Eye and vision (London, England)最新文献

{"title":"The influence of corneal ablation patterns on prediction error after cataract surgery in post-myopic-LASIK eyes.","authors":"Yunqian Yao,&nbsp;Jing Zhao,&nbsp;Jifeng Yu,&nbsp;Wenwen He,&nbsp;Ling Wei,&nbsp;Xingtao Zhou,&nbsp;Yi Lu,&nbsp;Xiangjia Zhu","doi":"10.1186/s40662-022-00295-1","DOIUrl":"https://doi.org/10.1186/s40662-022-00295-1","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the influence of corneal ablation patterns on the prediction error after cataract surgery in post-myopic-LASIK eyes.</p><p><strong>Methods: </strong>Eighty-three post-myopic-LASIK eyes of 83 patients that underwent uneventful cataract surgery were retrospectively included. Predicted postoperative spherical equivalence (SE) was calculated for the implanted lens using the Haigis-L and Barrett True-K formula. Prediction error at one month postsurgery was calculated as actual SE minus predicted SE. For each eye, area and decentration of the ablation zone was measured using the tangential curvature map. The associations between prediction errors and corneal ablation patterns were investigated.</p><p><strong>Results: </strong>The mean prediction error was - 0.83 ± 1.00 D with the Haigis-L formula and - 1.00 ± 0.99 D with the Barrett True-K formula. Prediction error was positively correlated with keratometry (K) value and negatively correlated with ablation zone area using either formula, and negatively correlated with decentration of the ablation zone using the Barrett True-K formula (all P < 0.05). In the K < 37.08 D group, prediction error was negatively correlated with decentration of the ablation zone with both formulas (all P < 0.05). Multivariate analysis showed that with the Haigis-L formula, prediction error was associated with axial length (AL), K value and decentration, and with the Barrett True-K formula, prediction error was associated with AL and decentration (all P < 0.05).</p><p><strong>Conclusion: </strong>A flatter cornea, larger corneal ablation zone and greater decentration will lead to more myopic prediction error after cataract surgery in post-myopic-LASIK eyes.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"23"},"PeriodicalIF":4.2,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40461348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weighted Zernike defocus coefficient of treatment zone is a meaningful indicator for myopia control efficacy of Ortho-K lenses.","authors":"Yuzhuo Fan,&nbsp;Yan Li,&nbsp;Kai Wang,&nbsp;Jia Qu,&nbsp;Mingwei Zhao","doi":"10.1186/s40662-022-00296-0","DOIUrl":"https://doi.org/10.1186/s40662-022-00296-0","url":null,"abstract":"<p><strong>Background: </strong>The goal of this study was to reproduce a three-dimensional representation of corneal defocus characteristics after orthokeratology (Ortho-K) treatment via an indicator defined as the weighted Zernike defocus coefficient of the treatment zone (C_{weighted defocus}). This could be used to predict the effectiveness of Ortho-K treatment quantitatively in a timely manner after the one-month visit.</p><p><strong>Methods: </strong>Seventy myopic children with axial length (AL) elongation after Ortho-K treatment (group A) and 63 myopic children with AL shortening after Ortho-K treatment (group B) were included in this one-year retrospective study. The proposed indicator was calculated by a customized MATLAB program. Multivariate binomial logistic regression and multivariate linear regression analyses were used to explore the association between AL change and the C_{weighted defocus}, age, sex, and other ocular biometric parameters.</p><p><strong>Results: </strong>The 12-month AL change, age, pupil diameter, and vertical decentration of the Ortho-K lens were significantly different between the two groups. Multivariate logistic regression analysis showed that a larger C_{weighted defocus} (≥ 0.35 D/mm²) (OR: 0.224; 95% CI: 0.078-0.646; P = 0.006) was correlated with the emergence of AL shortening after orthokeratology treatment. A multivariate linear regression model showed that a greater C_{weighted defocus} was associated with slower 12-month AL elongation (β =  - 0.51, P = 0.001).</p><p><strong>Conclusions: </strong>The C_{weighted defocus} is an effective predictive indicator of myopia control, and a larger C_{weighted defocus} may lead to slower elongation of AL. This meaningful indicator may help in the evaluation and adjustment of Ortho-K lens parameters in a timely manner and minimize the cost of clinical trial and error.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"24"},"PeriodicalIF":4.2,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40461278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Ex-PRESS implantation versus trabeculectomy combined with phacoemulsification in primary open-angle glaucoma: a retrospective in vivo confocal microscopy study.","authors":"Yuqiao Zhang,&nbsp;Beiting He,&nbsp;Yulin Zhang,&nbsp;Jin Zeng,&nbsp;Yanlei Chen,&nbsp;Yongyi Niu,&nbsp;Honghua Yu,&nbsp;Yongjie Qin,&nbsp;Hongyang Zhang","doi":"10.1186/s40662-022-00278-2","DOIUrl":"https://doi.org/10.1186/s40662-022-00278-2","url":null,"abstract":"<p><strong>Background: </strong>To compare the efficacy of Ex-PRESS implantation versus trabeculectomy combined with phacoemulsification.</p><p><strong>Methods: </strong>A retrospective 12-month study on patients with coincident primary open-angle glaucoma (POAG) and cataract. The patients underwent combined phacoemulsification and Ex-PRESS implant (Phaco-ExPRESS, n = 35) or phacotrabeculectomy (Phaco-Trab, n = 35). The morphological structures of the filtering bleb were examined by slit-lamp, anterior segment optical coherence tomography (AS-OCT) and in vivo confocal microscopy (IVCM). Complete success was defined as postoperative intraocular pressure (IOP) < 18 mmHg without the use of anti-glaucoma medication. Qualified success was defined as postoperative IOP < 18 mmHg with or without anti-glaucoma medications. The data were collected preoperatively and postoperatively at 2 weeks, 1 month, 3 months, 6 months, and 12 months.</p><p><strong>Results: </strong>No significant difference in the variables such as age, IOP and perimetry was found between the groups of Phaco-ExPRESS and Phaco-Trab. At the one-year postoperative visit for filtering blebs, Phaco-ExPRESS increased the mean area of epithelial microcysts significantly from 0.10 ± 0.05 to 0.20 ± 0.09 μm² per μm², while Phaco-Trab decreased the mean area significantly from 0.08 ± 0.04 to 0.04 ± 0.06 μm² per μm². Notably, the hyperreflective dots detected by IVCM decreased by 84.9% in Phaco-ExPRESS but increased by 36.3% in Phaco-Trab. The hyperreflective dots were further identified as neutrophil- and monocyte-like cells. The number of these cells were negatively correlated with the microcysts area (r =  - 0.7, P < 0.01) but positively associated with the grade of connective tissue (r = 0.5, P < 0.01). By creating different microstructural changes in the filtering blebs, Phaco-ExPRESS produced a higher complete success rate (84.9% vs. 41.2%, P < 0.01) and significant decrease in the number of anti-glaucoma medications (P < 0.01) when compared with those in Phaco-Trab. However, the qualified success showed no significant difference between the two groups (100.0% vs. 91.2%, P = 0.24).</p><p><strong>Conclusions: </strong>At the one-year follow-up, Phaco-ExPRESS generated better filtering bleb with larger area of microcysts, looser connective tissues, and less inflammation than that of Phaco-Trab, providing adequate IOP control and less IOP-lowering medications. These findings indicate that Phaco-ExPRESS could be more preferred than Phaco-Trab for the treatment of patients with coincident POAG and cataract.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"7"},"PeriodicalIF":4.2,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39913042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-year longitudinal change in choroidal and retinal thickness in school-aged myopic children: exploratory analysis of clinical trials for myopia progression.","authors":"Meiping Xu,&nbsp;Xinping Yu,&nbsp;Minghui Wan,&nbsp;Kemi Feng,&nbsp;Junxiao Zhang,&nbsp;Meixiao Shen,&nbsp;Björn Drobe,&nbsp;Hao Chen,&nbsp;Jia Qu,&nbsp;Jinhua Bao","doi":"10.1186/s40662-022-00276-4","DOIUrl":"https://doi.org/10.1186/s40662-022-00276-4","url":null,"abstract":"<p><strong>Background: </strong>With increasing axial length and myopia progression, the micro-structure of the retina and choroid gradually changes. Our study describes the longitudinal changes in retinal and choroidal thickness in school-aged children with myopia and explores the relationship between changes in choroidal thickness and myopia progression.</p><p><strong>Methods: </strong>An exploratory analysis of a randomized trial was performed. Children (n = 168, aged 7 to 12 years) with myopia from - 0.75 dioptre (D) to - 4.00 D were enrolled in this prospective longitudinal study. Cycloplegic refraction, axial length (AL), retinal and choroidal thicknesses were measured at baseline and at 1- and 2-year follow-ups. \"Rapid progression myopia\" was defined as increasing in myopia > 1.00 D and \"stable progression myopia\" was ≤ 1.00 D during the 2-year follow-up. Factors affecting the changes in choroidal thickness were analysed using linear mixed models.</p><p><strong>Results: </strong>AL significantly increased by 0.67 ± 0.24 mm with a myopic shift of - 1.50 ± 0.64 D over the 2 years. The overall retinal thickness increased from 251.12 ± 15.91 µm at baseline to 253.47 ± 15.74 µm at the 2-year follow-up (F = 23.785, P < 0.001). The subfoveal choroidal thickness decreased from 231.03 ± 54.04 µm at baseline to 206.53 ± 59.71 µm at the 2-year follow-up (F = 73.358, P < 0.001). Choroidal thinning was significantly associated with AL elongation (β =  - 43.579 μm/mm, P = 0.002) and sex (β =  - 17.258, P = 0.001). Choroidal thickness continued to decrease in subjects with rapid progression (F = 92.06, P < 0.001) but not in those with steady progression (F = 2.23, P = 0.119).</p><p><strong>Conclusion: </strong>Significant choroidal thinning was observed and was associated with rapid progression and sex. These findings indicate a need to understand the role of the choroid in eye growth and myopia development.</p><p><strong>Synopsis/precis: </strong>The macular choroidal thickness of myopic children is relevant to different degrees of myopic progression in this 2-year longitudinal study. These findings suggest that control of choroidal thickness might work to regulate human ocular growth. Trial registration Chinese Clinical Trial Register (ChiCTR): ChiCTR-INR-16007722.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"5"},"PeriodicalIF":4.2,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39875525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SUV39H1 regulates corneal epithelial wound healing via H3K9me3-mediated repression of p27.","authors":"Shuai Yang,&nbsp;Weiwei Chen,&nbsp;Shanshan Jin,&nbsp;Guangying Luo,&nbsp;Xia Jing,&nbsp;Qi Liu,&nbsp;Peter S Reinach,&nbsp;Jia Qu,&nbsp;Dongsheng Yan","doi":"10.1186/s40662-022-00275-5","DOIUrl":"https://doi.org/10.1186/s40662-022-00275-5","url":null,"abstract":"<p><strong>Background: </strong>Corneal epithelial wound healing (CEWH) is vital for maintaining the integrity and barrier function of the cornea. Although histone modifications mediating gene expression patterns is fundamental in some other tissues, it remains unclear whether these gene regulation patterns underlie CEWH. Suppressor of variegation 3-9 homolog 1 (SUV39H1) plays a vital role in mediating gene silencing via histone H3 trimethylation of lysine 9 (H3K9me3). This study aims to characterize the comprehensive signature of epigenetic modifiers and determine the role of SUV39H1 in CEWH.</p><p><strong>Methods: </strong>NanoString nCounter technology was used to detect the differentially expressed epigenetic modifiers during CEWH. Bioinformatic analyses were performed to reveal their involvement in this process. After knockdown of SUV39H1 with siRNA transfection, we determined the function of SUV39H1 on cell proliferation and migration in human corneal epithelial cells (HCECs) via MTS, EdU, and wound-healing assay, respectively. Flow cytometry analysis further confirmed the effect of SUV39H1 on the cell cycle of HCECs. Loss-of-function assays for SUV39H1 with siRNA injection or chaetocin assessed the role of SUV39H1 on CEWH in vivo. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) and Western blotting characterized the expression of SUV39H1 and its target genes. Chromatin immunoprecipitation assay was used to evaluate the distributions of H3K9me3 marks at the promoters of SUV39H1 target genes.</p><p><strong>Results: </strong>We first identified 92 differentially expressed epigenetic modifiers and revealed their involvement during CEWH. SUV39H1 was confirmed to be upregulated in response to corneal injury. Its downregulation significantly inhibited HCEC proliferation and retarded in vivo CEWH. Furthermore, knockdown of SUV39H1 upregulated the p27 expression level and reduced H3K9me3 marks at p27 promoter in HCECs. In addition, p27 was remarkably downregulated with elevated H3K9me3 marks at its promoter during in vivo CEWH.</p><p><strong>Conclusions: </strong>SUV39H1 plays a critical role in regulating corneal epithelial cell proliferation via H3K9me3-mediated suppression of p27 during CEWH. Our findings suggest that epigenetic modifiers such as SUV39H1 can be potential therapeutic approaches to accelerate corneal repair.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"4"},"PeriodicalIF":4.2,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39752882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of artificial intelligence in cataract management: current and future directions.","authors":"Laura Gutierrez,&nbsp;Jane Sujuan Lim,&nbsp;Li Lian Foo,&nbsp;Wei Yan Ng,&nbsp;Michelle Yip,&nbsp;Gilbert Yong San Lim,&nbsp;Melissa Hsing Yi Wong,&nbsp;Allan Fong,&nbsp;Mohamad Rosman,&nbsp;Jodhbir Singth Mehta,&nbsp;Haotian Lin,&nbsp;Darren Shu Jeng Ting,&nbsp;Daniel Shu Wei Ting","doi":"10.1186/s40662-021-00273-z","DOIUrl":"https://doi.org/10.1186/s40662-021-00273-z","url":null,"abstract":"<p><p>The rise of artificial intelligence (AI) has brought breakthroughs in many areas of medicine. In ophthalmology, AI has delivered robust results in the screening and detection of diabetic retinopathy, age-related macular degeneration, glaucoma, and retinopathy of prematurity. Cataract management is another field that can benefit from greater AI application. Cataract  is the leading cause of reversible visual impairment with a rising global clinical burden. Improved diagnosis, monitoring, and surgical management are necessary to address this challenge. In addition, patients in large developing countries often suffer from limited access to tertiary care, a problem further exacerbated by the ongoing COVID-19 pandemic. AI on the other hand, can help transform cataract management by improving automation, efficacy and overcoming geographical barriers. First, AI can be applied as a telediagnostic platform to screen and diagnose patients with cataract using slit-lamp and fundus photographs. This utilizes a deep-learning, convolutional neural network (CNN) to detect and classify referable cataracts appropriately. Second, some of the latest intraocular lens formulas have used AI to enhance prediction accuracy, achieving superior postoperative refractive results compared to traditional formulas. Third, AI can be used to augment cataract surgical skill training by identifying different phases of cataract surgery on video and to optimize operating theater workflows by accurately predicting the duration of surgical procedures. Fourth, some AI CNN models are able to effectively predict the progression of posterior capsule opacification and eventual need for YAG laser capsulotomy. These advances in AI could transform cataract management and enable delivery of efficient ophthalmic services. The key challenges include ethical management of data, ensuring data security and privacy, demonstrating clinically acceptable performance, improving the generalizability of AI models across heterogeneous populations, and improving the trust of end-users.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"3"},"PeriodicalIF":4.2,"publicationDate":"2022-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39671737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repeatability and reproducibility of corneal higher-order aberrations measurements after small incision lenticule extraction using the Scheimpflug-Placido topographer.","authors":"Rui Ning,&nbsp;Rongrong Gao,&nbsp;David P Piñero,&nbsp;Jun Zhang,&nbsp;Qingyi Gao,&nbsp;Yili Jin,&nbsp;Yiran Wang,&nbsp;Chenxiao Wang,&nbsp;Jinhai Huang","doi":"10.1186/s40662-021-00274-y","DOIUrl":"https://doi.org/10.1186/s40662-021-00274-y","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the precision of corneal higher-order aberrations measurements after small incision lenticule extraction (SMILE) using the Sirius Scheimpflug-Placido topographer (CSO, Italy).</p><p><strong>Methods: </strong>Seventy-five eyes from 75 postoperative subjects were included in this prospective study. Three consecutive corneal aberrometric measurements were obtained with the Scheimpflug-Placido topographer by two experienced operators to assess intra- and inter-observer reproducibility. The within-subject standard deviation (S_w), test-retest repeatability (TRT) and the intraclass correlation coefficient (ICC) were calculated.</p><p><strong>Results: </strong>For intraobserver repeatability of anterior and total corneal aberrations, all ICCs were more than 0.922, except for trefoil (0.722 to 0.768). The ICCs of total root mean square (RMS), coma Z (3, ± 1), and spherical aberration Z (4, 0) were over 0.810 while higher-order RMS, trefoil Z (3, ± 3), and astigmatism II Z (4, ± 2) were below 0.634 for posterior corneal surface aberrations. All S_w values for all types of aberrations were equal to or below 0.07 μm. Regarding interobserver reproducibility, all TRT values were no more than 0.12 μm, 0.05 μm, and 0.11 μm for anterior, posterior, and total corneal aberrations, respectively. The ICC values ranged from 0.875 to 0.989, from 0.686 to 0.976 and over 0.834 for anterior, posterior, and total corneal aberrations, respectively.</p><p><strong>Conclusions: </strong>The repeatability of measurements of anterior and total corneal aberrations with the Sirius system in corneas after SMILE surgery was high, except for trefoil. There was some variability in posterior corneal aberrometric measurements. High reproducibility of corneal aberrometric measurements was observed between measurements of both examiners, except for trefoil, with poor to moderate reproducibility.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"1"},"PeriodicalIF":4.2,"publicationDate":"2022-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39784684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor.","authors":"Miguel Faria Ribeiro","doi":"10.1186/s40662-021-00270-2","DOIUrl":"https://doi.org/10.1186/s40662-021-00270-2","url":null,"abstract":"","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"47"},"PeriodicalIF":4.2,"publicationDate":"2021-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39799417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the letter to the editor.","authors":"Jorge L Alio,&nbsp;Francesco Versaci,&nbsp;Francesco D'Oria","doi":"10.1186/s40662-021-00271-1","DOIUrl":"https://doi.org/10.1186/s40662-021-00271-1","url":null,"abstract":"","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"46"},"PeriodicalIF":4.2,"publicationDate":"2021-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8662855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39799418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choroidal thickness and choriocapillaris vascular density in myopic anisometropia.","authors":"Xinting Liu,&nbsp;Zhiyi Lin,&nbsp;Feifu Wang,&nbsp;Xiaoyi Peng,&nbsp;Wenwen He,&nbsp;Dan Chen,&nbsp;Meixiao Shen,&nbsp;Fan Lu,&nbsp;Jun Jiang","doi":"10.1186/s40662-021-00269-9","DOIUrl":"https://doi.org/10.1186/s40662-021-00269-9","url":null,"abstract":"<p><strong>Background: </strong>This study aims to examine interocular differences in the choroidal thickness and vascular density of the choriocapillaris in anisometropic myopes and to further explore the relationship between choroidal blood flow and myopia.</p><p><strong>Methods: </strong>The sample comprised 44 participants with anisometropic myopia, aged 9 to 18 years, with normal best-corrected visual acuity. All participants underwent a series of examinations, including spherical equivalent refraction (SER) and axial length (AL), measured by a Lenstar optical biometer and optical coherence tomography angiography (OCTA) scanner. OCT measured the choroidal thickness, vascular density, and flow voids of the choriocapillaris, and a customized algorithm was implemented in MATLAB R2017a with the post-correction of AL. The choroidal thickness was measured at the fovea and 0.5, 1.0, 1.5, 2.0, 2.5, and 3.0 mm nasally, temporally, inferiorly, and superiorly to the fovea. The vascular density and the flow voids of the choriocapillaris were measured at a 0.6-mm-diameter central circle, and the 0.6-2.5 mm diameter circle in the nasal, temporal, inferior, and superior regions. Repeated-measured ANOVAs were used to analyze the interocular differences. Partial correlations with the K value and age adjustments were used to study the relationships between the choroidal thickness, the choriocapillaris vascular density and flow voids, the SER and AL.</p><p><strong>Results: </strong>The choroidal thickness of the more myopic eyes was significantly thinner than less myopic eyes (P ≤ 0.001), and the flow voids in the more myopic eyes were more than less myopic eyes (P = 0.002). There was no significant difference in the vascular density of the choriocapillaris between the more and less myopic eyes (P = 0.525). However, when anisometropia was more than 1.50 D, the vascular density of choriocapillaris in the more myopic eyes was significantly less than the less myopic eyes (P = 0.026). The interocular difference of the choroidal thickness was significantly correlated with the interocular difference in SER and AL in the center, superior, and inferior regions but not in the nasal or temporal regions. The interocular differences of the vascular density and the flow voids of the choriocapillaris were not correlated with the interocular difference of SER and AL.</p><p><strong>Conclusions: </strong>The choroidal thickness is thinner in the more myopic eyes. The flow void is increased, and the vascular density of the choriocapillaris is reduced in the more myopic eyes of children with anisometropia exceeding 1.50 D.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"48"},"PeriodicalIF":4.2,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39685825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}