Diabetes & metabolic syndrome最新文献

{"title":"Comparing the ability of anthropometric indicators in determining the prevalence of hypertension among Indian tribes.","authors":"Gautam K Kshatriya,&nbsp;Anjali Kumari,&nbsp;Subhendu K Acharya","doi":"10.1016/j.dsx.2018.11.038","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.11.038","url":null,"abstract":"<p><strong>Objective: </strong>We compared the ability of the selected anthropometric indicators to best predict the prevalence of hypertension among the Indian tribes.</p><p><strong>Methods: </strong>A cross-sectional study was undertaken among 1431 adult participants (705 males and 726 females) between the ages of 20 and 60 years from six major tribes in India. Selected anthropometric indicators such as body mass index (BMI), waist-hip-ratio (WHR), waist-height-ratio (WHtR), percentage body fat (PBF), visceral fat (VF), minimum-waist-circumference (MWC) and sum-of-the-four skinfold thickness (SF4), along with the physiological parameters such as blood pressure were recorded. Discriminant analysis (DA) was performed to examine and compare the ability of the selected anthropometric indicators towards classifying hypertension among males, females and the total population.</p><p><strong>Results: </strong>Significant independent association was observed for hypertension and similar conditions within gender and selected age-group categories. The overall hypertension prevalence among the studied tribes was observed at 12.6%. Standardized function coefficients (SFCs) in discriminant analysis revealed PBF(0.89, 0.36, and 0.76 for overall, males, and females respectively) as the most powerful discriminator of hypertension. In addition, visceral fat (0.74, 1.46, and 0.58 for overall, males and females respectively) was observed to be the other significant indicator of hypertensive blood pressure. These exploratory findings for the first time indicate fat deposition, rather than body density alone, as an emerging physiological and metabolic risk among Indian tribes.</p><p><strong>Conclusion: </strong>In the context of the highly prevalent chronic undernutrition, internal fat deposition is a major classifying factor of physiological and metabolic intolerance. It also indicates the increasing trend in lifestyle changes and the associated adversities among the Indian tribes.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"696-706"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.11.038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36861901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High rates of atherogenic dyslipidemia, β-cell function loss, and microangiopathy among Turkish migrants with T2DM.","authors":"Michel P Hermans,&nbsp;Sylvie A Ahn,&nbsp;Shaukat Sadikot,&nbsp;Michel F Rousseau","doi":"10.1016/j.dsx.2018.11.049","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.11.049","url":null,"abstract":"<p><strong>Aims: </strong>Non-Caucasian migrants require dedicated approaches in diabetes management due to specific genetic; socio-cultural; demographic and anthropological determinants. Documenting such phenotypes allows for better understanding unmet needs and management priorities.</p><p><strong>Methods: </strong>This age- and sex-adjusted case-control (1:6 ratio) study compared 56 T2DM Turkish migrants (70% males) resident in Belgium [Tu] with 336 T2DM Caucasians [Ca], all benefiting from state-funded healthcare.</p><p><strong>Results: </strong>The 2 groups did not differ regarding BMI; waist circumference; fat mass; visceral fat; muscle mass; insulin sensitivity; insulinemia; metabolic syndrome; hypertension; lipid-modifying drugs; and macroangiopathy. They also had similar renal function and (micro)albuminuria. Education (low/high) and ethanol consumption were lower among [Tu]: 83/17% and 2.0 U/wk vs 43/57% and 13.6 U/wk in [Ca] (p < 0.0001). β-cell function loss (BCF) was higher in [Tu]: 1.58(0.45) vs 1.35(0.54)%/yr (p 0.0027), as was HbA1c: 8.39(1.91) vs 7.48(1.35)% in [Ca] (p < 0.0001). Diabetes duration and insulin use were increased in [Tu]: 19(9)yr and 70% vs 16(8)yr and 48% in [Ca] (p 0.0111 and 0.0024). Atherogenic dyslipidemia (AD) was more prevalent in [Tu]: 64% vs 49% (p 0.0309), who had higher non-HDL-C; apolipoprotein B₁₀₀; LDL-C; and triglycerides; and lower HDL-C and apolipoprotein A-I levels (all p < 0.05). Overall microangiopathy; retinopathy; and neuropathy were more prevalent in [Tu]: 55-35-37% vs 40-18-20% in [Ca] (all p < 0.05).</p><p><strong>Conclusions: </strong>These results should raise concerns about poor glycaemic control; rapid BCF loss; severe AD; and microangiopathy among Turkish migrants with T2DM. Targeting AD could improve the cardiometabolic profile of this minority given the relationship between AD and residual vascular risk.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"716-720"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.11.049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36861902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory markers and control of type 2 diabetes mellitus.","authors":"Hanan Elimam,&nbsp;Azza M Abdulla,&nbsp;Inas Mohamed Taha","doi":"10.1016/j.dsx.2018.11.061","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.11.061","url":null,"abstract":"<p><strong>Background: </strong>Subclinical inflammation and presence of almost all indicators of systemic inflammation are found in type 2 diabetic patients. Such a systemic and subclinical inflammatory process can be characterized by elevated circulating levels of inflammatory markers.</p><p><strong>Aim: </strong>To study the state of subclinical inflammation in patients with type 2 diabetes mellitus and establish a correlation between glycemic control and inflammatory markers.</p><p><strong>Methods: </strong>This research included 90 subjects divided into 2 groups; Group A: 70 patients with type 2 diabetes and Group B: 20 Age and sex matched people as the control group. All patients were clinically examined, had laboratory investigations including; fasting and 2 h postprandial blood sugar, HbA1c, serum ferritin., high sensitivity C-reactive protein hs-CRP, kidney functions tests, liver function tests, complete blood count and erythrocyte sedimentation rate and antinuclear antibody.</p><p><strong>Results: </strong>The estimated levels of ESR, FBS, serum ferritin, hs-CRP and HbA1c in T2DM were 10.69 ± 3.05, 186.01 ± 92.21, 6005.2 ± 2639.83, 155.75 ± 73.95, 7.5 ± 3.23, respectively. In a similar way, in control subject, the estimated levels for respective parameters were 12.4 ± 3.41, 83.25 ± 6.25, 45.088 ± 39.35, 19.97 ± 18.51, 4.555 ± 0.58, respectively. Mean values of all parameters, except ESR, were found to be significantly augmented in T2DM subjects when compared to control group. There is significant positive correlation between HbA1c and hs-CRP (r=0.761, p < 0.001). Moreover, serum ferritin has shown significant positive correlation with HbA1c (r = 0.853, p < 0.001).</p><p><strong>Conclusion: </strong>Strong correlation between inflammation and glycemic control in patient with type 2 diabetes mellitus suggests that inflammation plays an important role in the pathogenesis of diabetes.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"800-804"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.11.061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36863089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic kidney disease among US adults with type 2 diabetes and cardiovascular diseases: A national estimate of prevalence by KDIGO 2012 classification.","authors":"Tongtong Wang,&nbsp;Yuzhi Xi,&nbsp;Robert Lubwama,&nbsp;Hakima Hannanchi,&nbsp;Kristy Iglay,&nbsp;Carol Koro","doi":"10.1016/j.dsx.2018.11.026","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.11.026","url":null,"abstract":"<p><strong>Aim: </strong>Data on prevalence of chronic kidney disease (CKD) among US adults with type 2 diabetes (T2D) and cardiovascular diseases (CVD) are limited. The aim of this study was to provide such estimates for T2D, both overall and in those with CVD.</p><p><strong>Materials and methods: </strong>Using the NHANES 2007-2014 data, we conducted a cross-sectional analysis of an adult sample with diagnosed and undiagnosed T2D, aged ≥18 years. CVD was defined based on self-reported personal interview data on a broad range of health conditions-congestive heart failure, coronary heart disease, angina, stroke, or heart attack. T2D was defined as diagnosed T2D (self-reported provider diagnosis) and undiagnosed T2D (FPG ≥126 mg/dL or HbA1c ≥ 6.5% without self-reported diagnosis). Participants who started insulin within a year of T2D diagnosis, or were pregnant at the time of health examination were excluded. Appropriate sample weights were used to provide a national estimate.</p><p><strong>Results: </strong>The prevalence of moderate to severe renal impairment based on eGFR below 60 ml/min/1.73 m² among T2D was 18.0%. The prevalence of mild renal impairment was 36.9%: 28.3% with UACR<30 mg/g, 7.0% with UACR ≥30-300 mg/g and 1.6% with UACR >300 mg/g. For T2D and CVD subgroup, the prevalence was 33.6% for moderate to severe renal impairment and 42.8% for mild renal impairment.</p><p><strong>Conclusions: </strong>This study confirms the high prevalence of CKD in patients with multiple comorbidities: T2D and CVD. It also provides estimates of the prevalence of CKD categories based on KDIGO 2012 classification for US adults with T2D.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"612-615"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.11.026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36851486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of leukocytes, platelet indices and adipocytokines in metabolic syndrome patients.","authors":"Adel Abdel-Moneim,&nbsp;Basant Mahmoud,&nbsp;Eman A Sultan,&nbsp;Rania Mahmoud","doi":"10.1016/j.dsx.2018.12.016","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.12.016","url":null,"abstract":"<p><strong>Aims: </strong>The current study aimed to explore the correlation between leukocytes and platelets indices with adipocytokines (leptin and adiponectin) and MetS components.</p><p><strong>Methods: </strong>A total of 100 healthy subjects and 200 patients diagnosed with different MetS components were enrolled in the study. Eligible patients were allocated into four groups (50 patients). Group1 include patients with 2 criteria of MetS components, group 2 with 3 criteria, group 3 with 4 criteria and group 4 had patients with 5 criteria.</p><p><strong>Results: </strong>Regarding white blood cell indices, data showed that total leukocyte and neutrophil count as well as neutrophil/lymphocyte (N/L) ratio were significantly increased in all groups of MetS patients when compared to the healthy group. Additionally, platelets count, platelet distribution width (PDW), and main platelet volume (MPV) levels and platelets/lymphocyte (P/L) ratio were significantly higher in all patients with MetS as compared to the healthy subjects. Serum leptin concentration and leptin-to-adiponectin ratio (LAR) were elevated significantly, while adiponectin level was significantly diminished in all MetS groups when compared to the control.</p><p><strong>Conclusion: </strong>leukocytes and platelets indices were associated with hyperleptinemia and hypoadiponectinemia as well as MetS components. The study also suggested the necessary role of leukocytes, platelet indices, and LAR as markers in early diagnoses of individuals with MetS components.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"874-880"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.12.016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36851942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of dyslipidemia and its association with cardiometabolic factors and kidney function in the adult Romanian population: The PREDATORR study.","authors":"Simona Popa,&nbsp;Maria Mota,&nbsp;Adina Popa,&nbsp;Eugen Mota,&nbsp;Romulus Timar,&nbsp;Cristian Serafinceanu,&nbsp;Dan Cheta,&nbsp;Mariana Graur,&nbsp;Nicolae Hancu","doi":"10.1016/j.dsx.2018.11.033","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.11.033","url":null,"abstract":"<p><p>The aims were to assess the prevalence and characteristics of dyslipidemia phenotypes in a Romanian population-based sample from the PREDATORR study.</p><p><strong>Methods: </strong>PREDATORR was an epidemiological study with a cross-sectional, cluster random sampling design. Participants were classified into four dyslipidemia phenotypes based on the NCEP ATP III criteria: isolated hypertrigliceridemia, isolated hypoHDL-C, isolated hyperLDL-C and mixed dyslipidemia (≥2 standard lipid abnormalities). Overall, 2656 were included in the analysis by dyslipidemia phenotypes.</p><p><strong>Results: </strong>An estimated 67.1% of Romanian adults have at least one lipid abnormality: 27.5% (95%CI26.0-28.9%) have elevated TG, 29.4% (95%CI27.9-30.8%) have low HDL-C and 47.8% (95%CI46.3-49.2%) have elevated LDL-C (26.2% had LDL-C levels ≥2.58 mmol/l associated with CHD or CHD risk equivalent). Also, 30% Romanian adults have mixed dyslipidemia with 7.6% (95%CI6.1-9.0%) having all three lipid abnormalities. THE AGE: and sex-adjusted prevalence of isolated dyslipidemia phenotypes in Romanian adult population was 23.7% (95%CI22.2-25.1%) for hyperLDL-Cholesterolemia, 9.3% (95%CI7.8-10.7%) for hypoHDL-Cholesterolemia and 4.1% (95%CI2.6-5.5%) for hypertriglyceridemia. Among participants with triglycerides ≥2.25 mmol/l, 15.2% (95%CI13.7-16.6%) of Romanian adults have non-HDL-C levels ≥3.36 mmol/l.</p><p><strong>Conclusions: </strong>The PREDATORR survey indicated a high prevalence of dyslipidemia phenotypes in the Romanian population aged 20-79 years, providing data on its association with several cardiometabolic risk factors.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"596-602"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.11.033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36852507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of non-HDL cholesterol for cardiovascular disease in a population in far western Algeria with type 2 diabetes.","authors":"Youssouf Kachekouche,&nbsp;Majda Dali-Sahi,&nbsp;Rachid Bendaoud,&nbsp;Nouria Dennouni-Medjati,&nbsp;Meziane Abderahim","doi":"10.1016/j.dsx.2018.12.002","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.12.002","url":null,"abstract":"<p><strong>Background: </strong>Non high density lipoprotein cholesterol (non-HDL-C) is a risk factor for cardiovascular disease (CVD) in people with type 2 diabetes. The aim of our study is to estimate the relative multivariate risk of non-HDL-C in the occurrence of CVD in a population in the extreme western Algeria with type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>Our study was carried out in western Algeria on a population of 1111 subjects, 371 cardiopaths with T2DM and 740 controls. The biochemical balance was established using standard enzymatic procedures (SFBC or IFCC recommendations) on the Beckman CX7^® PLC (Beckman-Coulter^®, NY, USA). Information on the pathologies was collected by means of a questionnaire.</p><p><strong>Results: </strong>The logistic model retained the two levels of non-HDL-C: 130 mg/dl < non-HDL-C≤160 mg/dl (OR = 0.11; 95% CI = 0.03-0,47, P = 0.003) and 160 mg/dl < non-HDL-C≤190 mg/dl (OR = 5.02; 95% CI = 1.1-22.87, P = 0.037) and smoking (OR = 19.27; 95% CI = 3.39-109.63, P = 0.001), inbreeding (OR = 3.65; 95% CI = 1.12-11,85, P = 0.031) and the two age groups 60-70 years (OR = 2.36; 95% CI = 1.32-4.2, P<<0.01) and 70 years and over (OR = 2.26; 95% CI = 1.19-4.29, P<<0.05).</p><p><strong>Conclusions: </strong>Non-HDL-C is a powerful risk factor for the occurrence of cardiovascular disease in type 2 diabetics in the extreme western Algeria.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"826-829"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.12.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36852514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic confirmation of T2DM meta-analysis variants studied in gestational diabetes mellitus in an Indian population.","authors":"Imran Ali Khan,&nbsp;Parveen Jahan,&nbsp;Qurratulain Hasan,&nbsp;Pragna Rao","doi":"10.1016/j.dsx.2018.11.035","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.11.035","url":null,"abstract":"<p><strong>Background: </strong>Meta-analysis is useful for combining the results of different studies statistically to confirm genuine associations in genetics. Based on earlier reports, we aimed to investigate the association between type 2 diabetes mellitus (T2DM) genetic variants identified in a previous meta-analysis in gestational diabetes mellitus (GDM) in an Indian woman.</p><p><strong>Material and methods: </strong>In this study, 137 pregnant women with GDM and 150 pregnant women were selected on the basis of their serum glucose levels. The six single nucleotide polymorphisms (SNPs) of different genes studied had known involvement in pancreatic β-cell function, particular pathways linked to T2DM, and other biological functions. Genomic DNA was isolated from the 287 women for polymerase chain reaction and restriction fragment length polymorphism analyses.</p><p><strong>Results: </strong>The rs7903146, rs13266634, rs2283228, rs5210 and rs179881 SNPs were found to be positively associated with GDM when calculated for genotype and allele frequencies (p < 0.05), but rs680 (ApaI) variant did not show statistically significant association (p = 0.31). The rs7903146, rs2283228, rs5210 and rs680 variants showed a strong association with oral glucose tolerance test values.</p><p><strong>Conclusion: </strong>The SNPs studied in this GDM had the same role as those identified in a previous T2DM meta-analysis, and showed positive association in the Indian women. Meta-analyses should be implemented to assess the IGF2 gene in GDM subjects.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"688-694"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.11.035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36861900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential performance of surrogate indices of fasting insulin resistance in low-birthweight and normal-birth weight cohorts: Observations from Hyperinsulinaemic-Euglycaemic clamp studies in young, Asian Indian males.","authors":"Riddhi Dasgupta,&nbsp;Shajith Anoop,&nbsp;Padmanaban Venkatesan,&nbsp;Mercy Inbakumari,&nbsp;Geethanjali Finney,&nbsp;Nihal Thomas","doi":"10.1016/j.dsx.2018.11.067","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.11.067","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the predictive accuracy of surrogate measures of fasting insulin resistance/sensitivity like the Homeostasis model assessment for insulin resistance (HOMA -IR), Fasting glucose/insulin ratio (FG-IR), Quantitative insulin sensitivity check index (QUICKI), and the 20/fasting C peptide x fasting plasma glucose [20/(FCP × FPG)] index in comparison to M value derived from hyperinsulinaemic-euglycaemic clamp (HEC) studies in two birth weight based cohorts of Asian Indian males.</p><p><strong>Methods: </strong>HEC studies were performed in non-diabetic Asian Indian males (n = 117), born of normal birth weight (n = 59, birth weight > 2.5 kgs) and low birth weight (n = 58, birth weight < 2.5 kgs). Anthropometry and biochemical analysis were done. Surrogate indices of fasting insulin resistance were calculated and data were analysed by Pearson's correlation and Random calibration model analysis.</p><p><strong>Results: </strong>Amongst surrogate indices of fasting insulin resistance/sensitivity, the mean values for HOMA-IR, QUICKI, FG-IR, 20/(FCP × FPG) index and M value were similar between the two groups. Significant positive correlation was observed for FG-IR and QUICKI with M value (the gold standard measure of insulin sensitivity derived from HEC procedure) in the low birth weight cohort in contrast to the normal birth weight cohort, wherein no significant correlation was observed for any of the indices. Random calibration model analysis showed highest predictive accuracy for QUICKI in both the study groups.</p><p><strong>Conclusion: </strong>The QUICKI index showed highest predictive accuracy in the normal birth weight and the low birth weight cohorts of Asian Indian males.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"770-775"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.11.067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36862333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between physical activity and diabetic complications among Bangladeshi type 2 diabetic patients.","authors":"Mohammad Sadaat Bukht,&nbsp;Kazi Rumana Ahmed,&nbsp;Sahadat Hossain,&nbsp;Parisha Masud,&nbsp;Shuhana Sultana,&nbsp;Rasheda Khanam","doi":"10.1016/j.dsx.2018.11.069","DOIUrl":"https://doi.org/10.1016/j.dsx.2018.11.069","url":null,"abstract":"<p><strong>Background: </strong>The aim of the study was to assess the association of physical activity (PA) with the presence of diabetes related complications among Bangladeshi type 2 diabetic subjects.</p><p><strong>Methods: </strong>This cross-sectional study was conducted in the Out Patient Department (OPD) of BIRDEM, Bangladesh. A group of 977 subjects were randomly selected and followed up. Diabetes was diagnosed following the WHO study group criteria. The level of PA was categorized into inactive/low (<150 min/week) and moderate-to-vigorous (≥150 min/week). The WHO recommended Asian criteria was used to identify general obesity. Retinopathy was detected by fundal photography, CKD by serum creatinine and hypertension was diagnosed clinically. Univariate and multivariate analyses were used to assess the associations of PA with diabetes related complications.</p><p><strong>Results: </strong>Out of the 977 subjects investigated, 468 were male and 509 were female (mean ± SD of age, 56 ± 8 years). In the study subjects, 74% were either inactive or in low PA and of them 65.1% were overweight/obese. Analysis showed that inactive/low PA was associated with all the three diabetes related complications (p < 0.001)-hypertension, retinopathy, and nephropathy. Multivariate analysis showed that inactive/low level of PA was strongly associated with complications like retinopathy (p < 0.001) and hypertension (p = 0.01) in the female patients. It was also found to be highly associated with retinopathy (p < 0.001) among the male patients.</p><p><strong>Conclusion: </strong>A large number of urban Bangladeshi population are involved only in low PA or remain inactive themselves, which is leading to obesity and it seems to have a strong association with diabetes related complications in this population.</p>","PeriodicalId":520602,"journal":{"name":"Diabetes & metabolic syndrome","volume":" ","pages":"806-809"},"PeriodicalIF":10.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.dsx.2018.11.069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36863092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}