Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism最新文献_第5页

Serotonin 1B receptor density mapping of the human brainstem using positron emission tomography and autoradiography. 利用正电子发射断层扫描和放射自显像技术绘制人脑干血清素1B受体密度图。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2022-04-01 Epub Date: 2021-10-13 DOI: 10.1177/0271678X211049185

Emma R Veldman, Andrea Varrone, Katarina Varnäs, Marie M Svedberg, Zsolt Cselényi, Mikael Tiger, Balázs Gulyás, Christer Halldin, Johan Lundberg

{"title":"Serotonin 1B receptor density mapping of the human brainstem using positron emission tomography and autoradiography.","authors":"Emma R Veldman, Andrea Varrone, Katarina Varnäs, Marie M Svedberg, Zsolt Cselényi, Mikael Tiger, Balázs Gulyás, Christer Halldin, Johan Lundberg","doi":"10.1177/0271678X211049185","DOIUrl":"https://doi.org/10.1177/0271678X211049185","url":null,"abstract":"The serotonin 1B (5-HT1B) receptor has lately received considerable interest in relation to psychiatric and neurological diseases, partly due to findings based on quantification using Positron Emission Tomography (PET). Although the brainstem is an important structure in this regard, PET radioligand binding quantification in brainstem areas often shows poor reliability. This study aims to improve PET quantification of 5-HT1B receptor binding in the brainstem.Volumes of interest (VOIs) were selected based on a 3D [3H]AZ10419369 Autoradiography brainstem model, which visualized 5-HT1B receptor distribution in high resolution. Two previously developed VOI delineation methods were tested and compared to a conventional manual method. For a method based on template data, a [11C]AZ10419369 PET template was created by averaging parametric binding potential (BPND) images of 52 healthy subjects. VOIs were generated based on a predefined volume and BPND thresholding and subsequently applied to test-retest [11C]AZ10419369 parametric BPND images of 8 healthy subjects. For a method based on individual subject data, VOIs were generated directly on each individual parametric image.Both methods showed improved reliability compared to a conventional manual VOI. The VOIs created with [11C]AZ10419369 template data can be automatically applied to future PET studies measuring 5-HT1B receptor binding in the brainstem.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"630-641"},"PeriodicalIF":6.3,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39513964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary nitrate supplementation effect on dynamic cerebral autoregulation in normoxia and acute hypoxia. 饲粮中添加硝酸盐对常氧和急性缺氧状态下大脑动态自动调节的影响。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2022-03-01 Epub Date: 2020-03-09 DOI: 10.1177/0271678X20910053

Masahiro Horiuchi, Gabriella Mk Rossetti, Samuel J Oliver

{"title":"Dietary nitrate supplementation effect on dynamic cerebral autoregulation in normoxia and acute hypoxia.","authors":"Masahiro Horiuchi, Gabriella Mk Rossetti, Samuel J Oliver","doi":"10.1177/0271678X20910053","DOIUrl":"https://doi.org/10.1177/0271678X20910053","url":null,"abstract":"We tested the hypothesis that increasing the nitric oxide (NO) bioavailability by dietary nitrate would recover the hypoxia-induced reduction in dynamic cerebral autoregulation (CA). Twelve healthy males (age 21 ± 2 years) completed four days of dietary supplementation with a placebo or inorganic nitrate drink (140-ml beetroot juice per day) followed by 60-min of normoxia or hypoxia (fraction of inspired oxygen [FiO2] = 13%). Duplex ultrasonography was used to perform volumetric change-based assessment of dynamic CA in the internal carotid artery (ICA). Dynamic CA was assessed by rate of regulation (RoR) of vascular conductance using the thigh-cuff method. Four days of beetroot supplementation increased circulating nitrate by 208 [171,245] μM (mean difference [95% confidence interval]) compared with placebo. Dynamic CA was lower in hypoxia than normoxia (RoR Δ-0.085 [-0.116, -0.054]). Compared with placebo, nitrate did not alter dynamic CA in normoxia (RoR Δ-0.022 [-0.060, 0.016]) or hypoxia (RoR Δ0.017 [-0.019, 0.053]). Further, nitrate did not affect ICA vessel diameter, blood velocity or flow in either normoxia or hypoxia. Increased bioavailability of NO through dietary nitrate supplementation did not recover the hypoxia-induced reduction in dynamic CA. This suggests the mechanism of hypoxia-induced reduction in dynamic CA does not relate to the availability of NO.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"486-494"},"PeriodicalIF":6.3,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0271678X20910053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37720085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

How can integrative physiology advance stroke research and stroke care? 综合生理学如何促进脑卒中研究和治疗?

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2022-03-01 Epub Date: 2021-11-02 DOI: 10.1177/0271678X211057403

Jurgen Ahr Claassen

{"title":"How can integrative physiology advance stroke research and stroke care?","authors":"Jurgen Ahr Claassen","doi":"10.1177/0271678X211057403","DOIUrl":"https://doi.org/10.1177/0271678X211057403","url":null,"abstract":"Despite clear recent advances in stroke research and stroke care, many important questions remain unanswered. For example, what is optimal blood pressure treatment in stroke? This one question will likely receive many new questions in return. Do we mean optimal blood pressure treatment in the acute phase of stroke, or in the context of secondary prevention of stroke? Do we mean ischemic stroke, ICH, or SAB? Does it concern blood pressure treatment around thrombolysis or thrombectomy? Is the goal of treatment to prevent bleeding (through hyperperfusion or increased intracranial pressure), or is it to prevent ischemia (hypoperfusion)? When we think of optimal blood pressure control in such different settings, even other questions may come to mind. Blood pressure is acutely elevated in acute stroke. What is the mechanism behind this, and does it perhaps serve a purpose? Does the brain initiate this rise in blood pressure to maintain perfusion, and will blood pressure lowering treatment lead to hypoperfusion? We cannot, and should not, answer these questions without integrative physiology.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"383-386"},"PeriodicalIF":6.3,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985440/pdf/10.1177_0271678X211057403.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39837221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Integrative cerebral blood flow regulation in ischemic stroke. 缺血性脑卒中的综合脑血流调节。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2022-03-01 Epub Date: 2021-07-14 DOI: 10.1177/0271678X211032029

Jui-Lin Fan, Patrice Brassard, Caroline A Rickards, Ricardo C Nogueira, Nathalie Nasr, Fiona D McBryde, James P Fisher, Yu-Chieh Tzeng

{"title":"Integrative cerebral blood flow regulation in ischemic stroke.","authors":"Jui-Lin Fan, Patrice Brassard, Caroline A Rickards, Ricardo C Nogueira, Nathalie Nasr, Fiona D McBryde, James P Fisher, Yu-Chieh Tzeng","doi":"10.1177/0271678X211032029","DOIUrl":"https://doi.org/10.1177/0271678X211032029","url":null,"abstract":"Optimizing cerebral perfusion is key to rescuing salvageable ischemic brain tissue. Despite being an important determinant of cerebral perfusion, there are no effective guidelines for blood pressure (BP) management in acute stroke. The control of cerebral blood flow (CBF) involves a myriad of complex pathways which are largely unaccounted for in stroke management. Due to its unique anatomy and physiology, the cerebrovascular circulation is often treated as a stand-alone system rather than an integral component of the cardiovascular system. In order to optimize the strategies for BP management in acute ischemic stroke, a critical reappraisal of the mechanisms involved in CBF control is needed. In this review, we highlight the important role of collateral circulation and re-examine the pathophysiology of CBF control, namely the determinants of cerebral perfusion pressure gradient and resistance, in the context of stroke. Finally, we summarize the state of our knowledge regarding cardiovascular and cerebrovascular interaction and explore some potential avenues for future research in ischemic stroke.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"387-403"},"PeriodicalIF":6.3,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0271678X211032029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39182421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Association between tissue hypoxia, perfusion restrictions, and microvascular architecture alterations with lesion-induced impairment of neurovascular coupling. 组织缺氧、灌注限制和微血管结构改变与病变引起的神经血管耦合损伤之间的关系。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2022-03-01 Epub Date: 2020-08-12 DOI: 10.1177/0271678X20947546

Andreas Stadlbauer, Thomas M Kinfe, Max Zimmermann, Ilker Eyüpoglu, Nadja Brandner, Michael Buchfelder, Moritz Zaiss, Arnd Dörfler, Sebastian Brandner

{"title":"Association between tissue hypoxia, perfusion restrictions, and microvascular architecture alterations with lesion-induced impairment of neurovascular coupling.","authors":"Andreas Stadlbauer, Thomas M Kinfe, Max Zimmermann, Ilker Eyüpoglu, Nadja Brandner, Michael Buchfelder, Moritz Zaiss, Arnd Dörfler, Sebastian Brandner","doi":"10.1177/0271678X20947546","DOIUrl":"https://doi.org/10.1177/0271678X20947546","url":null,"abstract":"Functional magnetic resonance imaging (fMRI) has been mainly utilized for the preoperative localization of eloquent cortical areas. However, lesion-induced impairment of neurovascular coupling (NVC) in the lesion border zone may lead to false-negative fMRI results. The purpose of this study was to determine physiological factors impacting the NVC. Twenty patients suffering from brain lesions were preoperatively examined using multimodal neuroimaging including fMRI, magnetoencephalography (MEG) during language or sensorimotor tasks (depending on lesion location), and a novel physiologic MRI approach for the combined quantification of oxygen metabolism, perfusion state, and microvascular architecture. Congruence of brain activity patterns between fMRI and MEG were found in 13 patients. In contrast, we observed missing fMRI activity in perilesional cortex that demonstrated MEG activity in seven patients, which was interpreted as lesion-induced impairment of NVC. In these brain regions with impaired NVC, physiologic MRI revealed significant brain tissue hypoxia, as well as significantly decreased macro- and microvascular perfusion and microvascular architecture. We demonstrated that perilesional hypoxia with reduced vascular perfusion and architecture is associated with lesion-induced impairment of NVC. Our physiologic MRI approach is a clinically applicable method for preoperative risk assessment for the presence of false-negative fMRI results and may prevent severe postoperative functional deficits.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"526-539"},"PeriodicalIF":6.3,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0271678X20947546","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38259105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The INfoMATAS project: Methods for assessing cerebral autoregulation in stroke. INfoMATAS项目:评估脑卒中脑自动调节的方法。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2022-03-01 Epub Date: 2021-07-19 DOI: 10.1177/0271678X211029049

David M Simpson, Stephen J Payne, Ronney B Panerai

{"title":"The INfoMATAS project: Methods for assessing cerebral autoregulation in stroke.","authors":"David M Simpson, Stephen J Payne, Ronney B Panerai","doi":"10.1177/0271678X211029049","DOIUrl":"https://doi.org/10.1177/0271678X211029049","url":null,"abstract":"Cerebral autoregulation refers to the physiological mechanism that aims to maintain blood flow to the brain approximately constant when blood pressure changes. Impairment of this protective mechanism has been linked to a number of serious clinical conditions, including carotid stenosis, head trauma, subarachnoid haemorrhage and stroke. While the concept and experimental evidence is well established, methods for the assessment of autoregulation in individual patients remains an open challenge, with no gold-standard having emerged. In the current review paper, we will outline some of the basic concepts of autoregulation, as a foundation for experimental protocols and signal analysis methods used to extract indexes of cerebral autoregulation. Measurement methods for blood flow and pressure are discussed, followed by an outline of signal pre-processing steps. An outline of the data analysis methods is then provided, linking the different approaches through their underlying principles and rationale. The methods cover correlation based approaches (e.g. Mx) through Transfer Function Analysis to non-linear, multivariate and time-variant approaches. Challenges in choosing which method may be 'best' and some directions for ongoing and future research conclude this work.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"411-429"},"PeriodicalIF":6.3,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0271678X211029049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39198248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Integrative physiological assessment of cerebral hemodynamics and metabolism in acute ischemic stroke. 急性缺血性脑卒中脑血流动力学和代谢的综合生理评估。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2022-03-01 Epub Date: 2021-07-26 DOI: 10.1177/0271678X211033732

Jui-Lin Fan, Ricardo C Nogueira, Patrice Brassard, Caroline A Rickards, Matthew Page, Nathalie Nasr, Yu-Chieh Tzeng

{"title":"Integrative physiological assessment of cerebral hemodynamics and metabolism in acute ischemic stroke.","authors":"Jui-Lin Fan, Ricardo C Nogueira, Patrice Brassard, Caroline A Rickards, Matthew Page, Nathalie Nasr, Yu-Chieh Tzeng","doi":"10.1177/0271678X211033732","DOIUrl":"https://doi.org/10.1177/0271678X211033732","url":null,"abstract":"Restoring perfusion to ischemic tissue is the primary goal of acute ischemic stroke care, yet only a small portion of patients receive reperfusion treatment. Since blood pressure (BP) is an important determinant of cerebral perfusion, effective BP management could facilitate reperfusion. But how BP should be managed in very early phase of ischemic stroke remains a contentious issue, due to the lack of clear evidence. Given the complex relationship between BP and cerebral blood flow (CBF)-termed cerebral autoregulation (CA)-bedside monitoring of cerebral perfusion and oxygenation could help guide BP management, thereby improve stroke patient outcome. The aim of INFOMATAS is to 'identify novel therapeutic targets for treatment and management in acute ischemic stroke'. In this review, we identify novel physiological parameters which could be used to guide BP management in acute stroke, and explore methodologies for monitoring them at the bedside. We outline the challenges in translating these potential prognostic markers into clinical use.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"454-470"},"PeriodicalIF":6.3,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0271678X211033732","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39218119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Optimized mouse model of embolic MCAO: From cerebral blood flow to neurological outcomes. 栓塞性MCAO小鼠模型的优化:从脑血流到神经学预后。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2022-03-01 Epub Date: 2020-04-20 DOI: 10.1177/0271678X20917625

Rongrong Wang, Hailian Wang, Yaan Liu, Di Chen, Yangfan Wang, Marcelo Rocha, Ashutosh P Jadhav, Amanda Smith, Qing Ye, Yanqin Gao, Wenting Zhang

{"title":"Optimized mouse model of embolic MCAO: From cerebral blood flow to neurological outcomes.","authors":"Rongrong Wang, Hailian Wang, Yaan Liu, Di Chen, Yangfan Wang, Marcelo Rocha, Ashutosh P Jadhav, Amanda Smith, Qing Ye, Yanqin Gao, Wenting Zhang","doi":"10.1177/0271678X20917625","DOIUrl":"https://doi.org/10.1177/0271678X20917625","url":null,"abstract":"The embolic middle cerebral artery occlusion (eMCAO) model mimics ischemic stroke due to large vessel occlusion in humans and is amenable to thrombolytic therapy with rtPA. However, two major obstacles, the difficulty of the eMCAO surgery and unpredictable occurrence of clot autolysis, had impeded its application in mice. In this study, we modified catheters to produce suitable fibrin-rich embolus and optimized the eMCAO model using cerebral blood flow (CBF) monitored by both laser Doppler flowmetry (LDF) and 2D laser speckle contrast imaging (LSCI) to confirm occlusion of MCA. The results showed that longer embolus resulted in higher mortality. There was a compensatory increase in MCA territory perfusion after eMCAO associated with decreased infarct volume; however, this was only partly dependent on recanalization as clot autolysis was only observed in ∼30% of mice. Cortical CBF monitoring with LSCI showed that the size of peri-core area at 3 h displayed the best correlation with infarct volume that is attributed to compensatory collateral blood flow. The peri-core area best predicted functional outcome after eMCAO. In summary, we developed a reliable eMCAO mouse model that better mimics embolic ischemic stroke in humans, which will increase the potential for successful translation of stroke neuroprotective therapies.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"495-509"},"PeriodicalIF":6.3,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0271678X20917625","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37854303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome. 脑卒中急性期动态脑自动调节及其与临床预后关系的研究综述。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2022-03-01 Epub Date: 2021-09-13 DOI: 10.1177/0271678X211045222

Ricardo C Nogueira, Marcel Aries, Jatinder S Minhas, Nils H Petersen, Li Xiong, Jana M Kainerstorfer, Pedro Castro

{"title":"Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome.","authors":"Ricardo C Nogueira, Marcel Aries, Jatinder S Minhas, Nils H Petersen, Li Xiong, Jana M Kainerstorfer, Pedro Castro","doi":"10.1177/0271678X211045222","DOIUrl":"https://doi.org/10.1177/0271678X211045222","url":null,"abstract":"Acute stroke is associated with high morbidity and mortality. In the last decades, new therapies have been investigated with the aim of improving clinical outcomes in the acute phase post stroke onset. However, despite such advances, a large number of patients do not demonstrate improvement, furthermore, some unfortunately deteriorate. Thus, there is a need for additional treatments targeted to the individual patient. A potential therapeutic target is interventions to optimize cerebral perfusion guided by cerebral hemodynamic parameters such as dynamic cerebral autoregulation (dCA). This narrative led to the development of the INFOMATAS (Identifying New targets FOr Management And Therapy in Acute Stroke) project, designed to foster interventions directed towards understanding and improving hemodynamic aspects of the cerebral circulation in acute cerebrovascular disease states. This comprehensive review aims to summarize relevant studies on assessing dCA in patients suffering acute ischemic stroke, intracerebral haemorrhage, and subarachnoid haemorrhage. The review will provide to the reader the most consistent findings, the inconsistent findings which still need to be explored further and discuss the main limitations of these studies. This will allow for the creation of a research agenda for the use of bedside dCA information for prognostication and targeted perfusion interventions.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"430-453"},"PeriodicalIF":6.3,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985432/pdf/10.1177_0271678X211045222.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39412327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Effect of drug interventions on cerebral hemodynamics in ischemic stroke patients. 药物干预对缺血性脑卒中患者血流动力学的影响。

IF 6.3

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Pub Date : 2022-03-01 Epub Date: 2021-11-05 DOI: 10.1177/0271678X211058261

Osian Llwyd, Jui-Lin Fan, Martin Müller

{"title":"Effect of drug interventions on cerebral hemodynamics in ischemic stroke patients.","authors":"Osian Llwyd, Jui-Lin Fan, Martin Müller","doi":"10.1177/0271678X211058261","DOIUrl":"https://doi.org/10.1177/0271678X211058261","url":null,"abstract":"The ischemic penumbra is sensitive to alterations in cerebral perfusion. A myriad of drugs are used in acute ischemic stroke (AIS) management, yet their impact on cerebral hemodynamics is poorly understood. As part of the Cerebral Autoregulation Network led INFOMATAS project (Identifying New Targets for Management and Therapy in Acute Stroke), this paper reviews some of the most common drugs a patient with AIS will come across and their potential influence on cerebral hemodynamics with a particular focus being on cerebral autoregulation (CA). We first discuss how compounds that promote clot lysis and prevent clot formation could potentially impact cerebral hemodynamics, before focusing on how the different classes of antihypertensive drugs can influence cerebral hemodynamics. We discuss the different properties of each drug and their potential impact on cerebral perfusion and CA. With emerging interest in CA status of AIS patients, either during or soon after treatment when timely reperfusion and salvageable tissue is at its most critical, the properties of these pharmacological agents may be relevant for modelling cerebral perfusion accuracy and for setting individualised treatment strategies.","PeriodicalId":520660,"journal":{"name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","volume":" ","pages":"471-485"},"PeriodicalIF":6.3,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985436/pdf/10.1177_0271678X211058261.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39592426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4