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[Effects of rituximab on prognosis in myasthenia gravis: A single-center experience from Turkey]. [利妥昔单抗对重症肌无力预后的影响:来自土耳其的单中心经验]。
IF 0.8
Ideggyogyaszati szemle Pub Date : 2022-09-30 DOI: 10.18071/isz.75.0351
Mehmet Fatih Göl, Fatma Kara, Merve Boz, Abdüssamet Mutlu, Serdar Karakullukçu, Cavit Boz
{"title":"[Effects of rituximab on prognosis in myasthenia gravis: A single-center experience from Turkey].","authors":"Mehmet Fatih Göl,&nbsp;Fatma Kara,&nbsp;Merve Boz,&nbsp;Abdüssamet Mutlu,&nbsp;Serdar Karakullukçu,&nbsp;Cavit Boz","doi":"10.18071/isz.75.0351","DOIUrl":"https://doi.org/10.18071/isz.75.0351","url":null,"abstract":"<p><strong>Background and purpose: </strong>Management of treatment-resistant patients with myasthenia gravis (MG) remains an important issue. This study aimed to evaluate the effects of rituximab (RTX) treatment on the prognosis of patients with acetylcholine receptor autoantibody-positive (AChR-Ab+), muscle-specific kinase autoantibody-positive (MuSK-Ab+), or seronegative or double seropositive MG.</p><p><strong>Methods: </strong>Nineteen patients treated with RTX between 2015 and 2020 were included in this study. Demographic and clinical characteristics, prognosis, and prognostic predictors of MG were evaluated retrospectively. The Myas-thenia Gravis Foundation of America Post-Inter-vention Status (MGFA-PIS) before RTX treatment (pre-RTX) and after RTX treatment (post-RTX) were recorded.</p><p><strong>Results: </strong>A total of 10 patients (52.6%) were AchR Ab+, 6 patients (31.6%) were MuSK Ab+, 1 patient (5.3%) was seronegative, and 2 patients (10.5%) were double seropositive. Steroid dose was pre-RTX 38.9±5.7 (25-45), it was post-RTX 10.5±10.3 (0-30) (p<0.001). Post-RTX steroid treatment was discontinued in 6 of 19 patients (p=0.041). Only three patients received intravenous immunoglobulin at the post-RTX follow-up (p<0.001). In post-RTX 12th month, the MGFA-PIS score was as minimally manifestation or better in 9 patients (47.3%) and improved or was better in 18 patients (94.7%) (p-value 0.004; <0.001, respectively).</p><p><strong>Conclusion: </strong>The improvement in MGFA-PIS scores post-RTX was similar in MuSK-Ab+ and AChR-Ab+ patients. The data are insufficient in seronegative and double seropositive patients and RTX must be considered in the treatment of suitable patients with MuSK-Ab+ and AChR-Ab+ refractory MG.</p>","PeriodicalId":520642,"journal":{"name":"Ideggyogyaszati szemle","volume":" ","pages":"351-359"},"PeriodicalIF":0.8,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33500511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Adolescents' sleep quality in the context of Internet use]. [互联网使用背景下青少年的睡眠质量]。
IF 0.8
Ideggyogyaszati szemle Pub Date : 2022-09-30 DOI: 10.18071/isz.75.0317
Katalin Fusz, Viktória Bencsik, András Deák, Krisztina Takács, Annamária Pakai, András Oláh, Eszter Somlai
{"title":"[Adolescents' sleep quality in the context of Internet use].","authors":"Katalin Fusz,&nbsp;Viktória Bencsik,&nbsp;András Deák,&nbsp;Krisztina Takács,&nbsp;Annamária Pakai,&nbsp;András Oláh,&nbsp;Eszter Somlai","doi":"10.18071/isz.75.0317","DOIUrl":"https://doi.org/10.18071/isz.75.0317","url":null,"abstract":"<p><strong>Background and purpose: </strong>Background and purpose - The present study is a continuation of our previous research, our aim is to assess the sleep quality of adolescents in light of Internet use.</p><p><strong>Methods: </strong>We conducted a cross-sectional, quantitative, descriptive questionnaire survey among students aged 12-18 in primary and secondary education (n = 308). A self-edited questionnaire, a scale of sleep hygiene rules, and the Athens Insomnia Scale were used.</p><p><strong>Results: </strong>On the Athens Insomnia Scale, they scored an average of 5.39 (3.93) points, with 17% of adolescents considered insomniac. Students watch an average of 1.27 (1.04) hours of film a day, and 47% of them use the Internet for more than two hours a day. Excessive internet use (p < 0.001) and use of smart devices before falling asleep (p = 0.002) have a negative effect on sleep quality. Stress increases in parallel with Internet use (p = 0.001). Those who sleep better perform better in school (p = 0.034).</p><p><strong>Conclusion: </strong>Excessive use of smart devices is associated with higher stress levels and poorer sleep quality. Our goal is to draw the attention of parents and adolescents to the reduction of Internet use and the possible consequen-ces of deteriorating sleep quality.</p>","PeriodicalId":520642,"journal":{"name":"Ideggyogyaszati szemle","volume":" ","pages":"317-324"},"PeriodicalIF":0.8,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33500513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[EEG abnormalities indicating the genetic determination of epilepsies]. [脑电图异常表明癫痫的遗传决定]。
IF 0.8
Ideggyogyaszati szemle Pub Date : 2022-09-30 DOI: 10.18071/isz.75.0295
Béla Clemens, Szilvia Puskás, Johanna Dömötör
{"title":"[EEG abnormalities indicating the genetic determination of epilepsies].","authors":"Béla Clemens,&nbsp;Szilvia Puskás,&nbsp;Johanna Dömötör","doi":"10.18071/isz.75.0295","DOIUrl":"https://doi.org/10.18071/isz.75.0295","url":null,"abstract":"<p><p>Genetic and acquired factors contribute to epileptogenesis in all epilepsy syndromes and patients. A comprehensive evaluation of both components of etiology is essential in every patient. In this review, the authors enumerate the EEG abnormalities indicating the genetic determination of epilepsy. The authors briefly describe generalized spike-and-wave paroxysms, focal spikes and sharp waves, photosensitivity, 4-7 Hz theta rhythm, 2-4 Hz occipital intermittent rhythmic delta activity, phi rhythm, and generalized monomorphic alpha EEG background activity. For each abnormality, the authors review prior knowledge and add recent research results. The neurophysiological meaning of the abnormalities, age distribution, the relationship to epilepsy, the role of the EEG patterns in epileptogenesis, clinical presentation, and prognosis in the individual patient are the main aspects of description and discussion. These EEG abnormalities may shape the typical, syndrome-specific phenotype, forecast severity of the disease and difficulty of treatment or pharmacoresistance, and modify the syndrome-specific general prognosis of the syndrome. Relationship to epilepsy and heritability data of the EEG abnormalities can help to estimate the risk of epilepsy in the offspring. Epilepsy syndromes are taxonomic diagnostic categories that might be enriched with neurobiological meaning and heritability relations.</p>","PeriodicalId":520642,"journal":{"name":"Ideggyogyaszati szemle","volume":" ","pages":"295-305"},"PeriodicalIF":0.8,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33501004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Comparison of long-latency reflex and mixed nerve silent period responses in various hypokinetic movement disorders]. [各种低运动障碍的长潜伏期反射和混合神经沉默期反应的比较]。
IF 0.8
Ideggyogyaszati szemle Pub Date : 2022-09-30 DOI: 10.18071/isz.75.0333
Gul Bengi Turk, Aysegul Gunduz, Gunes Kiziltan, Meral Erdemir-Kiziltan
{"title":"[Comparison of long-latency reflex and mixed nerve silent period responses in various hypokinetic movement disorders].","authors":"Gul Bengi Turk,&nbsp;Aysegul Gunduz,&nbsp;Gunes Kiziltan,&nbsp;Meral Erdemir-Kiziltan","doi":"10.18071/isz.75.0333","DOIUrl":"https://doi.org/10.18071/isz.75.0333","url":null,"abstract":"<p><strong>Background and purpose: </strong>Long-latency reflex and mixed nerve silent period responses are electrophysiological methods to study the sensorimotor functions of the central nervous system. Here we aimed to study long-latency reflexes and mixed nerve silent period responses in different types of hypokinetic movement disorders in order to find an electrophysiological landmark to distinguish them.</p><p><strong>Methods: </strong>We included 39 patients with idiopathic Parkinson's disease (IPD), 12 patients with multiple system atrophy (MSA), 10 patients with corticobasal syndrome (CBS), 5 patients with progressive supranuclear palsy (PSP) and 26 healthy participants. We recorded the segmental reflex, the long-latency reflexes and the mixed nerve silent period responses for each participant.</p><p><strong>Results: </strong>C reflex, long-latency reflex-I and long-latency reflex-III responses were not obtained in any patients with PSP. Long-latency reflex amplitude/ F amplitude ratio was significantly lower in patients with IPD and PSP compared to healthy individuals (p=0.036, p=0.006 respectively). The mixed nerve silent period end latencies were significantly longer in IPD, MSA, CBS groups compared to the healthy individuals (p=0.026, p=0.050, p=0.008 respectively).</p><p><strong>Conclusion: </strong>We suggest that recording long-latency reflex, particularly C reflex responses may provide promising results in distinction of CBS and MSA from PSP. Prospective studies with clinical findings and brainstem reflexes may offer more information.</p>","PeriodicalId":520642,"journal":{"name":"Ideggyogyaszati szemle","volume":" ","pages":"333-339"},"PeriodicalIF":0.8,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33500512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Multiple ischemic stroke in Osler-Rendu-Weber disease]. [奥斯勒-伦度-韦伯病的多发性缺血性卒中]。
IF 0.8
Ideggyogyaszati szemle Pub Date : 2019-01-30 DOI: 10.18071/isz.72.0065
András Salamon, Péter Faragó, Viola Luca Németh, Noémi Szépfalusi, Emese Horváth, Andrea Vass, Zsuzsanna Bereczky, János Tajti, László Vécsei, Péter Klivényi, Dénes Zádori
{"title":"[Multiple ischemic stroke in Osler-Rendu-Weber disease].","authors":"András Salamon,&nbsp;Péter Faragó,&nbsp;Viola Luca Németh,&nbsp;Noémi Szépfalusi,&nbsp;Emese Horváth,&nbsp;Andrea Vass,&nbsp;Zsuzsanna Bereczky,&nbsp;János Tajti,&nbsp;László Vécsei,&nbsp;Péter Klivényi,&nbsp;Dénes Zádori","doi":"10.18071/isz.72.0065","DOIUrl":"https://doi.org/10.18071/isz.72.0065","url":null,"abstract":"<p><p>Hereditary hemorrhagic teleangiectasia (HHT, Osler-Rendu-Weber disease) is an autosomal dominantly inherited disorder caused by the mutation of several possible genes and characterized by malformations of the arteriovenous system in multiple organs. The clinical diagnosis is based on the Curaçao criteria ((1) spontaneous, recurrent epistaxis; (2) teleangiectasias in characteristic sites (lips, oral cavity, nose, fingers); (3) visceral lesions (gastrointestinal, pulmonary, cerebral, spinal); (4) affected first degree relative). The aim of this study is to present the first genetically confirmed Hungarian case of hereditary hemorrhagic teleangiectasia with multiple ischemic strokes. Our 70-year-old woman has been suffering from severe epistaxis since her childhood and presented gastrointestinal bleeding during her adulthood as well. The characteristic skin lesions developed in the 5th decade of life. She was admitted to our department with loss of consciousness and fluctuating speech and swallowing problems. MRI of the brain supplemented with angiography revealed multiple arteriovenous malformations and multiple subacute ischemic lesions. The EEG demonstrated slowing of electric activity in the left frontal lobe. The neuropsychological assessment showed deficits in anterograde memory and executive functions. The diagnostic work-up for other characteristic alterations identified an arteriovenous malformation in the left lung. The genetic analysis demonstrated a heterozygous mutation in the 7th exon of the ENG gene at position 834 resulting in a thymine duplication and an early stop codon by a frame shift. The present case is largely similar to those already described in literature and draws the attention to the importance of multidisciplinary collaboration in the care of HHT patients.</p>","PeriodicalId":520642,"journal":{"name":"Ideggyogyaszati szemle","volume":" ","pages":"65-70"},"PeriodicalIF":0.8,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36576005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[The effect of palliative neural therapy on the improvement of chronic pain]. 【姑息性神经疗法对慢性疼痛的改善作用】。
IF 0.8
Ideggyogyaszati szemle Pub Date : 2019-01-30 DOI: 10.18071/isz.72.0023
István Molnár, Gabriella Hegyi, Zoltán Kovács, Gábor Kapócs, Henrik Szôke
{"title":"[The effect of palliative neural therapy on the improvement of chronic pain].","authors":"István Molnár,&nbsp;Gabriella Hegyi,&nbsp;Zoltán Kovács,&nbsp;Gábor Kapócs,&nbsp;Henrik Szôke","doi":"10.18071/isz.72.0023","DOIUrl":"https://doi.org/10.18071/isz.72.0023","url":null,"abstract":"<p><strong>Background and purpose: </strong>To assess the extent to which pain therapy can improve chronic pain in a heterogeneous group of patients, its impact on their quality of life and the correlation of the changes with their age and the underlying disease. The investigation has its actuality by its impact on public health.</p><p><strong>Methods: </strong>a prospective, non-randomized, interventional, clinical cohort study was conducted under real-life conditions in a general pain clinic, which lasted for 6 months. Changes in pain intensity (VAS) and related quality of life changes (SF-36 HRQoL) were measured using validated internationally accepted questionnaires. The questionnaires were filled out by all patients on their own, so they provided information of self-esteem on their own. All patient post-treatment results were compared to pre-treatment results. The general quality of life changes found in our patients were compared to the representative norms of healthy population in Hungary. Subjects - patients participated voluntarily at their own decision in the survey. The underlying disease of chronic pain, age and gender of the patients did not limit the inclusion into the study.</p><p><strong>Results: </strong>Data of 231 patients were evaluated. After pain therapy, the decrease in intensity of pain was confirmed by VAS at p=0.002. This was linked to a quality of life change that has been shown to be p=0.003 for men, with p=0.002 in women with SF-36 HRQoL. Based on the correlation coefficients, the changes in quality of life improved regardless of the age of the patients and the nature of the underlying conditions causing the pain.</p><p><strong>Conclusion: </strong>Although analgesia is basicly a symptomatic therapy, our findings suggest that the reduction of pain improves the quality of life of patients independently from their, and the curability of the underlying and accompanying diseases.</p>","PeriodicalId":520642,"journal":{"name":"Ideggyogyaszati szemle","volume":" ","pages":"23-31"},"PeriodicalIF":0.8,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36982278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Selection of the optimal device-aided therapy in Parkinson's disease]. [帕金森病最佳器械辅助治疗的选择]。
IF 0.8
Ideggyogyaszati szemle Pub Date : 2019-01-30 DOI: 10.18071/isz.72.0005
Norbert Kovács, Zsuzsanna Aschermann, Annamária Juhász, Márk Harmat, Dávid Pintér, József Janszky
{"title":"[Selection of the optimal device-aided therapy in Parkinson's disease].","authors":"Norbert Kovács,&nbsp;Zsuzsanna Aschermann,&nbsp;Annamária Juhász,&nbsp;Márk Harmat,&nbsp;Dávid Pintér,&nbsp;József Janszky","doi":"10.18071/isz.72.0005","DOIUrl":"https://doi.org/10.18071/isz.72.0005","url":null,"abstract":"<p><p>For the treatment of advanced Parkinson's disease the deep brain stimulation (DBS) and the levodopa/carbidopa intestinal gel (LCIG) therapies are available in Hungary. Although they may have similar impact on the health-related quality of life and disabilities associated with the disease, they have different indications, and inclusion- and exclusion criteria. Consequently, the patient population treated with DBS and LCIG may be different. In the present review, the authors try to help the process of selection of the optimal device-aided therapy for the patients with advanced Parkinson's disease.</p>","PeriodicalId":520642,"journal":{"name":"Ideggyogyaszati szemle","volume":" ","pages":"5-11"},"PeriodicalIF":0.8,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36982276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Additional value of tau protein measurement in the diagnosis of Creutzfeldt-Jakob disease. tau蛋白测定在克雅氏病诊断中的附加价值。
IF 0.8
Ideggyogyaszati szemle Pub Date : 2019-01-30 DOI: 10.18071/isz.72.0039
Edit Katalin Cseh, Gábor Veres, Krisztina Danics, Levente Szalárdy, Nikolett Nánási, Péter Klivényi, László Vécsei, Dénes Zádori
{"title":"Additional value of tau protein measurement in the diagnosis of Creutzfeldt-Jakob disease.","authors":"Edit Katalin Cseh,&nbsp;Gábor Veres,&nbsp;Krisztina Danics,&nbsp;Levente Szalárdy,&nbsp;Nikolett Nánási,&nbsp;Péter Klivényi,&nbsp;László Vécsei,&nbsp;Dénes Zádori","doi":"10.18071/isz.72.0039","DOIUrl":"https://doi.org/10.18071/isz.72.0039","url":null,"abstract":"<p><p>Since the definite diagnosis of Creutzfeldt-Jakob disease (CJD) can currently only be provided by autopsy, there is a special need for fine diagnostic tools in live patients to achieve accurate diagnosis as early as possible. The aim of this study was to perform a preliminary retrospective analysis on the utility of the measurement of total Tau (tTau) and some other biomarkers from the cerebrospinal fluid (CSF) of patients with rapidly progressive dementia in the diagnostic work up of CJD. Beside the assessment of relevant clinical data and the findings of electroencephalography and brain magnetic resonance imaging, the presence of 14-3-3 protein and the levels of tTau were determined by Western blot technique and enzyme-linked immunosorbent assay from the CSF of 19 patients diagnosed with rapidly progressive dementia between the period of 2004-2017 at the Department of Neurology, University of Szeged. This preliminary study provided 100% sensitivity for 14-3-3, and interestingly, only 40% specificity to support the clinical diagnosis of CJD. Regarding tTau, the sensitivity values were calculated to be 100% or 83%, whereas the specificity values were 71% or 86%, depending on the applied cut-off levels. The poor specificity of 14-3-3 is not in line with literature data and may be the result of the small number of patients in the cohort with non-prion disease, predominantly consisting of disorders with considerable tissue damage, whereas tTau presented good sensitivity and specificity values. The combined application of these and novel chemical biomarkers may increase both sensitivity and specificity to a desired level.</p>","PeriodicalId":520642,"journal":{"name":"Ideggyogyaszati szemle","volume":" ","pages":"39-47"},"PeriodicalIF":0.8,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36576002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Axillary mononeuropathy after herpes zoster infection misdiagnosed as neuropathic pain 带状疱疹感染后腋窝单神经病变误诊为神经性疼痛
IF 0.8
Ideggyogyaszati szemle Pub Date : 2019-01-30 DOI: 10.18071/isz.72.0055
Sıdıka Sinem Gül, Emel Oguz Akarsu
{"title":"Axillary mononeuropathy after herpes zoster infection misdiagnosed as neuropathic pain","authors":"Sıdıka Sinem Gül,&nbsp;Emel Oguz Akarsu","doi":"10.18071/isz.72.0055","DOIUrl":"https://doi.org/10.18071/isz.72.0055","url":null,"abstract":"<p><p>Zoster-associated extremity paresis is a rare complication of herpes zoster (HZ) and is usually due to zoster-associated mononeuropathy. Complaints of a 77-year-old man started with pain in his right arm and 4 days later he developed itchy red HZ lesions in the same area. One week later, the patient developed weakness in his right arm. The patient was diagnosed with isolated axillary mononeuropathy by physical examination and electromyography. Here, we present a case of axillary mononeuropathy which is a rare complication of HZ infection and needs particular attention.</p>","PeriodicalId":520642,"journal":{"name":"Ideggyogyaszati szemle","volume":" ","pages":"55-58"},"PeriodicalIF":0.8,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36576004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Evaluation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in essential tremor. 特发性震颤患者中性粒细胞与淋巴细胞比值及血小板与淋巴细胞比值的评价。
IF 0.8
Ideggyogyaszati szemle Pub Date : 2019-01-30 DOI: 10.18071/isz.72.0033
Ali Zeynal Abidin Tak, Yildizhan Sengül
{"title":"Evaluation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in essential tremor.","authors":"Ali Zeynal Abidin Tak,&nbsp;Yildizhan Sengül","doi":"10.18071/isz.72.0033","DOIUrl":"https://doi.org/10.18071/isz.72.0033","url":null,"abstract":"<p><strong>Background and purpose: </strong>Although essential tremor (ET) is the most common cause of tremor, the pathology and underlying mechanisms have not fully understood yet. In addition to kinetic tremor, patients may present several types of tremor, gait ataxia, hearing deficits and eye movement abnormalities. Non-motor symptoms and signs have also added to definition of ET. There is significant evidence indicating the neurodegenerative nature of the disease. New studies indicate that inflammation may have a place in the etiology. The neutrophil-to lymphocyte ratio (NLR) and the platelet-to lymphocyte ratio (PLR) have recently begun to be used as a marker of systemic inflammation. Our study aims at finding a clue for systemic inflammation in ET.</p><p><strong>Methods: </strong>67 patients with ET and 40 healthy controls were recruited for the study. The total white blood cells (WBC), absolute neutrophil count, lymphocyte count and platelet count were retrieved. The NLR was calculated by dividing the neutrophil count by the lymphocyte count and the PLR was calculated by dividing the platelet count by the lymphocyte count.</p><p><strong>Results: </strong>Patient and control groups were similar in terms of age and gender. The mean age of patient group was 25.29 ± 8.24 years and that of control group was 26.77 ± 6.73 years. The NLRs were 1.85 ± 0.58 in the patient group and 1.96 ± 0.53 in the control group. For the patient group and the control group the PLRs were 103.52 ±32.80 and 91.26 ± 31.57 respectively. There were no statistically significant differences between the participants for both NLR and PLR.</p><p><strong>Conclusion: </strong>The pathophysiological mechanism for essential tremor (ET) remains unclear. However, there is an increasing amount of research being conducted on the subject. Discussions about ET's definition as a neurodegenerative disease are ongoing. Although previous studies showed that neuroinflammation could be a part of etiology of disease, this study has failed to demonstrate systemic inflammation in ET.</p>","PeriodicalId":520642,"journal":{"name":"Ideggyogyaszati szemle","volume":" ","pages":"33-38"},"PeriodicalIF":0.8,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36982279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
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