Angewandte Chemie (International ed. in English)最新文献_第9页

Unsaturated Phosphine Oxides for Modular Antibody Rebridging and Single Reagent Peptide-Cyclisation-Bioconjugation. 模块化抗体桥接和单试剂肽环化-生物偶联的不饱和膦氧化物。

Angewandte Chemie (International ed. in English) Pub Date : 2025-06-30 DOI: 10.1002/anie.202508656

Christian E Stieger, Alastair McMillan, Mark A R de Geus, Jan Vincent Arafiles, Luise Franz, Christian Hackenberger

{"title":"Unsaturated Phosphine Oxides for Modular Antibody Rebridging and Single Reagent Peptide-Cyclisation-Bioconjugation.","authors":"Christian E Stieger, Alastair McMillan, Mark A R de Geus, Jan Vincent Arafiles, Luise Franz, Christian Hackenberger","doi":"10.1002/anie.202508656","DOIUrl":"10.1002/anie.202508656","url":null,"abstract":"Achieving modular, selective and homogeneous protein modifications is of utmost importance for the design of next generation biopharmaceuticals; especially in the context of antibody-drug conjugates (ADCs). Here, we introduce unsaturated phosphine oxides as versatile triple-reactive reagents, allowing orthogonal chemoselective bioconjugation schemes. Starting from triethynyl-phosphine oxide, a variety of functionalized diethynyl-triazolyl-phosphine oxides (DTPOs) could be accessed by using CuI-catalysed azide-alkyne cycloaddition (CuAAC). We showcase DTPO-reagents in the fast and selective generation of various highly stable antibody-conjugates via antibody disulfide rebridging. A highlight from this methodology is the synthesis of a DAR 4 ADC following a modular 2-step strategy using bioorthogonal tetrazine-labeling with bicyclo[6.1.0]non-4-yne (BCN) or trans-cyclooctene (TCO) containing payloads. Notably, the DTPO-rebridged ADC exhibited potent cytotoxicity against Her2+ cancer cells. Moreover, we utilize triethynyl-phosphine oxide to obtain ethynyl-ditriazolyl-phosphine oxides (EDPOs) which enable a unique, single-reagent peptide-cyclization-bioconjugation protocol resulting in functional cyclic peptide-protein conjugates. Overall, our work provides versatile and powerful chemoselective modalities for the controlled modification of antibodies, peptide-cyclization and peptide-protein conjugation, expanding the toolkit for chemical biology and therapeutic development.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e202508656"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal-Responsive Up-Regulation of Bifunctional Disulfides for Suppressing Protein Misfolding and Promoting Oxidative Folding. 双功能二硫化物在抑制蛋白质错误折叠和促进氧化折叠中的金属响应性上调。

Angewandte Chemie (International ed. in English) Pub Date : 2025-06-30 DOI: 10.1002/anie.202502187

Keita Mori, Tsubura Kuramochi, Motonori Matsusaki, Yuki Hashiguchi, Masaki Okumura, Tomohide Saio, Yoshiaki Furukawa, Kenta Arai, Takahiro Muraoka

{"title":"Metal-Responsive Up-Regulation of Bifunctional Disulfides for Suppressing Protein Misfolding and Promoting Oxidative Folding.","authors":"Keita Mori, Tsubura Kuramochi, Motonori Matsusaki, Yuki Hashiguchi, Masaki Okumura, Tomohide Saio, Yoshiaki Furukawa, Kenta Arai, Takahiro Muraoka","doi":"10.1002/anie.202502187","DOIUrl":"10.1002/anie.202502187","url":null,"abstract":"The stress-responsive up-regulation process is a sophisticated biological response to maintain cellular homeostasis. In intracellular anti-oxidant systems, the expression level of oxidoreductases is up-regulated under oxidative stress, mitigating oxidative damage on biomolecules and enhancing protein folding capacity. Herein, inspired by the biological system, we developed a synthetic folding promotor whose reactivity is up-regulated under stress conditions. We conjugated two metal-binding 1,4,7,11-tetraazacyclotetradecane (cyclam) ligands and a redox-active disulfide to obtain cyclam-SS, whose reactivity can be enhanced under metal-induced stress. Metal coordination increased the redox potential of cyclam-SS, activating it as an oxidant. While CuII ions severely hampered the oxidative folding of substrate polypeptides, cyclam-SS exhibited bifunctional folding-promoting properties, i) suppressing CuII-mediated misfolding and aggregation, and ii) harnessing CuII to enhance oxidative folding. Cyclam-SS was also useful for disulfide-bond formation to promote oxidative folding of pharmaceutical and pathological proteins, as demonstrated with proinsulin and superoxide dismutase 1 (SOD1). Furthermore, cyclam-SS protected cultured cells from copper-induced stress. Thus, we demonstrated the induction of the stress-responsive up-regulation process by a bifunctional folding promotor controlling the folding status of biologically important proteins under metal-induced stress. The strategy of \"stress-responsive up-regulation\" could aid the development of novel synthetic materials for treating intracellular stress and related disorders.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e202502187"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photocatalytic Reduction of CO₂ to CO in 100%: The Synergistic Effect of Nickel and Europium in Heterometallic Clusters. 光催化将CO2还原为100%的CO：镍和铕异金属团簇的协同作用。

Angewandte Chemie (International ed. in English) Pub Date : 2025-06-30 DOI: 10.1002/anie.202511126

Kai-Peng Bai, Wei-Peng Chen, Meng-Di Cui, Yan-Zhen Zheng

{"title":"Photocatalytic Reduction of CO2 to CO in 100%: The Synergistic Effect of Nickel and Europium in Heterometallic Clusters.","authors":"Kai-Peng Bai, Wei-Peng Chen, Meng-Di Cui, Yan-Zhen Zheng","doi":"10.1002/anie.202511126","DOIUrl":"10.1002/anie.202511126","url":null,"abstract":"Heterometallic transition-rare earth metal (3d-4f) clusters with synergistic catalytic activity are rarely identified. Herein, two families of closely related 3d-Eu clusters were designed to analyze the role of Eu(III) ions during the photocatalytic reduction of CO2 into CO. The [M24Eu8] family, where M = Co or Ni, shows much lower activity (CO production < 2078 µmol g-1 h-1) compared to the [M24Eu10] family (CO production > 5838 µmol g-1 h-1). This is due to the two additional Eu(III) ions in the apical position of the latter which are very active for converting CO2 into CO. Moreover, we found the nickel analogues are better than the cobalt ones, especially for [Ni24Eu10] which exhibits 100% CO selectivity and very high efficacy of 6545.3 µmol g-1 h-1, while the [Co24Eu10] only shows 55% CO selectivity. Therefore, the coexistence of both apical Eu(III) and Ni(II) ions has been experimentally revealed to be critical for this exceptional catalytic performance of the [Ni24Eu10] cluster. As such, this work unambiguously reveals a synergistic effect of bimetallic catalysts and may open a new avenue for more sophisticated reaction design by using the heterometallic coordination clusters.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e202511126"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Highly Crystalline 2D Conjugated Metal-Organic Framework for Superior Sodium Storage. 一种高结晶二维共轭金属-有机框架，用于优越的钠储存。

Angewandte Chemie (International ed. in English) Pub Date : 2025-06-30 DOI: 10.1002/anie.202510698

Jia-Cheng Yin, Xin Lian, Jinli Zhang, Zhi-Gang Li, Ming Liu, Jiandong Pang, Wei Li, Yunhua Xu, Na Li, Xian-He Bu

{"title":"A Highly Crystalline 2D Conjugated Metal-Organic Framework for Superior Sodium Storage.","authors":"Jia-Cheng Yin, Xin Lian, Jinli Zhang, Zhi-Gang Li, Ming Liu, Jiandong Pang, Wei Li, Yunhua Xu, Na Li, Xian-He Bu","doi":"10.1002/anie.202510698","DOIUrl":"10.1002/anie.202510698","url":null,"abstract":"Two-dimensional conjugated metal-organic frameworks (2D c-MOFs) have emerged as promising electrode materials for sodium-ion batteries (SIBs). However, developing 2D c-MOFs with multiple redox-active sites and well-defined structures to enhance the performance of SIBs and elucidate the structure-property relationship remains challenging. Herein, a 2D c-MOF single crystal (Cu-TBP) with dual active centers was synthesized using an octahydroxyl tetrabenzophenazine (8OH-TBP) ligand. Three-dimensional electron diffraction (3D ED) analysis reveals the atomic-level crystal structure of Cu-TBP, characterized by a planar 2D rhombus network and a unique slipped AA layer-stacking. Cu-TBP exhibits typical semiconducting behavior with a high electrical conductivity (7.69 × 10-3 S m-1 at 298 K) and a low thermal activation energy. Owing to its abundant redox-active sites and superb electrical conductivity, Cu-TBP shows remarkable electrochemical performance as a SIB anode, achieving a high reversible capacity of 369.7 mAh g-1 at 0.25 A g-1, exceptional rate capability, and extraordinary cyclability (82.6% capacity retention after 800 cycles at 0.25 A g-1). Experimental studies combined with theoretical calculations further elucidate the Na+ storage mechanism.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e202510698"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hinge-Like Mechanochromic Mechanophores Based on [2.2]Paracyclophane. 基于[2.2]副环环烷的铰链状机械致色团。

Angewandte Chemie (International ed. in English) Pub Date : 2025-06-30 DOI: 10.1002/anie.202510114

Shohei Shimizu, Jess M Clough, Christoph Weder, Yoshimitsu Sagara

{"title":"Hinge-Like Mechanochromic Mechanophores Based on [2.2]Paracyclophane.","authors":"Shohei Shimizu, Jess M Clough, Christoph Weder, Yoshimitsu Sagara","doi":"10.1002/anie.202510114","DOIUrl":"10.1002/anie.202510114","url":null,"abstract":"A hinge-like supramolecular mechanophore based on a [2.2]paracyclophane core and two excimer-forming 1,6-bis(phenylethynyl)pyrene luminophores is presented. Each luminophore shares one phenyl group with the [2.2]paracyclophane, resulting in a rigid and strained structure that forces the two luminophores into close proximity. As a consequence, the photoluminescence of the mechanophore in THF solution and in solid films of a polyurethane containing the new motif is dominated by excimer emission. Stretching the polymer films causes an easily discernible change from bright yellow excimer to blue-green monomer-dominated emission. The ratio of excimer to monomer emission intensities traces the nonlinear stress-strain curves of the polymer well and is a good indicator for the macroscopically applied force. The reversibility of the mechanoresponse, theoretical analyses, and reference experiments with a similar mechanophore in which the emitters and the [2.2]paracyclophane core are connected by flexible linkers support the conclusion that the mechanoactivation is caused by distorting the molecule into a bent, more open conformation and not the scission of covalent bonds. The operating principle was further confirmed by investigating a second hinge-like mechanophore based on a [2.2]paracyclophane core and 1,4-bis(phenylethynyl)benzene emitters.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e202510114"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transform the World through Chemistry. 通过化学改变世界。

Angewandte Chemie (International ed. in English) Pub Date : 2025-06-30 DOI: 10.1002/anie.202512699

Paul T Anastas, Walter Leitner

引用次数: 0

NiH-Catalyzed Enantio- and Regioselective Hydroarylation of Unactivated Alkenes Enabled by Outer-Sphere Electron Transfer with Diaryliodonium Salts. nih催化非活化烯烃外球电子转移的对映和区域选择性氢化芳基化。

Angewandte Chemie (International ed. in English) Pub Date : 2025-06-30 DOI: 10.1002/anie.202503908

Hyung-Joon Kang, Leejae Kim, Juyeon Lee, Sungwoo Hong

{"title":"NiH-Catalyzed Enantio- and Regioselective Hydroarylation of Unactivated Alkenes Enabled by Outer-Sphere Electron Transfer with Diaryliodonium Salts.","authors":"Hyung-Joon Kang, Leejae Kim, Juyeon Lee, Sungwoo Hong","doi":"10.1002/anie.202503908","DOIUrl":"10.1002/anie.202503908","url":null,"abstract":"Asymmetric hydroarylation of unactivated alkenes provides a direct route to enantiomerically enriched C─C bonds in aryl-containing compounds, a key transformation in pharmaceutical and natural product synthesis. While recent advances have achieved high regio- and enantioselectivity with terminal alkenes, controlled hydroarylation of unactivated internal alkenes remains challenging. Here, we report a nickel-hydride-catalyzed protocol that overcomes this limitation through a mechanistic paradigm shift. By employing diaryliodonium salts as dual-function reagents, our method achieves high enantio- and regioselectivity in the hydroarylation of both internal and terminal unactivated alkenes. These salts enable a transition from concerted to stepwise oxidative addition via dissociative single-electron transfer (DSET), generating a cationic alkyl-nickel intermediate prone to fragmentation and aryl radical addition. Mechanistic studies, including a key experiment in 1,4-dioxane yielding an enantiomerically pure solvent-functionalized product, establish migratory insertion as the enantio- and regio-determining step. This approach not only expands the scope of asymmetric hydroarylation but also provides a new mechanistic framework for selective hydrofunctionalization reactions.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e202503908"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bicyclic Selenenyl Sulfides with Tuned Bioreductive Step Rates Reveal Constraints for Probes Targeting Thioredoxin Reductase. 具有调节生物还原步速的双环硒基硫化物揭示了针对硫氧还蛋白还原酶的探针的限制。

Angewandte Chemie (International ed. in English) Pub Date : 2025-06-30 DOI: 10.1002/anie.202508911

Lukas Zeisel, Lucas Dessen-Weissenhorn, Karoline Scholzen, Andrea Madabeni, Laura Orian, Elias S J Arnér, Oliver Thorn-Seshold

{"title":"Bicyclic Selenenyl Sulfides with Tuned Bioreductive Step Rates Reveal Constraints for Probes Targeting Thioredoxin Reductase.","authors":"Lukas Zeisel, Lucas Dessen-Weissenhorn, Karoline Scholzen, Andrea Madabeni, Laura Orian, Elias S J Arnér, Oliver Thorn-Seshold","doi":"10.1002/anie.202508911","DOIUrl":"10.1002/anie.202508911","url":null,"abstract":"The reductive activation of dichalcogenide probes by thiol-type oxidoreductases proceeds through a cascade of consecutive, partly reversible steps. Stereocontrol elements can modulate the reaction rates of these steps to reach substrate-controlled kinetic selectivity for reductase chemotypes in live cells. We now deploy regio-, diastereo-, template-, and pH-control elements to shape the reactivity of unprecedented bicyclic selenenyl sulfides (SeSP), arriving at probes that selectively target the mammalian selenoenzyme thioredoxin reductase TrxR1. We accessed these densely functionalised cis- or trans-fused 1,2-thiaselenanes on gram scale over 5 steps by using a regioselective key step that elaborates an unusual, differentially protected 2,2'-bis-aziridine intermediate through sequential one-pot chalcogen introduction and selenenyl sulfide formation. By profiling a set of regio- and diastereoisomeric bicycles for their partly or fully reversible reactivity during reductive activation, we show how effects that slow their reduction steps (addition then resolution) can compensate by vastly accelerating subsequent activation (cyclisation) speeds, such that cellular redox processing is effective and TrxR-selective. More broadly, this study shows how multistep cascade probes can leverage conformational effects and internal noncovalent interactions to differentiate step kinetics along their on-target versus off-target reaction pathways, thus achieving reaction-based target selectivity in complex biological settings.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e202508911"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low Molecular Weight Multistate Photoswitches Based on Simple Norbornadiene-Triazine Scaffolds. 基于简单降冰片二烯-三嗪支架的低分子量多态光开关。

Angewandte Chemie (International ed. in English) Pub Date : 2025-06-30 DOI: 10.1002/anie.202507999

Andreas Hirsch, Daniel Krappmann, Adrian Müller, Erik J Schulze, Harald Maid, Andreas Dreuw

{"title":"Low Molecular Weight Multistate Photoswitches Based on Simple Norbornadiene-Triazine Scaffolds.","authors":"Andreas Hirsch, Daniel Krappmann, Adrian Müller, Erik J Schulze, Harald Maid, Andreas Dreuw","doi":"10.1002/anie.202507999","DOIUrl":"10.1002/anie.202507999","url":null,"abstract":"We have synthesized and characterized a series of simple norbornadiene(NBD)-triazine architectures including multistate photoswitches with unprecedentedly high information storage densities. The simple mono-NBDs served as suitable model systems to investigate the underlying absorption and switching characteristics. To stepwise increase the complexity, a bis-NBD derivative with symmetric substituted pattern was investigated next. By combination of different NBD substituents with varying electron demands two asymmetric compounds, one bis-NBD and one tris-NBD were prepared and investigated. It turned out that in the case of the tris-NBD selective switching of the individual NBD chromophores is hampered by too closely related optical properties of all three NBD units. On the other hand, the asymmetric photoswitch system containing two NBD-substituents fulfilled the requirements of a selectively addressable multistate system with an extremely high information storage density. Here, all possible NBD/quadricyclane (QC) combinations including protonated forms thereof and their reversible interconversion could be realized. Our experimental findings were corroborated by quantum chemical calculations.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e202507999"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Symmetry Breaking Enabled Stable Oxygen Redox in Li-Rich Cathodes via π-Type Interaction. 对称性破缺通过π型相互作用实现富锂阴极的稳定氧氧化还原。

Angewandte Chemie (International ed. in English) Pub Date : 2025-06-30 DOI: 10.1002/anie.202506507

Fu-Da Yu, Zhe-Jian Yi, Hai-Nan Wang, Jia-Zhen Zhao, Yang-Qian Zhang, Yang Ren, Ji-Gang Zhou, Ji-Huai Wu, Zhang Lan, Yi-Ming Xie, Lan-Fang Que, Yun-Shan Jiang, Zhen-Bo Wang

{"title":"Symmetry Breaking Enabled Stable Oxygen Redox in Li-Rich Cathodes via π-Type Interaction.","authors":"Fu-Da Yu, Zhe-Jian Yi, Hai-Nan Wang, Jia-Zhen Zhao, Yang-Qian Zhang, Yang Ren, Ji-Gang Zhou, Ji-Huai Wu, Zhang Lan, Yi-Ming Xie, Lan-Fang Que, Yun-Shan Jiang, Zhen-Bo Wang","doi":"10.1002/anie.202506507","DOIUrl":"10.1002/anie.202506507","url":null,"abstract":"Effectively stabilizing oxygen redox is the most challenging task for the practical applications of high-energy-density Li-rich cathode materials. However, how to accurately tune the oxygen energy level to achieve reversible redox remains puzzling so far. In this work, we achieve stable oxygen redox in layered Li-rich materials over the whole voltage range without irreversible O2 release by adjusting the interlayer metal cation environment adjacent to the ligand. Combining synchrotron X-ray absorption spectroscopy and theoretical analysis of metal-ligand orbital combinations, we confirm the obvious charge transfer from O to Ni due to the π-type interaction between Ni 3d spin-down t2g orbitals and O 2p orbitals. Furthermore, Ab initio molecular dynamics simulations reveal the spontaneous symmetry breaking of the Ni coordination environment after Li extraction under the π-type interaction, which enhances the intrinsic competition between anion and cation oxidation, keeping π* state (from O 2p splitting) below the metal band to avoid over-oxidation. As a result, the modified material shows improved electrochemical performance and stable structural/interface evolution. This work provides new insights into the relationship between the adjacent metal environment and the ligand O redox reactions.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e202506507"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0