Learning & memory (Cold Spring Harbor, N.Y.)最新文献_第6页

Impact of conscious intent on chunking during motor learning. 运动学习中有意识意图对分块记忆的影响。

IF 2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2014-08-15 Print Date: 2014-09-01 DOI: 10.1101/lm.035824.114

Sunbin Song, Leonardo Cohen

引用次数: 21

A unifying model of the role of the infralimbic cortex in extinction and habits. 一个关于边缘下皮层在灭绝和习惯中的作用的统一模型。

IF 2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2014-08-15 Print Date: 2014-09-01 DOI: 10.1101/lm.035501.114

Jacqueline M Barker, Jane R Taylor, L Judson Chandler

引用次数: 65

Retrieval is not necessary to trigger reconsolidation of object recognition memory in the perirhinal cortex. 检索不是触发周围皮层中物体识别记忆再巩固的必要条件。

IF 2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2014-08-15 Print Date: 2014-09-01 DOI: 10.1101/lm.035428.114

Marianela Santoyo-Zedillo, Carlos J Rodriguez-Ortiz, Gianfranco Chavez-Marchetta, Federico Bermudez-Rattoni, Israela Balderas

引用次数: 25

17β-Estradiol regulates histone alterations associated with memory consolidation and increases Bdnf promoter acetylation in middle-aged female mice. 17β-雌二醇调节与记忆巩固相关的组蛋白改变，并增加中年雌性小鼠Bdnf启动子乙酰化。

IF 2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2014-08-15 Print Date: 2014-09-01 DOI: 10.1101/lm.034033.113

Ashley M Fortress, Jaekyoon Kim, Rachel L Poole, Thomas J Gould, Karyn M Frick

{"title":"17β-Estradiol regulates histone alterations associated with memory consolidation and increases Bdnf promoter acetylation in middle-aged female mice.","authors":"Ashley M Fortress, Jaekyoon Kim, Rachel L Poole, Thomas J Gould, Karyn M Frick","doi":"10.1101/lm.034033.113","DOIUrl":"https://doi.org/10.1101/lm.034033.113","url":null,"abstract":"Histone acetylation is essential for hippocampal memory formation in young adult rodents. Although dysfunctional histone acetylation has been associated with age-related memory decline in male rodents, little is known about whether histone acetylation is altered by aging in female rodents. In young female mice, the ability of 17β-estradiol (E2) to enhance object recognition memory consolidation requires histone H3 acetylation in the dorsal hippocampus. However, the extent to which histone acetylation is regulated by E2 in middle-aged females is unknown. The mnemonic benefits of E2 in aging females appear to be greatest in middle age, and so pinpointing the molecular mechanisms through which E2 enhances memory at this age could lead to the development of safer and more effective treatments for maintaining memory function without the side effects of current therapies. Here, we show that dorsal hippocampal infusion of E2 rapidly enhanced object recognition and spatial memory, and increased histone H3 acetylation in the dorsal hippocampus, while also significantly reducing levels of histone deacetylase (HDAC2 and HDAC3) proteins. E2 specifically increased histone H3 acetylation at Bdnf promoters pII and pIV in the dorsal hippocampus of both young and middle-aged mice, despite age-related decreases in pI and pIV acetylation. Furthermore, levels of mature BDNF and pro-BDNF proteins in the dorsal hippocampus were increased by E2 in middle-aged females. Together, these data suggest that the middle-aged female dorsal hippocampus remains epigenetically responsive to E2, and that E2 may enhance memory in middle-aged females via epigenetic regulation of Bdnf. ","PeriodicalId":520703,"journal":{"name":"Learning & memory (Cold Spring Harbor, N.Y.)","volume":" ","pages":"457-67"},"PeriodicalIF":2.0,"publicationDate":"2014-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1101/lm.034033.113","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32589465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 64

Role of the dorsal hippocampus in object memory load. 背侧海马在客体记忆负荷中的作用。

IF 2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2012-04-20 DOI: 10.1101/lm.025213.111

Sara Sannino, Fabio Russo, Giulia Torromino, Valentina Pendolino, Paolo Calabresi, Elvira De Leonibus

{"title":"Role of the dorsal hippocampus in object memory load.","authors":"Sara Sannino, Fabio Russo, Giulia Torromino, Valentina Pendolino, Paolo Calabresi, Elvira De Leonibus","doi":"10.1101/lm.025213.111","DOIUrl":"https://doi.org/10.1101/lm.025213.111","url":null,"abstract":"The dorsal hippocampus is crucial for mammalian spatial memory, but its exact role in item memory is still hotly debated. Recent evidence in humans suggested that the hippocampus might be selectively involved in item short-term memory to deal with an increasing memory load. In this study, we sought to test this hypothesis. To this aim we developed a novel behavioral procedure to study object memory load in mice by progressively increasing the stimulus set size in the spontaneous object recognition task. Using this procedure, we demonstrated that naive mice have a memory span, which is the number of elements they can remember for a short-time interval, of about six objects. Then, we showed that excitotoxic selective lesions of the dorsal hippocampus did not impair novel object discrimination in the condition of low memory load. In contrast, the same lesion impaired novel object discrimination in the high memory load condition, and reduced the object memory span to four objects. These results have important heuristic and clinical implications because they open new perspective toward the understanding of the role of the hippocampus in item memory and in memory span deficits occurring in human pathologies, such as Alzheimer's disease and schizophrenia.","PeriodicalId":520703,"journal":{"name":"Learning & memory (Cold Spring Harbor, N.Y.)","volume":" ","pages":"211-8"},"PeriodicalIF":2.0,"publicationDate":"2012-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1101/lm.025213.111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40173049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 44

Rapid and persistent suppression of feeding behavior induced by sensitization training in Aplysia. 致敏训练诱导的快速和持续的摄食行为抑制。

IF 2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2012-03-14 DOI: 10.1101/lm.024638.111

Ama Acheampong, Kathleen Kelly, Maria Shields-Johnson, Julie Hajovsky, Marcy Wainwright, Riccardo Mozzachiodi

引用次数: 18

NMDA signaling in CA1 mediates selectively the spatial component of episodic memory. CA1中的NMDA信号选择性地介导情景记忆的空间成分。

IF 2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2012-03-14 DOI: 10.1101/lm.025254.111

Ryan Place, Christy Lykken, Zachery Beer, Junghyup Suh, Thomas J McHugh, Susumu Tonegawa, Howard Eichenbaum, Magdalena M Sauvage

{"title":"NMDA signaling in CA1 mediates selectively the spatial component of episodic memory.","authors":"Ryan Place, Christy Lykken, Zachery Beer, Junghyup Suh, Thomas J McHugh, Susumu Tonegawa, Howard Eichenbaum, Magdalena M Sauvage","doi":"10.1101/lm.025254.111","DOIUrl":"https://doi.org/10.1101/lm.025254.111","url":null,"abstract":"Recent studies focusing on the memory for temporal order have reported that CA1 plays a critical role in the memory for the sequences of events, in addition to its well-described role in spatial navigation. In contrast, CA3 was found to principally contribute to the memory for the association of items with spatial or contextual information in tasks focusing on spatial memory. Other studies have shown that NMDA signaling in the hippocampus is critical to memory performance in studies that have investigated spatial and temporal order memory independently. However, the role of NMDA signaling separately in CA1 and CA3 in memory that combines both spatial and temporal processing demands (episodic memory) has not been examined. Here we investigated the effect of the deletion of the NR1 subunit of the NMDA receptor in CA1 or CA3 on the spatial and the temporal aspects of episodic memory, using a behavioral task that allows for these two aspects of memory to be evaluated distinctly within the same task. Under these conditions, NMDA signaling in CA1 specifically contributes to the spatial aspect of memory function and is not required to support the memory for temporal order of events.","PeriodicalId":520703,"journal":{"name":"Learning & memory (Cold Spring Harbor, N.Y.)","volume":" ","pages":"164-9"},"PeriodicalIF":2.0,"publicationDate":"2012-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1101/lm.025254.111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40167931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

The episodic nature of episodic-like memories. 类情景记忆的情景性。

IF 2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2012-03-12 DOI: 10.1101/lm.025676.112

Alexander Easton, Lisa A D Webster, Madeline J Eacott

引用次数: 66

Mushroom bodies of the honeybee brain show cell population-specific plasticity in expression of amine-receptor genes. 蜜蜂大脑的蘑菇体在胺受体基因的表达上表现出细胞群体特异性的可塑性。

IF 2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2012-03-12 DOI: 10.1101/lm.025353.111

H James McQuillan, Shinichi Nakagawa, Alison R Mercer

{"title":"Mushroom bodies of the honeybee brain show cell population-specific plasticity in expression of amine-receptor genes.","authors":"H James McQuillan, Shinichi Nakagawa, Alison R Mercer","doi":"10.1101/lm.025353.111","DOIUrl":"https://doi.org/10.1101/lm.025353.111","url":null,"abstract":"Dopamine and octopamine released in the mushroom bodies of the insect brain play a critical role in the formation of aversive and appetitive memories, respectively. As recent evidence suggests a complex relationship between the effects of these two amines on the output of mushroom body circuits, we compared the expression of dopamine- and octopamine-receptor genes in three major subpopulations of mushroom body intrinsic neurons (Kenyon cells). Using the brain of the honeybee, Apis mellifera, we found that expression of amine-receptor genes differs markedly across Kenyon cell subpopulations. We found, in addition, that levels of expression of these genes change dramatically during the lifetime of the bee and that shifts in expression are cell population-specific. Differential expression of amine-receptor genes in mushroom body neurons and the plasticity that exists at this level are features largely ignored in current models of mushroom body function. However, our results are consistent with the growing body of evidence that short- and long-term olfactory memories form in different regions of the mushroom bodies of the brain and that there is functional compartmentalization of the modulatory inputs to this multifunctional brain center.","PeriodicalId":520703,"journal":{"name":"Learning & memory (Cold Spring Harbor, N.Y.)","volume":" ","pages":"151-8"},"PeriodicalIF":2.0,"publicationDate":"2012-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1101/lm.025353.111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40158602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36

Same-different categorization in rats. 大鼠的相同-不同分类。

IF 2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2012-03-09 DOI: 10.1101/lm.025437.111

Edward A Wasserman, Leyre Castro, John H Freeman

引用次数: 25