Arhiv za higijenu rada i toksikologiju最新文献

{"title":"Integration of job satisfaction into the Personal Wellbeing Index: analysis of psychometric properties and sociodemographic influences among employees of the Croatian Health Insurance Fund.","authors":"Jozo Dubravac, Renata Barić","doi":"10.2478/aiht-2025-76-4060","DOIUrl":"10.2478/aiht-2025-76-4060","url":null,"abstract":"<p><p>This study examines subjective wellbeing (SWB) among administrative staff of a Croatian universal health insurance coverage provider in a transitional economy, hypothesising a moderate spillover effect from job satisfaction to overall life satisfaction. Our aim was to assess the psychometric properties of a modified Personal Wellbeing Index that incorporates job satisfaction (PWI-J), evaluate sociodemographic influences, and validate the job satisfaction domain inclusion in the index. The hypothesis was tested on a convenience sample of 1,051 Croatian employees of the Croatian Health Insurance Fund who completed an anonymous online survey in 2018. Analyses encompassed descriptive statistics, reliability testing, correlations, ANOVA/MANOVA for sociodemographic effects, and exploratory factor analysis (EFA). The PWI-J exhibited high reliability (Cronbach's α=0.896), and its two-factor structure (material-practical and socioemotional wellbeing) explained 65 % of the variance. The mean PWI-J score was 65.01 on a 0-100 scale. Standard of living and future security received the lowest score (around 52) and relationships and community the highest (77-81). Spillover was confirmed (ρ=0.633, P<0.001). Compared to the Australian wellbeing triage ranges, participants reported lower economic satisfaction but stronger community ties, with higher education associated with better material outcomes, female gender with enhanced social satisfaction, and younger workers (19-34 years old) with higher socioemotional scores. Our findings underscore economic vulnerabilities balanced by social resilience and validate PWI-J for occupational health assessments. Recommendations include targeted interventions for lower-educated and older workers. Limitations encompass cross-sectional design, self-report bias, and limited generalisability. Future research should pursue longitudinal studies on possible mediators, such as resilience.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":"76 4","pages":"265-273"},"PeriodicalIF":1.6,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12772485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Gentiana lutea</i> root aqueous extract mitigates hydroxyurea-induced genotoxicity through antioxidative action and DNA repair: an <i>in vitro</i> study in healthy human peripheral blood mononuclear cells.","authors":"Ksenija Radošević, Mila Kostić, Marijana Janić, Ivan Jovanović, Maja Živković, Ana Valenta Šobot, Jelena Filipović Tričković","doi":"10.2478/aiht-2025-76-4033","DOIUrl":"10.2478/aiht-2025-76-4033","url":null,"abstract":"<p><p>Hydroxyurea is a chemotherapeutic agent used to treat various conditions, including sickle cell anaemia and myeloproliferative malignancies. However, it has adverse genotoxic effects on normal cells. This <i>in vitro</i> study aimed to explore the genoprotective potential of yellow gentian (<i>Gentiana lutea</i> L.) root extract (GRE) against hydroxyurea-induced DNA damage in primary human peripheral blood mononuclear cells. We measured total phenolic and flavonoid GRE content (TPC and TFC, respectively) and its capacity to scavenge free radicals using the DPPH and ABTS assays. Before exposure to hydroxyurea, mononuclear cells were treated with non-cytotoxic and non-genotoxic GRE concentrations to assess their genoprotective (CBMN assay) and antioxidative effects (PAB and GSH assays). We also wanted to see how they affected the expression of DNA repair genes <i>PARP1</i>, <i>OGG1</i>, and <i>MnSOD</i>. GRE TPC was 8.42 mg GAE/g while the TFC was below the detection limit. Even so, GRE displayed radical-scavenging activity and restored hydroxyurea-disrupted cellular redox homeostasis, as PAB values returned to normal and GSH levels rose. GRE pre-treatment significantly reduced hydroxyurea-induced DNA damage in a concentration-dependent manner. <i>PARP1</i> and <i>MnSOD</i> were upregulated, but not <i>OGG1</i>, which indicates GRE's selective action. Our findings confirm its genoprotective effects against hydroxyurea-induced DNA damage in peripheral blood mononuclear cells, indicate a complex mechanism of action, and call for further research of this promising compound against secondary genotoxic effects of hydroxyurea.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":"76 4","pages":"282-291"},"PeriodicalIF":1.6,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poisoning with biocidal products before and after the COVID-19 pandemic: report from the Croatian Poison Control Centre.","authors":"Emin Veledar, Željka Babić, Jelena Macan","doi":"10.2478/aiht-2025-76-4059","DOIUrl":"10.2478/aiht-2025-76-4059","url":null,"abstract":"<p><p>Data collected by the Croatian Poison Control Centre (CPCC) in 2020 showed a significant increase in poisoning incidence with surface disinfectants and hand sanitisers compared to the same period in 2019. Considering that this rise in poisoning with biocidal products (BPs) coincided with the start of the COVID pandemic, we wanted to see if there was a trend by analysing six-years' worth of CPCC records of biocidal poisoning cases covering the COVID-19 pre-pandemic, pandemic, and post-pandemic period (2019-2024). During that period, we received 1320 BP-related calls (8.0 % of a total of 16.441 calls), and 99 % involved four types of BPs: surface disinfectants (542 cases), hand sanitisers (325 cases), insecticides (283 cases), and rodenticides (119 cases). Most poisonings were accidental and involved ingestion and inhalation as the exposure routes. Most patients were asymptomatic or had mild to moderate symptoms, while severe symptoms were mainly observed in suicide attempts, accounting for less than 3.0 % of the cases. Our analysis confirmed an increase in poisoning cases with hand sanitisers during the height of the pandemic (2020-2021) compared to the pre-pandemic 2019, with the numbers somewhat decreasing afterwards (2022-2024), although the number of cases remained higher than before the pandemic. The number of poisonings with surface disinfectants remained similar before and during the pandemic (2019-2021) but showed an increasing trend after the pandemic (2022-2024). Poisoning with rodenticides and insecticides remained stable across all periods. Our findings reinforce the need for greater public awareness of preventive measures, including appropriate labelling and packaging of biocidal products, and for the promotion of safe behaviour in households and workplaces.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":"76 4","pages":"259-264"},"PeriodicalIF":1.6,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12772482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary cotinine cut-off value in categorising cigarette smoking status in healthy pregnant women at term.","authors":"Nataša Brajenović, Irena Brčić Karačonji, Andreja Jurič, Jelena Kovačić, Sandra Stasenko, Tatjana Mioč, Iva Miškulin, Lana Škrgatić, Martina Piasek, Jasna Jurasović","doi":"10.2478/aiht-2025-76-4052","DOIUrl":"10.2478/aiht-2025-76-4052","url":null,"abstract":"<p><p>Future mothers tend to underreport intentional or unintentional tobacco smoke exposure to avoid social stigma, and urine levels of cotinine, the major metabolite of nicotine can serve as a valuable biomarker of tobacco smoke exposure to resolve such uncertainties. When establishing the cut-off level to discern non-smokers from active smokers, however, one should bear in mind the shorter half-life of cotinine in pregnant than non-pregnant women to avoid misclassification of maternal smoking status. The aim of our study was to determine the urinary cotinine cut-off level to objectively detect active smokers and to see if any participant characteristics were associated with underreporting. To do that, we collected spot urine samples from pregnant women with normal vaginal delivery at term, self-reported as non-smokers (n=123) or smokers (n=33), in the maternity ward before delivery. We also took their sociodemographic, cigarette smoking, and clinical data, as well as clinical data on their newborns using a questionnaire. To ensure objective classification of participants by smoking status, cotinine levels were quantified in urine using gas chromatography-mass spectrometry. The receiver operating characteristic (ROC) curve analysis showed that the optimal cut-off value of urinary cotinine to discern pregnant non-smokers from smokers at term were 120 µg/L or 144 µg/g creatinine, yielding 94 % sensitivity and 96 % or 97 % specificity. Respective to these cut-off values, 4.1 % and 3.3 % of self-reported non-smokers were classified as current smokers. Our findings support the use of urinary cotinine, whenever feasible, to reduce reporting bias in pregnancy studies, and, given the altered nicotine metabolism during pregnancy, future epidemiological studies should bear in mind that urinary cotinine cut-off values may depend on the stage of pregnancy.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":"76 4","pages":"251-258"},"PeriodicalIF":1.6,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12772481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with burnout among the Belgrade University medical students.","authors":"Jovana Todorović, Kontstantinos Stratakis, Dejan Nešić, Ratko Tomašević, Zorica Terzić-Šupić","doi":"10.2478/aiht-2025-76-3986","DOIUrl":"10.2478/aiht-2025-76-3986","url":null,"abstract":"<p><p>Although the 11^th Revision of the International Classification of Diseases defines burnout as an occupational syndrome, research has investigated it extensively in medical students. The aim of this cross-sectional study was to determine the prevalence of burnout among fifth-year medical students in Serbia along with the social, lifestyle, and health status characteristics associated with it. The study included 431 Belgrade University students attending classes in social medicine and took place in the last week of November 2024. According to the Copenhagen Burnout Inventory (CBI), the mean score was 43.67±15.81 and overall burnout prevalence 35.3 %. The prevalence of personal burnout was 35 %, of study-related burnout 36.9 %, and of faculty-related burnout 29 %. The multivariate logistic regression analysis of overall burnout showed positive association with the grade point average (OR: 4.02; 95 % CI: 2.12-7.64) and Zung Self-Rating Anxiety Scale score (OR: 1.14; 95 % CI: 1.06-1.22) and a negative association with the study engagement score (OR: 0.86; 95 % CI: 0.81-0.92). Our findings identify variables that need addressing to lower burnout prevalence among students. One is anxiety, which was significantly associated with burnout, and the other is study engagement, which was inversely associated with burnout. We believe that medical schools should provide mental health support programmes to address these and other potential issues.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":"76 4","pages":"274-281"},"PeriodicalIF":1.6,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12772483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of heat inactivation on RT-per detection of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2): an experience from the University Clinical Centre of Vojvodina, Serbia.","authors":"Jelena Stojčević Maletić, Iva Barjaktarović, Ljiljana Andrijević, Katarina Bačulov, Slobodanka Bogdanović Vasić, Diandra Pintać Šarac","doi":"10.2478/aiht-2025-76-3973","DOIUrl":"10.2478/aiht-2025-76-3973","url":null,"abstract":"<p><p>Handling clinical samples from patients suspected of SARS-CoV-2 infection puts healthcare workers at risk of exposure to infectious particles. To reduce this risk, samples are often heat-inactivated before nucleic acid isolation, but this procedure may affect the analytical sensitivity of the test. The aim of this study was therefore to evaluate the effects of heat inactivation (56 °C for 30 min) on RT-qPCR results of samples taken from nasopharyngeal and oropharyngeal (NP/OP) swabs collected from 200 symptomatic patients. Each sample was split into two aliquots - one subjected to heat inactivation and the other stored at 4 °C - followed by nucleic acid isolation and RT-qPCR analysis using the GeneFinder COVID-19 nucleic acid test. Heat inactivation did not significantly affect the overall SARS-CoV-2 detection rate (55.5 % vs. 55.0 % in untreated and heat-treated groups; χ²=0.01; p=0.91). However, discrepancies occurred in 15.3 % of samples, all with quantification cycle (Cq) values >31, including target loss, gain, or complete signal disappearance after heat treatment. Heat inactivation also slightly decreased Cq values for the RNA-dependent RNA polymerase (<i>RdRp</i>) and envelope (<i>E</i>) genes and increased those for the nucleocapsid (<i>N</i>) gene, with significant changes in strongly positive samples (Cq≤33). In positive samples (Cq≤40), the human ribonuclease (<i>RNase</i>) P gene also exhibited significantly higher Cq values after heat treatment. In the strongly positive subgroup, correlation analysis showed moderate correlation for <i>RdRp</i> and very strong correlation for the <i>N</i> and <i>E</i> genes, and a weaker correlation for weakly positive samples. In conclusion, heat inactivation at 56 °C for 30 min does not significantly affect viral gene detection but may diminish it in samples with low viral load.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":"76 4","pages":"242-250"},"PeriodicalIF":1.6,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12772480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing and monitoring indoor air quality and surface decontamination in healthcare environments.","authors":"Giovanni Cappelli, Ilaria Rapi, Stefano Dugheri, Niccolò Fanfani, Veronica Traversini, Antonio Baldassarre, Anna Korelidou, Maali-Amel Mersel, Filippo Baravelli, Marinos Louka, Nicola Mucci, Lina Kourtella","doi":"10.2478/aiht-2025-76-4013","DOIUrl":"10.2478/aiht-2025-76-4013","url":null,"abstract":"<p><p>Indoor air quality (IAQ) in healthcare facilities is a critical yet often underestimated factor associated with adverse health effects and increased risk of infectious outbreaks. Key pollutants include volatile organic compounds (VOCs), particulate matter, and various biological agents such as bacteria and viruses. While numerous variables contribute to IAQ, European regulations still have significant gaps, having historically focused more on individual substances than on the overall air environment. This review examines the most relevant IAQ parameters, current technologies available for their detection, and the regulatory landscape at the European level. Special attention is given to real-time monitoring systems. We also propose a concise operational guideline for IAQ management which combines continuous monitoring, evidence-based mitigation, and improvements to reduce exposure, increase resilience to airborne and surface threats, and produce measurable safety outcomes for patients and healthcare personnel within hospital settings.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":"76 4","pages":"222-241"},"PeriodicalIF":1.6,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12772487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of <i>N</i>-alkyl quaternary quinuclidines on oxidative stress biomarkers in SH-SY5Y cells.","authors":"Antonio Zandona, Lucija Marcelić, Suzana Žunec, Josip Madunić, Maja Katalinić","doi":"10.2478/aiht-2025-76-4007","DOIUrl":"10.2478/aiht-2025-76-4007","url":null,"abstract":"<p><p>Having a broad spectrum of biological and pharmacological activities, including anticholinergic, antihistaminic, antiparasitic, antioxidant, and antitumour, quinuclidine derivatives have piqued much interest in the field of drug discovery and biomedical research. This study investigates the oxidative stress effects of six <i>N</i>-alkyl quaternary quinuclidine derivatives, namely three oximes (QNOH-C_12,14,16) and three alcohols (QOH-C_12,14,16) in SH-SY5Y neuroblastoma cells to evaluate their safety profile as potential therapeutics. We treated SH-SY5Y cells with their lowest-observed-adverse-effect levels (LOAEL) for 4 h and measured reactive oxygen/nitrogen species (ROS/RNS), lipid peroxidation, glutathione (GSH), superoxide dismutase (SOD) activity, and DNA damage. Q(N)OHs significantly increased ROS and RNS levels, particularly the QNOHs, while lipid peroxidation remained unaffected, and GSH depletion was minimal. Cytosolic Cu/Zn-SOD activity increased significantly with longer alkyl chain substituents, while Mn-SOD activity decreased, indicating mitochondrial damage. DNA damage was not elevated. The observed effects of the tested quinuclidine derivatives appear to depend on their structural properties, as compounds containing hydroxyl groups and shorter alkyl chains had a lower impact. Furthermore, even non-cytotoxic doses of the tested compounds affected cell homeostasis, which underlines the importance of such testing early in the evaluation of new potential drugs.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":"76 3","pages":"203-210"},"PeriodicalIF":1.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic insights into the cytotoxic and apoptotic effects of 1-butyl-3-methylimidazolium bromide and 1-butylpyridinium bromide on human cell lines.","authors":"Lu Gao, Charles Obinwanne Okoye, Bonaventure Chidi Ezenwanne, Jianxiong Jiang, Guizhu Wu, Lin Yu, Daolin Du, Yonglai Xue","doi":"10.2478/aiht-2025-76-3966","DOIUrl":"10.2478/aiht-2025-76-3966","url":null,"abstract":"<p><p>Ionic liquids (ILs) are a novel class of salts with growing industrial applications due to their tunable physicochemical properties. However, their popularity has given rise to concerns about their cytotoxic potential. This study investigates the cytotoxic, apoptotic, and cell cycle effects of two ILs, namely 1-butyl-3-methylimidazolium bromide ([Bmim]Br) and 1-butylpyridinium bromide ([Bpy]Br), on three human cell lines: HeLa (cervical cancer), MCF-7 (breast cancer), and HEK293T (human embryonic kidney). Using real-time cell analysis (RTCA), we determined that the half-maximal inhibition concentrations (IC₅₀) for [Bmim]Br were 841.86 μmol/L in MCF-7, 538.38 μmol/L in HeLa, and 654.78 μmol/L in HEK293T cells. Respective [Bpy]Br IC₅₀ values were 341.74 μmol/L, 333.27 μmol/L, and 328.98 μmol/L. Flow cytometry revealed that both ILs induced dose-dependent apoptosis and that [Bpy]Br showed stronger pro-apoptotic effects. At 1000 μmol/L, [Bpy]Br reduced live cell population to 33.86 % in MCF-7 and to 38.32 % in HeLa cells. Both ILs induced the G0/G1 phase arrest and significantly suppressed the expression of cyclin D1, CDK2, and CDK4 at both mRNA and protein levels. MTT and Transwell assays further confirmed inhibited cell proliferation and migration, particularly in MCF-7 and HeLa cells. These findings demonstrate that [Bmim]Br and [Bpy]Br inhibit cell growth by triggering apoptosis and by interfering with cell cycle progression. Stronger effects observed with [Bpy]Br suggest its therapeutic potential, but given the toxicity of both ILs in non-cancerous HEK293T cells, further research is necessary to evaluate their biosafety and long-term effects.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":"76 3","pages":"195-202"},"PeriodicalIF":1.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational triangular fibrocartilage complex injury in a sewing machine operator.","authors":"Elif Reyhan Şahin, Mustafa Kahraman","doi":"10.2478/aiht-2025-76-4003","DOIUrl":"10.2478/aiht-2025-76-4003","url":null,"abstract":"<p><p>Triangular fibrocartilage complex (TFCC) injuries are associated with repetitive wrist movements and have mostly been reported in athletes but not in sewing machine operators, even though their jobs involve repetitive wrist movements. Our patient had operated a sewing machine for nine years across various workplaces. Two years ago, she began experiencing lateral ulnar pain, tenderness, and mild swelling in her left wrist. She was initially evaluated by her family physician, then by an orthopaedic surgeon, and was eventually referred to an occupational medicine specialist. TFCC compression test, TFCC stress test, grind test, and supination test were all positive. Ergonomic assessment showed an arm-wrist score of 5, a total rapid upper limb assessment (RULA) score of 5, and a job strain index (JSI) score of 13.5. Magnetic resonance imaging (MRI) of the left wrist showed changes consistent with a TFCC injury. Treatment included wrist immobilisation, oral painkillers, and rest, but her symptoms persisted upon return to the sewing machine, despite temporary use of a brace. Partial symptom improvement was observed only after job reassignment. This report presents the first confirmed case of a TFCC injury in a sewing machine operator and suggests that its potential occupational risks may have been overlooked in this population.</p>","PeriodicalId":520565,"journal":{"name":"Arhiv za higijenu rada i toksikologiju","volume":"76 3","pages":"218-221"},"PeriodicalIF":1.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}