Hormones (Athens, Greece)最新文献

{"title":"Practical considerations for AMH interpretation in female children and adolescents.","authors":"Ömer Faruk Öz, Can Dinç","doi":"10.1007/s42000-026-00788-x","DOIUrl":"https://doi.org/10.1007/s42000-026-00788-x","url":null,"abstract":"","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147849178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of AGAHR with metabolic dysfunction-associated steatotic liver disease (MASLD).","authors":"Ziran Wang, Yanan Shi, Cun Liu, Fan Ma, Zhou Lv","doi":"10.1007/s42000-026-00786-z","DOIUrl":"https://doi.org/10.1007/s42000-026-00786-z","url":null,"abstract":"<p><strong>Objective: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) is an increasing global health concern. This cross-sectional study aimed to evaluate the association between the AGAHR index [calculated as (alanine aminotransferase (ALT)×plasma fasting glucose (PFG)) to (aspartate aminotransferase (AST)×high-density lipoprotein cholesterol (HDL-C)) ratio] and MASLD.</p><p><strong>Methods: </strong>Data from 2508 participants in the NHANES 2017-2020 cycle were analyzed. Weighted multivariable logistic regression, restricted cubic spline (RCS), receiver operating characteristic (ROC), and decision curve analysis (DCA) were performed. The findings were further assessed in an independent local cohort (n = 56).</p><p><strong>Results: </strong>After adjustment for potential confounders, AGAHR was positively associated with MASLD [odds ratio (OR): 1.17, 95% confidence interval (CI): 1.10-1.24, P < 0.001]. RCS analysis suggested a nonlinear association pattern. In the NHANES cohort, AGAHR demonstrated good discriminative ability [area under the curve (AUC): 0.752, 95% CI: 0.733-0.771], outperforming the PFG/HDL-C ratio (GHR) and ALT/AST ratio (AAR). These findings were consistent in the validation cohort (AUC: 0.756, 95% CI: 0.624-0.889). DCA indicated that AGAHR provided a greater net benefit across a range of threshold probabilities compared with the reference indicators.</p><p><strong>Conclusion: </strong>AGAHR is significantly associated with MASLD and may serve as a simple indicator reflecting metabolic features related to hepatic steatosis. Further studies in larger and more diverse populations are warranted to confirm these findings.</p>","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147849139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin manifestations of hyperandrogenism: an update.","authors":"Stefania Magkou, Evangelia Sali, Ioanna A Paschou, Sofia M Dimopoulou, Anna Tagka, Vasiliki Chasapi, Andromachi Vryonidou, Stavroula A Paschou","doi":"10.1007/s42000-026-00785-0","DOIUrl":"https://doi.org/10.1007/s42000-026-00785-0","url":null,"abstract":"<p><strong>Purpose: </strong>Skin manifestations of hyperandrogenism are common and clinically diverse findings, indicating the complex interplay between metabolic, endocrine, and dermatologic systems. The aim of this review was to collect and analyze data on skin manifestations of hyperandrogenism and review the current treatment options for these diseases.</p><p><strong>Methods: </strong>We conducted a narrative review of the current literature focusing on cutaneous manifestations associated with hyperandrogenism. A search was performed on PubMed/MEDLINE which includes relevant articles published until February 2026. The search strategy included combinations of MeSH keywords (\"hyperandrogenism,\" \"polycystic ovary syndrome,\" \"skin diseases,\" \"hirsutism,\" \"acne Vulgaris,\" \"alopecia,\" \"acanthosis nigricans,\" \"acrochordons,\" and \"hyperhidrosis\") and screening of reference lists of selected articles. Eligible articles were considered those addressing epidemiology, pathophysiology, clinical presentation, diagnosis, and treatment of dermatologic manifestations associated with hyperandrogenism, with an emphasis on more recent bibliographic evidence.</p><p><strong>Results: </strong>The dermatologic spectrum of hyperandrogenism-induced manifestations primarily includes hirsutism, acne vulgaris, androgenetic alopecia, acanthosis nigricans, acrochordons, and hyperhidrosis. These cutaneous features are often the earliest clinical indicators of hyperandrogenism and are tightly associated with androgen receptor (AR) activation, local enzymatic conversion, and downstream metabolic and inflammatory pathways. Multiple therapeutic strategies were reviewed with an emphasis on hormonal agents which target AR in the skin.</p><p><strong>Conclusions: </strong>Hyperandrogenism and the expression of AR in the skin precipitate the development of androgen-associated dermatologic conditions. Androgen-targeted treatment appears to be more effective when compared with other non-androgen-targeted therapeutic options. Further research is required to analyze the existing treatments and develop new approaches.</p>","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147849195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dyslipidemia, hormonal profiles, and sleep characteristics in men with androgenetic alopecia: an analysis based on data from the EPISONO study.","authors":"Ellen M S Xerfan, Maingredy Rodrigues Souza, Paula Araujo, Sergio Tufik, Monica L Andersen","doi":"10.1007/s42000-025-00751-2","DOIUrl":"https://doi.org/10.1007/s42000-025-00751-2","url":null,"abstract":"","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147849153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The STROBE guidelines and the Αristotelian mesotes curve.","authors":"George P Chrousos, Nektaria Papadopoulou-Marketou, Panagiotis Tsiamyrtzis","doi":"10.1007/s42000-026-00758-3","DOIUrl":"https://doi.org/10.1007/s42000-026-00758-3","url":null,"abstract":"<p><p>The STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guidelines aim to improve the reporting of observational studies, including cohort, case-control, and cross-sectional designs, relevant to assessing associations, risks, and outcomes in real-world clinical settings. They are conceived to optimize the meaningfulness of epidemiological and clinical studies, aligning them with the Aristotelian \"mesotes\" curve, namely, the principle of achieving balance and avoiding extremes to best reflect the most truthful approximation of reality. This commentary addresses situations where strict adherence to STROBE guidelines may be impossible or inappropriate, potentially distorting results, and shows how statistical tools can mitigate these issues. Specific challenges arise in real-life randomization scenarios, situations lacking placebo arms, and in correcting for multiple comparisons. We discuss these challenges, examine the role of Bonferroni and similar corrections, and propose alternative approaches such as false discovery rate (FDR) and Bayesian hierarchical models. We illustrate these points with examples from the literature and a simulation study evaluating p-value adjustments in multiple hypothesis testing. This work provides a framework for researchers to navigate STROBE guidelines thoughtfully, ensuring that observational studies are both rigorous and relevant.</p>","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147849156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting parathyroid carcinoma through the lens of the 2022 WHO classification.","authors":"Esma Pehlivan Koroglu, Gokcen Unal Kocabas, Yesim Ertan, Murat Ozdemir, Ilgin Yildirim Simsir, Pinar Banu Sarer Yurekli","doi":"10.1007/s42000-026-00776-1","DOIUrl":"https://doi.org/10.1007/s42000-026-00776-1","url":null,"abstract":"","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147795300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there an association between hyperandrogenic states in women and endrometrial cancer? A narrative review.","authors":"Radmila Sparić, Mladen Andjić, Andrea Tinelli, Giovanni Pecorella, Dušan Ilić, Sarantis Livadas, Lena Radić, George Mastorakos, Jelica Bjekic-Macut","doi":"10.1007/s42000-026-00762-7","DOIUrl":"https://doi.org/10.1007/s42000-026-00762-7","url":null,"abstract":"","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147795305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between the weight-adjusted waist circumference index (WWI) and thyroid function: an NHANES study.","authors":"Qiangbin Ding, Ke Li, Suqiong Lin, Rongliang Qiu, Guoyang Wu","doi":"10.1007/s42000-026-00781-4","DOIUrl":"https://doi.org/10.1007/s42000-026-00781-4","url":null,"abstract":"<p><strong>Introduction: </strong>Obesity has become a significant global public health issue that seriously threatens the health of more than one billion individuals worldwide. The weight-adjusted waist index (WWI) is a novel adiposity indicator calculated as waist circumference (cm) divided by the square root of body weight (kg). However, the association between WWI and thyroid function has not been reported to date. This study aims to investigate the relationship between WWI and thyroid function among U.S. adults.</p><p><strong>Methods: </strong>A total of 7,642 participants were enrolled in this study based on the National Health and Nutrition Examination Survey (NHANES) dataset from 2007 to 2012. Weighted statistical analyses were performed and three regression models were constructed sequentially, namely Model 1 (unadjusted), Model 2 (adjusted for age, sex, race, and survey cycle), and Model 3 (further adjusted for educational level, marital status, smoking status, alcohol consumption, diabetes mellitus, urinary iodine concentration, and poverty income ratio [PIR]). Stratified analyses and interaction effect tests were also conducted. Additionally, a retrospective validation cohort comprising 60 health check-up patients was extracted from Zhongshan Hospital Affiliated to Xiamen University between December 2024 and December 2025 to evaluate the association between WWI and free triiodothyronine (FT3) across WWI quartiles. The thyroid function indicators assessed included free triiodothyronine (FT3), free thyroxine (FT4), total triiodothyronine (TT3), total thyroxine (TT4), thyroid-stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), and thyroglobulin (Tg).</p><p><strong>Results: </strong>A total of 7,642 participants were included in this study. A positive correlation between WWI and FT3 levels was observed in Models 2 and 3, and this positive association persisted in both models after stratifying WWI into quartiles. The only exception was the WWI Q2 stratum in Model 3 where the 95% confidence interval (CI) for the association between WWI and FT3 included zero, indicating no statistical significance. Further stratified analyses revealed that the positive WWI-FT3 association was primarily evident in males, individuals under 50 years of age, and those of other Hispanic ethnicity. The positive WWI-FT3 correlation identified in NHANES was successfully replicated in our institutional validation cohort.</p><p><strong>Conclusion: </strong>A positive association between WWI and FT3 is suggested; however, further investigations are warranted to confirm this observation.</p>","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147795315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fasting safely during Ramadan with diabetes: clinical practice recommendations for Arab populations from the Arab Diabetes Forum (FSR-ADF).","authors":"Abbass Orabi, Ibrahim Elsherif, Issam Hajjaji, Awad Elghweiry, Sirelkhatim Ismaeil Sirri Farah, Nasser Aljuhani, Faris A K Khazaal, Abdulgader A Almasri, Amal Said, Awad Alshahrani, Bahlul Ben Masaud, Khater D, Eltayeb Elfaki, Faten Ben Rajab, Haidar Fadhil Al-Rubaye, Hala Aly Gamal El Din, Magdy Elsharkawy, Mussa Gebreil, Naweed Alzaman, Sufian K Noor, Athar Reda Ibrahim, Aly A Abdel-Rahim","doi":"10.1007/s42000-026-00783-2","DOIUrl":"https://doi.org/10.1007/s42000-026-00783-2","url":null,"abstract":"","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147795258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocrine disruptors are contributing to type 2 diabetes mellitus.","authors":"Sébastien Magnifico, Charlotte Hinault-Boyer, Nicolas Chevalier","doi":"10.1007/s42000-026-00779-y","DOIUrl":"https://doi.org/10.1007/s42000-026-00779-y","url":null,"abstract":"","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147795255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}