Diabetes & metabolic syndrome最新文献

{"title":"Impact of the COVID-19 lockdown on diabetes patients in Jeddah, Saudi Arabia.","authors":"Reem Alshareef,&nbsp;Abdullah Al Zahrani,&nbsp;Alhussain Alzahrani,&nbsp;Lama Ghandoura","doi":"10.1016/j.dsx.2020.07.051","DOIUrl":"https://doi.org/10.1016/j.dsx.2020.07.051","url":null,"abstract":"<p><strong>Aims: </strong>To explore the impact of the coronavirus disease lockdown on diabetes patients living in Jeddah, Saudi Arabia, in terms of their compliance with medication intake and lifestyle habits, and quality of life.</p><p><strong>Methods: </strong>In this cross-sectional, qualitative prospective study, a questionnaire was administered over the telephone to diabetes patients who had attended National Guard primary care centers in Jeddah, Saudi Arabia. The survey included questions on demographic data, type of diabetes, medications used, comorbidities, medication compliance, and daily habits before and after the lockdown, and those assessing patients' psychological parameters during the past month by using the Kessler Psychological Distress Scale (K10). Data analysis was performed using SPSS program version 26.</p><p><strong>Results: </strong>Totally, 394 patients participated. All of them had type 2 diabetes, and 37.6% had only one comorbidity. Antidiabetic monotherapy was used in 76.4% of the patients, while combination therapy was used in 23.6%. The compliance score before the lockdown was significantly higher (18.49 ± 3.05) than that after it (17.40 ± 3.25) (p-value <0.001). The average psychological assessment score was 9.78 ± 4.14 (range 8-35). Male participants and smokers had a significantly better psychological status than female participants (p-value = 0.002) and non-smokers (p value < 0.001), respectively.</p><p><strong>Conclusions: </strong>The patients' levels of compliance with medications and healthy lifestyle habits were significantly reduced after the lockdown. These findings highlight the need for healthcare professionals to encourage diabetes patients to adhere to healthy lifestyle habits and use telemedicine during lockdowns to ensure optimal blood glucose control and reduce the incidence of complications.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"1583-1587"},"PeriodicalIF":10.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2020.07.051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38395201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediabetes and gastrointestinal (GI) symptoms; a cross-sectional study.","authors":"Akram Ghadiri-Anari,&nbsp;Somaye Gholami,&nbsp;Fariba Zolfaghari,&nbsp;Nasim Namiranian","doi":"10.1016/j.dsx.2018.12.005","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.12.005","url":null,"abstract":"<p><strong>Aims: </strong>Prediabetes associate with known micro and macrovascular complications of diabetes. Also gastrointestinal symptoms are present in diabetics higher than general population. The aim of this study was evaluation of gastrointestinal symptoms in subjects with prediabetes.</p><p><strong>Methods: </strong>This analytical cross-sectional study was conducted on 130 persons 30-65 years old, 65 pre-diabetic patients and 65 persons without glucose disorders from 2014 to 2015 in YAZD province. FBS and HbA1c used for diagnosis prediabetes. Demographic and medical history were collected. A questionnaire according to Rome III Criteria was used to collect digestive information (diarrhea, abdominal pain, constipation, abdominal bloating, heartburn, increased gas passing, nausea, intermittent diarrhea and constipation in the last 6 months ago). Frequency of GI symptoms in subjects with and without glucose disorders were compared. Data were analyzed by SPSS software Version 20. Data were reported as mean ± standard deviation or frequency and T-test, Chi Square and Spearman correlation coefficient tests were used. P-value less than 0.05 were considered statistically significant.</p><p><strong>Results: </strong>Higher frequency of bloating, early satiety, nausea, heartburn, gas passing and constipation are seen in the pre-diabetes group than in the control group; (p-value 0.0001, 0.0001, 0.0001, 0.0001, 0.001 and 0.0001 respectively). 96.9% in prediabetics had at least one gastrointestinal symptom, while in the normal groups 50% had at least one GI symptom (p-value: 0.0001).</p><p><strong>Conclusions: </strong>Gastrointestinal symptoms were seen in prediabetics higher than healthy persons. So, prediabetes can not be considered an entirely benign and asymptomatic condition. Lifestyle interventions maybe necessary at this state.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"844-846"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.12.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36852516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why are so huge differences reported in the occurrence rate of skin lipohypertrophy? Does it depend on method defects or on lack of interest?","authors":"S Gentile,&nbsp;F Strollo,&nbsp;G Guarino","doi":"10.1016/j.dsx.2018.11.042","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.11.042","url":null,"abstract":"<p><p>Lipohypertophy (LH) is the most common skin complication of incorrect injection technique which does not only represent an aesthetic defect but also severely disrupts insulin pharmacokinetics/pharmacodynamics. As a consequence of that, hormone release is delayed and unexplained/unpredictable hypoglycemia occurs, both deteriorating metabolic control while negatively affecting adherence to treatment and quality of life. The economic burden due to unwanted intra-LH injections is accounted for by inappropriately high insulin requirements, increased emergency-related hospitalizations, and loss of work days. Greater attention has to be paid by diabetes care teams to education programs with periodic refreshers to achieve better metabolic control and reduce the economic burden of diabetes.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"682-686"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.11.042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36861899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioimpedance analysis with a novel predictive equation - A reliable technique to estimate fat free mass in birth weight based cohorts of Asian Indian males.","authors":"Riddhi Dasgupta,&nbsp;Shajith Anoop,&nbsp;Prasanna Samuel,&nbsp;Mathews E Kurian,&nbsp;Mercy Inbakumari,&nbsp;Geethanjali Finney,&nbsp;Nihal Thomas","doi":"10.1016/j.dsx.2018.11.070","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.11.070","url":null,"abstract":"<p><strong>Aim: </strong>To validate bioimpedance based predictive equations for fat free mass (FFM) against DEXA and to derive a novel birth weight based predictive equation for FFM in a birth weight based cohort of healthy Asian Indian men.</p><p><strong>Methodology: </strong>Whole body composition was done using DEXA and bioimpedance in 117 young Asian Indian men, born of normal birth weight (n = 59, birth weight ≥2.5 kg) or low birth weight (n = 58, birth weight < 2.5 kg). Predictive accuracy of 11 different bioimpedance based equations for FFM was evaluated using Pearson's correlation analysis and the root of mean squared prediction error (RMSE) analysis.</p><p><strong>Results: </strong>The mean FFM (on DEXA) and total lean mass & impedance index (on bioimpedance) were significantly higher in the low birth weight cohort. Significantly higher body fat percentage was noted on bioimpedance, for the normal birth weight cohort, but not on DEXA. In addition, the mean values of predicted FFM were significantly higher in the low birth weight cohort for 9 different predictive equations. Specifically, the mean FFM values obtained using the predictive equations of Schaefer et al., Hoot cooper et al. and Hughes et al. were in close agreement with the actual FFM values on DEXA. A novel predictive equation (CMC equation) for FFM based on birth weight was derived. FFM = 32.637 + (-0.222*age) + (-32.51*waist-to-hip ratio) + (0.33*body mass index) + (1.58 * 1 or 2 (1 = normal birth weight, 2 = low birth weight) + (0.510*waist circumference).</p><p><strong>Conclusions: </strong>Our study findings substantiate the validity of Bio-impedance analysis (BIA) as a reliable and noninvasive tool for estimating body composition measures in birth-weight based cohorts of Asian Indian males. Further, we have devised a novel BIA-based predictive equation that can be useful in larger epidemiological studies to look at alterations in body fat in this cohort.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"738-742"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.11.070","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36861905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma endoglin in Type2 diabetic patients with nephropathy.","authors":"Ahmed S Doghish,&nbsp;Atef A Bassyouni,&nbsp;Mohamed H Mahfouz,&nbsp;Heba G Abd El-Aziz,&nbsp;Rania Y Zakaria","doi":"10.1016/j.dsx.2018.11.058","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.11.058","url":null,"abstract":"<p><strong>Background: </strong>Diabetic nephropathy may be a common complication of diabetes mellitus. Endoglin is glycoprotein located on cell surfaces of endothelial cells and is part of the transforming growth factor beta (TGF- β) receptor. Endoglin expression is enhanced in endothelial cells during injury and inflammation. The aim of this study was to estimate the plasma level of soluble endoglin (sEng) in type 2 diabetic patients (with and without nephropathy). Also to explore its availability as marker for disease progression.</p><p><strong>Methods: </strong>In this study, sixty eight patients with type 2 diabetes mellitus (T2DM) were included; the patients were sub-grouped to normoalbuminuria without nephropathy and moderately increased albuminuria (microalbuminuria) with nephropathy groups with 13 individuals as control group. Plasma soluble endoglin level was determined using ELISA technique. Fasting plasma glucose (FPG), glycated haemoglobin (HbA1c), lipid profile, and creatinine were determined using colorimetric assay, whereas glomerular filtration rate (GFR) was calculated.</p><p><strong>Results: </strong>The plasma level of sEng of both normoalbuminuria group 1 and microalbuminuria group 2 were significantly higher when compared to control group. While, the plasma level of sEng in microalbuminuria group 2 was nonsignificant lower when compared to normoalbuminuria group 1. Also, there was a significant positive association between plasma level of sEng and HbA1c, HDL-C and urinary albumin concentration in normoalbuminuria group.</p><p><strong>Conclusion: </strong>Plasma level of soluble Endoglin is markedly increase prior to alteration in endothelial function, and increases to lesser extent with the developing of diabetic nephropathy which indicated disease progression and development of vascular abnormalities.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"764-768"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.11.058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36862332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic nephropathy: An update on pathogenesis and drug development.","authors":"Vikram Rao A/L B Vasanth Rao,&nbsp;Sean Hong Tan,&nbsp;Mayuren Candasamy,&nbsp;Subrat Kumar Bhattamisra","doi":"10.1016/j.dsx.2018.11.054","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.11.054","url":null,"abstract":"<p><p>Diabetic nephropathy (DN) is a major cause of end-stage renal disease and affects a large number of individuals with diabetes. However, the development of specific treatments for DN has not yet been identified. Hence, this review is concisely designed to understand the molecular pathways leading to DN in order to develop suitable therapeutic strategies. Extensive literature search have been carried in regard with the pathogenesis and pathophysiology of DN, drug targets and updates on clinical trials, the consequences associated with DN and the potential biomarkers for diagnosis and prediction of DN are discussed in this review. DN is characterised by microalbuminuria and macroalbuminuria, and morphological changes such as glomerular thickening, interstitial fibrosis, formation of nodular glomerulosclerosis and decreased endothelial cell fenestration. Besides, the involvement of renin-angiotensin-aldosterone system, inflammation and genetic factors are the key pathways in the progression of DN. In regard with drug development drugs targeted to epidermal growth factor, inflammatory cytokines, ACTH receptor and TGFβ1 receptors are in pipeline for clinical trials whereas, several drugs have also failed in phase III and phase IV of clinical trials due to lack of efficacy and severe adverse effect. The research on DN is limited with respect to its pathogenesis and drug development. Thus, a more detailed understanding of the pathogenesis of DN is very essential to progress in the drug development process.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"754-762"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.11.054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36862336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multicentre study evaluating the risk and prevalence of diabetic retinopathy in children and young people with type 1 diabetes mellitus.","authors":"S M Ng,&nbsp;O O Ayoola,&nbsp;M P McGuigan,&nbsp;S Chandrasekaran","doi":"10.1016/j.dsx.2018.11.063","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.11.063","url":null,"abstract":"<p><strong>Introduction: </strong>There is currently limited data published on the prognostic factors and prevalence of diabetic eye disease in children and young people (CYP) with Type 1 diabetes mellitus (T1DM), yet diabetic retinopathy remains one of the commonest causes of blindness in young adults. The aim of this study was to determine the risk and prevalence of diabetic retinopathy (DR) and to evaluate the risk factors associated with diabetic retinopathy in CYP with T1DM.</p><p><strong>Methods: </strong>All CYP with Type 1 diabetes between 12 and 18 years of age, registered with the regional diabetic retinopathy screening programme were evaluated from 2012 to 2013 in four diabetes units within the north west region of the United Kingdom. Patients who had evidence of diabetic retinopathy were reviewed to identify risk factors for presence or absence of diabetic retinopathy.</p><p><strong>Results: </strong>237 patients between the ages 12-18 years were included in the. The prevalence of diabetic retinopathy was 11%. Out of 27 patients with evidence of diabetic retinopathy, 44% were reported as background changes and 56% had pre-proliferative DR. Significant risk factors for diabetic retinopathy disease in the population using univariate analyses were duration of diabetes, puberty, age at diagnosis and mean HbA1c in the preceding 12 months. Multivariate logistic regression analysis found age of diagnosis (p = 0.04) and mean HbA1c as significant independent risk factors for presence of diabetic retinopathy (p = 0.02).</p><p><strong>Conclusions: </strong>The prevalence of diabetic retinopathy in this paediatric population was 11%. Early age at diagnosis and poor metabolic control are independent risk factors for diabetic retinopathy.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"744-746"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.11.063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36862331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum vitamin E as a significant prognostic factor in patients with dyslipidemia disorders.","authors":"Maral Barzegar-Amini,&nbsp;Hamideh Ghazizadeh,&nbsp;Seyed Mohammad Reza Seyedi,&nbsp;Hamid Reza Sadeghnia,&nbsp;Akram Mohammadi,&nbsp;Mahdi Hassanzade-Daloee,&nbsp;Elham Barati,&nbsp;Sara Kharazmi-Khorassani,&nbsp;Jasmin Kharazmi-Khorassani,&nbsp;Maryam Mohammadi-Bajgiran,&nbsp;Shima Tavallaie,&nbsp;Gordon A Ferns,&nbsp;Mohsen Mouhebati,&nbsp;Mahmoud Ebrahimi,&nbsp;Maryam Tayefi,&nbsp;Majid Ghayour-Mobarhan","doi":"10.1016/j.dsx.2018.11.034","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.11.034","url":null,"abstract":"<p><strong>Objectives: </strong>Obesity and overweight are among the main causes of cardiovascular disease (CVD) mortality. Dyslipidemia, fatty liver index, is strongly related to CVD. Vitamin E as an antioxidant protects the hepatic cells against oxidative stress and prevents fatty liver disease. The aim of the current study is to evaluate the relationship between anthropometric parameters and fasted lipid profile with serum vitamin E levels.</p><p><strong>Study design: </strong>A randomized trial was designed based on data from the Mashhad stroke and heart atherosclerotic disorders (MASHAD: 2010-2020).</p><p><strong>Methods: </strong>363 CVD subjects (173 males and 190 females) was selected at random, among 9704 subjects in three regions of Mashhad, northeast of Iran to investigate the specific correlations among their serum vitamin E, lipid profile (TG, HDL-C, LDL-C and TC), and anthropometric features (height, weight, BMI, hip and waist circumferences.</p><p><strong>Result: </strong>The results indicated the significant relationships between vitamin E, and fasting serum lipid profile in subjects. Serum vitamin E was negatively correlated to TC, TG, and LDL-C and positively related to HDL-C. Also, statistically negative correlations were found between vitamin E and anthropometric parameters (weight, waist and hip circumference, middle Arm, and Systolic Blood Pressure). Moreover, vitamin E ratios such as vitamin E/(TC + TG) and vitamin E/TC values as standardized vitamin E, had significant negative correlation with BMI, the whole of anthropometric parameters, and dyslipidemia risk factors including TC, TG and LDL-C.</p><p><strong>Conclusion: </strong>We found that vitamin E profile was significantly lower in the dyslipidemia subjects. It is generally suggested that vitamin E monitoring might be used as a useful prognostic and therapeutic agent in dyslipidemia disorder.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"666-671"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.11.034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36906456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High prevalence of prediabetes among the family members of individuals with diabetes. Findings from targeted screening program from south India.","authors":"Gomathi Ramaswamy,&nbsp;Palanivel Chinnakali,&nbsp;Sriram Selvaraju,&nbsp;Divya Nair,&nbsp;Pruthu Thekkur,&nbsp;Kalaiselvi Selvaraj,&nbsp;Roopa Shivashankar,&nbsp;Akash Ranjan Singh,&nbsp;Halevoor Nanjundappa Vrushabhendra","doi":"10.1016/j.dsx.2018.12.001","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.12.001","url":null,"abstract":"<p><strong>Aim: </strong>We aimed to screen for prediabetes, diabetes and other cardiovascular risk factors among family members of people with diabetes registered for care in a primary health centre in South India.</p><p><strong>Methods: </strong>During 2017-2018, we screened eligible family members of individuals with diabetes at their homes. We measured fasting capillary blood glucose (FCBG); for those with FCBG≥126 mg/dl, we confirmed the diagnosis of diabetes with fasting plasma glucose (FPG). We defined prediabetes as FCBG between 100 and 125 mg/dl; diabetes as both FCBG and FPG ≥126 mg/dl. We assessed non-communicable disease risk factors using WHO STEPS questionnaire.</p><p><strong>Results: </strong>Of total 884 participants, 873 (99%) underwent screening; 280 (32%) had prediabetes, and 19 (2.2%) were confirmed with diabetes. Of newly diagnosed, 17 (90%) were initiated on treatment. Of 873 participants, 180 (20.6%) were newly diagnosed with hypertension. Of the total, 7.3%, 5.2% and 16% reported tobacco use, alcohol use and high salt intake respectively. Nearly half (48%) had overweight.</p><p><strong>Conclusion: </strong>Though the yield for diabetes is modest (3%), the house to house approach was able to screen 99% of eligible population. High prevalence of prediabetes and undiagnosed hypertension emphasize the need for screening and life style modifications.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"866-872"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.12.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36851940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose vitamin D supplementations improve peripheral diabetic neuropathy? A before-after clinical trial.","authors":"Akram Ghadiri-Anari,&nbsp;Zohre Mozafari,&nbsp;Somaye Gholami,&nbsp;Seyed-Ali Khodaei,&nbsp;Marzieh Aboutorabi-Zarchi,&nbsp;Fariba Sepehri,&nbsp;Azade Nadjarzade,&nbsp;Masoud Rahmanian,&nbsp;Nasim Namiranian","doi":"10.1016/j.dsx.2018.12.014","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.12.014","url":null,"abstract":"<p><strong>Objective: </strong>Peripheral neuropathy is a common complication of diabetes mellitus. This study was set to assess the effect of vitamin D supplementation on peripheral neuropathy in patients with type 2 diabetes (T2DM).</p><p><strong>Materials and methods: </strong>This study was a quasi-experimental trial in Yazd diabetic research center. Sixty T2DM subjects (30-65 years old) with painful diabetic neuropathy enrolled in this study from March 2017 till April 2018. Patients received weekly 50000 IU of vitamin D3 for 12 weeks orally. Evaluation of diabetic neuropathy was performed by using Michigan Neuropathy Screening Instrument (MNSI) before and after trial. Also fasting plasma glucose, HbA1c, calcium and vitamin D checked before and after the trial. SPSS version 20 software was used for statistical analysis. P ≤ 0.05 was considered to be statistically significant.</p><p><strong>Results: </strong>Among 60 T2DM patients, 58 completed the study. Most of them (53.4%) were male. At the end of study, HbA1c, vitamin D, MNSI (both questionnaire and physical examination) improved that is statistically significant (p-value: <0.001).</p><p><strong>Conclusion: </strong>Oral supplementation of vitamin D 3 (50,000 IU) once weekly for 12 weeks was associated with improvement in the serum level of vitamin D and significant decrease in the symptoms and sign of diabetic neuropathy. So serum vitamin D level should be checked in persons with diabetic neuropathy and low levels of it should be corrected in order to reducing neuropathy severity.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"890-893"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.12.014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36851944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}