Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism最新文献_第6页

Common and unique structural plasticity after left and right hemisphere stroke. 左、右半球中风后常见而独特的结构可塑性。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2021-12-01 Epub Date: 2021-08-20 DOI: 10.1177/0271678X211036606

Yijun Chen, Yaya Jiang, Xiangyu Kong, Chenxi Zhao, Suyu Zhong, Liyuan Yang, Tao Feng, Shaoling Peng, Yanchao Bi, Maurizio Corbetta, Gaolang Gong

{"title":"Common and unique structural plasticity after left and right hemisphere stroke.","authors":"Yijun Chen, Yaya Jiang, Xiangyu Kong, Chenxi Zhao, Suyu Zhong, Liyuan Yang, Tao Feng, Shaoling Peng, Yanchao Bi, Maurizio Corbetta, Gaolang Gong","doi":"10.1177/0271678X211036606","DOIUrl":"https://doi.org/10.1177/0271678X211036606","url":null,"abstract":"Strokes to the left and right hemisphere lead to distinctive behavioral profiles. Are left and right hemisphere strokes (LHS and RHS) associated with distinct or common poststroke neuroplasticity patterns? Understanding this issue would reveal hemispheric neuroplasticity mechanisms in response to brain damage. To this end, we investigated poststroke structural changes (2 weeks to 3 months post-onset) using longitudinal MRI data from 69 LHS and 55 RHS patients and 31 demographic-matched healthy control participants. Both LHS and RHS groups showed statistically common plasticity independent of the lesioned hemisphere, including 1) gray matter (GM) expansion in the ipsilesional and contralesional precuneus, and contralesional superior frontal gyrus; 2) GM shrinkage in the ipsilesional medial orbital frontal gyrus and middle cingulate cortex. On the other hand, only RHS patients had significant GM expansion in the ipsilesional medial superior and orbital frontal cortex. Importantly, these common and unique GM changes post-stroke largely overlapped with highly-connected cortical hub regions in healthy individuals. Moreover, they correlated with behavioral recovery, indicating that post-stroke GM volumetric changes in cortical hubs reflect compensatory rather than maladaptive mechanisms. These results highlight the importance of structural neuroplasticity in hub regions of the cortex, along with the hemispheric specificity, for stroke recovery.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"3350-3364"},"PeriodicalIF":6.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669287/pdf/10.1177_0271678X211036606.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39328905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Glyceryl trinitrate for the treatment of ischaemic stroke: Determining efficacy in rodent and ovine species for enhanced clinical translation. 三硝酸甘油治疗缺血性中风:确定啮齿动物和绵羊物种的疗效，以增强临床翻译。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2021-12-01 Epub Date: 2021-05-26 DOI: 10.1177/0271678X211018901

Annabel J Sorby-Adams, Annastazia E Learoyd, Philip M Bath, Fiona Burrows, Tracy D Farr, Anna V Leonard, Ingo Schiessl, Stuart M Allan, Renée J Turner, Rebecca C Trueman

{"title":"Glyceryl trinitrate for the treatment of ischaemic stroke: Determining efficacy in rodent and ovine species for enhanced clinical translation.","authors":"Annabel J Sorby-Adams, Annastazia E Learoyd, Philip M Bath, Fiona Burrows, Tracy D Farr, Anna V Leonard, Ingo Schiessl, Stuart M Allan, Renée J Turner, Rebecca C Trueman","doi":"10.1177/0271678X211018901","DOIUrl":"https://doi.org/10.1177/0271678X211018901","url":null,"abstract":"Hypertension is a leading risk factor for death and dependency after ischaemic stroke. However, administering anti-hypertensive medications post-stroke remains contentious with concerns regarding deleterious effects on cerebral blood flow and infarct expansion. This study sought to determine the effect of glyceryl trinitrate (GTN) treatment in both lissencephalic and gyrencephalic pre-clinical stroke models. Merino sheep underwent middle cerebral artery occlusion (MCAO) followed by GTN or control patch administration (0.2 mg/h). Monitoring of numerous physiologically relevant measures over 24 h showed that GTN administration was associated with decreased intracranial pressure, infarct volume, cerebral oedema and midline shift compared to vehicle treatment (p < 0.05). No significant changes in blood pressure or cerebral perfusion pressure were observed. Using optical imaging spectroscopy and laser speckle imaging, the effect of varying doses of GTN (0.69-50 µg/h) on cerebral blood flow and tissue oxygenation was examined in mice. No consistent effect was found. Additional mice undergoing MCAO followed by GTN administration (doses varying from 0-60 µg/h) also showed no improvement in infarct volume or neurological score within 24 h post-stroke. GTN administration significantly improved numerous stroke-related physiological outcomes in sheep but was ineffective in mice. This suggests that, whilst GTN administration could potentially benefit patients, further research into mechanisms of action are required.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"3248-3259"},"PeriodicalIF":6.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0271678X211018901","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39021085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Evaluation of [¹⁸F]-JNJ-64326067-AAA tau PET tracer in humans. [18F]-JNJ-64326067-AAA tau PET示踪剂的人体评价。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2021-12-01 Epub Date: 2021-07-14 DOI: 10.1177/0271678X211031035

Suzanne L Baker, Karine Provost, Wesley Thomas, A J Whitman, Mustafa Janabi, Mark E Schmidt, Maarten Timmers, Hartmuth C Kolb, Gil D Rabinovici, William J Jagust

{"title":"Evaluation of [18F]-JNJ-64326067-AAA tau PET tracer in humans.","authors":"Suzanne L Baker, Karine Provost, Wesley Thomas, A J Whitman, Mustafa Janabi, Mark E Schmidt, Maarten Timmers, Hartmuth C Kolb, Gil D Rabinovici, William J Jagust","doi":"10.1177/0271678X211031035","DOIUrl":"https://doi.org/10.1177/0271678X211031035","url":null,"abstract":"The [18F]-JNJ-64326067-AAA ([18F]-JNJ-067) tau tracer was evaluated in healthy older controls (HCs), mild cognitive impairment (MCI), Alzheimer's disease (AD), and progressive supranuclear palsy (PSP) participants. Seventeen subjects (4 HCs, 5 MCIs, 5 ADs, and 3 PSPs) received a [11C]-PIB amyloid PET scan, and a tau [18F]-JNJ-067 PET scan 0-90 minutes post-injection. Only MCIs and ADs were amyloid positive. The simplified reference tissue model, Logan graphical analysis distribution volume ratio, and SUVR were evaluated for quantification. The [18F]-JNJ-067 tau signal relative to the reference region continued to increase to 90 min, indicating the tracer had not reached steady state. There was no significant difference in any bilateral ROIs for MCIs or PSPs relative to HCs; AD participants showed elevated tracer relative to controls in most cortical ROIs (P < 0.05). Only AD participants showed elevated retention in the entorhinal cortex. There was off-target signal in the putamen, pallidum, thalamus, midbrain, superior cerebellar gray, and white matter. [18F]-JNJ-067 significantly correlated (p < 0.05) with Mini-Mental State Exam in entorhinal cortex and temporal meta regions. There is clear binding of [18F]-JNJ-067 in AD participants. Lack of binding in HCs, MCIs and PSPs suggests [18F]-JNJ-067 may not bind to low levels of AD-related tau or 4 R tau.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"3302-3313"},"PeriodicalIF":6.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0271678X211031035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39182422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Mitochondrial quality control in acute ischemic stroke. 急性缺血性脑卒中线粒体质量控制。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2021-12-01 Epub Date: 2021-09-22 DOI: 10.1177/0271678X211046992

Hong An, Bing Zhou, Xunming Ji

{"title":"Mitochondrial quality control in acute ischemic stroke.","authors":"Hong An, Bing Zhou, Xunming Ji","doi":"10.1177/0271678X211046992","DOIUrl":"https://doi.org/10.1177/0271678X211046992","url":null,"abstract":"Mitochondria play a central role in the pathophysiological processes of acute ischemic stroke. Disruption of the cerebral blood flow during acute ischemic stroke interrupts oxygen and glucose delivery, leading to the dysfunction of mitochondrial oxidative phosphorylation and cellular bioenergetic stress. Cells can respond to such stress by activating mitochondrial quality control mechanisms, including the mitochondrial unfolded protein response, mitochondrial fission and fusion, mitophagy, mitochondrial biogenesis, and intercellular mitochondrial transfer. Collectively, these adaptive response strategies contribute to retaining the integrity and function of the mitochondrial network, thereby helping to recover the homeostasis of the neurovascular unit. In this review, we focus on mitochondrial quality control mechanisms occurring in acute ischemic stroke. A better understanding of how these regulatory pathways work in maintaining mitochondrial homeostasis will provide a rationale for developing innovative neuroprotectants when these mechanisms fail in acute ischemic stroke.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"3157-3170"},"PeriodicalIF":6.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669286/pdf/10.1177_0271678X211046992.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39461378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Endogenous zinc protoporphyrin formation critically contributes to hemorrhagic stroke-induced brain damage. 内源性原卟啉锌的形成对出血性中风引起的脑损伤至关重要。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2021-12-01 Epub Date: 2021-06-29 DOI: 10.1177/0271678X211028475

Rong Pan, Song Yu, Haikun Zhang, Graham S Timmins, John Weaver, Yirong Yang, Xixi Zhou, Ke Jian Liu

{"title":"Endogenous zinc protoporphyrin formation critically contributes to hemorrhagic stroke-induced brain damage.","authors":"Rong Pan, Song Yu, Haikun Zhang, Graham S Timmins, John Weaver, Yirong Yang, Xixi Zhou, Ke Jian Liu","doi":"10.1177/0271678X211028475","DOIUrl":"https://doi.org/10.1177/0271678X211028475","url":null,"abstract":"Hemorrhagic stroke is a leading cause of death. The causes of intracerebral hemorrhage (ICH)-induced brain damage are thought to include lysis of red blood cells, hemin release and iron overload. These mechanisms, however, have not proven very amenable to therapeutic intervention, and so other mechanistic targets are being sought. Here we report that accumulation of endogenously formed zinc protoporphyrin (ZnPP) also critically contributes to ICH-induced brain damage. ICH caused a significant accumulation of ZnPP in brain tissue surrounding hematoma, as evidenced by fluorescence microscopy of ZnPP, and further confirmed by fluorescence spectroscopy and supercritical fluid chromatography-mass spectrometry. ZnPP formation was dependent upon both ICH-induced hypoxia and an increase in free zinc accumulation. Notably, inhibiting ferrochelatase, which catalyzes insertion of zinc into protoporphyrin, greatly decreased ICH-induced endogenous ZnPP generation. Moreover, a significant decrease in brain damage was observed upon ferrochelatase inhibition, suggesting that endogenous ZnPP contributes to the damage in ICH. Our findings reveal a novel mechanism of ICH-induced brain damage through ferrochelatase-mediated formation of ZnPP in ICH tissue. Since ferrochelatase can be readily inhibited by small molecules, such as protein kinase inhibitors, this may provide a promising new and druggable target for ICH therapy.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"3232-3247"},"PeriodicalIF":6.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0271678X211028475","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39141297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A CBF decrease in the left supplementary motor areas: New insight into postoperative pediatric cerebellar mutism syndrome using arterial spin labeling perfusion MRI. 左辅助运动区脑血流减少:动脉自旋标记灌注MRI对小儿术后小脑缄默综合征的新认识。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2021-12-01 Epub Date: 2021-07-14 DOI: 10.1177/0271678X211031321

Jennifer Boisgontier, Ludovic Fillon, Caroline Rutten, Ana Saitovitch, Christelle Dufour, Hervé Lemaître, Kévin Beccaria, Thomas Blauwblomme, Raphaël Levy, Volodia Dangouloff-Ros, David Grévent, Charles-Joris Roux, Jacques Grill, Alice Vinçon-Leite, Lila Saidoun, Franck Bourdeaut, Monica Zilbovicius, Nathalie Boddaert, Stéphanie Puget

{"title":"A CBF decrease in the left supplementary motor areas: New insight into postoperative pediatric cerebellar mutism syndrome using arterial spin labeling perfusion MRI.","authors":"Jennifer Boisgontier, Ludovic Fillon, Caroline Rutten, Ana Saitovitch, Christelle Dufour, Hervé Lemaître, Kévin Beccaria, Thomas Blauwblomme, Raphaël Levy, Volodia Dangouloff-Ros, David Grévent, Charles-Joris Roux, Jacques Grill, Alice Vinçon-Leite, Lila Saidoun, Franck Bourdeaut, Monica Zilbovicius, Nathalie Boddaert, Stéphanie Puget","doi":"10.1177/0271678X211031321","DOIUrl":"https://doi.org/10.1177/0271678X211031321","url":null,"abstract":"Postoperative pediatric cerebellar mutism syndrome (pCMS), characterized mainly by delayed onset transient mutism is a poorly understood complication that may occur after pediatric medulloblastoma (MB) resection. Our aim was to investigate postoperative changes in whole-brain cerebral blood flow (CBF) at rest in pCMS patients using arterial spin labeling (ASL) perfusion imaging. This study compared preoperative and postoperative T2-weighted signal abnormalities and CBF using a voxel-wise, whole-brain analysis in 27 children undergoing MB resection, including 11 patients who developed mutism and 16 who did not. Comparison of postoperative T2 signal abnormalities between patients who developed pCMS (mean age 7.0 years) and those who did not showed that pCMS (mean age 8.9 years) patients were significantly more likely to present with T2-weighted hyperintensities in the right dentate nucleus (DN) (p = 0.02). Comparison of preoperative and postoperative CBF in patients with pCMS showed a significant postoperative CBF decrease in the left pre-supplementary motor area (pre-SMA) (p = 0.007) and SMA (p = 0.009). In patients who did not develop pCMS, no significant differences were observed. Findings provide evidence of an association between pCMS, injury to the right DN, and left pre-SMA/SMA hypoperfusion, areas responsible for speech. This supports the relevance of CBF investigations in pCMS.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"3339-3349"},"PeriodicalIF":6.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0271678X211031321","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39182423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Deep-learning-based attenuation correction in dynamic [¹⁵O]H₂O studies using PET/MRI in healthy volunteers. 健康志愿者PET/MRI动态[15O]H2O研究中基于深度学习的衰减校正

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2021-12-01 Epub Date: 2021-07-11 DOI: 10.1177/0271678X211029178

Oriol Puig, Otto M Henriksen, Flemming L Andersen, Ulrich Lindberg, Liselotte Højgaard, Ian Law, Claes N Ladefoged

{"title":"Deep-learning-based attenuation correction in dynamic [15O]H2O studies using PET/MRI in healthy volunteers.","authors":"Oriol Puig, Otto M Henriksen, Flemming L Andersen, Ulrich Lindberg, Liselotte Højgaard, Ian Law, Claes N Ladefoged","doi":"10.1177/0271678X211029178","DOIUrl":"https://doi.org/10.1177/0271678X211029178","url":null,"abstract":"Quantitative [15O]H2O positron emission tomography (PET) is the accepted reference method for regional cerebral blood flow (rCBF) quantification. To perform reliable quantitative [15O]H2O-PET studies in PET/MRI scanners, MRI-based attenuation-correction (MRAC) is required. Our aim was to compare two MRAC methods (RESOLUTE and DeepUTE) based on ultrashort echo-time with computed tomography-based reference standard AC (CTAC) in dynamic and static [15O]H2O-PET. We compared rCBF from quantitative perfusion maps and activity concentration distribution from static images between AC methods in 25 resting [15O]H2O-PET scans from 14 healthy men at whole-brain, regions of interest and voxel-wise levels. Average whole-brain CBF was 39.9 ± 6.0, 39.0 ± 5.8 and 40.0 ± 5.6 ml/100 g/min for CTAC, RESOLUTE and DeepUTE corrected studies respectively. RESOLUTE underestimated whole-brain CBF by 2.1 ± 1.50% and rCBF in all regions of interest (range -2.4%- -1%) compared to CTAC. DeepUTE showed significant rCBF overestimation only in the occipital lobe (0.6 ± 1.1%). Both MRAC methods showed excellent correlation on rCBF and activity concentration with CTAC, with slopes of linear regression lines between 0.97 and 1.01 and R2 over 0.99. In conclusion, RESOLUTE and DeepUTE provide AC information comparable to CTAC in dynamic [15O]H2O-PET but RESOLUTE is associated with a small but systematic underestimation.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"3314-3323"},"PeriodicalIF":6.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0271678X211029178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39176447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Assessing cortical cerebral microinfarcts on iron-sensitive MRI in cerebral small vessel disease. 脑小血管疾病的铁敏感MRI评估皮质性脑微梗死。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2021-12-01 Epub Date: 2021-08-20 DOI: 10.1177/0271678X211039609

Kim Wiegertjes, Kwok-Shing Chan, Annemieke Ter Telgte, Benno Gesierich, David G Norris, Catharina Jm Klijn, Marco Duering, Anil M Tuladhar, José P Marques, Frank-Erik de Leeuw

{"title":"Assessing cortical cerebral microinfarcts on iron-sensitive MRI in cerebral small vessel disease.","authors":"Kim Wiegertjes, Kwok-Shing Chan, Annemieke Ter Telgte, Benno Gesierich, David G Norris, Catharina Jm Klijn, Marco Duering, Anil M Tuladhar, José P Marques, Frank-Erik de Leeuw","doi":"10.1177/0271678X211039609","DOIUrl":"https://doi.org/10.1177/0271678X211039609","url":null,"abstract":"Recent studies suggest that a subset of cortical microinfarcts may be identifiable on T2* but invisible on T1 and T2 follow-up images. We aimed to investigate whether cortical microinfarcts are associated with iron accumulation after the acute stage. The RUN DMC - InTENse study is a serial MRI study including individuals with cerebral small vessel disease (SVD). 54 Participants underwent 10 monthly 3 T MRIs, including diffusion-weighted imaging, quantitative R1 (=1/T1), R2 (=1/T2), and R2* (=1/T2*) mapping, from which MRI parameters within areas corresponding to microinfarcts and control region of interests (ROIs) were retrieved within 16 participants. Finally, we compared pre- and post-lesional values with repeated measures ANOVA and post-hoc paired t-tests using the mean difference between lesion and control ROI values. We observed 21 acute cortical microinfarcts in 7 of the 54 participants (median age 69 years [IQR 66-74], 63% male). R2* maps demonstrated an increase in R2* values at the moment of the last available follow-up MRI (median [IQR], 5 [5-14] weeks after infarction) relative to prelesional values (p = .08), indicative of iron accumulation. Our data suggest that cortical microinfarcts are associated with increased R2* values, indicative of iron accumulation, possibly due to microhemorrhages, neuroinflammation or neurodegeneration, awaiting histopathological verification.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"3391-3399"},"PeriodicalIF":6.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39328904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Wdfy3 regulates glycophagy, mitophagy, and synaptic plasticity. Wdfy3调节糖吞噬、线粒体自噬和突触可塑性。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2021-12-01 Epub Date: 2021-06-29 DOI: 10.1177/0271678X211027384

Eleonora Napoli, Alexios A Panoutsopoulos, Patricia Kysar, Nathaniel Satriya, Kira Sterling, Bradley Shibata, Denise Imai, David N Ruskin, Konstantinos S Zarbalis, Cecilia Giulivi

{"title":"Wdfy3 regulates glycophagy, mitophagy, and synaptic plasticity.","authors":"Eleonora Napoli, Alexios A Panoutsopoulos, Patricia Kysar, Nathaniel Satriya, Kira Sterling, Bradley Shibata, Denise Imai, David N Ruskin, Konstantinos S Zarbalis, Cecilia Giulivi","doi":"10.1177/0271678X211027384","DOIUrl":"https://doi.org/10.1177/0271678X211027384","url":null,"abstract":"Autophagy is essential to cell function, as it enables the recycling of intracellular constituents during starvation and in addition functions as a quality control mechanism by eliminating spent organelles and proteins that could cause cellular damage if not properly removed. Recently, we reported on Wdfy3's role in mitophagy, a clinically relevant macroautophagic scaffold protein that is linked to intellectual disability, neurodevelopmental delay, and autism spectrum disorder. In this study, we confirm our previous report that Wdfy3 haploinsufficiency in mice results in decreased mitophagy with accumulation of mitochondria with altered morphology, but expanding on that observation, we also note decreased mitochondrial localization at synaptic terminals and decreased synaptic density, which may contribute to altered synaptic plasticity. These changes are accompanied by defective elimination of glycogen particles and a shift to increased glycogen synthesis over glycogenolysis and glycophagy. This imbalance leads to an age-dependent higher incidence of brain glycogen deposits with cerebellar hypoplasia. Our results support and further extend Wdfy3's role in modulating both brain bioenergetics and synaptic plasticity by including glycogen as a target of macroautophagic degradation.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"3213-3231"},"PeriodicalIF":6.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0271678X211027384","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39141295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Nrf2-BDNF-TrkB pathway contributes to cortical hemorrhage-induced depression, but not sex differences. Nrf2-BDNF-TrkB通路与皮质出血性抑郁有关，但与性别差异无关。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2021-12-01 Epub Date: 2021-07-08 DOI: 10.1177/0271678X211029060

Honglei Ren, Ranran Han, Xi Liu, Limin Wang, Raymond C Koehler, Jian Wang

{"title":"Nrf2-BDNF-TrkB pathway contributes to cortical hemorrhage-induced depression, but not sex differences.","authors":"Honglei Ren, Ranran Han, Xi Liu, Limin Wang, Raymond C Koehler, Jian Wang","doi":"10.1177/0271678X211029060","DOIUrl":"https://doi.org/10.1177/0271678X211029060","url":null,"abstract":"Post-stroke depression, observed in 30-50% of stroke patients, negatively affects quality of life and mortality. The pathogenesis of post-stroke depression is complex, but heightened reactive oxygen species production and inflammation might be two key factors. We have reported that intracerebral hemorrhage (ICH) in cerebral cortex produces depression-like behavior in young male mice. Here, we found that mice lacking nuclear factor erythroid-derived 2-related factor 2 (Nrf2), a transcription factor that upregulates antioxidant proteins and trophic factors such as brain-derived neurotrophic factor (BDNF), had more severe depression-like behavior than wild-type mice at days 21 to 28 after cortical ICH (c-ICH). Moreover, the expression of Nrf2, heme oxygenase-1, BDNF, and TrkB were significantly decreased in wild-type mice after c-ICH. Interestingly, TP-500 (2 mg/kg), a potent Nrf2 inducer, decreased the inflammatory response and reactive oxygen species production on day 28 after c-ICH and improved depression-like behaviors. TrkB receptor antagonist ANA-12 abolished this anti-depression effect. Depression was more severe in female than in male wild-type mice after ICH, but TP-500 improved depression-like behavior in females. These results suggest that downregulation of Nrf2-BDNF-TrkB signaling contributes to development of post-stroke depression, and that Nrf2 inducer TP-500 might improve depression after c-ICH.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"3288-3301"},"PeriodicalIF":6.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0271678X211029060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39164872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10