Arhiv za higijenu rada i toksikologiju最新文献

{"title":"Fatal pufferfish poisoning 1000 km inland: a case series from eastern Turkey.","authors":"Mehmet Tatlı, Selin Bulut","doi":"10.2478/aiht-2026-77-4088","DOIUrl":"10.2478/aiht-2026-77-4088","url":null,"abstract":"<p><p>We report the first tetrodotoxin (TTX) poisoning cases from Van, Eastern Turkey, a city located more than 1000 km inland. Three male patients presented in December 2020 after eating <i>Lagocephalus sceleratus</i>, which a local vendor mistook for an edible fish. One patient, a 41-year-old man who consumed the fish liver, rapidly developed severe signs of poisoning (adverse event grade 4) with complete paralysis and respiratory failure. Arterial blood gas analysis showed severe acidosis (pH 7.179) and high lactate levels (5.3 mmol/L). Despite intensive care, including mechanical ventilation and high-dose vasopressors, the patient died on the fourth day of hospitalisation due to refractory cardiac arrest. The other two patients, who consumed less fish and no liver, had only mild symptoms (adverse event grades 1 and 2) and recovered completely within 24 h. This incident illustrates the extreme danger of consuming pufferfish and particularly its visceral organs, which typically contain substantially higher tetrodotoxin levels. Finding these cases so far inland reveals serious gaps in the Turkish food distribution system. The fish likely travelled from Mediterranean ports to Van in mixed fish crates without having been identified. Fish vendors need proper training to identify toxic species, and supply chains require better oversight to prevent such tragedies.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":"77 2","pages":"149-152"},"PeriodicalIF":1.6,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13331359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148383557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glyphosate internal dose estimation: comparing passive dosimetry and biomonitoring in simulated heavy residential herbicide application.","authors":"Daniel G Kougias, Rongcan Sun, Kenneth M Unice, Eric W Miller, Jennifer Pierce, Michael Kovochich","doi":"10.2478/aiht-2026-77-4101","DOIUrl":"10.2478/aiht-2026-77-4101","url":null,"abstract":"<p><p>Glyphosate exposure is commonly assessed using either passive dosimetry or biomonitoring. This study tests the hypothesis that internal dose estimates derived from passive dosimetry are higher and more uncertain than those derived from biomonitoring by comparing concurrently collected passive dosimetry and biomonitoring data from a controlled simulation of heavy residential herbicide application. The two predominant exposure routes were evaluated separately: six applicators were protected from dermal exposures with hooded Tyvek^® coveralls and gloves and six were protected from inhalation exposure with a respirator. Urine was serially collected from all applicators between 30 min prior to and up to 36 h after application, while breathing-zone air samplers (left and right lapel) and four dermal patches were collected from dermally protected applicators. Internal doses were independently estimated from air and dermal patch measurements (passive dosimetry) and from urinary glyphosate residues (biomonitoring; dilution-adjusted). Average total internal daily doses of glyphosate estimated from passive dosimetry were approximately seven times greater than biomonitoring-based estimates. This overestimation appeared attributable to the dermal pathway and was consistent with the uncertainty in the assumed dermal absorption and clothing penetration factors as well as with the uncertainty introduced by extrapolating a limited number of dermal patch measurements to larger body regions. Even so, the highest individual internal daily dose of glyphosate derived from passive dosimetry remained below the internal-dose benchmark derived from conservative regulatory health-based guidance values (60 µg/kg/day), suggesting a low likelihood of adverse health effects under the tested conditions. By directly comparing concurrently collected passive dosimetry and biomonitoring data in applicators with detectable urinary glyphosate, this study provides empirical support for using biomonitoring to evaluate and refine dermal passive-dosimetry assumptions in glyphosate exposure assessment.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":"77 2","pages":"84-95"},"PeriodicalIF":1.6,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13331363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148383520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testicular toxicity of Aroclor 1254 in selenium-deficient and selenium-supplemented rats.","authors":"Pınar Erkekoğlu, Aylin Balcı-Özyurt, Naciye Dilara Zeybek, Hülya Tezel-Yalçın, Ünzile Yaman, Gizem Yildiztekin, Sevtap Aydın-Dilsiz, Murat Kızılgün, Evin İşcan, Tuğçe Batur, Mehmet Öztürk, Oğuz Han Edebal, Nurşen Başaran, Belma Koçer-Gumusel","doi":"10.2478/aiht-2026-77-4027","DOIUrl":"10.2478/aiht-2026-77-4027","url":null,"abstract":"<p><p>Aroclor 1254 (A1254) is a mixture of polychlorinated biphenyl (PCB) congeners known to induce testicular toxicity through oxidative stress, apoptosis, and hormonal disruption. Selenium (Se), an essential trace element for male reproduction, contributes to antioxidant defence, DNA repair, and spermatogenesis. Given the worldwide prevalence of Se deficiency and its potential impact on reproductive health, this study investigated the effects of A1254 exposure on testicular function in Sprague-Dawley rats with different Se status. Rats assigned to the Se-deficient group were receiving a ≤0.05 mg/kg Se diet, while those assigned to the Se-supplemented group were receiving 1 mg/kg Se for five weeks. A1254-treated groups were receiving 10 mg/kg/day of A1254 by oral gavage for 15 consecutive days. A1254 exposure caused significant reductions in testis weight, sperm count, motility, and plasma testosterone levels, accompanied by extensive germ cell apoptosis and enhanced lipid and protein oxidation. Total antioxidant capacity also dropped significantly, confirming redox imbalance in A1254-exposed testes. These adverse effects were substantially exacerbated in the Se-deficient group, whereas Se supplementation ameliorated but did not fully prevent histological and biochemical changes induced by A1254. Our findings demonstrate that Se plays a crucial protective role against PCB-associated testicular injury, primarily by mitigating oxidative stress and apoptotic pathways. However, Se supplementation alone may not completely counteract the reproductive toxicity caused by persistent environmental contaminants such as A1254.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":"77 2","pages":"102-113"},"PeriodicalIF":1.6,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13331366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148383551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marked variations in the effectiveness of commercial disinfectants against clinically relevant antibiotic-resistant bacteria and fungi.","authors":"Josip Figl, Stjepan Nemec, Zrinka Bošnjak, Ana Budimir, Tomislav Ivanković","doi":"10.2478/aiht-2026-77-4065","DOIUrl":"10.2478/aiht-2026-77-4065","url":null,"abstract":"<p><p>Effective disinfection of noncritical hospital surfaces may be essential for limiting the transmission of antibiotic-resistant bacteria (ARB), which seem to persist despite clear disinfection guidelines and raise concern about the potency of real-world disinfectants and about the consistency of disinfection practices. This study compared the bactericidal efficacy of eight commercially available disinfectants - alcohols, hydrogen peroxide, quaternary ammonium compounds (QACs), and chlorhexidine (CHX) - against multidrug-resistant clinical isolates of <i>Klebsiella pneumoniae</i>, <i>Acinetobacter baumannii</i>, <i>Staphylococcus aureus</i>, <i>Enterococcus faecium</i>, carbapenem-resistant <i>Pseudomonas aeruginosa</i>, and model organism <i>Candida albicans</i> as the most frequent causes of hospital-acquired infections in Croatia. Several formulations, particularly those based on QACs and CHX, retained full bactericidal activity even when diluted 10-32 times after only 1 min of contact, while alcohols were ineffective when diluted more than twice. However, all the formulations were effective when applied at full concentration. These findings highlight marked differences in the intrinsic bactericidal strength of commercial products, especially if not applied properly, which may explain variable outcomes observed in routine hospital disinfection practices. These issues may be overcome by rotating different disinfectant classes during routine surface decontamination and by optimising disinfectant strength to improve ARB and fungal control in clinical settings.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":"77 2","pages":"132-139"},"PeriodicalIF":1.6,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13331360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148383521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute toxicity and genotoxicity assessment of environmental contaminants using <i>Artemia salina</i>.","authors":"Jelena Đorđević Aleksić, Luka Gačić, Margareta Kračun-Kolarević, Jovana Jovanović Marić, Branka Vuković-Gačić, Stoimir Kolarević","doi":"10.2478/aiht-2026-77-4111","DOIUrl":"10.2478/aiht-2026-77-4111","url":null,"abstract":"<p><p>The widespread presence of pharmaceuticals and industrial pollutants in aquatic environments necessitates rapid screening tools capable of detecting hazards and adverse biological effects. In this study, we selected the nauplii of <i>Artemia salina</i> (brine shrimp) as a model to screen for the acute toxicity and genotoxicity of three cytostatics (5-fluorouracil, cisplatin, and etoposide), one pesticide (glyphosate), one surfactant (benzalkonium chloride), and one antifouling agent (tributyltin chloride), all applied in graded concentrations for 24 and 48 h. Acute toxicity was quantified by determining median lethal concentrations (LC₅₀), and the genotoxicity of cytostatics was assessed using the alkaline comet assay. All substances caused concentration and time-dependent mortality. Among cytostatics, cisplatin was the most toxic (48 h LC₅₀≈35 µg/mL), followed by etoposide (~130 µg/mL), while 5-fluorouracil was the least toxic (>500 µg/mL). Tributyltin chloride showed the strongest effect among non-pharmaceuticals (0.55 µg/mL), followed by benzalkonium chloride (~7.5 µg/mL) and glyphosate (~43 µg/mL). Cytostatics induced concentration-dependent DNA damage, with etoposide exhibiting the highest tail intensity (~60 %). These findings demonstrate that <i>A. salina</i> is an effective model for early, cost-effective hazard screening and highlight the importance of including genotoxic endpoints, particularly when assessing chemicals with DNA-targeting mechanisms.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":"77 2","pages":"114-122"},"PeriodicalIF":1.6,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13331365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148383553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colonisation potential of microplastic particles containing organic pollutants by a river-isolated environmental <i>Acinetobacter baumannii</i>.","authors":"Svjetlana Dekić Rozman, Maja Vujić, Jasna Hrenović, Vesna Gvoić, Miljana Prica, Aleksandra Tubić","doi":"10.2478/aiht-2026-77-4049","DOIUrl":"10.2478/aiht-2026-77-4049","url":null,"abstract":"<p><p>Microplastics in aquatic environments raise concern about their role as potential carriers of pathogens and organic pollutants. This study investigates the survival of the extensively drug-resistant <i>Acinetobacter baumannii</i> in the presence of selected priority substances including benzene derivatives (trichlorobenzene, pentachlorobenzene, and hexachlorobenzene), trifluralin, and primary polyethylene microplastics. The results indicate that the amount of adsorbed priority substances on microplastics from a mixture solution is slightly lower than the adsorption from individual solutions. Furthermore, GC/MS analysis shows that other chemicals used in plastic manufacturing can be released from microplastics into the environment over time and should be taken into account when assessing the environmental impact of microplastics. The proliferation of the environmental Sava 4 <i>A. baumannii</i> strain was not affected by the presence of benzene derivatives and microplastic particles at concentrations of up to 10 g/L in the water medium, and microscopy confirmed that it can colonise and form a biofilm on microplastic particles with adsorbed benzene derivatives, which demonstrates that microplastics have the potential to spread pollutants and potentially harmful bacteria over long distances and introduce them into various aquatic environments.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":"77 2","pages":"140-148"},"PeriodicalIF":1.6,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13331362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148383539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined <i>in vitro</i> effects of temozolomide and erucic acid on U87 MG cell viability, oxidative stress, and expression of genes involved in apoptotic signalling.","authors":"İbrahim Gecili, Sıdıka Genç, Ahmet Hacımüftüoğlu, Adem Güner, Esmanur Niğde, Kübra Karabulut, Dündar Okan Yıllar, Ali Taghizadehehghalehjoughi, Abdelaty Mostafa Abdelaty Hassibelnaby","doi":"10.2478/aiht-2026-77-4098","DOIUrl":"10.2478/aiht-2026-77-4098","url":null,"abstract":"<p><p>Limited efficacy of glioblastoma treatment with temozolomide (TMZ) due to resistance has prompted researchers to look for adjuvants capable of enhancing TMZ-associated cytotoxicity. The aim of our <i>in vitro</i> study was to evaluate such effects of erucic acid when combined with TMZ in human U87 MG cells. Cells were treated for 24 or 72 h with vehicle (control), TMZ (200 ng/mL), or TMZ plus EA (20, 40, 80, or 160 µg/mL). Cell viability was assessed using the MTT assay, membrane integrity with lactate dehydrogenase (LDH) release, and intracellular redox balance by measuring total antioxidant capacity (TAC) and total oxidant status (TOS). The mRNA expression of apoptosis-related genes (<i>p53, p21, Bax, Bcl-2, Bcl-xL</i>, and <i>caspase-3</i>) was analysed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Compared with the vehicle control, TMZ plus EA reduced cell viability and increased LDH release, with more pronounced effects at higher EA concentrations and at 72 h. These changes were accompanied by lower TAC and higher TOS, indicating a shift toward a pro-oxidant intracellular environment. At the transcriptional level, the combination induced increased pro-apoptotic Bax, caspase-3, p53, and p21 expression and reduced Bcl-2 and Bcl-xL expression. In conclusion, EA potentiated TMZ-associated cytotoxic responses in U87 MG cells with accompanying oxidative imbalance and apoptosis-related transcriptional changes.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":"77 2","pages":"123-131"},"PeriodicalIF":1.6,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13331364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148383524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasal carriage of <i>Staphylococcus aureus</i> and hygiene practices among food handlers in Skopje, North Macedonia.","authors":"Jansun Bukovetz, Jovan Todorovski, Gyltene Zendeli, Dragan Mijakoski, Mihail Kočubovski, Vesna Kotevska, Igor Spiroski","doi":"10.2478/aiht-2026-77-4035","DOIUrl":"10.2478/aiht-2026-77-4035","url":null,"abstract":"<p><p>Nasal carriage plays a key role in <i>Staphylococcus aureus</i> transmission, particularly among individuals working in the food sector. The aim of this cross-sectional study was to investigate the relationship between personal hygiene and nasal carriage of <i>S. aureus</i> among workers in food production, distribution, and trade. It was conducted in Skopje from November 2021 to March 2022 and included 289 workers undergoing mandatory health and hygiene examinations. Data were collected through a structured questionnaire and microbiological testing of nasal swabs. The overall prevalence of <i>S. aureus</i> nasal carriage was 12.5 % (95 % CI: 8.7-16.3 %). Methicillin-susceptible <i>S. aureus</i> (MSSA) prevailed in 11.8 % (95 % CI: 8.1-15.5 %) and the methicillin-resistant variety (MRSA) in only 0.7 % (95 % CI: 0-1.7 %). We found no significant associations between nasal carriage and demographic or hygiene variables (assessed using the chi-squared test) but did observe higher carriage rates among men (15.7 %), cooks (28.6 %), and individuals with untidy nails (17 %). However, our findings should be interpreted with caution, and future studies should address the limitations of the present study. Targeted training, routine screening, and consistent adherence to good hygiene practices remain important for minimising colonisation and reducing the risk of <i>S. aureus</i> transmission.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":"77 2","pages":"96-101"},"PeriodicalIF":1.6,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13331361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148383535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indoor air bacterial and fungal burden in the environment of an atopic child: implications for elevated urine mycotoxin levels.","authors":"Ivona Majić, Adela Krivohlavek, Elvira Kovač Andrić, Ranka Godec","doi":"10.2478/aiht-2026-77-4024","DOIUrl":"10.2478/aiht-2026-77-4024","url":null,"abstract":"<p><p>Here we present a case of an atopic boy from Zagreb, Croatia, whose elevated urine mycotoxin levels prompted us investigate whether they were associated with microbial indoor air burden in the child's primary and music school and family home. The music school had been water-damaged / mould-infested but had been repaired by the time of our measurements. We also measured urine mycotoxin in one healthy child who attended the same elementary school and in all household members of the atopic boy. The results showed no microbial contamination at any of the measurement locations, with bacterial concentrations ranging from 172 to over 570 CFU/m³ of air and fungal concentrations between 67 and 82 CFU/m³, all determined only in the music school classroom. The dominant species isolated in the music school were <i>Aspergillus fumigatus</i> (55 CFU/m³) and <i>Penicillium verrucosum</i> (24 CFU/m³), both potential mycotoxin producers. Considering that only the atopic boy had elevated urine mycotoxin levels, we believe that mould in the music school cannot be ruled out as the source of exposure. In fact, we believe our case illustrates that safety thresholds for mould exposure can vary and may be much lower for immunocompromised or sensitive individuals.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":"77 1","pages":"65-72"},"PeriodicalIF":1.6,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13061072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noise exposure patterns and health risk assessment among nurses in a Chinese paediatric intensive care unit.","authors":"Yan Liu, Junlin Tan","doi":"10.2478/aiht-2026-77-4077","DOIUrl":"10.2478/aiht-2026-77-4077","url":null,"abstract":"<p><p>Starting from the hypothesis that occupational noise exposure among paediatric intensive care unit (PICU) nurses at our hospital exceeds the recommended health guidelines and is associated with adverse non-auditory health outcomes, the aim of this cross-sectional study was to quantify personal noise exposure patterns and assess correlations with perceived stress, sleep quality, and hearing handicap in a convenience sample of 60 registered nurses wearing personal noise dosimeters over a 12-hour shift. The participants also completed a survey including the 10-item Perceived Stress Scale (PSS-10), the Pittsburgh Sleep Quality Index (PSQI), and the Hearing Handicap Inventory for Adults (HHIA). The main finding was that the cohort's mean 8-hour time-weighted average (L_{Aeq,8 h}) exposure to noise was 78.5±4.2 dBA, and that all measured shifts exceeded the World Health Organization (WHO) hospital guidelines. Peak noise levels (L_Cpeak) frequently surpassed 115 dBC. Most nurses (N=39) were classified as \"poor sleepers\" (PSQI>5). Significant positive correlations were found between L_{Aeq,8 h} and PSS-10 scores (r=0.45, p<0.001) and global PSQI scores (r=0.52, p<0.001). For every 1 dBA increase in L_{Aeq,8 h}, the odds of being a poor sleeper increased by 25 % (odds ratio 1.25; 95 % CI: 1.05-1.48). Even though this is a \"snapshot study\", it clearly indicates that PICU noise bears significant occupational risks of high stress and poor sleep, which warrants immediate intervention. Further research should focus on longitudinal measurements to get a better idea of noise exposure in healthcare environments, PICUs in particular.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":"77 1","pages":"39-48"},"PeriodicalIF":1.6,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13061083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}