Ideggyogyaszati szemle最新文献_第2页

Evaluation of body image perception in multiple sclerosis patients without neurological deficit. 无神经功能缺损的多发性硬化症患者身体形象感知的评价。

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Ideggyogyaszati szemle Pub Date : 2019-01-30 DOI: 10.18071/isz.71.0049

Hakan S Sengul, Yıldızhan Sengul, Ali Zeynel Abidin Tak, Müge Kocak, Abdulkadir Tunc

{"title":"Evaluation of body image perception in multiple sclerosis patients without neurological deficit.","authors":"Hakan S Sengul, Yıldızhan Sengul, Ali Zeynel Abidin Tak, Müge Kocak, Abdulkadir Tunc","doi":"10.18071/isz.71.0049","DOIUrl":"https://doi.org/10.18071/isz.71.0049","url":null,"abstract":"Background and purpose: There is a lack of research on the association between body image perception (BIP) and multiple sclerosis (MS). The aim of this study was to evaluate BIP in MS patients and its correlation with depression, anxiety, duration of the disease, and sociodemographic characteristics of the patients.Methods: Fifty patients with MS who applied to our outpatient clinic were examined. Forty-five healthy control were recruited for the study. All patients were diagnosed with MS according to 2010 revisions of McDonald criteria. Expanded Disability Status Scale (EDSS) was performed by the same neurologist for all patients. The participants were asked to complete a sociodemographic form, Body Cathexis Scale (BCS), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI).Results: The mean BCS score was 86.54 ± 32.24 in MS patients and 155.00 ± 20.90 in the healthy subjects (p<0.001). While MS patients had significantly higher anxiety levels, depression scores were similar in both groups. The mean BAI score was 18.50 ± 14.03 for MS patients and 10.06 ± 7.96 in the control group (p=0.001). The BDI score of the patients was 13.77 ± 11.61 and 11.91 ± 8.65 for the controls (p=0.34). Early age of the disease onset, increased number of attacks, increased depressive symptoms, and higher anxiety levels were significantly correlated with higher BCS scores. Age and being single/ divorced/ widowed were also correlated with BCS scores.Conclusion: It is important to preserve the mental well-being of patients. Even in apparently healthy patients, the body perception may be severely impaired.","PeriodicalId":520642,"journal":{"name":"Ideggyogyaszati szemle","volume":" ","pages":"49-54"},"PeriodicalIF":0.8,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36576003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

[Tension type headache and its treatment possibilities]. [紧张性头痛及其治疗可能性]。

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Ideggyogyaszati szemle Pub Date : 2019-01-30 DOI: 10.18071/isz.72.0013

Csaba Ertsey, Máté Magyar, Tamás Gyüre, Eszter Balogh, György Bozsik

{"title":"[Tension type headache and its treatment possibilities].","authors":"Csaba Ertsey, Máté Magyar, Tamás Gyüre, Eszter Balogh, György Bozsik","doi":"10.18071/isz.72.0013","DOIUrl":"https://doi.org/10.18071/isz.72.0013","url":null,"abstract":"Tension type headache, the most common type of primary headaches, affects approximately 80% of the population. Mainly because of its high prevalence, the socio-economic consequences of tension type headache are significant. The pain in tension type headache is usually bilateral, mild to moderate, is of a pressing or tightening quality, and is not accompanied by other symptoms. Patients with frequent or daily occurrence of tension type headache may experience significant distress because of the condition. The two main therapeutic avenues of tension type headache are acute and prophylactic treatment. Simple or combined analgesics are the mainstay of acute treatment. Prophylactic treatment is needed in case of attacks that are frequent and/or difficult to treat. The first drugs of choice as preventatives of tension type headache are tricyclic antidepressants, with a special focus on amitriptyline, the efficacy of which having been documented in multiple double-blind, placebo-controlled studies. Among other antidepressants, the efficacy of mirtazapine and venlafaxine has been documented. There is weaker evidence about the efficacy of gabapentine, topiramate, and tizanidin. Non-pharmacological prophylactic methods of tension type headache with a documented efficacy include certain types of psychotherapy and acupuncture.","PeriodicalId":520642,"journal":{"name":"Ideggyogyaszati szemle","volume":" ","pages":"13-21"},"PeriodicalIF":0.8,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36982277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Oxygen-glucose deprivation-induced changes in organotypic cultures of the rat hippocampus. 氧-葡萄糖剥夺诱导的大鼠海马器官型培养的变化。

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Ideggyogyaszati szemle Pub Date : 2007-03-30

Balázs Bali, Zoltán Nagy, Krisztina J Kovács

{"title":"Oxygen-glucose deprivation-induced changes in organotypic cultures of the rat hippocampus.","authors":"Balázs Bali, Zoltán Nagy, Krisztina J Kovács","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: (-)Deprenyl is an irreversible inhibitor of type B monoamine oxidase (MAO-B), which is now used for treatment of Parkinson's or Alzheimer's diseases. Evidence suggests that the neuroprotective effect of deprenyl may not be related exclusively to the inhibition of the enzyme MAO-B.Methods: To test the impact of deprenyl on ischemia-induced changes in vitro, we followed the time course of propidium iodide (PI) uptake as an indicator of neuronal cell death as well as the expression of apoptotic factors in organotypic hippocampal slice cultures exposed to oxygen-glucose deprivation (OGD) for 45 min.Results: The first signs of neuronal death were detected 2 hours after OGD and were extended to all subfields of the hippocampus by 24 hours post-injury. Presence of deprenyl (10(-9) M) significantly delayed the cell death induced by the insult. Exposure of control cultures to deprenyl significantly increased the abundance of Bcl-2 and Bcl-xl mRNAs as revealed by RT-PCR. OGD resulted in an elevation of anti-apoptotic factors, while the expression of pro-apoptotic bax remained unchanged.Conclusion: These data suggest that deprenyl is neuroprotective in an in vitro model of ischemia. Although deprenyl upregulates the expression of Bcl-2 under basal conditions, its effect on anti-apoptotic factors is not significantly manifested during OGD.","PeriodicalId":520642,"journal":{"name":"Ideggyogyaszati szemle","volume":" ","pages":"140-3"},"PeriodicalIF":0.8,"publicationDate":"2007-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26679818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human trypsin(ogen) 4-like immunoreactivity in the white matter of the cerebral cortex and the spinal cord. 人脑皮层和脊髓白质中胰蛋白酶(原)4样免疫反应性。

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Ideggyogyaszati szemle Pub Date : 2007-03-30

Katalin Gallatz, Péter Medveczky, Péter Németh, László Szilágyi, László Gráf, Miklós Palkovits

引用次数: 0

Association of apolipoprotein E polymorphism with age-related macular degeneration and Alzheimer's disease in south-western Hungary. 载脂蛋白E多态性与匈牙利西南部年龄相关性黄斑变性和阿尔茨海默病的关系

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Ideggyogyaszati szemle Pub Date : 2007-03-30

Katalin A Kovács, Zsuzsanna Pámer, Attila Kovács, Sándor Fekete, Attila Miseta, Bálint Kovács, Gábor L Kovács

{"title":"Association of apolipoprotein E polymorphism with age-related macular degeneration and Alzheimer's disease in south-western Hungary.","authors":"Katalin A Kovács, Zsuzsanna Pámer, Attila Kovács, Sándor Fekete, Attila Miseta, Bálint Kovács, Gábor L Kovács","doi":"","DOIUrl":"","url":null,"abstract":"Background: Age-related macular degeneration (AMD) and Alzheimer dementia (AD) show similarities (advanced age, formation of deposits of similar content). Recently apolipoprotein E 2 (apoE 2) has been associated with AMD, while apoE4 with AD. The question of coexistence, especially with respect to the genetic background has not been studied earlier. We investigated, therefore, the occurrence of AMD in AD patients and compared their lipid profile and apoE polymorphism.Methods: - 49 AMD, 32 AD and 27 control patients were examined (risk factors, visual acuity, slit lamp biomicroscopy, fundoscopy). Following measurement of triglyceride, total and HDL cholesterol levels, apoE mutation analysis was performed.Results: AMD was found in 8% of the cooperating AD patients. The prevalence of the apoE 4 isoforms in the AMD, AD and the control patients was 2%, 47% and 22%, while that of apoE 2 was 17%, 6% and 7%, respectively. The prevalence of apoE 3 isoform was 82%, 41% and 71%, respectively. Triglyceride, total and HDL cholesterol were in the reference range; however, AD patients were characterized by a lower total cholesterol value.Conclusion: The new finding of this publication is the rare occurrence of AMD among AD patients. The higher frequency of apoE 4 among the AD population, and the higher frequency of apoE 2 among AMD patients in the South-Western region of Hungary confirms the findings of other investigators.","PeriodicalId":520642,"journal":{"name":"Ideggyogyaszati szemle","volume":" ","pages":"169-72"},"PeriodicalIF":0.8,"publicationDate":"2007-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26680754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The ghrelin system: physiopathological involvement in the control of body growth and energy metabolism. 胃饥饿素系统:生理病理参与控制身体生长和能量代谢。

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Ideggyogyaszati szemle Pub Date : 2007-03-30

Jacques Epelbaum

引用次数: 0

Histochemistry of the extracellular matrix in the snail central nervous system. 蜗牛中枢神经系统细胞外基质的组织化学。

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Ideggyogyaszati szemle Pub Date : 2007-03-30

Zoltán Serfozo, Károly Elekes

{"title":"Histochemistry of the extracellular matrix in the snail central nervous system.","authors":"Zoltán Serfozo, Károly Elekes","doi":"","DOIUrl":"","url":null,"abstract":"Even tough the central nervous system (CNS) of gastropods has long been used as a model for studying different neuronal networks underlying behaviors, there is only little information on the molecular components of the extracellular matrix (ECM) of the nervous tissue. Therefore, the aim of the present study was to identify some of the ECM molecules by acid-base histochemistry. Staining with alcian blue at strong acidic pH, and with acridine orange at different pH and salt concentrations was carried out on cryostat sections taken from CNS preparations of adult specimens of the terrestrial snail, Helix pomatia, and the aquatic species, Lymnaea stagnolis, in order to visualize mild (carboxyl) and strong (sulphate) acidic groups, which are characteristic for different glucosaminoglycans. According to our findings, sulphated proteoglycans were abundant in the periganglionic sheath of both species, and they also occurred in the neuropil of Helix, whereas they were absent in Lymnaea. The interperikaryonal space contained mainly carboxyl residues, which might refer to the presence of hyaluronic acid. It is concluded that the ECM of the snail CNS, similarly to that in vertebrates, is partly composed of polymer macromolecules of different chemical properties. It is suggested that adaptation to environmental conditions and/or altered neuronal plasticity are responsible for the differences found in chemical characters of the ECM molecules between the two snail species.","PeriodicalId":520642,"journal":{"name":"Ideggyogyaszati szemle","volume":" ","pages":"173-6"},"PeriodicalIF":0.8,"publicationDate":"2007-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26680755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The supraspinal innervation of the left adrenal is more intense than that of the right one. 左侧肾上腺的棘上神经支配比右侧肾上腺更为强烈。

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Ideggyogyaszati szemle Pub Date : 2007-03-30

Ida Gerendai, Ory Wiesel, Zsolt Boldogkoi, Ida E Tóth

{"title":"The supraspinal innervation of the left adrenal is more intense than that of the right one.","authors":"Ida Gerendai, Ory Wiesel, Zsolt Boldogkoi, Ida E Tóth","doi":"","DOIUrl":"","url":null,"abstract":"Background and purpose: Previous studies using the viral transneuronal tracing technique demonstrated that central autonomic circuits are involved in the innervation of the adrenal gland. Since increasing number of data indicate laterality in the neuroendocrine system, we aimed to investigate whether the supraspinal innervation of the adrenal gland exhibits asymmetry or not.Methods: The central circuitry involved in the innervation of the left and the right adrenal gland was studied in individual rats by dual transneuronal tracing using isogenic recombinant strains (BDG and BDL) of Bartha strain of pseudorabies virus.Results: Viral infection of brain nuclei (dorsal vagal nucleus, nucleus of the solitary tract, caudal raphe nuclei, A5 cell group, hypothalamic paraventricular nucleus) from the left adrenal was more severe than that from the right organ. Dual-infected neurons from the two adrenals were also detected both in the brain stem and in the hypothalamus.Conclusion: The results indicate a predominance in the supraspinal innervation of the left adrenal gland. Data further suggest that each adrenal gland is innervated both by side-specific neurons and by neurons which project to both organs.","PeriodicalId":520642,"journal":{"name":"Ideggyogyaszati szemle","volume":" ","pages":"159-61"},"PeriodicalIF":0.8,"publicationDate":"2007-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26680751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immobilization induced fos expression in the medial and lateral hypothalamic areas: a limited response of hypocretin neurons. 固定诱导下丘脑内侧和外侧区fos表达:下丘脑分泌素神经元的有限反应。

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Ideggyogyaszati szemle Pub Date : 2007-03-30

Alexander Kiss

{"title":"Immobilization induced fos expression in the medial and lateral hypothalamic areas: a limited response of hypocretin neurons.","authors":"Alexander Kiss","doi":"","DOIUrl":"","url":null,"abstract":"Induction of Fos, a proto-oncogene c-fos protein product, was immunohistochemically examined in the rat hypothalamic neurons 3 h after a single (1 x120 min) or repeated (7x 120 min) immobilization (IMO) stress. The aim of the present study was to reveal a possible parallelism in the cell activation between the medial and lateral hypothalamic neurons, especially between the stress responsive neurons in the hypothalamic paraventricular nucleus (PVN) and hypocretin (Hcrt) synthesizing neurons, i.e. suspected stress active neurons of the lateral hypothalamus. After IMO, the animals were perfused and their brains processed with immunohistochemistry for Fos or Fos/Hcrt proteins. Acute IMO elicited extensive Fos expression in both the examined areas. Excessive Fos expression was mainly seen in the PVN, while Hcrt neurons failed to show a broad response (appr. 5%) to single IMO. Clear occurrence of Fos signal was also seen in both hypothalamic areas of IMO-habituated rats. However, in these animals, in both areas examined, the number of Fos neurons was considerably suppressed, including the PVN. These results indicate that IMO is able to evoke a concurrent activation of Fos in many medial and lateral hypothalamic neurons. However, the scanty response of Hcrt neurons to acute IMO does not allow to assort them to a distinct IMO stress-responsive neuronal phenotypes of the brain.","PeriodicalId":520642,"journal":{"name":"Ideggyogyaszati szemle","volume":" ","pages":"192-5"},"PeriodicalIF":0.8,"publicationDate":"2007-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26680689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pituitary atrial natriuretic peptide of paraventricular nucleus origin. 脑室旁核起源的垂体房利钠肽。

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Ideggyogyaszati szemle Pub Date : 2007-03-30

Mariann Fodor, Gábor B Makara, Miklós Palkovits

引用次数: 0