{"title":"男性不育症生殖功能障碍的流行病学特征和危险因素：一项荟萃分析。","authors":"Shenghui Wang, Jin Zhou","doi":"10.1007/s42000-025-00689-5","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Reproductive dysfunction, encompassing semen abnormalities and sexual dysfunction, is a significant global concern with diverse etiological factors. This meta-analysis investigated the demographic, lifestyle, and health-related risk factors that contribute to reproductive dysfunction in men.</p><p><strong>Methods: </strong>A comprehensive search of electronic databases yielded 3,931 publications, of which 28 articles (44 studies) involving 23,316 infertile men and 40,934 healthy controls were included. Data extraction and analysis followed the PRISMA guidelines. Risk factors were assessed using standardized mean difference (SMD) and odds ratio (OR) metrics, with stratified and subgroup analyses based on the population and condition.</p><p><strong>Results: </strong>Advanced age was identified as a significant risk factor for reproductive dysfunction (SMD = 1.15, 95% CI [0.68, 1.61], P < 0.001, I<sup>2</sup> = 99.6%) and subgroup analyses revealed associations across European, Asian, and Caucasian populations, as well as conditions such as asthenozoospermia, teratozoospermia, and erectile dysfunction. Elevated BMI (SMD = 1.68, 95% CI [0.17, 3.18], P < 0.001, I<sup>2</sup> = 100%) and obesity (OR = 1.43, 95% CI [1.02, 1.99], P < 0.001, I<sup>2</sup> = 76.2%) were also notable contributors. Lifestyle factors, such as smoking (OR = 1.33, 95% CI [1.16, 1.53], P < 0.001, I<sup>2</sup> = 79.2%) and alcohol consumption (OR = 1.36, 95% CI [1.00, 1.85], P < 0.001, I<sup>2</sup> = 94.8%), were consistently associated with reproductive dysfunction across multiple populations and conditions. Health-related factors, including hypertension (OR = 1.34, 95% CI [1.04, 1.74], P = 0.003, I<sup>2</sup> = 67.5%), diabetes (OR = 2.53, 95% CI [1.48, 4.33], P = 0.008, I<sup>2</sup> = 68.1%), depression (OR = 4.24, 95% CI [1.25, 14.41], P < 0.001, I<sup>2</sup> = 91.9%), and anxiety (OR = 2.16, 95% CI [1.60, 2.90], P = 0.714, I<sup>2</sup> = 0.0%) were also significantly associated with reproductive dysfunction, emphasizing the multifaceted nature of its etiology.</p><p><strong>Conclusions: </strong>This meta-analysis highlights advanced age, elevated BMI, smoking, alcohol consumption, hypertension, diabetes, and mental health disorders as critical risk factors for male reproductive dysfunction. These findings underscore the importance of targeted interventions and lifestyle modifications in mitigating these risks.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":520640,"journal":{"name":"Hormones (Athens, Greece)","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Epidemiological characteristics and risk factors of reproductive dysfunction in male infertility: a meta-analysis.\",\"authors\":\"Shenghui Wang, Jin Zhou\",\"doi\":\"10.1007/s42000-025-00689-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Reproductive dysfunction, encompassing semen abnormalities and sexual dysfunction, is a significant global concern with diverse etiological factors. This meta-analysis investigated the demographic, lifestyle, and health-related risk factors that contribute to reproductive dysfunction in men.</p><p><strong>Methods: </strong>A comprehensive search of electronic databases yielded 3,931 publications, of which 28 articles (44 studies) involving 23,316 infertile men and 40,934 healthy controls were included. Data extraction and analysis followed the PRISMA guidelines. Risk factors were assessed using standardized mean difference (SMD) and odds ratio (OR) metrics, with stratified and subgroup analyses based on the population and condition.</p><p><strong>Results: </strong>Advanced age was identified as a significant risk factor for reproductive dysfunction (SMD = 1.15, 95% CI [0.68, 1.61], P < 0.001, I<sup>2</sup> = 99.6%) and subgroup analyses revealed associations across European, Asian, and Caucasian populations, as well as conditions such as asthenozoospermia, teratozoospermia, and erectile dysfunction. Elevated BMI (SMD = 1.68, 95% CI [0.17, 3.18], P < 0.001, I<sup>2</sup> = 100%) and obesity (OR = 1.43, 95% CI [1.02, 1.99], P < 0.001, I<sup>2</sup> = 76.2%) were also notable contributors. Lifestyle factors, such as smoking (OR = 1.33, 95% CI [1.16, 1.53], P < 0.001, I<sup>2</sup> = 79.2%) and alcohol consumption (OR = 1.36, 95% CI [1.00, 1.85], P < 0.001, I<sup>2</sup> = 94.8%), were consistently associated with reproductive dysfunction across multiple populations and conditions. Health-related factors, including hypertension (OR = 1.34, 95% CI [1.04, 1.74], P = 0.003, I<sup>2</sup> = 67.5%), diabetes (OR = 2.53, 95% CI [1.48, 4.33], P = 0.008, I<sup>2</sup> = 68.1%), depression (OR = 4.24, 95% CI [1.25, 14.41], P < 0.001, I<sup>2</sup> = 91.9%), and anxiety (OR = 2.16, 95% CI [1.60, 2.90], P = 0.714, I<sup>2</sup> = 0.0%) were also significantly associated with reproductive dysfunction, emphasizing the multifaceted nature of its etiology.</p><p><strong>Conclusions: </strong>This meta-analysis highlights advanced age, elevated BMI, smoking, alcohol consumption, hypertension, diabetes, and mental health disorders as critical risk factors for male reproductive dysfunction. These findings underscore the importance of targeted interventions and lifestyle modifications in mitigating these risks.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>\",\"PeriodicalId\":520640,\"journal\":{\"name\":\"Hormones (Athens, Greece)\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Hormones (Athens, Greece)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s42000-025-00689-5\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hormones (Athens, Greece)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s42000-025-00689-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
背景：生殖功能障碍，包括精液异常和性功能障碍，是全球关注的重要问题，其病因多种多样。本荟萃分析调查了导致男性生殖功能障碍的人口统计学、生活方式和健康相关风险因素。方法：对电子数据库进行全面检索，共获得3931篇出版物，其中28篇（44项研究），涉及23316名不育男性和40934名健康对照。数据提取和分析遵循PRISMA指南。使用标准化平均差（SMD）和优势比（OR）指标评估危险因素，并根据人群和病情进行分层和亚组分析。结果：高龄被确定为生殖功能障碍的重要危险因素（SMD = 1.15, 95% CI [0.68, 1.61], P 2 = 99.6%），亚组分析显示欧洲、亚洲和高加索人群以及弱精子症、畸形精子症和勃起功能障碍等疾病与高龄相关。BMI升高（SMD = 1.68, 95% CI [0.17, 3.18], P 2 = 100%）和肥胖（OR = 1.43, 95% CI [1.02, 1.99], P 2 = 76.2%）也是显著因素。生活方式因素，如吸烟（OR = 1.33, 95% CI [1.16, 1.53], P 2 = 79.2%）和饮酒（OR = 1.36, 95% CI [1.00, 1.85], P 2 = 94.8%）与多种人群和条件下的生殖功能障碍一致相关。与健康相关的因素，包括高血压（OR = 1.34, 95% CI [1.04, 1.74], P = 0.003, I2 = 67.5%）、糖尿病（OR = 2.53, 95% CI [1.48, 4.33], P = 0.008, I2 = 68.1%）、抑郁（OR = 4.24, 95% CI [1.25, 14.41], P = 91.9%）和焦虑（OR = 2.16, 95% CI [1.60, 2.90], P = 0.714, I2 = 0.0%）也与生殖功能障碍显著相关，强调其病因的多层面性。结论：该荟萃分析强调高龄、BMI升高、吸烟、饮酒、高血压、糖尿病和精神健康障碍是男性生殖功能障碍的关键危险因素。这些发现强调了有针对性的干预和改变生活方式对减轻这些风险的重要性。临床试验号：不适用。
Epidemiological characteristics and risk factors of reproductive dysfunction in male infertility: a meta-analysis.
Background: Reproductive dysfunction, encompassing semen abnormalities and sexual dysfunction, is a significant global concern with diverse etiological factors. This meta-analysis investigated the demographic, lifestyle, and health-related risk factors that contribute to reproductive dysfunction in men.
Methods: A comprehensive search of electronic databases yielded 3,931 publications, of which 28 articles (44 studies) involving 23,316 infertile men and 40,934 healthy controls were included. Data extraction and analysis followed the PRISMA guidelines. Risk factors were assessed using standardized mean difference (SMD) and odds ratio (OR) metrics, with stratified and subgroup analyses based on the population and condition.
Results: Advanced age was identified as a significant risk factor for reproductive dysfunction (SMD = 1.15, 95% CI [0.68, 1.61], P < 0.001, I2 = 99.6%) and subgroup analyses revealed associations across European, Asian, and Caucasian populations, as well as conditions such as asthenozoospermia, teratozoospermia, and erectile dysfunction. Elevated BMI (SMD = 1.68, 95% CI [0.17, 3.18], P < 0.001, I2 = 100%) and obesity (OR = 1.43, 95% CI [1.02, 1.99], P < 0.001, I2 = 76.2%) were also notable contributors. Lifestyle factors, such as smoking (OR = 1.33, 95% CI [1.16, 1.53], P < 0.001, I2 = 79.2%) and alcohol consumption (OR = 1.36, 95% CI [1.00, 1.85], P < 0.001, I2 = 94.8%), were consistently associated with reproductive dysfunction across multiple populations and conditions. Health-related factors, including hypertension (OR = 1.34, 95% CI [1.04, 1.74], P = 0.003, I2 = 67.5%), diabetes (OR = 2.53, 95% CI [1.48, 4.33], P = 0.008, I2 = 68.1%), depression (OR = 4.24, 95% CI [1.25, 14.41], P < 0.001, I2 = 91.9%), and anxiety (OR = 2.16, 95% CI [1.60, 2.90], P = 0.714, I2 = 0.0%) were also significantly associated with reproductive dysfunction, emphasizing the multifaceted nature of its etiology.
Conclusions: This meta-analysis highlights advanced age, elevated BMI, smoking, alcohol consumption, hypertension, diabetes, and mental health disorders as critical risk factors for male reproductive dysfunction. These findings underscore the importance of targeted interventions and lifestyle modifications in mitigating these risks.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
