Breast cancer (Tokyo, Japan)最新文献

{"title":"Impact of postoperative complications on patient-reported outcomes in deep inferior epigastric perforator flap breast reconstruction.","authors":"Xuhui Guo, Xilong Gong, Lina Wang, Hui Xiao, Yue Yang, Dechuang Jiao, Jiao Zhang, Zhenzhen Liu","doi":"10.1007/s12282-025-01754-y","DOIUrl":"https://doi.org/10.1007/s12282-025-01754-y","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the factors that influence the occurrence of complications following deep inferior epigastric perforator (DIEP) flap breast reconstruction, and to determine whether these complications have an impact on the patient's quality of life in China.</p><p><strong>Methods: </strong>We collected clinical data from patients who underwent DIEP flap breast reconstruction at the Department of Breast, Affiliated Cancer Hospital of Zhengzhou University between December 2019 and December 2023. We analyzed the incidence of postoperative complications and their relationship with patient clinical data and surgical parameters. We also used the BREAST-Q 2.0 Chinese version scale to assess the impact of postoperative complications on patient-reported outcomes.</p><p><strong>Results: </strong>A total of 109 patients underwent DIEP flap breast reconstruction, including 91 stage I reconstructions and 18 stage II reconstructions. Postoperative complications occurred in 26 cases (23.9%), including flap complications in 13 cases (11.9%) and abdominal donor-site complications in 13 cases (11.9%). Univariate and multivariate analyses showed that the overall incidence of complications was associated with high BMI and early surgery (P < 0.05). Flap complications were associated with high BMI, early surgery, and the use of internal mammary vascular branches as recipient vessels (P < 0.05). Abdominal complications were associated with previous abdominal surgery scars (P < 0.05). Approximately 20% of patients did not complete the BREAST-Q questionnaires (including the two patients who experienced total flap loss). BREAST-Q scores showed no significant differences between the surgical complication group and the no-complication group in terms of breast satisfaction, mental health, physical health-chest, physical health-abdomen, satisfaction with abdomen, sexual health, etc. (P > 0.05).</p><p><strong>Conclusion: </strong>Patients who underwent DIEP flap breast reconstruction revealed that high BMI, neoadjuvant therapy, and abdominal incision scars may influence postoperative complications. The limited follow-up data indicated that postoperative complications did not impact patient-reported outcomes.</p>","PeriodicalId":520574,"journal":{"name":"Breast cancer (Tokyo, Japan)","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of radiation therapy on breast satisfaction and health-related quality of life after breast reconstruction: a multicenter cross-sectional controlled study (Reborn study-02).","authors":"Hirohito Seki, Noriyuki Watanabe, Naomi Nagura, Akiko Ogiya, Ayaka Shimo, Natsue Uehiro, Wakako Tsuji, Shoichi Tomita, Takahiro Tsukioki, Hirotsugu Isaka, Tomohiro Shiraishi, Yutaka Nishida, Chikako Yamauchi, Shinsuke Sasada","doi":"10.1007/s12282-025-01765-9","DOIUrl":"https://doi.org/10.1007/s12282-025-01765-9","url":null,"abstract":"<p><strong>Background: </strong>Post-mastectomy radiation therapy (PMRT) is essential for reducing recurrence in patients with high-risk breast cancer but may negatively impact breast reconstruction outcomes. The impacts of PMRT on breast satisfaction and health-related quality of life (HR-QOL) remain unclear, particularly in Japanese patients. We evaluated the impact of PMRT on breast satisfaction and HR-QOL using BREAST-Q.</p><p><strong>Methods: </strong>A multicenter, cross-sectional study was conducted at 10 institutions in Japan. Patients who underwent breast reconstruction with or without PMRT were surveyed using the Japanese version of the BREAST-Q. Endpoints included breast satisfaction and HR-QOL domains (physical, psychosocial, and sexual well-being). Multivariate analysis was performed to identify factors influencing these outcomes.</p><p><strong>Results: </strong>Overall, 1078 patients with primary breast cancer who underwent breast reconstruction were included in this study, with a questionnaire response rate of 77.0% (830/1,078). Data from 830 patients were analyzed (PMRT group: 214, non-PMRT group: 616). The PMRT group had significantly lower breast satisfaction (50.7 vs. 57.5, P < 0.001), physical well-being (70.2 vs. 82.4, P < 0.001), and psychosocial well-being (51.2 vs. 56.4, P < 0.001). There was no significant difference in sexual well-being. PMRT was a predictor of reduced breast satisfaction, physical well-being, and psychosocial well-being.</p><p><strong>Conclusions: </strong>PMRT was associated with decreased breast satisfaction and HR-QOL in patients with reconstructed breasts. Patients should be given comprehensive information regarding the potential impacts of PMRT on breast satisfaction and HR-QOL. Shared decision-making based on realistic preoperative expectations is critical for optimal patient outcomes and satisfaction with treatment modalities.</p>","PeriodicalId":520574,"journal":{"name":"Breast cancer (Tokyo, Japan)","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustained-release of 4-hydroxytamoxifen inhibits capsular contracture after breast implant placement in a mouse model.","authors":"Nozomi Matsumoto, Masako Muguruma, Yoshiya Horimoto, Miki Okazaki, Mariko Asaoka, Takako Komiya, Eiichi Sato, Utako Yokoyama, Hajime Matsumura, Takashi Ishikawa","doi":"10.1007/s12282-025-01750-2","DOIUrl":"https://doi.org/10.1007/s12282-025-01750-2","url":null,"abstract":"<p><strong>Background: </strong>Capsular contracture is a major complication of breast reconstruction with silicone implants, affecting patients' quality of life due to pain and esthetic concerns. Capsular contracture is considered to result from an excessive fibrous foreign body reaction to the implant, but its precise mechanism remains unclear, and no effective preventative approaches have been established. Previously, we reported that transdermal application of 4-hydroxytamoxifen (4-OH TAM), an active metabolite of TAM, inhibited capsule formation in a mouse model. Building on this, we examined whether a sustained-release system, directly delivering 4-OH TAM around the silicone implant, could achieve a similar effect with clinical applications in mind.</p><p><strong>Methods: </strong>Fifty-one female ICR mice were divided into three groups: non-treated control (NT), 0.1 mg 4-OH TAM (0.1mg_TAM), and 1.0 mg 4-OH TAM (1.0mg_TAM). A silicone implant was inserted subcutaneously on the back of each mouse, with a silk elastin sponge impregnated with 4-OH TAM placed on top as a sustained-release system. After four weeks, capsule formation was evaluated by measuring capsule thickness, fibrillar collagen density, and chronic inflammation (CD45R).</p><p><strong>Results: </strong>The 1.0mg_TAM group showed a significantly reduced capsule thickness compared to the NT group (p = 0.048). Although no statistical significance was observed, a decreasing trend was noted in fibrillar collagen density and CD45R-positive cell infiltration in the 1.0mg_TAM group (p = 0.175 and p = 0.260, respectively).</p><p><strong>Conclusion: </strong>We demonstrated that sustained-release administration of 4-OH TAM effectively suppresses capsule formation. Further investigations are required to explore its potential for clinical application.</p>","PeriodicalId":520574,"journal":{"name":"Breast cancer (Tokyo, Japan)","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144985753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overall survival and subsequent therapy patterns in Japanese patients with ER+/HER2- advanced breast cancer treated with palbociclib plus letrozole in the first-line setting: a final analysis.","authors":"Masato Takahashi, Hiroyuki Yasojima, Tomofumi Osako, Kenichi Inoue, Masahiro Kawashima, Hideki Maeda, Mitsuya Ito, Yasuaki Sagara, Kan Yonemori, Masaya Hattori, Naohito Yamamoto, Yasuaki Muramatsu, Akiko Matsui, Norikazu Masuda","doi":"10.1007/s12282-025-01760-0","DOIUrl":"https://doi.org/10.1007/s12282-025-01760-0","url":null,"abstract":"<p><strong>Background: </strong>An open-label, single-arm, multicenter Japanese phase 2 study (J-Ph2) found first-line palbociclib plus letrozole to be effective and tolerable in postmenopausal Japanese women with estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER+/HER2-) advanced breast cancer (ABC), but overall survival (OS) data were immature. Here, we report the final analysis of a follow-up study of J-Ph2 evaluating OS and subsequent therapy.</p><p><strong>Methods: </strong>Patients (N = 42) who participated in J-Ph2 were included in this follow-up study. Primary endpoint was OS; other endpoints included chemotherapy-free survival (CFS) and type and duration of subsequent therapy. Median OS, CFS, and duration of subsequent therapy were estimated using the Kaplan-Meier method; outcomes were stratified by baseline demographic, disease characteristics, and type of second-line therapies.</p><p><strong>Results: </strong>At median follow up of 101.0 months, median OS was 85.4 months (95% CI, 64.3-not estimable) and median CFS was 69.1 months (95% CI, 24.2-85.4). Eighty-one percent of patients (34/42) received a second-line therapy; of those, 85.3% (29/34) received endocrine-based therapy and 8.8% (3/34) received chemotherapy. Median duration of second-line therapy was 7.6 months. Sixty-nine percent of patients (29/42) received a third-line therapy; of those, 58.6% (17/29) received endocrine-based therapy and 31.0% (9/29) received chemotherapy; median duration of third-line therapy was 6.0 months.</p><p><strong>Conclusion: </strong>This analysis showed a median OS of  > 7 years with first-line palbociclib plus letrozole in Japanese patients with ER+/HER2- ABC. Patient demographics, disease characteristics, and subsequent therapy decisions may have contributed to the extended median OS observed in this study.</p><p><strong>Clinical trial registration: </strong>ClinicalTrials.gov, NCT04735367.</p>","PeriodicalId":520574,"journal":{"name":"Breast cancer (Tokyo, Japan)","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective randomized-controlled trial: efficacy of 37 °C-preheated thermoplastic elastomer (TPE) bolus in postoperative radiotherapy for breast cancer patients.","authors":"Lihua Zhang, Bo Li, Rong Wang, Jie Li, Rong Cai, Fengbin Zhang, Fating Yang, Zixuan Liu, Lin Yang, Juan Ma, Xiaowei Yao, Qiuxia Hu, Linlin Xu, Jian Zang, Fei Bai, Lina Zhao","doi":"10.1007/s12282-025-01763-x","DOIUrl":"https://doi.org/10.1007/s12282-025-01763-x","url":null,"abstract":"<p><strong>Objective: </strong>This randomized-controlled trial aimed to investigate whether preheating thermoplastic elastomer (TPE) bolus to 37 °C reduces setup errors and improves patient comfort during post-mastectomy radiotherapy (PMRT).</p><p><strong>Methods: </strong>From July 2023 to June 2024, breast cancer patients requiring PMRT were randomized (1:1) to receive either preheated (37 °C, 30 min) or room-temperature TPE bolus. Bolus was applied during the first half of treatment (15/25 or 8/15 fractions). Weekly cone-beam computed tomography (CBCT) assessed setup errors (lateral [Lat], longitudinal [Lng], vertical [Vrt], and rotational [Rtn]). Secondary endpoints included thorax anteroposterior diameter changes (ΔZ), skin toxicity (CTCAE v3.0), and comfort (modified Likert scale).</p><p><strong>Results: </strong>Among 154 analyzed patients, preheating significantly reduced Vrt (0.24 ± 2.43 mm vs. - 0.64 ± 2.46 mm, p < 0.01) and Lat errors (- 0.12 ± 2.49 mm vs. 0.63 ± 2.49 mm, p < 0.01). The preheating group reported higher temperature comfort scores (4.32 ± 0.55 vs. 3.59 ± 0.72, p < 0.01). No significant differences were observed in Grade 2 (46.6% vs. 44.3%, p = 0.661) or Grade 3 (2.7% vs. 2.9%, p = 1.000) radiation dermatitis.</p><p><strong>Conclusion: </strong>Preheated TPE bolus improves setup accuracy in the Vrt and Lat directions, enhances patient comfort, and maintains skin safety, supporting its clinical utility in PMRT.</p>","PeriodicalId":520574,"journal":{"name":"Breast cancer (Tokyo, Japan)","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144985735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing breast cancer care through reasoning-aware LLMs: quality evaluation and risk prediction.","authors":"Partha Pratim Ray","doi":"10.1007/s12282-025-01756-w","DOIUrl":"https://doi.org/10.1007/s12282-025-01756-w","url":null,"abstract":"","PeriodicalId":520574,"journal":{"name":"Breast cancer (Tokyo, Japan)","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of exercise interventions on cognitive function in breast cancer patients and survivors: a systematic review with meta-analysis.","authors":"Chen-Sin Hung, Yi-Ting Cheng, Ruei-Hong Li, Charles H Hillman, Neha P Gothe, Feng-Tzu Chen, Hsing-Jung Yeh, Fei-Fei Ren, Yu-Kai Chang","doi":"10.1007/s12282-025-01757-9","DOIUrl":"10.1007/s12282-025-01757-9","url":null,"abstract":"<p><strong>Background: </strong>Exercise has been shown to facilitate cognitive function; however, data on changes in cognitive function in response to exercise interventions among breast cancer patients and survivors, who frequently experience cognitive impairment, have not been comprehensively synthesized. Therefore, this study aims to examine the impact of exercise interventions on cognitive function among breast cancer patients and survivors.</p><p><strong>Methods: </strong>Electronic databases including PubMed, Scopus, and Web of Science were searched from inception to December 25, 2024. A three-level meta-analysis was performed in R utilizing the standard mean difference. Moderators including cognitive function domains, sample characteristics (i.e., age and timing of exercise), and exercise regimen (i.e., frequency, intensity, type, session time, and length) were examined for subgroup analysis. The methodological quality and the certainty of evidence were evaluated using criteria of the Physiotherapy Evidence Database (PEDro) scale and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach, respectively.</p><p><strong>Results: </strong>A total of 21 identified studies comprising 114 effect sizes were included in the final analysis. Overall, exercise demonstrated a positive small effect size on cognitive function in breast cancer patients and survivors (g = 0.22; 95% confidence interval [CI] 0.07-0.36; p < .001).</p><p><strong>Conclusions: </strong>Exercise demonstrated a facilitative effect on various cognitive functions among breast cancer patients during both treatment and survivorship. The non-significant moderation effects further suggest that diverse exercise regimens offer cognitive benefits. However, limited research highlights the need to identify optimal exercise modalities for cognitive enhancement in this population.</p>","PeriodicalId":520574,"journal":{"name":"Breast cancer (Tokyo, Japan)","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of specialist palliative care on healthcare utilization among patients with breast cancer: a nationwide register-based cohort study.","authors":"Nelli-Sofia Nåhls, Timo Carpén, Mikko Nuutinen, Tiina Saarto","doi":"10.1007/s12282-025-01759-7","DOIUrl":"https://doi.org/10.1007/s12282-025-01759-7","url":null,"abstract":"<p><strong>Background: </strong>The incidence of breast cancer and the related mortality in Finland are among the highest in the world. Specialist palliative care (SPC) has been shown to improve quality of life and potentially reduce intensive resource use at the end of life among patients with advanced cancer. We aimed to perform a nationwide evaluation of the timing of the first SPC contact and its impact on hospital resource utilization in patients with breast cancer.</p><p><strong>Methods: </strong>A nationwide retrospective cohort analysis included 881 breast cancer patients who died in Finland in 2019, with data drawn from national registries. Patients were divided into two groups according to the time of their first SPC contact: Group I (> 30 days before death) and Group II (≤ 30 days before death or no SPC contact).</p><p><strong>Results: </strong>SPC contact was established for 288 (35%) patients, with a median interval of 89 days from initial SPC contact to death. During the last month of life, patients in Group I had fewer emergency department contacts (46% vs. 58%, p = 0.004) and fewer hospitalizations in secondary care (28% vs. 48%, p < 0.001), compared patients in Group II. Additionally, patients in Group I utilized hospital-at-home services more often (42% vs. 7%, p < 0.001) and had a higher likelihood of dying in SPC wards (15% vs. 3%, p < 0.001) rather than in hospital (65% vs. 77%, p < 0.001).</p><p><strong>Conclusion: </strong>Timely SPC contact was associated with fewer acute hospital contacts and a reduced likelihood of hospital death, underscoring the importance of timely palliative care integration for patients with advanced breast cancer.</p>","PeriodicalId":520574,"journal":{"name":"Breast cancer (Tokyo, Japan)","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of adiponectin gene polymorphism with adipokine and lipid profile in breast cancer patients from Kano, Nigeria.","authors":"Ummukulthum K Muhammad, Sulyman B Sulyman, Idris Saleh, Muhammad Y Gwarzo, Kamaluddeen Babagana, Yabagi A Muhammad, Aliyu Muhammad, Abdulwasiu Ibrahim, Suleiman A Muhammad, Aminu Z Mohammed, Mansurah A Abdulazeez","doi":"10.1007/s12282-025-01758-8","DOIUrl":"10.1007/s12282-025-01758-8","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer constitutes 25% of all cancer cases diagnosed in Kano State, Nigeria. This study investigated the relationship between adiponectin gene polymorphisms (AGP) and adipokine and lipid profile in breast cancer patients in Kano.</p><p><strong>Methods: </strong>The study population was composed of 80 randomly consented breast cancer patients from the three major hospitals in Kano State, Nigeria, and 40 age-matched controls across the metropolis. Biochemical assays were analyzed using standard procedures and ELISA. Furthermore, AGP was investigated using PCR-PCR-restriction fragment length polymorphism.</p><p><strong>Results: </strong>The incidence of breast cancer was highest in patients aged 41-50 years (25%), with a high frequency of overweight and obesity. Serum adiponectin and HDL levels were lower (p < 0.05) in the patients, whereas those of leptin, TC, TG, and LDL were higher (p < 0.05) relative to control subjects. A positive significant correlation was observed between leptin and adiponectin (r = 0.522, p < 0.0001), TG vs TC (0.446, p = 0.001), LDL vs TG (0.419, p = 0.002), and TC vs LDL (r = 0.965, p < 0.0001) in the patients. No significant association in genotype frequencies for 276G/T (χ2 = 4.35, p = 0.11) and 45 T/G (χ2 = 2.45, p = 0.12) polymorphisms between patients and controls. Furthermore, BMI was significantly associated with the 276G/T genotype.</p><p><strong>Conclusion: </strong>This study suggests that the adiponectin 45 T/G and 276 G/T gene polymorphisms may not significantly influence the risk of breast cancer among patients attending these hospitals in Kano State. However, the 276 T/G genotype shows a potential association with obesity in this population. Notably, variations in adiponectin and leptin levels appear to be linked to breast cancer risk, highlighting their potential as novel biomarkers for predicting breast cancer prognosis and progression.</p>","PeriodicalId":520574,"journal":{"name":"Breast cancer (Tokyo, Japan)","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Female breast cancer burden among adolescent and young adults in North Africa.","authors":"Davidi Tawfiles, Jenny Chen, Miriam Tawfiles, Sybil Jones, Frances Dominique V Ho, Erin Jay G Feliciano, James Fan Wu, Jonas Willmann, Puneeth Iyengar, Maria Jocelyn Kara Magsanoc-Alikpala, Khaled Elsayad, Abeir El-Mogassabi, Adda Bounedjar, Edward Christopher Dee","doi":"10.1007/s12282-025-01755-x","DOIUrl":"https://doi.org/10.1007/s12282-025-01755-x","url":null,"abstract":"<p><strong>Introduction: </strong>This study examines the growing burden of breast cancer among adolescents and young adults (AYAs, ages 15-39) in North Africa from 1990 to 2021. Despite breast cancer primarily affecting postmenopausal women, its increasing incidence among AYAs presents unique clinical and biological challenges that remain under explored in North Africa.</p><p><strong>Methods: </strong>Using Global Burden of Disease 2021 data, we analyzed temporal trends in AYA breast cancer incidence and mortality across North Africa compared to other global regions (seven GBD super regions and Central Africa, Eastern Africa, Northern Africa, Southern Africa, and Western Africa). For individual North African countries (Algeria, Egypt, Libya, Mauritania, Morocco, and Tunisia), we calculated the relative percentage change from 1990 to 2021 for all regions and the Estimated Annual Percent Change (EAPC), derived from log-linear expression models.</p><p><strong>Results: </strong>North Africa demonstrated the second-highest global increase in AYA breast cancer incidence (166%) and third-highest increase in mortality (58%), significantly exceeding global averages. Within Africa, North Africa exhibited the steepest rise in incidence and was one of only two regions showing a statistically significant increase in mortality. In North Africa, Libya showed the most alarming trajectory with the highest annual percent change in both incidence (4.36%) and mortality (3.06%), while Algeria maintained the lowest regional mortality rates.</p><p><strong>Interpretation: </strong>AYA breast cancer in North Africa poses challenges including limited screening, cultural barriers, and healthcare disparities. Despite varied infrastructures, rising trends demand action. Solutions include AYA-specific awareness, mobile screening, better registries, and regional collaboration for early detection and treatment.</p>","PeriodicalId":520574,"journal":{"name":"Breast cancer (Tokyo, Japan)","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}