Endocrinology and metabolism (Seoul, Korea)最新文献

{"title":"A Meaningful Journey to Predict Fractures with Deep Learning.","authors":"Jeonghoon Ha","doi":"10.3803/EnM.2022.403","DOIUrl":"https://doi.org/10.3803/EnM.2022.403","url":null,"abstract":"Osteoporotic fractures worsen patients’ quality of life and increase the mortality rate [1]. The mortality rate within the first 12 months after a hip fracture in Koreans aged 50 years or older was 14.0% for women and 21.0% for men [2]. Osteoporosis is an in-evitable consequence of aging, but fracture prediction is the start-ing point to preventing fractures; therefore, accurate fracture prediction is more important than ever. Although lower bone miner-al density (BMD) increases the risk of fracture, fractures also oc-cur in patients with less marked reduced bone mass. In Korea, the 10-year cumulative incidence of fragility fractures was 31.1% and 37.5% in postmenopausal women with normal BMD and osteopenia, respectively, whereas it was 44.3% in women with osteoporosis [3]. Therefore, BMD measurements and bone quality should be reflected in evaluations of bone strength. analyzing the microstructure of high-resolution peripheral (TBS) indirect indicator of bone microarchitecture. evaluates bone quality based on the information obtained by lumbar dual-energy","PeriodicalId":520607,"journal":{"name":"Endocrinology and metabolism (Seoul, Korea)","volume":" ","pages":"617-619"},"PeriodicalIF":3.4,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/63/f3/enm-2022-403.PMC9449114.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40351969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life of Survivors of Thyroid Cancer Is Not Inferior to That in Subjects without Cancer: Long-Term after Over 5 Years.","authors":"Jeongmin Lee,&nbsp;Youn-Ju Lee,&nbsp;Dong-Jun Lim,&nbsp;Jung-Min Lee,&nbsp;Sang-Ah Chang,&nbsp;Min-Hee Kim","doi":"10.3803/EnM.2022.1499","DOIUrl":"https://doi.org/10.3803/EnM.2022.1499","url":null,"abstract":"<p><strong>Backgruound: </strong>Patients with thyroid cancer undergo less extensive surgery and additional therapies compared to those with other cancers. We aimed to compare the quality of life (QoL) between patients with thyroid cancer and healthy subjects using representative data from Korea. Differences in QoL of thyroid cancer survivors according to the duration after cancer diagnosis was also evaluated.</p><p><strong>Methods: </strong>This population-based cohort study included 50,278 subjects who participated in the Korea National Health and Nutrition Examination Survey between 2007 and 2017. QoL was compared between patients with thyroid cancer and healthy subjects using self-reported data from the EuroQoL (EQ)-5 dimension (5D) and EQ-visual analog scale (VAS). Propensity score matching was used to match thyroid cancer survivors to healthy subjects (1:5 matching).</p><p><strong>Results: </strong>Linear regression with univariate analysis showed that the presence of thyroid cancer was positively correlated with better EQ-5D index scores (β-coefficient=0.010, p=0.046). After adjusting for multiple covariables, statistical significance was maintained. EQ-VAS fails to demonstrate any significant correlation. Among the EQ-5D categories, patients with thyroid cancer showed better self-care than healthy subjects. Thyroid cancer duration did not correlate with the EQ-5D index score. In subgroup analyses, compared to patients with thyroid cancer duration of <5 years, no significant difference was observed in the correlation between the EQ-5D index score and survival duration in those with thyroid cancer duration of 5 to 9 years and ≥10 years.</p><p><strong>Conclusion: </strong>Using a large-scale nationwide population-based database, our study demonstrated better QoL, especially in terms of self-care, among thyroid cancer survivors than among healthy subjects without cancer.</p>","PeriodicalId":520607,"journal":{"name":"Endocrinology and metabolism (Seoul, Korea)","volume":" ","pages":"664-673"},"PeriodicalIF":3.4,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/36/85/enm-2022-1499.PMC9449106.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40351970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the Blautia/Bacteroides Ratio and Altered Body Mass Index after Bariatric Surgery.","authors":"Yoonhong Kim,&nbsp;Dooheon Son,&nbsp;Bu Kyung Kim,&nbsp;Ki Hyun Kim,&nbsp;Kyung Won Seo,&nbsp;Kyoungwon Jung,&nbsp;Seun Ja Park,&nbsp;Sanghyun Lim,&nbsp;Jae Hyun Kim","doi":"10.3803/EnM.2022.1481","DOIUrl":"https://doi.org/10.3803/EnM.2022.1481","url":null,"abstract":"<p><strong>Backgruound: </strong>Current evidence support that the gut microbiota plays a potential role in obesity. Bariatric surgery can reduce excess weight and decrease the risk of life-threatening weight-related health problems and may also influence gut microbiota. In this study, we aimed to investigate the changes in gut microbiota before and after bariatric surgery and evaluate the association of the gut microbial shift and altered body mass index (BMI) after bariatric surgery.</p><p><strong>Methods: </strong>Between January 2019 and July 2020, stools from 58 patients scheduled for bariatric surgery were collected. Six months after bariatric surgery, stools from 22 of these patients were re-collected, and the changes in gut microbiota before and after bariatric surgery were evaluated. In addition, the differences in gut microbiota between patients with severe obesity (BMI >35 kg/m2, n=42) and healthy volunteers with normal BMI (18.8 to 22.8 kg/m2, n=41) were investigated.</p><p><strong>Results: </strong>The gut microbiota of patients who underwent bariatric surgery showed increased α-diversity and differed β-diversity compared with those before surgery. Interestingly, Blautia was decreased and Bacteriodes was increased at the genus level after bariatric surgery. Further, the Blautia/Bacteroides ratio showed a positive correlation with BMI. To validate these results, we compared the gut microbiota from severely obese patients with high BMI with those from healthy volunteers and demonstrated that the Blautia/Bacteroides ratio correlated positively with BMI.</p><p><strong>Conclusion: </strong>In the gut microbial analysis of patients who underwent bariatric surgery, we presented that the Blautia/Bacteroides ratio had changed after bariatric surgery and showed a positive correlation with BMI.</p>","PeriodicalId":520607,"journal":{"name":"Endocrinology and metabolism (Seoul, Korea)","volume":" ","pages":"475-486"},"PeriodicalIF":3.4,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/af/a5/enm-2022-1481.PMC9262679.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40479114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Healthy and Unhealthy Lifestyles by a Wearable Activity Tracker in Type 2 Diabetes: A Machine Learning-Based Analysis.","authors":"Kyoung Jin Kim,&nbsp;Jung-Been Lee,&nbsp;Jimi Choi,&nbsp;Ju Yeon Seo,&nbsp;Ji Won Yeom,&nbsp;Chul-Hyun Cho,&nbsp;Jae Hyun Bae,&nbsp;Sin Gon Kim,&nbsp;Heon-Jeong Lee,&nbsp;Nam Hoon Kim","doi":"10.3803/EnM.2022.1479","DOIUrl":"https://doi.org/10.3803/EnM.2022.1479","url":null,"abstract":"<p><p>Lifestyle is a critical aspect of diabetes management. We aimed to define a healthy lifestyle using objectively measured parameters obtained from a wearable activity tracker (Fitbit) in patients with type 2 diabetes. This prospective observational study included 24 patients (mean age, 46.8 years) with type 2 diabetes. Expectation-maximization clustering analysis produced two groups: A (n=9) and B (n=15). Group A had a higher daily step count, lower resting heart rate, longer sleep duration, and lower mean time differences in going to sleep and waking up than group B. A Shapley additive explanation summary analysis indicated that sleep-related factors were key elements for clustering. The mean hemoglobin A1c level was 0.3 percentage points lower at the end of follow-up in group A than in group B. Factors related to regular sleep patterns could be possible determinants of lifestyle clustering in patients with type 2 diabetes.</p>","PeriodicalId":520607,"journal":{"name":"Endocrinology and metabolism (Seoul, Korea)","volume":" ","pages":"547-551"},"PeriodicalIF":3.4,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e1/e9/enm-2022-1479.PMC9262687.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40479116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Insulin Resistance on Hepatic Fibrosis among United States Adults with Non-Alcoholic Fatty Liver Disease: NHANES 2017 to 2018.","authors":"Ji Cheol Bae,&nbsp;Lauren A Beste,&nbsp;Kristina M Utzschneider","doi":"10.3803/EnM.2022.1434","DOIUrl":"https://doi.org/10.3803/EnM.2022.1434","url":null,"abstract":"<p><strong>Backgruound: </strong>We aimed to investigate the association of hepatic steatosis with liver fibrosis and to assess the interactive effects of hepatic steatosis and insulin resistance on liver fibrosis in a nationally representative sample of United States adults.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis using data from National Health and Nutrition Examination Survey 2017 to 2018, which for the first time included transient elastography to assess liver stiffness and hepatic steatosis. We evaluated the association between hepatic steatosis (using controlled attenuation parameter [CAP]) and clinically significant liver fibrosis (defined as liver stiffness ≥7.5 kPa) using logistic regression with an interaction term for hepatic steatosis and insulin resistance (defined as homeostatic model assessment of insulin resistance ≥3.0).</p><p><strong>Results: </strong>Among adults undergoing transient elastography (n=2,023), 45.9% had moderate or greater hepatic steatosis and 11.3% had clinically significant liver fibrosis. After adjustment for demographic and metabolic factors, the odds of significant liver fibrosis increased as CAP score rose (odds ratio, 1.35 per standard deviation increment; 95% confidence interval, 1.11 to 1.64). We detected a significant interaction effect between CAP score and insulin resistance on the probability of significant liver fibrosis (P=0.016 for interaction). The probability of significant liver fibrosis increased in the presence of insulin resistance with increasing CAP score, while those without insulin resistance had low probability of significant liver fibrosis, even with high CAP scores.</p><p><strong>Conclusion: </strong>Individuals with hepatic steatosis had higher odds of fibrosis when insulin resistance was present. Our findings emphasize the importance of the metabolic aspects of the disease on fibrosis risk and suggest a need to better identify patients with metabolic associated fatty liver disease.</p>","PeriodicalId":520607,"journal":{"name":"Endocrinology and metabolism (Seoul, Korea)","volume":" ","pages":"455-465"},"PeriodicalIF":3.4,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/07/d8/enm-2022-1434.PMC9262684.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40105681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Tissue-Engineered Skeletal Muscle: A Tool for Metabolic Research.","authors":"Ji-Hoon Kim,&nbsp;Seung-Min Yu,&nbsp;Jang Won Son","doi":"10.3803/EnM.2022.302","DOIUrl":"https://doi.org/10.3803/EnM.2022.302","url":null,"abstract":"<p><p>Skeletal muscle is now regarded as an endocrine organ based on its secretion of myokines and exerkines, which, in response to metabolic stimuli, regulate the crosstalk between the skeletal muscle and other metabolic organs in terms of systemic energy homeostasis. This conceptual basis of skeletal muscle as a metabolically active organ has provided insights into the potential role of physical inactivity and conditions altering muscle quality and quantity in the development of multiple metabolic disorders, including insulin resistance, obesity, and diabetes. Therefore, it is important to understand human muscle physiology more deeply in relation to the pathophysiology of metabolic diseases. Since monolayer cell lines or animal models used in conventional research differ from the pathophysiological features of the human body, there is increasing need for more physiologically relevant in vitro models of human skeletal muscle. Here, we introduce recent studies on in vitro models of human skeletal muscle generated from adult myogenic progenitors or pluripotent stem cells and summarize recent progress in the development of three-dimensional (3D) bioartificial muscle, which mimics the physiological complexity of native skeletal muscle tissue in terms of maturation and functionality. We then discuss the future of skeletal muscle 3D-organoid culture technology in the field of metabolic research for studying pathological mechanisms and developing personalized therapeutic strategies.</p>","PeriodicalId":520607,"journal":{"name":"Endocrinology and metabolism (Seoul, Korea)","volume":" ","pages":"408-414"},"PeriodicalIF":3.4,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0b/ff/enm-2022-302.PMC9262682.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40478215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fancd2os Reduces Testosterone Production by Inhibiting Steroidogenic Enzymes and Promoting Cellular Apoptosis in Murine Testicular Leydig Cells.","authors":"Xiang Zhai,&nbsp;Xin-Yang Li,&nbsp;Yu-Jing Wang,&nbsp;Ke-Ru Qin,&nbsp;Jin-Rui Hu,&nbsp;Mei-Ning Li,&nbsp;Hai-Long Wang,&nbsp;Rui Guo","doi":"10.3803/EnM.2022.1431","DOIUrl":"https://doi.org/10.3803/EnM.2022.1431","url":null,"abstract":"<p><strong>Backgruound: </strong>It is well-established that serum testosterone in men decreases with age, yet the underlying mechanism of this change remains elusive.</p><p><strong>Methods: </strong>The expression patterns of Fancd2 opposite-strand (Fancd2os) in BALB/c male mice and testicular tissue derived cell lines (GC-1, GC-2, TM3, and TM4) were assessed using real-time polymerase chain reaction (RT-PCR), Western blot and immunofluorescence. The Fancd2os-overexpressing or knockdown TM3 cells were constructed by infecting them with lentivirus particles and were used to evaluated the function of Fancd2os. The testosterone production was measured using enzyme linked immunosorbent assay (ELISA) and the steroidogenic enzymes such as steroidogenic acute regulatory protein (StAR), P450 cholesterol side-chain cleavage (P450scc), and 3β-hydroxysteroid dehydrogenase (3β-HSD) were analysed using RT-PCR. The apoptosis of TM3 cells induced by ultraviolet light or testicular tissues was detected using flow cytometry, Western blot or dUTP-biotin nick end labeling (TUNEL) assays. Pearson correlation analysis was used to assess the correlation between the Fancd2os expression and TUNEL-positive staining in mouse testicular Leydig cells.</p><p><strong>Results: </strong>The Fancd2os protein was predominantly expressed in mouse testicular Leydig cells and its expression increased with age. Fancd2os overexpression inhibited testosterone levels in TM3 Leydig cells, whereas knockdown of Fancd2os elevated testosterone production. Fancd2os overexpression downregulated the levels of StAR, P450scc and 3β-HSD, while Fancd2os knockdown reversed this effect. Fancd2os overexpression promoted ultraviolet light-induced apoptosis of TM3 cells. In contrast, Fancd2os knockdown restrained apoptosis in TM3 cells. In vivo assays revealed that higher Fancd2os levels and mouse age were associated with increased apoptosis in Leydig cells and decreased serum testosterone levels. Pearson correlation analysis exhibited a strong positive correlation between the expression of Fancd2os and TUNEL-positive staining in mouse testicular Leydig cells.</p><p><strong>Conclusion: </strong>Our findings suggest that Fancd2os regulates testosterone synthesis via both steroidogenic enzymes and the apoptotic pathway.</p>","PeriodicalId":520607,"journal":{"name":"Endocrinology and metabolism (Seoul, Korea)","volume":" ","pages":"533-546"},"PeriodicalIF":3.4,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/2a/enm-2022-1431.PMC9262688.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40479115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sestrin2 Regulates Beneficial β3-Adrenergic Receptor-Mediated Effects Observed in Inguinal White Adipose Tissue and Soleus Muscle.","authors":"Min Jeong Park,&nbsp;Joo Won Kim,&nbsp;Eun Roh,&nbsp;Kyung Mook Choi,&nbsp;Sei Hyun Baik,&nbsp;Hwan-Jin Hwang,&nbsp;Hye Jin Yoo","doi":"10.3803/EnM.2022.1421","DOIUrl":"https://doi.org/10.3803/EnM.2022.1421","url":null,"abstract":"<p><p>Sestrin2, a well-known adenosine monophosphate-activated protein kinase (AMPK) regulator, plays a protective role against metabolic stress. The β3-adrenergic receptor (β3AR) induces fat browning and inhibits muscle atrophy in an AMPK-dependent manner. However, no prior research has examined the relationship of sestrin2 with β3AR in body composition changes. In this study, CL 316,243 (CL), a β3AR agonist, was administered to wild-type and sestrin2-knockout (KO) mice for 2 weeks, and fat and muscle tissues were harvested. CL induced AMPK phosphorylation, expression of brown-fat markers, and mitochondrial biogenesis, which resulted in the reduction of lipid droplet size in inguinal white adipose tissue (iWAT). These effects were not observed in sestrin2-KO mice. In CL-treated soleus muscle, sestrin2-KO was related to decreased myogenic gene expression and increased levels of muscle atrophy-related molecules. Our results suggest that sestrin2 is associated with beneficial β3AR-mediated changes in body composition, especially in iWAT and in the soleus.</p>","PeriodicalId":520607,"journal":{"name":"Endocrinology and metabolism (Seoul, Korea)","volume":" ","pages":"552-557"},"PeriodicalIF":3.4,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/09/16/enm-2022-1421.PMC9262693.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40479117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Euthyroid Thyroperoxidase Antibody Positivity during Pregnancy, to Treat or Not to Treat?","authors":"Tim I M Korevaar","doi":"10.3803/EnM.2022.301","DOIUrl":"https://doi.org/10.3803/EnM.2022.301","url":null,"abstract":"<p><p>Thyroperoxidase antibody (TPOAb) positivity is a well-known risk factor for thyroid dysfunction during pregnancy and is associated with a suboptimal response to thyroidal stimulation by human chorionic gonadotropin. About 75% of TPOAb positive women are euthyroid and there seems to be a higher risk of predominantly miscarriage and preterm birth in this subgroup. Nonetheless, clinical decision making with regards to gestational levothyroxine treatment remains difficult due to a lack of large randomized trials. Future studies assessing dose-dependent associations and additional biomarkers that can distinguish low-risk from high-risk individuals will be key in disentangling the crude clinical data.</p>","PeriodicalId":520607,"journal":{"name":"Endocrinology and metabolism (Seoul, Korea)","volume":" ","pages":"387-391"},"PeriodicalIF":3.4,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b3/a5/enm-2022-301.PMC9262680.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40478213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sclerostin as a Putative Myokine in Sarcopenia.","authors":"Hyon-Seung Yi","doi":"10.3803/EnM.2022.303","DOIUrl":"https://doi.org/10.3803/EnM.2022.303","url":null,"abstract":"Sclerostin is an osteocyte-derived circulating protein that suppresses the Wnt/β-catenin signaling pathway and bone formation [1]. Sclerostin deficiency in humans and mice causes inherited high bone mass conditions characterized by exaggerated bone formation [1,2]. Many studies have demonstrated the role of sclerostin as a regulator of bone mass, and emerging studies have suggested that circulating sclerostin could serve as a biomarker for non-skeletal diseases [3,4]. However, relatively few studies have shown the effects of sclerostin on muscle physiology and pathology in humans. Sarcopenia, an age-associated multifactorial disease, includes a notable decline in muscle mass and strength, neuromuscular function, and performance [5-8]. Despite its effects on mortality and morbidity, sarcopenia biomarkers remain unknown. Based on the coexistence of sarcopenia and osteoporosis in the population with aging and frailty, as well as considerable overlap in the pathophysiology of these two diseases, in an article titled, “Decreased serum level of sclerostin in older adults with sarcopenia,” Ahn et al. [9] investigated whether circulating sclerostin is associated with sarcopenic indices in older adults. The authors showed that higher circulating levels of sclerostin were significantly associated with a lower risk of sarcopenia, low muscle mass, and muscle weakness in Korean older adults [9]. These data were statistically significant, even after considering the confounding effects of age, sex, and body mass index. These findings are consistent with previous investigations showing a negative correlation between serum sclerostin levels and skeletal muscle mass index in Korean subjects without diabetes [10]. Therefore, it is plausible to predict that sclerostin could serve as a potential novel biomarker for sarcopenia. However, this observational study could not determine the causal relationship between the variables. Thus, it would be interesting to determine how decreased serum sclerostin levels affect muscle mass and function, which may provide a new therapeutic target for sarcopenia. Moreover, further studies are needed to clarify the role of sclerostin in the muscle-bone relationship in a variety of racial and ethnic populations. Since it has been recognized that many hormones and growth factors regulate muscle mass and protein metabolism [7,11,12], it would be valuable to investigate the role of sclerostin in the myopathies of endocrine disorders.","PeriodicalId":520607,"journal":{"name":"Endocrinology and metabolism (Seoul, Korea)","volume":" ","pages":"430-431"},"PeriodicalIF":3.4,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/99/b3/enm-2022-303.PMC9262685.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40478217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}