Arhiv za higijenu rada i toksikologiju最新文献

{"title":"Association between leisure noise exposure and hearing status in young Croatian adults.","authors":"Selma Cvijetić, Marija Kujundžić, Zrinka Franić, Mislav Malić, Davor Šušković, Siniša Fajt, Jelena Macan","doi":"10.2478/aiht-2025-76-3968","DOIUrl":"10.2478/aiht-2025-76-3968","url":null,"abstract":"<p><p>Young people often use headphones or speakers and most visit noisy places recreationally. The aim of this cross-sectional study was to determine the relationship between exposure to recreational noise and hearing in 108 young Croatian participants aged 18-28 years. Hearing was assessed with audiometry and noise exposure by measuring the headphone volume to which each participant was accustomed while listening to music. Data on the daily use of headphones/speakers, visits to recreational noisy places, self-assessment of hearing, and health and demographics data were obtained with a questionnaire developed for this purpose. Mild sensorineural hearing loss was found in 5.5 % of participants (one man and six women). While all men reported their hearing as good, 13.9 % of women (n=9) described their hearing as average. Those women had significantly higher hearing thresholds than women who rated their hearing as good (p=0.036). Men spent significantly more time using headphones/speakers than women (1.9±1.2 vs 1.3±0.8 hours, p=0.002). Both men and women spent similar amount of time in recreational noisy venues, averaging 12.0 hours per month. More men used headphones at volumes exceeding 70 dB than women (52.2 % vs 27.7 %, p=0.009). Participants who self-reported hearing loss had significantly higher hearing thresholds than those who did not (p=0.036). Although we found no clear link between recreational noise and hearing loss, elevated thresholds in participants who reported hearing difficulties highlight the need for targeted hearing loss prevention.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":"76 3","pages":"211-217"},"PeriodicalIF":1.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unsafe commute driving behaviour among healthcare workers: a combined scoping review and concept analysis.","authors":"Khairil Idham Ismail, Hanin Farhana Kamaruzaman, Mohd Faiz Ibrahim, Jonathan Michael Bryce, Rosnah Ismail, Hanizah Mohd Yusoff","doi":"10.2478/aiht-2025-76-3930","DOIUrl":"10.2478/aiht-2025-76-3930","url":null,"abstract":"<p><p>Unsafe driving behaviour is associated with the risk of crashes. Although commuting crashes prevail among healthcare workers (HCWs), unsafe driving behaviour during daily commutes remains unexplored in this group. The aim of our study was therefore to address this gap and to clarify the concept of unsafe driving behaviour among HCWs while commuting. To do that, we ran literature search in Medline, CINAHL, Scopus, and Web of Science and selected appropriate articles following the scoping review procedure, while data extraction and analysis followed the procedure for concept analysis. A total of 46 published studies met inclusion criteria. Most were from the USA (n=30), predominantly involved medical doctors (n=21), and were cross-sectional (n=24) in design. Concept analysis identified four properties of unsafe driving behaviour: 1) pressure and negative emotion, 2) drowsy driving, 3) risky driving and rules violation, and 4) distraction/inattention. Work scheduling factors emerged as the most frequently reported antecedents, while crashes were the most reported consequences. By identifying the core elements of unsafe driving behaviour among HCWs this study proposes a conceptual framework to guide future research and interventions. This framework can serve as a valuable resource for policymakers and researchers, enabling them to develop targeted strategies to address unsafe driving behaviour of HCWs during commuting, with the ultimate goal to reduce the associated crash risks.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":"76 3","pages":"148-158"},"PeriodicalIF":1.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of exposure to insecticides on sleep and neurobehavioural functioning in puberty and adolescence: a scoping review.","authors":"Patricia Tomac, Adrijana Košćec Bjelajac, Ivana Hromatko, Veda Marija Varnai","doi":"10.2478/aiht-2025-76-4020","DOIUrl":"10.2478/aiht-2025-76-4020","url":null,"abstract":"<p><p>Insecticides are pervasive in modern world, with humans being exposed through multiple pathways including dietary intake, occupational exposure, farming activities, residential proximity to crops, and household use. Most commonly used insecticides are neonicotinoids, pyrethroids, organophosphates, and carbamates. Recent evidence suggests that even low-level exposure to these substances may have adverse effects. Adolescence, characterised by intensive maturation processes, is a period of heightened vulnerability to environmental toxicants which may increase the risk of suboptimal developmental outcomes. This review aimed to synthesise the evidence of association between insecticide exposure in childhood/adolescence and sleep and neurobehavioural functioning in children and adolescents aged 8-20 years. Literature search across Web of Science, PubMed, Scopus, and PsycINFO produced 1,492 unique records, of which 48 studies met the inclusion criteria and underwent full-text analysis. Nine of the analysed studies investigated occupational exposure. Most employed cross-sectional design. Insecticide exposure was most often assessed through biomonitoring, questionnaires or interviews, temporal or spatial proximity to crops, and environmental sampling. Occupational exposure studies were primarily conducted in Africa, whereas nonoccupational studies were mostly based in the Americas, Asia, and Europe. Cognitive functioning was the most evaluated aspect of neurobehavioural functioning, while sleep was assessed only in one study. Although the findings are heterogeneous, they suggest that both work-related and residential exposures may affect neurobehaviour and sleep in puberty and adolescence. However, further longitudinal research is needed to clarify causation and also incorporate sleep health and pubertal maturation into the design, both as outcomes and mediators of neurobehavioral effects.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":"76 3","pages":"159-182"},"PeriodicalIF":1.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mathematical models for predicting the toxicity of micropollutant mixtures in water.","authors":"Josipa Papac Zjačić, Hrvoje Kušić, Ana Lončarić Božić","doi":"10.2478/aiht-2025-76-3976","DOIUrl":"10.2478/aiht-2025-76-3976","url":null,"abstract":"<p><p>Water pollution caused by micropollutants has been a global issue for decades, prompting the scientific community and industry professionals to develop new and effective wastewater treatment methods. Understanding the interactions of these compounds in real water samples is particularly challenging, as they contain complex mixtures that may alter the mechanism of action and toxic effects of these compounds on aquatic organisms. To address such challenges, computational methods and mathematical models have been developed to complement experimental research and predict the toxicity of micropollutant mixtures in water. This narrative review summarises current literature on such mathematical models, including the concentration addition (CA), independent action model (IA), and their combinations to predict the toxicity of mixtures involving pharmaceuticals, pesticides, and perfluorinated compounds. We also discuss computational methods like quantitative structure-activity relationship (QSAR) modelling and machine learning (ML). While the CA and IA models provide basic frameworks for predicting toxicity in chemical mixtures, their practical application is often limited by the assumption of additivity and by the complexity of real water mixtures. QSAR and ML approaches, though promising, face challenges such as limited data availability, overfitting, and difficult interpretation. Future research should focus on enhancing model robustness, incorporating mechanistic data, and developing hybrid approaches that integrate experimental and computational methods to improve the reliability of toxicity predictions for complex environmental mixtures.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":"76 3","pages":"183-194"},"PeriodicalIF":1.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxic, genotoxic, and oxidative stress-related effects of lysergic acid diethylamide (LSD) and phencyclidine (PCP) in the human neuroblastoma SH-SY5Y cell line.","authors":"Andreja Jurič,&nbsp;Antonio Zandona,&nbsp;Blanka Tariba Lovaković,&nbsp;Dubravka Rašić,&nbsp;Alica Pizent,&nbsp;Goran Kozina,&nbsp;Maja Katalinić,&nbsp;Ana Lucić Vrdoljak,&nbsp;Irena Brčić Karačonji","doi":"10.2478/aiht-2021-72-3604","DOIUrl":"https://doi.org/10.2478/aiht-2021-72-3604","url":null,"abstract":"<p><p>Lysergic acid diethylamide (LSD) is a classic hallucinogen, widely abused for decades, while phencyclidine (PCP) has increased in popularity in recent years, especially among the adolescents. Very little is known about the general toxicity of these compounds, especially about their possible neurotoxic effects at the cell level. The aim of this study was to address these gaps by assessing the toxic effects of 24-hour exposure to LSD and PCP in the concentration range of 0.39-100 μmol/L in the human neuroblastoma SH-SY5Y cell line. After cell viability was established, cells treated with concentrations that reduced their viability up to 30 % were further subjected to the alkaline comet assay and biochemical assays that enable estimation of oxidative stress-related effects. Treatment with LSD at 6.25 μmol/L and with PCP at 3.13 μmol/L resulted with 88.06±2.05 and 84.17±3.19 % of viable cells, respectively, and led to a significant increase in primary DNA damage compared to negative control. LSD also caused a significant increase in malondialdehyde level, reactive oxygen species (ROS) production, and glutathione (GSH) level, PCP significantly increased ROS but lowered GSH compared to control. Treatment with LSD significantly increased the activities of all antioxidant enzymes, while PCP treatment significantly increased superoxide dismutase (SOD) and glutathione peroxidase (GPx) but decreased catalase (CAT) activity compared to control. Our findings suggest that LSD has a greater DNA damaging potential and stronger oxidative activity than PCP in SH-SY5Y cells.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":" ","pages":"333-342"},"PeriodicalIF":2.1,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c4/d2/aiht-72-4-333.PMC8785105.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39647611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malaria among Croatian seafarers between 2004 and 2014: evaluation of chemoprophylaxis use and occupational disease reporting.","authors":"Fani Žunić-Pedisić,&nbsp;Bojana Knežević","doi":"10.2478/aiht-2021-72-3597","DOIUrl":"https://doi.org/10.2478/aiht-2021-72-3597","url":null,"abstract":"<p><p>In Croatia, malaria was eradicated in 1964 and has since been imported, ten cases a year in average, mostly by Croatian migrant workers, seafarers in particular. About 80 % of registered cases were infected in Africa and the main reason for infection was negligence in the use of chemoprophylaxis. The aim of the study was to establish the incidence of malaria among Croatian seafarers from 2004 to 2014, how many of them took chemoprophylaxis properly, and whether malaria was acknowledged as occupational disease. To get our answers we analysed epidemiological surveys of the Croatian Institute of Public Health completed by patients and reviewed epidemiological bulletins and the national Register of Occupational Diseases. Over the investigated period, a total of 102 people fell ill with malaria, of whom 25 were seafarers. Seventeen did not take chemoprophylaxis at all and eight took them without following instructions. In addition, none of them had malaria recognised as occupational disease under Croatian law, nor is there any information that they exercised their rights in any other way. All this clearly points out that seafarers and their employers need to be informed much better about the benefits of preventive measures and their labour rights.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":" ","pages":"295-298"},"PeriodicalIF":2.1,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/40/48/aiht-72-4-295.PMC8785109.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39788454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection and characterisation of extended-spectrum and plasmid-mediated AmpC β-lactamase produced by <i>Escherichia coli</i> isolates found at poultry farms in Bosnia and Herzegovina.","authors":"Majda Fetahagić,&nbsp;Amir Ibrahimagić,&nbsp;Selma Uzunović,&nbsp;Nataša Beader,&nbsp;Vesna Elveđi-Gašparović,&nbsp;Josefa Luxner,&nbsp;Muhamed Gladan,&nbsp;Branka Bedenić","doi":"10.2478/aiht-2021-72-3560","DOIUrl":"https://doi.org/10.2478/aiht-2021-72-3560","url":null,"abstract":"<p><p>Extended-spectrum β-lactamases (ESBLs) hydrolyse extended-spectrum cephalosporins (ESC) and aztreonam. As ESBL-producing organisms have been identified in food producing animals, the aim of our study was to detect and analyse such <i>Escherichia coli</i> isolates from poultry. Antibiotic susceptibility of the isolates was determined with disk-diffusion and broth microdilution methods. ESBLs were detected with the double-disk synergy and inhibitor-based test with clavulanic acid. The transferability of cefotaxime resistance was determined with conjugation experiments, and genes encoding ESBLs, plasmid-mediated AmpC β-lactamases, and quinolone resistance determinants identified by polymerase chain reaction. The study included 108 faecal samples (cloacal swabs) from 25 different poultry farms in the Zenica-Doboj Canton, Bosnia and Herzegovina. Of these, 75 (69.4 %) were positive for <i>E. coli</i>, of which 27 were resistant to cefotaxime, amoxicillin, cefazoline, and cefriaxone, and susceptible to imipenem, meropenem, ertapenem, and amikacin. All 27 cefotaxime-resistant isolates were positive in double-disk synergy and combined disk tests. Eighteen isolates transferred cefotaxime resistance to <i>E. coli</i> recipient. Twenty-one isolates were positive for the <i>bla</i> _CTX-M-1 cluster genes and seven for <i>bla</i> _CTX-M-15. Fourteen were positive for the <i>bla</i> _TEM genes. The most frequent plasmid incompatibility group was IncFIB, whereas IncFIA and Inc HI1 were present in only a few isolates. Two different sequence types (STs) were identified: ST117 and ST155. The emergence of ESBL-producing <i>E. coli</i> in farm animals presents a public health threat, as they can colonise the intestine and cause infections in humans.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":" ","pages":"305-314"},"PeriodicalIF":2.1,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/06/e4/aiht-72-4-305.PMC8785107.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39647612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Ortho</i>-substituted PCB 153: effects in CHO-K1 cells.","authors":"Marina Miletić,&nbsp;Teuta Murati,&nbsp;Branimir Šimić,&nbsp;Nina Bilandžić,&nbsp;Anamaria Brozović,&nbsp;Ivana Kmetič","doi":"10.2478/aiht-2021-72-3588","DOIUrl":"https://doi.org/10.2478/aiht-2021-72-3588","url":null,"abstract":"<p><p>Non-planar di-<i>ortho</i>-substituted PCB 153 (2,2',4,4',5,5'-hexachlorobiphenyl), one of the most abundant PCB congeners in the environment and in biological and human tissues, has been identified as potential endocrine disruptor affecting the reproductive and endocrine systems in rodents, wildlife, and humans. The aim of this study was to gain a deeper insight into its mode/mechanism of action in Chinese hamster ovary K1 cells (CHO-K1). PCB 153 (10-100 μmol/L) inhibited CHO-K1 cell proliferation, which was confirmed with four bioassays (Trypan Blue, Neutral Red, Kenacid Blue, and MTT), of which the MTT assay proved the most sensitive. PCB 153 also induced ROS formation in a dose-dependent manner. Apoptosis was seen after 6 h of exposure to PCB 153 doses ≥50 μmol/L, while prolonged exposure resulted in the activation of the necrotic pathway. PCB 153-induced disturbances in normal cell cycle progression were time-dependent, with the most significant effects occurring after 72 h.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":" ","pages":"326-332"},"PeriodicalIF":2.1,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a2/ce/aiht-72-4-326.PMC8785106.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39788453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of unintentional ingestion of oral non-steroidal anti-inflammatory drugs and analgesics in preschool children.","authors":"Željka Babić,&nbsp;Nikolina Benco Kordić,&nbsp;Arnes Rešić,&nbsp;Rajka Turk","doi":"10.2478/aiht-2021-72-3596","DOIUrl":"https://doi.org/10.2478/aiht-2021-72-3596","url":null,"abstract":"<p><p>We characterised accidental ingestion of non-steroidal anti-inflammatory drugs and non-opioid analgesics in children aged 0-5 years between 2009 and 2019 by analysing records of telephone consultations with the Croatian Poison Control Centre (CPCC) and cases treated at the Children's Hospital Zagreb (CHZ). Among the total of 466 identified cases (411 from CPPCC records and 55 from CHS hospital records), the most frequently ingested drugs were ibuprofen (47 %), paracetamol (20 %), ketoprofen (15 %), and diclofenac (11 %). In 94 % of the cases unsupervised children ingested the drug left within their reach. The remaining 6 % were dosing errors by parents or caregivers and involved liquid formulations as a rule. Our findings can serve as real-life examples informing preventive measures.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":" ","pages":"299-304"},"PeriodicalIF":2.1,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e2/db/aiht-72-4-299.PMC8785113.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39788458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotoxicity of aluminium oxide, iron oxide, and copper nanoparticles in mouse bone marrow cells.","authors":"Rakhshinda Sadiq,&nbsp;Qaiser Mahmood Khan,&nbsp;Ameena Mobeen,&nbsp;Asma Shah","doi":"10.2478/aiht-2021-72-3578","DOIUrl":"https://doi.org/10.2478/aiht-2021-72-3578","url":null,"abstract":"<p><p>The aim of this study was to evaluate the genotoxic effects of Al₂O₃, Fe₂O₃, and Cu nanoparticles with chromosomal aberration (CA), micronucleus (MN), and comet assays on the bone marrow of male BALB/c mice. Three doses of Al₂O₃, Fe₂O₃ (75, 150, and 300 mg/kg), or Cu (5, 10, and 15 mg/kg) nanoparticles were administered to mice through intraperitoneal injection once a day for 14 days and compared with negative control (distilled water) and positive control (mitomycin C and methyl methanesulphonate). Al₂O₃ and Fe₂O₃ did not show genotoxic effects, but Cu nanoparticles induced significant (P<0.05) genotoxicity at the highest concentration compared to negative control. Our findings add to the health risk information of Al₂O₃, Fe₂O₃, and Cu nanoparticles regarding human exposure (occupational and/or through consumer products or medical treatment), and may provide regulatory reference for safe use of these nanoparticles. However, before they can be used safely and released into the environment further chronic <i>in vivo</i> studies are essential.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":" ","pages":"315-325"},"PeriodicalIF":2.1,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/db/86/aiht-72-4-315.PMC8785108.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39788455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}