools allow precise manipulation of biofilm structure, composition, and metabolic output. Biofilms are increasingly optimized for applications such as wastewater treatment, bioremediation, bioenergy, and diagnostics. Enhancements in stability and function are achieved via engineered circuits and extracellular polymeric substances adjustments, while antimicrobial approaches help control pathogenic biofilms. Despite these innovations, challenges remain, including biosafety, heterogeneity, scalability, and regulatory compliance. Continued interdisciplinary efforts are essential for translating these systems into viable technologies. .","PeriodicalId":520708,"journal":{"name":"Medical principles and practice : international journal of the Kuwait University, Health Science Centre","volume":" ","pages":"201-209"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0