Hormones (Athens, Greece)最新文献

{"title":"The association between body mass index and total lumbar bone mineral density in obese adults: the national health and nutrition examination survey (NHANES) 2011-2020.","authors":"Chao Su, Peng Wang, Dandan Lian, Chen Sun, Cunchuan Wang","doi":"10.1007/s42000-025-00699-3","DOIUrl":"https://doi.org/10.1007/s42000-025-00699-3","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to investigate the relationship between BMI and total lumbar BMD in obese adults.</p><p><strong>Methods: </strong>The current cross-sectional study included 3,708 obese individuals. The data on BMI, total lumbar BMD, and other covariates were obtained from the National Health and Nutritional Examination Survey (NHANES) ( http://www.cdc.gov/nchs/nhanes/ ) between 2011 and March 2020 prior to the COVID-19 pandemic. Multivariate logistic regression models were utilized to investigate the association between BMI and total lumbar BMD. Smooth curve fittings and generalized additive models were used to analyze the potential non-linearity.</p><p><strong>Results: </strong>A total of 3,708 participants (1,610 males and 2,098 females) were included in the study. In multivariate regression analysis, the association between BMI and total lumbar BMD was positive (β = 0.003, 95% CI: 0.002, 0.004). This relationship still existed after being adjusted for gender, age, and race (β = 0.003, 95% CI: 0.002, 0.004) and fully adjusted for all covariates (β = 0.003, 95% CI: 0.002, 0.004). In threshold effect analysis, the relationship between BMI and total lumbar BMD followed a U-shaped curve, with the inflection point at 36.1 kg/m².</p><p><strong>Conclusion: </strong>The present study revealed a positive association between BMI and lumbar BMD in obese adults, the association notably following a U-shaped curve with an inflection point at a BMI of 36.1 kg/m².</p>","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GLP-1 agonists on a roll: from obesity to psoriasis - an elixir to watch!","authors":"Constantine A Stratakis","doi":"10.1007/s42000-025-00697-5","DOIUrl":"https://doi.org/10.1007/s42000-025-00697-5","url":null,"abstract":"","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological characteristics and risk factors of reproductive dysfunction in male infertility: a meta-analysis.","authors":"Shenghui Wang, Jin Zhou","doi":"10.1007/s42000-025-00689-5","DOIUrl":"https://doi.org/10.1007/s42000-025-00689-5","url":null,"abstract":"<p><strong>Background: </strong>Reproductive dysfunction, encompassing semen abnormalities and sexual dysfunction, is a significant global concern with diverse etiological factors. This meta-analysis investigated the demographic, lifestyle, and health-related risk factors that contribute to reproductive dysfunction in men.</p><p><strong>Methods: </strong>A comprehensive search of electronic databases yielded 3,931 publications, of which 28 articles (44 studies) involving 23,316 infertile men and 40,934 healthy controls were included. Data extraction and analysis followed the PRISMA guidelines. Risk factors were assessed using standardized mean difference (SMD) and odds ratio (OR) metrics, with stratified and subgroup analyses based on the population and condition.</p><p><strong>Results: </strong>Advanced age was identified as a significant risk factor for reproductive dysfunction (SMD = 1.15, 95% CI [0.68, 1.61], P < 0.001, I² = 99.6%) and subgroup analyses revealed associations across European, Asian, and Caucasian populations, as well as conditions such as asthenozoospermia, teratozoospermia, and erectile dysfunction. Elevated BMI (SMD = 1.68, 95% CI [0.17, 3.18], P < 0.001, I² = 100%) and obesity (OR = 1.43, 95% CI [1.02, 1.99], P < 0.001, I² = 76.2%) were also notable contributors. Lifestyle factors, such as smoking (OR = 1.33, 95% CI [1.16, 1.53], P < 0.001, I² = 79.2%) and alcohol consumption (OR = 1.36, 95% CI [1.00, 1.85], P < 0.001, I² = 94.8%), were consistently associated with reproductive dysfunction across multiple populations and conditions. Health-related factors, including hypertension (OR = 1.34, 95% CI [1.04, 1.74], P = 0.003, I² = 67.5%), diabetes (OR = 2.53, 95% CI [1.48, 4.33], P = 0.008, I² = 68.1%), depression (OR = 4.24, 95% CI [1.25, 14.41], P < 0.001, I² = 91.9%), and anxiety (OR = 2.16, 95% CI [1.60, 2.90], P = 0.714, I² = 0.0%) were also significantly associated with reproductive dysfunction, emphasizing the multifaceted nature of its etiology.</p><p><strong>Conclusions: </strong>This meta-analysis highlights advanced age, elevated BMI, smoking, alcohol consumption, hypertension, diabetes, and mental health disorders as critical risk factors for male reproductive dysfunction. These findings underscore the importance of targeted interventions and lifestyle modifications in mitigating these risks.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the serum uric acid threshold with increasing risk for diabetic nephropathy in type 1 diabetes.","authors":"Mei Huang, Qianying Wei, Xin Chen, Yao Qin, Liuyan Dai, Yuxiao Li, Yong Gu, Yang Chen, Tao Yang, Mei Zhang","doi":"10.1007/s42000-025-00690-y","DOIUrl":"https://doi.org/10.1007/s42000-025-00690-y","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the correlation between serum uric acid (SUA) levels and the risk for diabetic nephropathy (DN) in Chinese patients with type 1 diabetes mellitus (T1DM) and determine the potential optimal SUA threshold.</p><p><strong>Methods: </strong>In this case-control study, 913 T1DM patients were matched 1:1 with healthy controls by age and sex. Multivariable adjusted logistic regression analysis was used to investigate the association between SUA levels and the risk of developing DN. Restricted cubic spline (RCS) was applied to investigate the optimal threshold for SUA. Additionally, longitudinal analysis of 94 patients with at least three visits accessed SUA variability correlations with estimated glomerular filtration rate (eGFR) and urinary albumin creatinine ratio (UACR) changes using Spearman's correlation analysis. A linear mixed-effects model was performed to access the correlations in SUA, eGFR, and UACR over time.</p><p><strong>Results: </strong>T1DM patients exhibited significantly lower median SUA levels (4.24 vs. 4.93 mg/dL, P < 0.001) than controls. The incidence of DN was 12% in T1DM patients. After adjusting for confounding factors, the SUA level was inversely significantly correlated with the risk for DN as a continuous variable (OR: 1.47; 1.25-1.74) and in quartile 4 (OR: 3.01; 1.44-6.50), respectively. The RCS plot revealed an identified threshold of SUA as being 4.30 mg/dL with increasing risk for DN. Correlation analysis showed the SUA variability significantly correlate with eGFR variability (r = 0.206, P = 0.046) and UACR variability (r = 0.405, P = 0.025). The linear mixed-effects model revealed a significant negative relationship between SUA and eGFR over time (R² = 0.035, P < 0.001), as well as a significant positive relationship between SUA and UACR (R² = 0.041, P < 0.001).</p><p><strong>Conclusions: </strong>Our study revealed that decreased SUA level is common in T1DM and identified the threshold as being 4.30 mg/dL for increased DN risk.</p>","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare metastatic sites in three patients with RAI-refractory differentiated thyroid cancer (DTC).","authors":"Olga Karapanou, Grigoris Effraimidis, Effie Petinellis, Marina Michalaki, Miltiadis Krokidis, Katerina Saltiki","doi":"10.1007/s42000-025-00694-8","DOIUrl":"https://doi.org/10.1007/s42000-025-00694-8","url":null,"abstract":"<p><strong>Purpose: </strong>While the majority of patients with differentiated thyroid cancer (DTC) have favourable outcomes, less than 5% may have metastatic disease that is refractory to radioiodine (RAI) treatment. Distant metastases from thyroid cancer usually involve the lungs and bones. However, it is essential to accurately identify and treat rare sites of metastasis.</p><p><strong>Methods: </strong>In this report, we present three cases of rare metastatic sites originating from RAI-refractory DTC. The first patient had a cystic calcaneous metastasis, the second patient developed bilateral metachronous renal metastases, and the third patient presented with a large thigh metastasis, which was later followed by a large pelvic mass.</p><p><strong>Results: </strong>None of the patients had a targetable mutation. A multidisciplinary therapeutic approach was implemented for their treatment, incorporating both local and systemic therapies.</p><p><strong>Conclusion: </strong>Managing cases with unusual metastases can be particularly challenging, especially in patients with advanced disease. The combination of local and systemic treatments is crucial, as it may help prolong survival.</p>","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of pan-immune-inflammation index in the diagnosis of masked hypertension in patients with type 2 diabetes mellitus.","authors":"Erdoğan Sökmen, Muhammet Salih Ateş, Mustafa Celik, Muhammed Fatih Kaleli","doi":"10.1007/s42000-025-00695-7","DOIUrl":"https://doi.org/10.1007/s42000-025-00695-7","url":null,"abstract":"","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel approach for classifying patients with adrenal tumors based on decision support systems and artificial intelligence.","authors":"Dimitrios A Binas, Grigoria Betsi, Theodore Economopoulos, Chrysoula Mytareli, Charis Bourgioti, Paraskevi Xekouki, Anna Angelousi, George K Matsopoulos","doi":"10.1007/s42000-025-00682-y","DOIUrl":"https://doi.org/10.1007/s42000-025-00682-y","url":null,"abstract":"<p><strong>Aims: </strong>Adrenal incidentalomas (AIs) encompass a wide range of clinical entities, from incidental benign neoplasms that need to be monitored to aggressive malignancies requiring urgent medical intervention and treatment. The incidence of adrenal tumors is steadily rising, reflecting a growing trend in their prevalence and highlighting the necessity for heightened awareness and advanced diagnostic strategies to address this escalating health concern. This retrospective study was undertaken in order to explore the possibility of developing a decision support system for classifying adrenal tumors as benign and malignant or suspicious for malignancy.</p><p><strong>Methods: </strong>A powerful combination of 12 clinical, biochemical, epidemiological, and radiological features of 256 patients with adrenal tumors was analyzed to make predictions and various machine learning models were trained and compared to identify the model that consistently achieves the highest accuracy.</p><p><strong>Results: </strong>An average accuracy of over 91% and a balanced accuracy surpassing 94% was achieved based on a small amount of data and a small number of patients, without using imaging radiomics.</p><p><strong>Conclusion: </strong>The present study provided a decision-making process in healthcare systems permitting reliable automated classification of adrenal tumors. This is a promising candidate for integration into an initial screening tool for adrenal cancer, offering clinicians a valuable resource for early detection and intervention.</p>","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and management of hypoparathyroidism: recommendations of the working group of the Bone Section of the Hellenic Endocrine Society.","authors":"Evanthia Kassi, Fotini Adamidou, Maria P Yavropoulou, Athanasios D Anastasilakis, Polyzois Makras, Andromachi Vryonidou, Symeon Tournis","doi":"10.1007/s42000-025-00693-9","DOIUrl":"https://doi.org/10.1007/s42000-025-00693-9","url":null,"abstract":"<p><p>Hypoparathyroidism (HypoPT) is a rare endocrine disorder characterized by hypocalcemia accompanied by low or inappropriately normal parathyroid hormone (PTH) levels. The Bone Section of the Hellenic Endocrine Society reviewed the available evidence and the recent international guidelines and provided updated clinical practice recommendations for the diagnosis and optimal management of patients with HypoPT. Specifically, permanent post-surgical HypoPT should be considered if the disorder persists for more than 12 months after surgery, while in non-surgical cases, appropriate genetic testing should be applied, especially in young patients or those with syndromic features. In addition, the current report provides recommended and suggested laboratory and imaging examinations for the optimal management of patients with HypoPT. Concerning management, the panel recommends conventional therapy with calcium and vitamin D analogs as first-line treatment, while in patients with inadequate disease control, PTH replacement therapy should be considered with close monitoring. Finally, the challenges of the diagnosis and management of HypoPT in pregnancy are also discussed.</p>","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cisapride for gastric emptying in diabetic patients: a meta-analysis on its efficacy and safety.","authors":"Yifan Lu, Yixuan Xie, Xinyi Yang, Lijuan Nie, Zhe Cheng, Yixian He, Tiansu Lv, Qibiao Wu, Xiqiao Zhou","doi":"10.1007/s42000-025-00688-6","DOIUrl":"https://doi.org/10.1007/s42000-025-00688-6","url":null,"abstract":"<p><strong>Background: </strong>Diabetic gastroparesis is a common complication of diabetes, characterized by delayed gastric emptying, significantly impacting patients' quality of life. Current treatment options are limited often resulting in unsatisfactory outcomes. This meta-analysis aims to evaluate the efficacy and safety of cisapride in diabetic patients suffering from gastroparesis.</p><p><strong>Methods: </strong>A systematic literature search identified 13 studies involving 185 participants. Data on gastric emptying rates, symptom relief, and safety profiles were extracted and analyzed. Effectiveness was measured through gastric emptying half-life (T1/2, measured in min), 120-min gastric emptying rate (measured as a percentage), and adverse events.</p><p><strong>Key results: </strong>The analysis revealed that cisapride significantly improved gastric emptying compared to placebo, with a mean difference (MD) of -33.74 for T1/2 (95% CI: -68.84 to -2.65, P = 0.03). Additionally, the 120-min gastric emptying rate improved by -25.84 (95% CI: -16.80 to -25.84, P < 0.001). The occurrence of adverse events was low, with most patients tolerating the treatment well.</p><p><strong>Conclusion and inferences: </strong>Cisapride demonstrates notable efficacy in improving gastric emptying in diabetic gastroparesis, with a generally acceptable safety profile. Clinicians should consider cisapride as a viable treatment option while monitoring patients for any potential side effects. Further research is warranted to explore long-term safety and effectiveness.</p>","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between thyroid function and type 2 diabetes mellitus based on the NHANES and Mendelian randomization study.","authors":"Cheng Su, Qifu Chen, Baijing Dong, Ming Chu","doi":"10.1007/s42000-025-00691-x","DOIUrl":"https://doi.org/10.1007/s42000-025-00691-x","url":null,"abstract":"<p><strong>Objectives: </strong>Many observational studies have reported an association between thyroid function and type 2 diabetes mellitus (T2DM), but the causal relationship remains unclear. This study aims to examine the association between thyroid function and T2DM by using the National Health and Nutrition Examination Survey (NHANES) database 2007-2012 and Mendelian randomization (MR) analysis.</p><p><strong>Methods: </strong>A cross-sectional analysis was performed utilizing data from the NHANES, and logistic regression was employed to investigate the relationship between thyroid function and T2DM. Genome-wide association studies (GWAS) data of thyroid function and T2DM were obtained from the website of the IEU OpenGWAS project and the Thyroidomics Consortium. Single nucleotide polymorphisms (SNPs) strongly related to thyroid function were used as instrumental variables. Moreover, the inverse-variance weighting MR-Egger regression model and weighting median method were used to analyze the causal effect of thyroid function on T2DM. Cochran's Q test, the MR-Egger intercept test, and \"leave one out\" cross-validation were applied to evaluate the pleiotropy and heterogeneity levels of the above included SNPs.</p><p><strong>Results: </strong>In the NHANES study, no association was identified between thyroid function and the risk of T2DM in a fully adjusted model. A total of 17, 31, 7, and 79 SNPs were identified in the cohorts for free thyroxine (FT4), thyroid-stimulating hormone (TSH), hyperthyroidism, and hypothyroidism, respectively. The ORs with 95% confidence intervals (95% CIs) derived from MR-Egger regression, WME, and inverse variance weighting (IVW) for TSH and T2DM were 0.86 (0.75-0.99), 0.91 (0.85-0.98), and 0.94 (0.89-0.99), respectively. For hypothyroidism and T2DM, the ORs (95% CI) from MR-Egger regression, WME, and IVW were 5.71 (1.76-18.53), 3.33 (1.57-7.04), and 2.60 (1.50-4.49), respectively. Additionally, Cochran's Q test results demonstrated no heterogeneity among the SNPs associated with TSH and T2DM, while heterogeneity was observed among the SNPs related to hypothyroidism and T2DM (Q = 133.40, P < 0.05), necessitating the use of the IVW random effects model.</p><p><strong>Conclusions: </strong>The findings of the present study point to a potential causal relationship between TSH, hypothyroidism, and T2DM. Further research is needed to explore the relationship between thyroid function and T2DM.</p>","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}