Dyslipidaemia as a risk factor for erectile dysfunction in type 2 diabetes mellitus patients.

IF 3.4

Diabetes & metabolic syndrome Pub Date : 2019-01-01 Epub Date: 2018-11-30 DOI:10.1016/j.dsx.2018.11.052

Abul Kalam Azad, Sumudu Setunge, Shahjada Selim, Shahabul Huda Chowdhury, Mohammad Ferdousur Rahaman, Md Abdul Jalil Chowdhury, Barbora de Courten, Dragan Ilic, Md Nazmul Karim

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引用次数: 10

Abstract

Background: Despite epidemiological studies worldwide have documented erectile dysfunction (ED) as a major complication of type 2 diabetes Mellitus (T2DM) in men, only limited research reported on determinants of ED in this population. The study aimed at examining the association of ED with dyslipidaemia in T2DM patients.

Methods: The study enrolled 813 consecutive eligible adult male T2DM patients attending the endocrinology departments of a tertiary teaching hospital in Bangladesh. Sexual function was assessed using modified International Index of Erectile Function (IIEF) in face-to-face interview and collected along with sociodemographic information. Diabetes and lipid profile and treatment history were collected from patient's treatment records. Association of ED with dyslipidaemia was assessed using multivariable logistic regression adjusting for potential confounders.

Result: Prevalence of ED among the T2DM patients was very high (72.7%), of which around half had moderated-to-severe ED. Odds of having dyslipidaemia among T2DM patients with ED is 2.3 times higher than those without. The odds increased by approximately 3 fold for an abnormal High Density Lipoprotein level and by 2.7 fold for abnormal Low Density Lipoprotein.

Conclusion: Dyslipidaemia was associated with increased ED risk among T2DM. Abnormal lipoprotein level particularly were found to pose greater risk.

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血脂异常是2型糖尿病患者勃起功能障碍的危险因素。

背景:尽管世界范围内的流行病学研究表明，勃起功能障碍(ED)是男性2型糖尿病(T2DM)的主要并发症，但只有有限的研究报道了这一人群中ED的决定因素。该研究旨在探讨ED与2型糖尿病患者血脂异常的关系。方法:本研究招募了813名连续在孟加拉国某三级教学医院内分泌科就诊的符合条件的成年男性2型糖尿病患者。采用改良的国际勃起功能指数(IIEF)面对面访谈评估性功能，并收集社会人口统计信息。从患者的治疗记录中收集糖尿病、血脂和治疗史。使用多变量logistic回归对潜在混杂因素进行校正，评估ED与血脂异常的关系。结果:2型糖尿病患者中ED的患病率非常高(72.7%)，其中约一半患有中度至重度ED，伴有ED的2型糖尿病患者发生血脂异常的几率是无ED患者的2.3倍。异常高密度脂蛋白水平增加约3倍，异常低密度脂蛋白增加约2.7倍。结论:血脂异常与T2DM患者ED风险增加有关。尤其发现异常的脂蛋白水平会带来更大的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes & metabolic syndrome

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