Learning & memory (Cold Spring Harbor, N.Y.)最新文献_第10页

Reinforcement in an in vitro analog of appetitive classical conditioning of feeding behavior in Aplysia: blockade by a dopamine antagonist. 多巴胺拮抗剂阻断豚鼠进食行为食欲经典条件反射的体外模拟强化。

IF 2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2005-05-01 DOI: 10.1101/lm.92905

Fredy D Reyes, Riccardo Mozzachiodi, Douglas A Baxter, John H Byrne

引用次数: 27

Protein synthesis inhibition blocks consolidation of an acrobatic motor skill. 蛋白质合成抑制阻碍杂技运动技能的巩固。

IF 2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2004-07-01 DOI: 10.1101/lm.72604

Andreas R Luft, Manuel M Buitrago, Alain Kaelin-Lang, Johannes Dichgans, Jörg B Schulz

引用次数: 25

Contributions of striatal subregions to place and response learning. 纹状体亚区对位置和反应学习的贡献。

IF 2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2004-07-01 DOI: 10.1101/lm.81004

Henry H Yin, Barbara J Knowlton

引用次数: 228

Calcium signaling in mitral cell dendrites of olfactory bulbs of neonatal rats and mice during olfactory nerve Stimulation and beta-adrenoceptor activation. 新生大鼠和小鼠嗅球二尖瓣细胞树突在嗅神经刺激和β -肾上腺素能受体激活过程中的钙信号。

IF 2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2004-07-01 DOI: 10.1101/lm.75204

Qi Yuan, Hiroki Mutoh, Franck Debarbieux, Thomas Knöpfel

{"title":"Calcium signaling in mitral cell dendrites of olfactory bulbs of neonatal rats and mice during olfactory nerve Stimulation and beta-adrenoceptor activation.","authors":"Qi Yuan, Hiroki Mutoh, Franck Debarbieux, Thomas Knöpfel","doi":"10.1101/lm.75204","DOIUrl":"https://doi.org/10.1101/lm.75204","url":null,"abstract":"Synapses formed by the olfactory nerve (ON) provide the source of excitatory synaptic input onto mitral cells (MC) in the olfactory bulb. These synapses, which relay odor-specific inputs, are confined to the distally tufted single primary dendrites of MCs, the first stage of central olfactory processing. beta-adrenergic modulation of electrical and chemical signaling at these synapses may be involved in early odor preference learning. To investigate this possibility, we combined electrophysiological recordings with calcium imaging in olfactory bulb slices prepared from neonatal rats and mice. Activation of ON-MC synapses induced postsynaptic potentials, which were associated with large postsynaptic calcium transients. Neither electrical nor calcium responses were affected by beta-adrenergic agonists or antagonist. Immunocytochemical analysis of MCs and their tufted dendrites revealed clear immunoreactivity with antibodies against alpha1A (Cav2.1, P/Q-type) and alpha1B (Cav2.2, N-type), but not against alpha1C (Cav1.2, L-type) or alpha1D (Cav1.3, L-type) calcium channel subunits. Moreover, nimodipine, a blocker of L-type calcium channels, had no effect on either electrical or calcium signaling at ON-MC synapses. In contrast to previous evidence, we concluded that in neonatal rats and mice (P5-P8), mitral cells do not express significant amounts of L-type calcium channels, the calcium channel type that is often targeted by beta-adrenergic modulation. The absence of beta-adrenergic modulation on either electrical or calcium signaling at ON-MC synapses of neonatal rats and mice excludes the involvement of this mechanism in early odor preference learning.","PeriodicalId":520703,"journal":{"name":"Learning & memory (Cold Spring Harbor, N.Y.)","volume":" ","pages":"406-11"},"PeriodicalIF":2.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1101/lm.75204","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40881244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

The roles of MAPK cascades in synaptic plasticity and memory in Aplysia: facilitatory effects and inhibitory constraints. MAPK级联在海马突触可塑性和记忆中的作用:促进效应和抑制约束。

IF 2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2004-07-01 DOI: 10.1101/lm.81104

Shiv K Sharma, Thomas J Carew

引用次数: 92

Preserved fronto-striatal plasticity and enhanced procedural learning in a transgenic mouse model of Alzheimer's disease overexpressing mutant hAPPswe. 过表达突变hAPPswe的阿尔茨海默病转基因小鼠模型中保留额纹状体可塑性和增强程序学习

IF 2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2004-07-01 DOI: 10.1101/lm.80604

Silvia Middei, Raffaella Geracitano, Antonio Caprioli, Nicola Mercuri, Martine Ammassari-Teule

{"title":"Preserved fronto-striatal plasticity and enhanced procedural learning in a transgenic mouse model of Alzheimer's disease overexpressing mutant hAPPswe.","authors":"Silvia Middei, Raffaella Geracitano, Antonio Caprioli, Nicola Mercuri, Martine Ammassari-Teule","doi":"10.1101/lm.80604","DOIUrl":"https://doi.org/10.1101/lm.80604","url":null,"abstract":"Mutations in the amyloid precursor protein (APP) gene inducing abnormal processing and deposition of beta-amyloid protein in the brain have been implicated in the pathogenesis of Alzheimer's disease (AD). Although Tg2576 mice with the Swedish mutation (hAPPswe) exhibit age-related Abeta-plaque formation in brain regions like the hippocampus, the amygdala, and the cortex, these mice show a rather specific deficit in hippocampal-dependent learning and memory tasks. In view of recent findings showing that neural systems subserving different forms of learning are not simply independent but that depressing or enhancing one system affects learning in another system, we decided to investigate fronto-striatal synaptic plasticity and related procedural learning in these mutants. Fronto-striatal long-term depression (LTD) induced by tetanic stimulation of the cortico-striatal input was similar in Tg2576 and wild-type control mice. Behavioral data, however, pointed to an enhancement of procedural learning in the mutants that showed robust motor-based learning in the cross maze and higher active avoidance scores. Thus, in this mouse model of AD, an intact striatal function associated with an impaired hippocampal function seems to provide neural conditions favorable to procedural learning. Our results suggest that focusing on preserved or enhanced forms of learning in AD patients might be of interest to describe the functional reorganization of the brain when one memory system is selectively compromised by neurological disease.","PeriodicalId":520703,"journal":{"name":"Learning & memory (Cold Spring Harbor, N.Y.)","volume":" ","pages":"447-52"},"PeriodicalIF":2.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1101/lm.80604","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40881246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 48