Hormones (Athens, Greece)最新文献

{"title":"Dynamic modulation of LH secretion by continuous kisspeptin infusion in healthy men.","authors":"Amna Naveed, Margaret F Lippincott, Maria Stamou, Ravi Balasubramanian, Nora K Bryant, Stephanie B Seminara","doi":"10.1007/s42000-026-00795-y","DOIUrl":"10.1007/s42000-026-00795-y","url":null,"abstract":"<p><strong>Purpose: </strong>Kisspeptin stimulates gonadotropin-releasing hormone (GnRH) release and, by extension, gonadotropin secretion. Although continuous kisspeptin administration has been shown to dampen kisspeptin-induced GnRH release in non-human primates [1, 2], this has not been replicated in the limited human studies reported to date. The objective of this study was to examine the effects of continuous kisspeptin administration on luteinizing hormone (LH) secretion in healthy men.</p><p><strong>Methods: </strong>Three healthy adult men received a continuous intravenous infusion of kisspeptin-10 at a dose of 12.5 mcg/kg/h for 24 h and underwent frequent blood sampling to characterize the effect on reproductive hormones.</p><p><strong>Results: </strong>Continuous administration of kisspeptin resulted in an immediate increase in LH concentrations, from a baseline of 2.8-3.8 mIU/mL to the highest values of 17.5-30.6 mIU/mL (5- to eightfold above baseline), reached within 12-20 h of infusion onset. LH concentrations subsequently declined by 13-47% from max to end of the infusion, settling at 10.7-22.8 mIU/mL. FSH and testosterone rose modestly in parallel.</p><p><strong>Conclusion: </strong>While kisspeptin boluses have been employed to probe GnRH pulse generation, continuous infusion of kisspeptin is a complementary physiologic tool used to study dynamic changes in GnRH-induced LH secretion. Further studies are warranted to further elucidate the physiologic response of the kisspeptin receptor to non-pulsatile ligand administration.</p><p><strong>Clinical trial registration: </strong>NCT01438073 (August 24, 2011).</p>","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13386888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148153141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone health in gender-diverse individuals: current challenges and future directions.","authors":"Konstantina Barouti, Jeroen Vervalcke, Steven Van Offel, Charlotte Verroken, Guy T'Sjoen","doi":"10.1007/s42000-026-00793-0","DOIUrl":"https://doi.org/10.1007/s42000-026-00793-0","url":null,"abstract":"<p><strong>Introduction: </strong>Gender-affirming hormone therapy (GAHT) alters sex-steroid exposure, raising important questions about skeletal health in transgender and gender-diverse populations. Evidence remains fragmented and centred on areal bone mineral density (BMD), with sparse fracture data and little integration of other parameters such as muscle. This narrative review synthesises evidence on skeletal health in transgender individuals, bone density, fracture risk and the muscle-bone unit, bone health screening, and effects of gonadotropin-releasing hormone (GnRH) agonists during adolescence.</p><p><strong>Methods: </strong>We performed a narrative review of clinical studies and guidelines addressing BMD, fractures, puberty suppression, and GAHT in transgender populations, prioritising clinically relevant data.</p><p><strong>Results: </strong>Multiple cohorts report low pre-GAHT BMD, particularly in individuals assigned-male-at-birth (AMAB), likely reflecting minority stress, low physical activity, suboptimal vitamin D status, and sedentary lifestyles. Adequately dosed GAHT generally maintains or modestly improves BMD, especially in individuals assigned-female-at-birth (AFAB) on testosterone, while modest lumbar spine deficits may persist in some AMAB individuals. Fracture data are limited but reassuring. In adolescents, GnRH-agonists predictably reduce BMD Z-scores during hormonal suppression, with partial recovery after GAHT-initiation. However, implications for peak bone mass remain uncertain. Emerging evidence favours risk-stratified rather than universal dual-energy X-ray absorptiometry (DXA) screening, alongside optimisation of GAHT, nutrition, and physical activity.</p><p><strong>Conclusions: </strong>Current evidence does not indicate an increased skeletal risk when GAHT is appropriately managed. Pre-existing vulnerabilities appear central to bone health risk stratification, underscoring the need for risk-based care that integrates bone parameters alongside non-skeletal factors, such as muscle.</p>","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148153144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress-related disorders and nonpeptidic CRH antagonists.","authors":"Dimitrios Vlachakis, George P Chrousos","doi":"10.1007/s42000-026-00765-4","DOIUrl":"10.1007/s42000-026-00765-4","url":null,"abstract":"","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":"633-638"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13582233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146145732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiofrequency ablation as an alternative treatment for hyperparathyroidism: a case study of a single parathyroid adenoma and review of the literature.","authors":"Maria Chrysoula Tatarida Palla, Aspasia Drosou, Pyrros Gkousis, Anna Drakopoulou, Styliani Kalaitzidou, Eirini Veniou, Myrsini Gkeli","doi":"10.1007/s42000-026-00772-5","DOIUrl":"10.1007/s42000-026-00772-5","url":null,"abstract":"","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":"377-387"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147523863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal trends and demographic and regional disparities in adrenocortical insufficiency-related mortality in the United States from 1999 to 2020.","authors":"Ahmed Faizan, Zain Shahzad, Muhammad Sarosh Tahir, Rabail Abdul Qadir, Eeshal Fatima","doi":"10.1007/s42000-026-00768-1","DOIUrl":"10.1007/s42000-026-00768-1","url":null,"abstract":"","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":"615-621"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147523874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there an association between hyperandrogenic states in women and endrometrial cancer? A narrative review.","authors":"Radmila Sparić, Mladen Andjić, Andrea Tinelli, Giovanni Pecorella, Dušan Ilić, Sarantis Livadas, Lena Radić, George Mastorakos, Jelica Bjekic-Macut","doi":"10.1007/s42000-026-00762-7","DOIUrl":"10.1007/s42000-026-00762-7","url":null,"abstract":"","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":"583-591"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147795305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between serum 25-hydroxyvitamin D level and sex steroid hormone among 6-19-year old children and adolescents based on NHANES 2013-2016 data.","authors":"Yachao Wang, Haibo Li, Lei Luo, Yinan Guo","doi":"10.1007/s42000-025-00748-x","DOIUrl":"10.1007/s42000-025-00748-x","url":null,"abstract":"<p><strong>Introduction: </strong>Recent pediatric growth research is increasingly examining serum 25(OH)D and sex hormone interactions. While 25(OH)D is crucial for regulation of skeletal health and calcium-phosphorus homeostasis, sex hormones direct pubertal onset and maturation. Given that emerging evidence has revealed intricate 25(OH)D-sex hormone interplay in child development, the current research evaluates potential correlations of sex hormone profiles with 25(OH)D among 6-19-year old children and adolescents.</p><p><strong>Materials and methods: </strong>This cross-sectional study utilized 2013-2016 NHANES data. Participants aged 6-19 years with complete serum 25(OH)D and sex hormone measurements were included. Multivariable regression with subgroup stratification examined independent 25(OH)D-sex hormone relationships.</p><p><strong>Results: </strong>The study enrolled 3,789 participants in the final cohort, averaging 12.3 ± 4.0 years of age, 50.62% being male and 49.37% female. Significant positive correlations were observed between 25(OH)D concentrations and sex hormone-binding globulin (SHBG) and the testosterone-to-estradiol ratio (TT/E2) in both sexes. Conversely, 25(OH)D demonstrated inverse associations with the free androgen index (FAI) and estradiol (E2) in males, while negatively correlating with FAI in females alone. Subgroup analyses revealed differential associations across pubertal stages and body mass index categories. Notably, the 25(OH)D-SHBG relationship exhibited nonlinearity, with piecewise linear regression identifying a J-shaped association in males (threshold: 60.451 nmol/L) and a U-shaped pattern in females (threshold: 68.051 nmol/L).</p><p><strong>Conclusion: </strong>These findings demonstrate significant sex-specific associations between 25(OH)D status and sex hormone profiles in the pediatric population. Prospective longitudinal and experimental studies are warranted to validate these observations and elucidate the underlying mechanisms.</p>","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":"673-683"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145937298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision medicine in thyroid nodules: current strategies, challenges, and future directions.","authors":"Marcio J Concepción-Zavaleta, Jenyfer M Fuentes-Mendoza, Cristian A Rojas-Hipólito, Daniela Sánchez-Mejía, Mariana A López-Torres, Luis Concepción-Urteaga, Cristian D Armas, José Paz-Ibarra","doi":"10.1007/s42000-026-00757-4","DOIUrl":"10.1007/s42000-026-00757-4","url":null,"abstract":"","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":"649-665"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147523845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between the weight-adjusted waist circumference index (WWI) and thyroid function: an NHANES study.","authors":"Qiangbin Ding, Ke Li, Suqiong Lin, Rongliang Qiu, Guoyang Wu","doi":"10.1007/s42000-026-00781-4","DOIUrl":"10.1007/s42000-026-00781-4","url":null,"abstract":"<p><strong>Introduction: </strong>Obesity has become a significant global public health issue that seriously threatens the health of more than one billion individuals worldwide. The weight-adjusted waist index (WWI) is a novel adiposity indicator calculated as waist circumference (cm) divided by the square root of body weight (kg). However, the association between WWI and thyroid function has not been reported to date. This study aims to investigate the relationship between WWI and thyroid function among U.S. adults.</p><p><strong>Methods: </strong>A total of 7,642 participants were enrolled in this study based on the National Health and Nutrition Examination Survey (NHANES) dataset from 2007 to 2012. Weighted statistical analyses were performed and three regression models were constructed sequentially, namely Model 1 (unadjusted), Model 2 (adjusted for age, sex, race, and survey cycle), and Model 3 (further adjusted for educational level, marital status, smoking status, alcohol consumption, diabetes mellitus, urinary iodine concentration, and poverty income ratio [PIR]). Stratified analyses and interaction effect tests were also conducted. Additionally, a retrospective validation cohort comprising 60 health check-up patients was extracted from Zhongshan Hospital Affiliated to Xiamen University between December 2024 and December 2025 to evaluate the association between WWI and free triiodothyronine (FT3) across WWI quartiles. The thyroid function indicators assessed included free triiodothyronine (FT3), free thyroxine (FT4), total triiodothyronine (TT3), total thyroxine (TT4), thyroid-stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), and thyroglobulin (Tg).</p><p><strong>Results: </strong>A total of 7,642 participants were included in this study. A positive correlation between WWI and FT3 levels was observed in Models 2 and 3, and this positive association persisted in both models after stratifying WWI into quartiles. The only exception was the WWI Q2 stratum in Model 3 where the 95% confidence interval (CI) for the association between WWI and FT3 included zero, indicating no statistical significance. Further stratified analyses revealed that the positive WWI-FT3 association was primarily evident in males, individuals under 50 years of age, and those of other Hispanic ethnicity. The positive WWI-FT3 correlation identified in NHANES was successfully replicated in our institutional validation cohort.</p><p><strong>Conclusion: </strong>A positive association between WWI and FT3 is suggested; however, further investigations are warranted to confirm this observation.</p>","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":"505-514"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13582219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147795315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A patient with ROHHAD syndrome and leptin-melanocortin pathway gene variations. Correlation or just a coincidence? Case report.","authors":"Eirini Kostopoulou, Alexandra Efthymiadou, Aristeidis Giannakopoulos, Dionisios Chrysis","doi":"10.1007/s42000-025-00754-z","DOIUrl":"10.1007/s42000-025-00754-z","url":null,"abstract":"","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":"685-691"},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13582127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146069546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}