Breast cancer (Tokyo, Japan)最新文献

{"title":"Breast cancer associated with mammary hamartoma.","authors":"Masaya Kai,&nbsp;Keiichiro Tada,&nbsp;Miki Tamura,&nbsp;Naoya Gomi,&nbsp;Rie Horii,&nbsp;Futoshi Akiyama,&nbsp;Takuji Iwase","doi":"10.1007/s12282-009-0147-3","DOIUrl":"https://doi.org/10.1007/s12282-009-0147-3","url":null,"abstract":"<p><p>Mammary hamartoma is an infrequent, nonmalignant lesion. Only 12 cases of carcinomas associated with a hamartoma have been previously documented in the literature. We describe a case of invasive ductal carcinoma arising in the mammary hamartoma during the follow-up period of a previously diagnosed hamartoma.</p>","PeriodicalId":520574,"journal":{"name":"Breast cancer (Tokyo, Japan)","volume":" ","pages":"183-6"},"PeriodicalIF":4.0,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12282-009-0147-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40014480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paradigm shift in axilla surgery for breast cancer patients treated with sentinel node biopsy.","authors":"Shigeru Imoto,&nbsp;Hirotsugu Isaka,&nbsp;Noriko Sakemura,&nbsp;Hiroki Ito,&nbsp;Kentaro Imi,&nbsp;Kaisuke Miyamoto","doi":"10.1007/s12282-011-0305-2","DOIUrl":"https://doi.org/10.1007/s12282-011-0305-2","url":null,"abstract":"<p><strong>Background: </strong>Sentinel node biopsy (SNB) is a standard technique for the diagnosis of regional lymph node metastases in clinically node-negative breast cancer patients. In the case of pathologically negative sentinel lymph nodes (SLN), axillary lymph node dissection (ALND) can be avoided.</p><p><strong>Methods: </strong>Recent clinical studies on SNB in breast cancer were reviewed regarding the pathological and molecular diagnosis of SLN, the tools used to predict non-SLN metastases, the prognostic significance of isolated tumor cells (ITC) and micrometastases (MIC), and axilla surgery.</p><p><strong>Results: </strong>ITC or MIC in SLN was associated with worse survival in patients treated with SNB alone or SNB followed by ALND. However, this effect was limited and adjuvant therapy improved survival. If T1 and one SLN-positive breast cancer patients are treated with whole-breast irradiation and adjuvant therapy, additional ALND may not be necessary.</p><p><strong>Conclusions: </strong>SNB without ALND can be adopted for patients with a small number of SLN metastases. Although the lack of apparent regional lymph node recurrence, similar to tumor dormancy, cannot be fully explained, ALND should be performed in cases that are highly suspected to be non-SLN metastases.</p>","PeriodicalId":520574,"journal":{"name":"Breast cancer (Tokyo, Japan)","volume":" ","pages":"104-9"},"PeriodicalIF":4.0,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12282-011-0305-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40115603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stereotactic directional vacuum-assisted breast biopsy using lateral approach.","authors":"Yuko Nakamura,&nbsp;Masaki Urashima,&nbsp;Akiko Matsuura,&nbsp;Reisuke Nishihara,&nbsp;Atsushi Itoh,&nbsp;Masayuki Kagemoto,&nbsp;Kenji Higaki","doi":"10.1007/s12282-009-0162-4","DOIUrl":"https://doi.org/10.1007/s12282-009-0162-4","url":null,"abstract":"<p><strong>Background: </strong>In recent years, stereotactic vacuum-assisted breast biopsy [so-called Mammotome® biopsy (ST-MMT)] has been established as a reliable method for diagnosis of nonpalpable and mammographically detected lesions with microcalcification. However, there are few reports regarding the lateral approach. We performed ST-MMT using the lateral approach. The purpose of this study was to determine the usefulness of the lateral approach.</p><p><strong>Materials and methods: </strong>124 women with microcalcifications underwent stereotactic vacuum-assisted breast biopsy (median age, 52.5 years). All underwent stereotactic biopsy using the lateral approach. We compared our data with those of other institutes using the vertical approach.</p><p><strong>Results: </strong>We removed microcalcifications and used an 11-gauge vacuum-assisted probe in all cases. The range of breast thickness was 10-45 mm. 12 patients had vasovagal reactions, however they quickly recovered without drug intervention. No patients had major complications. Of 124 cases, cancer was diagnosed in 37 patients. In other institutes using the vertical approach, it was impossible to use 11G probes in some cases due to the breast being too thin. In our study, minimum breast thickness was 10 mm (7 cases) and we were able to use 11G probes in all 7 cases with only polyethylene foam.</p><p><strong>Conclusion: </strong>With the lateral approach, it is possible to use 11G probes if the breast is thin (in our study minimum thickness was 10 mm) with only polyethylene foam. We believe this to be an advantage of the lateral approach. This advantage is very important in stereotactic biopsy, especially in Japan, as Japanese women's breasts are generally thinner than most Western women's.</p>","PeriodicalId":520574,"journal":{"name":"Breast cancer (Tokyo, Japan)","volume":" ","pages":"286-9"},"PeriodicalIF":4.0,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12282-009-0162-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40039403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apocrine metaplasia of breast cancer: clinicopathological features and predicting response.","authors":"Akiko Ogiya,&nbsp;Rie Horii,&nbsp;Tomo Osako,&nbsp;Yoshinori Ito,&nbsp;Takuji Iwase,&nbsp;Yoshinobu Eishi,&nbsp;Futoshi Akiyama","doi":"10.1007/s12282-009-0178-9","DOIUrl":"https://doi.org/10.1007/s12282-009-0178-9","url":null,"abstract":"<p><strong>Background: </strong>Tailor-made therapies are currently gaining prominence, and the clarification of predictive markers for anticancer agents represents an important research issue. From our institutional neoadjuvant experience, apocrine carcinoma showed a high correlation with therapeutic effect against breast cancer. We thus considered that apocrine metaplasia (AM) might represent a predictive marker for breast cancer.</p><p><strong>Methods: </strong>A total of 210 primary invasive breast cancers from Japanese patients were scored according to the size of cytoplasmic granules and abundance of cytoplasm, then classified into three categories: non-AM, incomplete AM and complete AM. Clinicopathological features were evaluated based on these classifications.</p><p><strong>Results: </strong>Distribution according to the classification of AM was: non-AM, 61%; incomplete AM, 36%; and complete AM, 3%. No significant differences with regard to estrogen receptor, progesterone receptor, human epidermal growth factor receptor type 2, androgen receptor or bcl-2 were observed among the three groups. Gross cystic fluid protein-15 showed a high positive rate (83%) for complete AM. Cases of incomplete AM and complete AM were combined to form the AM group. Among lymph node-positive patients without chemotherapy, the 10-year recurrence-free survival (RFS) rate was 85% for non-AM and 44% for AM (p < 0.05). Conversely, among the lymph node-positive group with chemotherapy, the 10-year RFS rate was 45% for non-AM and 75% for AM (p < 0.05). Prognoses for non-AM and AM were turned around by chemotherapy. Lymph node metastasis was related to prognosis in multivariate analysis, although AM did not remain an independent prognosticator.</p><p><strong>Conclusions: </strong>Apocrine metaplasia appears to offer an effective predictive marker for anticancer therapy.</p>","PeriodicalId":520574,"journal":{"name":"Breast cancer (Tokyo, Japan)","volume":" ","pages":"290-7"},"PeriodicalIF":4.0,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12282-009-0178-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40044554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multicentre cross-sectional study of arm lymphedema four or more years after breast cancer treatment in Iranian patients.","authors":"Peiman Haddad,&nbsp;Mostafa Farzin,&nbsp;Farnaz Amouzegar-Hashemi,&nbsp;Bita Kalaghchi,&nbsp;Shadi Babazadeh,&nbsp;Hamid-Reza Mirzaei,&nbsp;Ahmad Mousavizadeh,&nbsp;Iraj Harirchi,&nbsp;Jahangir Rafat","doi":"10.1007/s12282-009-0165-1","DOIUrl":"https://doi.org/10.1007/s12282-009-0165-1","url":null,"abstract":"<p><strong>Background: </strong>We performed a cross-sectional multicentre study to assess the prevalence of lymphedema after breast cancer treatment in Iran.</p><p><strong>Patients and methods: </strong>All female breast cancer patients who attended our follow-up clinics four or more years after their surgery with no sign of disease were asked to participate in this study. Lymphedema was defined as an increase of 10% in the circumference of the arm on the involved side compared to the opposite arm.</p><p><strong>Results: </strong>The total number of patients participating in this study was 355. The prevalence of lymphedema in the study patients was 17.5%, with the rate varying significantly (between 4 and 21%) among the three study centres (p = 0.007). The mean number of months post surgery was larger for patients with lymphedema (84 months) than for those without (79 months), though this was not statistically significant (p > 0.1). The relationships of various treatment factors and the education levels of the patients to the presence of lymphedema were also evaluated. None of the observed differences were statistically significant aside from those for the type of surgery (mastectomy vs. conservative surgery, p = 0.055), treatment with radiotherapy (p = 0.099), and prescription of a supraclavicular radiation field (p = 0.057), which were only just significant.</p><p><strong>Conclusion: </strong>The rate of lymphedema in our patients was 17.5%, ranging from 4 to 21% in different study centres. Time post surgery, treatment with radiotherapy and the technique used, and nodal radiation seem to be factors that are related to this large variation.</p>","PeriodicalId":520574,"journal":{"name":"Breast cancer (Tokyo, Japan)","volume":" ","pages":"281-5"},"PeriodicalIF":4.0,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12282-009-0165-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40044561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of prophylactic pyridoxine on occurrence of hand-foot syndrome in patients receiving capecitabine for advanced or metastatic breast cancer.","authors":"Nobuyasu Yoshimoto,&nbsp;Toshinari Yamashita,&nbsp;Takashi Fujita,&nbsp;Hironori Hayashi,&nbsp;Nobuyuki Tsunoda,&nbsp;Mariko Kimura,&nbsp;Norimasa Tsuzuki,&nbsp;Hiroko Yamashita,&nbsp;Tatsuya Toyama,&nbsp;Naoto Kondo,&nbsp;Hiroji Iwata","doi":"10.1007/s12282-009-0171-3","DOIUrl":"https://doi.org/10.1007/s12282-009-0171-3","url":null,"abstract":"<p><strong>Background: </strong>Capecitabine, an oral fluoropyrimidine, has shown consistently high efficacy in anthracycline- and/or taxane-pretreated advanced and metastatic breast cancer. The safety profile of capecitabine is characterized by hand-foot syndrome (HFS), which, although not life threatening, can impair patients' quality of life if it is not managed promptly and effectively. We conducted a study to assess the impact of prophylactic pyridoxine on HFS.</p><p><strong>Methods: </strong>Prophylactic pyridoxine was given to 38 patients receiving capecitabine (alone or in combination with cyclophosphamide) for metastatic breast cancer and compared with historical data from 40 patients receiving capecitabine without pyridoxine in our clinic. The impact of urea ointment on HFS was also assessed.</p><p><strong>Results: </strong>HFS developed in 20 patients (52.6%) receiving pyridoxine compared with historical data showing an 82.5% rate in patients receiving no pyridoxine prophylaxis (p < 0.01). A nonsignificant trend towards less severe HFS was seen among patients who received urea ointment at first appearance of symptoms. In addition, nonsignificant trends towards higher rates of HFS were seen among those who were ≥61 years and those who derived clinical benefit (clinical response or stable disease).</p><p><strong>Conclusions: </strong>Prophylactic pyridoxine and urea ointment at first appearance of symptoms appears to reduce the risk of severe capecitabine-induced HFS. However, randomized data are required to determine the true effect of these measures.</p>","PeriodicalId":520574,"journal":{"name":"Breast cancer (Tokyo, Japan)","volume":" ","pages":"298-302"},"PeriodicalIF":4.0,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12282-009-0171-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40044558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saline replacement after local resection of the breast: a simple technique with good control and improved patient satisfaction.","authors":"Fumiaki Tanaka,&nbsp;Koshi Mimori,&nbsp;Kouichirou Tahara,&nbsp;Hiroshi Inoue,&nbsp;Masaki Mori","doi":"10.1007/s12282-009-0145-5","DOIUrl":"https://doi.org/10.1007/s12282-009-0145-5","url":null,"abstract":"<p><strong>Background: </strong>Here we report a study on the use of saline replacement after local resection of the breast. Local resection of breast tissue is widely used in the treatment of breast cancer due to the development of imaging analysis technology such as mammography, ultrasound sonography, computed tomography, and magnetic resonance. Preserving the size and shape of the breast after treatment is beneficial for the patient, and deformity of the residual breast can be a serious problem.</p><p><strong>Methods: </strong>Following resection, the subcutaneous tissue was sutured with 4-0 polydioaxanone, and a 20-G syringe was inserted through the skin into the hole. After suturing the skin with 4-0 nylon, an adequate volume of saline was injected. A conservative treatment group did not receive saline injections and was used as controls. We sent self-administered questionnaires to 60 patients who had undergone local resection of the breast and received 55 responses (92%).</p><p><strong>Results: </strong>Saline replacement was performed in 28 of the 55 patients, and conservative treatment (no saline replacement) was performed in 27 patients. The average volume of injected saline was 46 ml (range, 5-150 ml). There were no statistically significant differences in skin irritation, pain, fatigue, or daily activity between the two groups, but the saline replacement group was more satisfied with the surgical scar (p < 0.05) and shape of the breast (p = 0.05) after surgery.</p><p><strong>Conclusions: </strong>Saline replacement after local resection of the breast is a simple technique that provides benefits for patients undergoing conservative surgery of the breast.</p>","PeriodicalId":520574,"journal":{"name":"Breast cancer (Tokyo, Japan)","volume":" ","pages":"261-4"},"PeriodicalIF":4.0,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12282-009-0145-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40009484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary hyperparathyroidism with breast carcinoma.","authors":"Yuko Tanaka","doi":"10.1007/s12282-009-0158-0","DOIUrl":"https://doi.org/10.1007/s12282-009-0158-0","url":null,"abstract":"<p><strong>Background: </strong>Although hypercalcemia is a common complication of breast carcinoma (BC), it may be due to primary hyperparathyroidism (pHPT), which has a similar sex or age predilection to that of BC. The rate of underlying asymptomatic pHPT in BC patients with hypercalcemia is exceptionally high, so the clinical data were retrospectively analyzed.</p><p><strong>Method: </strong>To investigate coexistent pHPT in BC patients, the medical records of persons who had undergone surgery for primary BC without bone metastases between October 2004 and March 2008 at the Tsuchiura Kyodo General Hospital were retrospectively reviewed. The corrected serum calcium level was measured in all 243 patients. Ten patients who noted hypercalcemia above 11.0 mg/dl via the corrected serum calcium were selected in order to investigate pHPT.</p><p><strong>Result: </strong>Among the 243 patients investigated, 7 were diagnosed with pHPT, and 5 of those patients required surgical treatment. In all five patients, the parathyroids were pathologically diagnosed to have adenoma.</p><p><strong>Conclusion: </strong>Primary hyperparathyroidism was diagnosed in 2.88% of the BC patients, which was more than expected, in comparison to the incidence of pHPT in adult women, which is 0.04-0.08%. It is important to assess whether pHPT is associated with the treatment of BC.</p>","PeriodicalId":520574,"journal":{"name":"Breast cancer (Tokyo, Japan)","volume":" ","pages":"265-8"},"PeriodicalIF":4.0,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12282-009-0158-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40015653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Axillary reverse mapping for preventing lymphedema in axillary lymph node dissection and/or sentinel lymph node biopsy.","authors":"Masakuni Noguchi","doi":"10.1007/s12282-009-0173-1","DOIUrl":"https://doi.org/10.1007/s12282-009-0173-1","url":null,"abstract":"","PeriodicalId":520574,"journal":{"name":"Breast cancer (Tokyo, Japan)","volume":" ","pages":"155-7"},"PeriodicalIF":4.0,"publicationDate":"2010-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12282-009-0173-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40044556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-center study evaluating circulating tumor cells as a surrogate for response to treatment and overall survival in metastatic breast cancer.","authors":"Seigo Nakamura,&nbsp;Hiroshi Yagata,&nbsp;Shinji Ohno,&nbsp;Hiroshi Yamaguchi,&nbsp;Hiroji Iwata,&nbsp;Nobuyuki Tsunoda,&nbsp;Yoshinori Ito,&nbsp;Nahomi Tokudome,&nbsp;Masakazu Toi,&nbsp;Katsumasa Kuroi,&nbsp;Eiji Suzuki","doi":"10.1007/s12282-009-0139-3","DOIUrl":"https://doi.org/10.1007/s12282-009-0139-3","url":null,"abstract":"<p><strong>Background: </strong>Evaluating circulating tumor cells (CTCs) is one way to predict outcome and monitor treatment in patients with MBC. In this prospective study, we evaluated CTCs in predicting treatment efficacy and overall survival (OS) using the CellSearch System (Veridex, LLC, Raritan, NJ).</p><p><strong>Methods: </strong>One hundred nineteen patients with MBC with measurable disease were enrolled. Samples of 7.5 ml of blood from 107 eligible patients were tested for CTCs before starting therapy (baseline), after one cycle of therapy (3-4 weeks) and at 12 weeks. We compared CTC levels and imaging at baseline and at 12 weeks. Next, we determined the hazard ratios (HR) by comparing cases with zero CTCs to those with one or more CTCs. Moreover, HR was calculated when comparing cases that had greater than or equal to a certain number of CTCs to those with less than the number of CTCs.</p><p><strong>Results: </strong>This study shows the incidence of detection of CTCs in patients with metastatic breast cancers. Of the patients, 64.4% (76/118) had one or more CTCs, and 37.3% (44/118) had five or more CTCs. First we set the baseline number of CTCs as 100%. Of the seven cases whose level of CTCs decreased more than 90%, six (85.7%) demonstrated a positive response (complete response and partial response) by imaging after one cycle (3-4 weeks later). For the patients whose CTC levels increased above 100% after one cycle (3-4 weeks later), 7 of 11 (63.6%) had progressive disease (PD). The HR for cases with five to ten CTCs was greater than 1.00 [HR = 2.450; 95% confidence interval (CI) 0.727-8.248]. Statistical significance was observed when comparing patients who had > or =3 CTCs to those with <3 CTCs (P = 0.0273). When comparing cases with > or =5 CTCs to those with <5 CTCs, the hazard ratio was 3.069 (95% CI 1.496-6.295; P = 0.0022).</p><p><strong>Conclusions: </strong>Because the change in the number of CTCs was highly correlated with results from imaging before and after therapy, CTCs can be considered a biomarker that may predict the effect of treatment earlier than imaging modalities.</p>","PeriodicalId":520574,"journal":{"name":"Breast cancer (Tokyo, Japan)","volume":" ","pages":"199-204"},"PeriodicalIF":4.0,"publicationDate":"2010-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12282-009-0139-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40006098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}