Hormones (Athens, Greece)最新文献

{"title":"The impact of obesity-related anthropometric indices on diabetic foot ulcer and mortality: analysis of a nationally representative sample.","authors":"ZhaoLiang Zhang, LiMing Zhou, YunFei Xu, LieHui Yao, Tao Ma, XiaYun Pan","doi":"10.1007/s42000-025-00745-0","DOIUrl":"10.1007/s42000-025-00745-0","url":null,"abstract":"<p><strong>Aims and background: </strong>Diabetic foot ulcer (DFU) is a serious diabetes complication and a leading cause of non-traumatic lower extremity amputation. Obesity-related anthropometric indices may serve as early predictors of DFU. This study examined associations between the following four indices: body mass index (BMI), weight-adjusted waist index (WWI), body roundness index (BRI), and relative fat mass (RFM), and DFU risk.</p><p><strong>Methods: </strong>Data were drawn from the 1999-2004 U.S. National Health and Nutrition Examination Survey (NHANES). Weighted multivariable regression, restricted cubic spline models, and ROC curve analyses were used to assess associations. Subgroup and sensitivity analyses were also conducted.</p><p><strong>Results: </strong>Among 1,487 people with diabetes, 100 had DFU and 733 had pre-DFU symptoms. DFU patients showed higher HbA1c and UACR levels. After adjusting for confounders, all four indices were positively associated with DFU: BMI (OR = 1.07), WWI (OR = 1.95), BRI (OR = 1.47), and RFM (OR = 1.13). However, no significant associations were found between the indices and pre-DFU. Non-linear analysis suggested a potential curved relationship between WWI and DFU. Additionally, WWI (HR = 1.34) and BRI (HR = 1.18) were linked to increased all-cause mortality. Subgroup and sensitivity analyses confirmed robustness of the results.</p><p><strong>Conclusions: </strong>BMI, WWI, BRI, and RFM were all independently associated with DFU, while WWI and BRI were also predictors of all-cause mortality in people with diabetes. These anthropometric markers may aid in early identification and management of high-risk individuals.</p>","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":"447-461"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics insights into metastatic pheochromocytomas and paragangliomas: Mechanisms, signatures, and prediction models.","authors":"Yue Zhou, Yunying Cui, Tianyi Li, Anli Tong","doi":"10.1007/s42000-026-00792-1","DOIUrl":"10.1007/s42000-026-00792-1","url":null,"abstract":"<p><p>Pheochromocytomas and paragangliomas (PPGLs), rare neuroendocrine tumors, have been generally considered, since the 2017 WHO classification, as malignant neoplasms with various metastatic potential. Approximately 10-25% of PPGLs will develop metastases, with a varying 5-year-overall-survial of 40%-77%. Previous studies have extensively elucidated the mechanisms by which SDHB mutations promote tumor metastasis through inducing the pseudohypoxic and hypermethylation phenotype. Recent multi-omics studies further profiled the additional landscape of metastatic PPGLs, involving ATRX/TERT alterations, higher tumor mutational burden, microsatellite instability score, and somatic copy-number alteration, distinct microRNA (miRNA) profiling, aberrant kynurenine metabolic pathway, and immunosuppressive microenvironment, advancing our understanding of metastatic mechanisms. Consequently, beyond conventional predictors (e.g., SDHB mutation status, tumor size and location, levels of dopamine and methoxytyramine, Ki-67 labeling index, and loss of S100), emerging biomarkers for metastasis prediction were discovered and evaluated, including levels of circulating miR-483-5p, plasma succinate, tissue xanthurenic acid, and CDK1 expression, etc. Several scoring systems integrating tumor clinicopathological characteristics have been constructed to predict metastatic PPGLs; however, their clinical utility may be limited by high observer variation and low positive predictive value. Recent prediction models integrating multi-omics signatures of metastatic tumors have also been established, but without validation. This review comprehensively synthesizes current and emerging multi-omics signatures of metastatic PPGLs to elucidate underlying metastatic mechanisms. A systematic review of existing scoring systems and emerging predictive models for metastasis prediction was also conducted to highlight their advantages and limitations in the clinical application.</p>","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":"399-416"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148153155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-613 regulates osteogenic differentiation by targeting TIMP3 in postmenopausal osteoporosis.","authors":"Yuan Ruan, Sicheng Ding, Yingxuan Huang, Ningning Zhang","doi":"10.1007/s42000-026-00770-7","DOIUrl":"10.1007/s42000-026-00770-7","url":null,"abstract":"","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":"429-437"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147523836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting parathyroid carcinoma through the lens of the 2022 WHO classification.","authors":"Esma Pehlivan Koroglu, Gokcen Unal Kocabas, Yesim Ertan, Murat Ozdemir, Ilgin Yildirim Simsir, Pinar Banu Sarer Yurekli","doi":"10.1007/s42000-026-00776-1","DOIUrl":"10.1007/s42000-026-00776-1","url":null,"abstract":"","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":"389-397"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147795300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prothrombotic fibrin clot phenotype in pregnant women after ovarian stimulation: associations with neuropeptides.","authors":"Magdalena Piróg, Robert Jach, Michał Ząbczyk, Joanna Natorska","doi":"10.1007/s42000-026-00774-3","DOIUrl":"10.1007/s42000-026-00774-3","url":null,"abstract":"","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":"561-570"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147523857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hair cortisol outperforms urinary free cortisol in diagnosing Cushing's syndrome: a cross-sectional study.","authors":"Hilal Yildirim Deryol, Semih Tek, Ebubekir Akpinar, Buruc Erkan, Umran Keskin, Mazhar Tuna, Mutlu Niyazoglu, Esra Suheda Hatipoglu","doi":"10.1007/s42000-025-00750-3","DOIUrl":"10.1007/s42000-025-00750-3","url":null,"abstract":"","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":"623-632"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145992827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of melatonin on muscle and liver bioenergetic profiles: focus on acylcarnitines following endurance swimming exercise in rats.","authors":"Alinson Eduardo Cipriano, Alex Aparecido Rosini Silva, Vanessa Bertolucci, Andreia de Melo Porcari, Leonardo Henrique Dalcheco Messias, Wladimir Rafael Beck","doi":"10.1007/s42000-026-00796-x","DOIUrl":"10.1007/s42000-026-00796-x","url":null,"abstract":"<p><strong>Introduction: </strong>Melatonin (N-acetyl-5-methoxytryptamine) plays a key role in lipid metabolism regulation, directly influencing fatty acid oxidation and lipid transport and modulating pathways related to energy homeostasis.</p><p><strong>Objective: </strong>This study aimed to evaluate its acute effects on tissue bioenergetics during post-exercise recovery.</p><p><strong>Methods: </strong>Thirty Wistar rats performed a 60-min swimming at 90% of their individual maximal aerobic capacity and received melatonin (10 mg.kg^-¹) or vehicle immediately after exercise. The animals were euthanized at 1, 3, or 24 h post-exercise.</p><p><strong>Results: </strong>Melatonin did not alter the acylcarnitine pool in the muscle or liver, indicating no synergistic effect on β-oxidation. However, it significantly reduced serum glucose levels (F = 11.01; p < 0.001), increased glycogen levels in the red gastrocnemius (F = 82.81; p < 0.001), gluteus maximus (F = 19.55; p < 0.001), and liver (F = 6.24; p < 0.001), and decreased triglyceride content in several skeletal muscles. The integrated biomarker response (IBR) revealed time-dependent shifts in specific acylcarnitine species, although melatonin did not influence these shifts.</p><p><strong>Conclusion: </strong>In conclusion, despite not modulating the acylcarnitine pool, melatonin induced favorable metabolic adaptations by enhancing glycogen replenishment and altering lipid availability in a tissue-specific manner. These findings suggest that melatonin may favor the transport or utilization of larger fatty acid molecules, potentially bypassing the conventional acylcarnitine-mediated oxidation pathways. This highlights its role as a modulator of post-exercise recovery and underscores the need for temporally resolved analyses to unravel its bioenergetic effects.</p>","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":"489-503"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13582139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148207582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines on reporting epidemiological observational studies and their proper use in endocrine research.","authors":"Constantine A Stratakis","doi":"10.1007/s42000-026-00821-z","DOIUrl":"10.1007/s42000-026-00821-z","url":null,"abstract":"","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":"339-341"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exogenous parathyroid hormone (1-34) attenuates knee osteoarthritis in mice through activating the TGF-β/Smad signaling pathway.","authors":"Peng Sun, Haoran Jin, Qirui Ding, Haonan Qin, Yunru Ge, Shouguo Wang, Huan Liu","doi":"10.1007/s42000-025-00749-w","DOIUrl":"10.1007/s42000-025-00749-w","url":null,"abstract":"<p><strong>Objective: </strong>Parathyroid hormone (PTH) has been reported to delay the progression of osteoarthritis (OA), while the mechanism remains unclear. The TGF-β/Smad signaling pathway plays a key role in chondrocyte regulation and OA development. We aimed to explore the effect and mechanism of PTH on knee OA (KOA) in mice.</p><p><strong>Methods: </strong>Anterior cruciate ligament transection (ACLT) was performed in 40 mice to induce KOA. They were randomly divided into the ACLT + PTH and ACLT + vehicle groups. Another 20 mice that underwent only arthrotomy and normal saline were allocated to the sham-vehicle group. The knee phenotypes were analyzed using radiograph, micro-CT, and histology. The mRNA and protein expression levels of related factors were detected by immunohistochemistry and qRT-PCR.</p><p><strong>Results: </strong>PTH (1-34) attenuated knee OA phenotypes induced by ACLT, including reducing the modified Mankin's scores (p = 0.002, 0.001) and OARSI scores (p = 0.06, 0.02), enhancing type II collagen synthesis (p = 0.001, p < 0.001), and inhibiting type X collagen (p = 0.014, 0.011) and MMP-13 expression (p = 0.002, p < 0.001) in articular cartilage of ACLT mice at 2 weeks and 4 weeks. PTH also significantly increased the percentage of parathyroid hormone receptor 1 (PTH1R) (p < 0.001), p-cAMP response element binding protein (p-CREB) (p < 0.001), proliferating cell nuclear antigen (PCNA) (p = 0.011, p < 0.001), TGF-β receptor I (TβRI) (p = 0.002, p < 0.001), TβRII (p < 0.001), Smad2 (p = 0.014, p < 0.001), and p-Smad2/3 positive cells (p < 0.001) in the articular cartilage of ACLT mice. PTH significantly increased mRNA expression levels of PTH1R, p-CREB, PCNA, TβRI, TβRII, and Smad2 in the articular cartilage of ACLT mice (p < 0.001).</p><p><strong>Conclusion: </strong>PTH (1-34) attentuates knee OA induced by ACLT by stimulating proliferation, inhibiting hypertrophy and maturation of chondrocytes and the degradation of articular cartilage, and activating the TGF-β/Smad signaling pathway.</p>","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":"417-428"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13582118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual target, dual benefit: real-world effects of SGLT2 inhibitors and GLP-1 receptor agonists on the FIB-4 score in people with type 2 diabetes mellitus.","authors":"Virginia Markoutsaki, Georgios Dimakopoulos, Emmanouil Sinakos, Kalliopi Kotsa, Theocharis Koufakis","doi":"10.1007/s42000-025-00743-2","DOIUrl":"10.1007/s42000-025-00743-2","url":null,"abstract":"<p><strong>Background: </strong>Liver fibrosis is a serious comorbidity of type 2 diabetes mellitus (T2DM) in which non-invasive indices such as FIB-4 are used to monitor hepatic health. This study assesses the impact of GLP-1 receptor agonists (GLP-1RA), SGLT2 inhibitors (SGLT2i), and their combinations on FIB-4 scores in people with T2DM.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 133 adults with T2DM on one of the three treatment regimens, with FIB-4 calculated at baseline and after 12 months.</p><p><strong>Results: </strong>FIB-4 scores had significantly declined in all groups at 12-month follow-up. The GLP-1RA group exhibited the largest average reduction in FIB-4 (0.280, p < 0.001), followed by combination therapy (0.231, p = 0.001) and SGLT2i (0.206, p < 0.001). All treatment groups experienced significant improvements in glycemia and body weight.</p><p><strong>Conclusions: </strong>GLP-1RA and SGLT2i, either alone or in combination, may reduce liver fibrosis risk in T2DM patients as reflected by improved FIB-4 scores.</p>","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":"475-479"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}