Diabetes & metabolic syndrome最新文献

{"title":"Severe and persistent hypoglycemia with lactic acidosis in an elderly lady with type 2 diabetes mellitus and lymphoma∖leukemia: A rare case report.","authors":"Pradeep G Talwalkar","doi":"10.1016/j.dsx.2018.11.037","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.11.037","url":null,"abstract":"<p><p>We present here a case of hypoglycemia and lactic acidosis in an elderly diabetic lady with underlying leukemia∖lymphoma. Possible mechanisms responsible for both hypoglycemia as well as lactic acidosis are discussed. The case emphasizes the need for thorough chasing of all clinical leads obtained from history taking, physical examination, as well as laboratory evaluation in order to avoid getting misled by apparently obvious diagnosis. To the best of the author's knowledge, this is the first time such a case is reported in Indian literature.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"648-650"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.11.037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36906458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dyslipidaemia as a risk factor for erectile dysfunction in type 2 diabetes mellitus patients.","authors":"Abul Kalam Azad,&nbsp;Sumudu Setunge,&nbsp;Shahjada Selim,&nbsp;Shahabul Huda Chowdhury,&nbsp;Mohammad Ferdousur Rahaman,&nbsp;Md Abdul Jalil Chowdhury,&nbsp;Barbora de Courten,&nbsp;Dragan Ilic,&nbsp;Md Nazmul Karim","doi":"10.1016/j.dsx.2018.11.052","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.11.052","url":null,"abstract":"<p><strong>Background: </strong>Despite epidemiological studies worldwide have documented erectile dysfunction (ED) as a major complication of type 2 diabetes Mellitus (T2DM) in men, only limited research reported on determinants of ED in this population. The study aimed at examining the association of ED with dyslipidaemia in T2DM patients.</p><p><strong>Methods: </strong>The study enrolled 813 consecutive eligible adult male T2DM patients attending the endocrinology departments of a tertiary teaching hospital in Bangladesh. Sexual function was assessed using modified International Index of Erectile Function (IIEF) in face-to-face interview and collected along with sociodemographic information. Diabetes and lipid profile and treatment history were collected from patient's treatment records. Association of ED with dyslipidaemia was assessed using multivariable logistic regression adjusting for potential confounders.</p><p><strong>Result: </strong>Prevalence of ED among the T2DM patients was very high (72.7%), of which around half had moderated-to-severe ED. Odds of having dyslipidaemia among T2DM patients with ED is 2.3 times higher than those without. The odds increased by approximately 3 fold for an abnormal High Density Lipoprotein level and by 2.7 fold for abnormal Low Density Lipoprotein.</p><p><strong>Conclusion: </strong>Dyslipidaemia was associated with increased ED risk among T2DM. Abnormal lipoprotein level particularly were found to pose greater risk.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"748-753"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.11.052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36862335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of anthropometric, cardiovascular, autonomic, baroreflex sensitivity, aerobic fitness, inflammatory markers and oxidative stress parameters between first degree relatives of diabetes and controls.","authors":"Vivek Kumar Sharma,&nbsp;Hanumanthappa Nandeesha,&nbsp;Kolar Vishwanath Vinod,&nbsp;Senthil Kumar Subramanian,&nbsp;Devanarayanan Siva Sankar,&nbsp;Rajathi Rajendran","doi":"10.1016/j.dsx.2018.11.047","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.11.047","url":null,"abstract":"<p><strong>Aim: </strong>We aimed at assessing cardiovascular risk of first degree relatives of diabetes (FDRD).</p><p><strong>Methods: </strong>A cross sectional study involving 90 apparently healthy normoglycemic volunteers aged between 15 and 50 years (45 FDRD and 45 FDRs of non-diabetics). We measured anthropometric parameters, baroreflex sensitivity, heart rate variability, cardiac autonomic function tests, and aerobic capacity, fasting blood glucose and insulin, lipid profile, inflammatory markers, nitric oxide and oxidative stress markers.</p><p><strong>Results: </strong>FDRD had significantly higher hip circumference and BF%. Blood pressure, total peripheral resistance and cardiac output were comparable. FDRD had higher HR and rate pressure product. There were no significant differences in cardio-respiratory fitness (VO2max) and physical activity level. Time and Frequency domain parameters were comparable except for reduced NN50 and total power. Baroreflex sensitivity, 30:15 ratio and E: I ratio were significantly less in FDRD. Fasting glucose was comparable. Fasting Insulin, HOMA IR, HOMA %B and HOMA AD were higher while HOMA %S and QUICKI index were lower in FDRD. Lipid profile or lipid derived parameters were comparable except for higher non-HDLc in FDRD. Adiponectin was lower while Leptin and Leptin/apidonectin ratio was higher in FDRD. IL-6, hsCRP, TNF- alpha and MDA were significantly higher in FDRD, while TAS and nitric oxide were significantly lower in FDRD.</p><p><strong>Conclusion: </strong>Higher body fat percentage, with insulin resistance, deranged cardiac autonomic function, higher oxidative stress and inflammation, lower adiponectin and nitric oxide levels places FDRD at higher cardiovascular risk and necessitates early lifestyle modification/intervention.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"652-658"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.11.047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36905960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of metabolic syndrome in Iran: A meta-analysis of 69 studies.","authors":"Khadijeh Kalan Farmanfarma,&nbsp;Mahmoud Ali Kaykhaei,&nbsp;Hosein Ali Adineh,&nbsp;Mehdi Mohammadi,&nbsp;Soroosh Dabiri,&nbsp;Alireza Ansari-Moghaddam","doi":"10.1016/j.dsx.2018.11.055","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.11.055","url":null,"abstract":"<p><strong>Aims: </strong>Metabolic syndrome increases the risk of chronic diseases including cardiovascular diseases and diabetes. The present study investigated the prevalence of metabolic syndrome in Iran.</p><p><strong>Materials and methods: </strong>Published articles in English and Persian during 2000-2016 identified using keywords of prevalence, metabolic syndrome, and Iran in the following databases: Web of Science, PubMed, Scopus, Google scholar, SID and Magiran. Random effect model used to calculate the pooled estimates. Heterogeneity of studies assessed using Q statistic, and geographical distribution of metabolic syndrome demonstrated via GIS map. Data were analyzed by STATA-11.</p><p><strong>Results: </strong>The overall prevalence of metabolic syndrome was 30.4% (95%CI: 28.3-32.6) with no significant heterogeneity by diagnostic criteria. The lowest frequency was reported in Sistan and Baluchestan Province [18.3% (95% CI: 12.9-25.8)] compared to the highest in Bushehr [57.8% (95% CI: 41.8-80.0)]. It was significantly more prevalent in women [(34.8% (95%CI: 31.2-38.8)] compared to men [25.7% (95%CI: 23.4-28.3)] (P = 0.001)]. A significant increasing trend (P = 0.001) was observed in different age groups, as metabolic syndrome increased from 12.1% (95% CI: 9.37-15.6) in 20-29 years-old age group to 51.7% (95%CI: 47.4-56.4) in the over 60 years-old age group.</p><p><strong>Conclusions: </strong>Approximately one-third of Iranian adults have metabolic syndrome which varied by regions, age and gender. Then, appropriate intervention based on behavioral patterns of inhabitants and local conditions may help to reduce the burden of disease.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"792-799"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.11.055","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36862674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of Peyronie's disease in diabetic patients -2018- Yazd.","authors":"Maryam Askari,&nbsp;Seyed Ali Mohamad Mirjalili,&nbsp;Mina Bozorg,&nbsp;Reyhane Azizi,&nbsp;Nasim Namiranian","doi":"10.1016/j.dsx.2018.11.039","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.11.039","url":null,"abstract":"<p><strong>Introduction: </strong>Peyronie's disease (PD) is the fibrous scar tissue inside the penis that causes curved and painful erections. PD is associated with, diabetes, hypertension, dyslipidemia and low testosterone. PD causes erectile dysfunction (ED). The aim of this study was to evaluate the prevalence of PD in type 2 diabetic (T2DM) patients in Yazd.</p><p><strong>Methods: </strong>This cross-sectional study was conducted on 317 patients with T2DM referred to the Diabetes Research Center of Yazd. Inclusion Criteria were: T2DM, ages 30-65 years old, having a medical record at the Yazd diabetes research center, willingness to participate in research. Exclusin criteria contain: history of smoking and using anti-depressive drugs. Data was analyzed using with SPSS-16 and Stata software. Descriptive tables and charts were used and statistical tests such as independent sample T-test and Fisher's exact test were used.</p><p><strong>Results: </strong>A total number of 317 male patients were enrolled. The prevalence of diabetes microvascular complications were as following; neuropathy 36.30% (30.97-41.38), retinopathy 24.30% (19.67-29.39), nephropathy 20.50% (16.19-25.37), and PD 3.80% (1.97-6.51).</p><p><strong>Conclusion: </strong>There was no difference in the prevalence of PD in our study with the global studies. But there is a higher prevalence of PD in diabetic patients than the general population.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"604-607"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.11.039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36852509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mobile care teams improve metabolic control for adults with Type II diabetes in the Southern West Bank, Palestine.","authors":"Ahmad Abu Al-Halaweh,&nbsp;Thomas Almdal,&nbsp;Norm O'Rourke,&nbsp;Nadav Davidovitch","doi":"10.1016/j.dsx.2018.11.066","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.11.066","url":null,"abstract":"<p><strong>Aim: </strong>The purpose of this study is to assess the effectiveness of the Diabetes Comprehensive Care Model (DCCM) intervention on diabetes care outcomes. We hypothesized that participants receiving diabetes care from the mobile diabetes clinic (intervention group) would demonstrate significant improvement in glycemic control compared to those receiving treatment as usual (control group).</p><p><strong>Materials and methods: </strong>We conducted a longitudinal, quasi-experimental study in which two similar clinics were identified. From both, we recruited 100 patients diagnosed with Type II diabetes. At baseline, patients were similar in terms of both socio-demographic and diabetes health variables. The team visited patients at the Bethlehem clinic at the beginning and end of the study (control group). Mobile diabetes care teams implemented the DCCM in Hebron four times over one year (treatment group).</p><p><strong>Results: </strong>Most participants were female (63.5%) with average diabetes duration of 7.9 years. Initial HbA1c was 9.49% on average (SD = 1.93) and 9.20% (SD = 1.92) for the control and intervention groups, respectively. Statistically significant change in HbA1c, cholesterol, creatinine and systolic BP were observed in the intervention group (differences in change between recruitment and follow-up). That is, significant improvement over time was observed for the treatment group whereas little or no change was observed for the control group.</p><p><strong>Conclusion: </strong>The DCCM-based intervention leads to improved glycemic control parameters indicative of diabetes control. Clinically significant change was observed in treatment group only. Integrative diabetes care appears especially well suited for fragmented healthcare systems with limited resources.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"782-785"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.11.066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36862673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-sectional correlates of oxidative stress and inflammation with glucose intolerance in prediabetes.","authors":"Roshan Kumar Mahat,&nbsp;Neelima Singh,&nbsp;Vedika Rathore,&nbsp;Manisha Arora,&nbsp;Tapeshwar Yadav","doi":"10.1016/j.dsx.2018.11.045","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.11.045","url":null,"abstract":"<p><strong>Background: </strong>Prediabetes is a condition in which blood glucose level is above the normal but below the diagnostic value of diabetes mellitus. Besides progression to diabetes mellitus, prediabetic subjects are at risk for cardiovascular disease (CVD). It is associated with oxidative stress and inflammation and therefore this research was conducted with the aim to evaluate the risk of cardiovascular disease in prediabetic subjects by measuring the markers of oxidative stress and inflammation and their possible correlation with glucose intolerance.</p><p><strong>Materials and methods: </strong>A total of 400 human subjects were recruited for the present cross-sectional study. Of them, 200 were prediabetic subjects and 200 were age and gender-matched control subjects. Blood samples were collected from all participants and analyzed for 8-hydroxy-2'-deoxy-guanosine (8-OHdG), malondialdehyde (MDA), reduced glutathione (GSH) and high sensitivity C-reactive protein (hs-CRP).</p><p><strong>Results: </strong>The markers of oxidative stress i.e. 8-OHdG and MDA were found to be significantly increased in prediabetic subjects as compared to control subjects except GSH, which was significantly reduced in prediabetic subjects. Similarly, hs-CRP (a marker of inflammation) was significantly increased in prediabetic subjects compared to controls. On correlation analysis, 8-OHdG, MDA and hs-CRP were significantly and positively correlated with glucose intolerance in prediabetes whereas GSH showed significant negative correlation with glucose intolerance.</p><p><strong>Conclusion: </strong>In conclusion, markers of oxidative stress and inflammation should be taken into consideration while evaluating the risk for CVD in prediabetes since these markers were well correlated with glucose intolerance in prediabetic subjects.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"616-621"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.11.045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36851487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The antidiabetic and antioxidant properties of some phenolic phytochemicals: A review study.","authors":"Akram Ahangarpour,&nbsp;Majed Sayahi,&nbsp;Miaad Sayahi","doi":"10.1016/j.dsx.2018.11.051","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.11.051","url":null,"abstract":"<p><strong>Background: </strong>One class of phytochemicals are phenols with (OH) group bounded to aromatic hydrocarbon group. The aim of this study was to review the anti-diabetic and anti-oxidant properties of important phenols.</p><p><strong>Methods: </strong>This is a review study with ethic number (95s108) from AJUMS. About 450 articles (original, review,etc) been screened; 40 of them in the range of (1992-2017) were used due to their correlation to the study purpose. 28 of them were indexed by \"Web of science (ISI)\", 24 of them indexed by pubmed and also 29 of them were indexed by scopus data center.</p><p><strong>Findings: </strong>Phenols affect diabetes in different ways. CGA suppress hepatic gluconeogenesis through the inhibition of G6Pase and is also an insulin sensitizer that potentiates insulin action. Curcumin reduce insulin resistance so decrease AGE's products in diabetes mellitus. Hydroxytyrosol regulates the calcium channels which plays key role in insulin secretion. Resveratrol increase the stimulation of glucose uptake and insulin secretion. CGA has similar antioxidant activity as vitamin E and ellagic acid maybe is even more potent than vitamin E. curcumin inhibits lipid peroxidation and scavenge superoxide anion and hydroxyl radicals. The antioxidant activity of hydroxytyrosol protects pancreatic cells from damage and death. Treatment with resveratrol significantly decreases the level of glucosylated hemoglobin.</p><p><strong>Conclusion: </strong>All these phytochemicals have potent antidiabetic and antioxidant effects in different ways beside their other effects like anti-inflammatory and anti-carcinogenic properties in ellagic acid, or like anti-angiogenic and apoptogenic activities in curcumin. So we suggest further studies in the field of diabetes and antioxidation.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"854-857"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.11.051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36852517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of iodine supplementation program on thyroid function in Sudan.","authors":"Nagi I Ali,&nbsp;Sami N A Elgak,&nbsp;Yousif Mohamed Y Abdallah,&nbsp;Hajo Idriss","doi":"10.1016/j.dsx.2018.11.036","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.11.036","url":null,"abstract":"<p><p>The aim of this Study is to investigate whether the Iodine Supplementation Programme is successful or not. This Programme was implemented in Nyala to treat the Iodine deficiency. In this Study Nyala was selected to act as (a study area), due to the history of Iodine deficiency of this region, while Khartoum was selected to act as (a control area). 2000 samples were collected from Khartoum versus 450 samples from Nyala. Thyroxine (T₄) and triiodothyronine (T₃) levels in two regions were measured and performed by using radioimmunoassay (RIA), also the immunoradiometric assay (IRMA) used for measurement of thyroid stimulating hormone (TSH). The obtained results analyzed by using Statistical Package for Social Sciences (SPSS). (Coherent retrospective) used to determine differences between the study groups. The results of this study showed, there was no significant difference between the mean serum concentrations of T3 and TSH for Khartoum and Nyala. T4of Khartoum (117.93 ± 42.797) nmol/L and the mean serum T4 of Nyala (114.54 ± 45.526) nmol/L, the (P-value = 0.133).T3for Khartoum (1.8040 ± 0.99047) nmol/L and T3of Nyala (1.7307 ± 0.96508) nmol/L, the (P-value = 0.153). TSH for Khartoum (1.4480 ± 0.95807)mIU/Land the mean serum TSH of Nyala (1.4553 ± 1.0244) mIU/L, the (P-value = 0.885). The study showed a clear observation of improvement of hypothyroidism cases in Nyala while the ratio decreased from 64.09% to 0.6%. All the results were carried out according to normal range of Sudanese. The conclusion from this study the iodine supplementation programme is successful. The study recommends rising the health awareness among people by explain the severity of iodine deficiency, and continue in iodine supplementation programme, also establishment of monitoring system including monitoring the presence of iodized diets (sugar, salt, oils, and bread) in the markets. Finally, further studies are needed in other parts of Sudan to assess the size of iodine deficiency problem.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"678-680"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.11.036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36906457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibroblast growth factor 21 association with subclinical atherosclerosis and arterial stiffness in type 2 diabetes.","authors":"Saeed Yafei,&nbsp;Fathy Elsewy,&nbsp;Eman Youssef,&nbsp;Mohammed Ayman,&nbsp;Mohamed El-Shafei","doi":"10.1016/j.dsx.2018.12.007","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.12.007","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the association of serum FGF21 with subclinical atherosclerosis and pulse wave velocity, a marker of arterial stiffness, in type 2 diabetes Egyptian patients.</p><p><strong>Patients and methods: </strong>Fasting serum FGF21 was measured in 120 type 2 diabetes patients without clinical atherosclerotic cardiovascular disease (mean age 51.1 ± 7.7 years; 63.3 women). In addition to basic laboratory tests, serum adiponectin and ultrasonographic examination of CIMT, ankle brachial index (ABI) and carotid-femoral pulse wave velocity (cfPWV) were performed.</p><p><strong>Results: </strong>Patients with subclinical atherosclerosis have higher serum FGF21 than those without (218 ± 66.8 pg/mL Vs 170 ± 43.1 pg/mL, P < 0.001). FGF21 correlated positively with CIMT and cfPWV (P < 0.001) regardless of patient gender. In logistic regression analysis, circulating FGF21 was found to be an independent predictor for subclinical atherosclerosis (P = 0.023) in addition to dyslipidemia, hypertension and adiponectin. FGF21 was also found to be an independent determinant of cfPWV in stepwise multiple regression analysis. ROC curve analysis was done and cutoff high risk FGF21 level of 184 pg/mL for the prediction of subclinical atherosclerosis with a sensitivity and specificity of 66.7%.</p><p><strong>Conclusions: </strong>Serum FGF21 levels correlated with carotid intima media thickness and predict subclinical atherosclerosis. Serum FGF21 is also correlated positively with cfPWV and arterial stiffness in type 2 diabetes patients.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"882-888"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.12.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36851941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}