放射治疗对乳房再造后乳房满意度和健康相关生活质量的影响:一项多中心横断面对照研究(Reborn study-02)。

IF 2.9
Hirohito Seki, Noriyuki Watanabe, Naomi Nagura, Akiko Ogiya, Ayaka Shimo, Natsue Uehiro, Wakako Tsuji, Shoichi Tomita, Takahiro Tsukioki, Hirotsugu Isaka, Tomohiro Shiraishi, Yutaka Nishida, Chikako Yamauchi, Shinsuke Sasada
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引用次数: 0

摘要

背景:乳房切除术后放射治疗(PMRT)对于减少高危乳腺癌患者的复发至关重要,但可能对乳房重建结果产生负面影响。PMRT对乳房满意度和健康相关生活质量(HR-QOL)的影响尚不清楚,特别是在日本患者中。我们使用breast - q评估PMRT对乳房满意度和HR-QOL的影响。方法:在日本10家机构进行多中心横断面研究。使用日本版breast - q对接受乳房重建的患者进行了调查,无论是否进行了PMRT。终点包括乳房满意度和HR-QOL域(生理、心理和性健康)。进行多变量分析以确定影响这些结果的因素。结果:本研究共纳入1078例行乳房再造术的原发性乳腺癌患者,问卷应答率为77.0%(830/ 1078)。830例患者的数据被分析(PMRT组214例,非PMRT组616例)。PMRT组乳房满意度明显降低(50.7比57.5,P)结论:PMRT与乳房重建患者乳房满意度和HR-QOL下降有关。应向患者提供有关PMRT对乳房满意度和HR-QOL的潜在影响的全面信息。基于现实术前期望的共同决策对于最佳患者结果和治疗方式的满意度至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of radiation therapy on breast satisfaction and health-related quality of life after breast reconstruction: a multicenter cross-sectional controlled study (Reborn study-02).

Background: Post-mastectomy radiation therapy (PMRT) is essential for reducing recurrence in patients with high-risk breast cancer but may negatively impact breast reconstruction outcomes. The impacts of PMRT on breast satisfaction and health-related quality of life (HR-QOL) remain unclear, particularly in Japanese patients. We evaluated the impact of PMRT on breast satisfaction and HR-QOL using BREAST-Q.

Methods: A multicenter, cross-sectional study was conducted at 10 institutions in Japan. Patients who underwent breast reconstruction with or without PMRT were surveyed using the Japanese version of the BREAST-Q. Endpoints included breast satisfaction and HR-QOL domains (physical, psychosocial, and sexual well-being). Multivariate analysis was performed to identify factors influencing these outcomes.

Results: Overall, 1078 patients with primary breast cancer who underwent breast reconstruction were included in this study, with a questionnaire response rate of 77.0% (830/1,078). Data from 830 patients were analyzed (PMRT group: 214, non-PMRT group: 616). The PMRT group had significantly lower breast satisfaction (50.7 vs. 57.5, P < 0.001), physical well-being (70.2 vs. 82.4, P < 0.001), and psychosocial well-being (51.2 vs. 56.4, P < 0.001). There was no significant difference in sexual well-being. PMRT was a predictor of reduced breast satisfaction, physical well-being, and psychosocial well-being.

Conclusions: PMRT was associated with decreased breast satisfaction and HR-QOL in patients with reconstructed breasts. Patients should be given comprehensive information regarding the potential impacts of PMRT on breast satisfaction and HR-QOL. Shared decision-making based on realistic preoperative expectations is critical for optimal patient outcomes and satisfaction with treatment modalities.

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