Angewandte Chemie (International ed. in English)最新文献_第8页

Dual-Affinity Host Engineering for Highly Reversible Zinc-Iodine Batteries. 高可逆锌碘电池的双亲和主机工程。

IF 16.9

Angewandte Chemie (International ed. in English) Pub Date : 2026-10-19 Epub Date: 2026-09-02 DOI: 10.1002/anie.5243975

Meijia Chen, Chuang Sun, Yuxuan Zhu, Mengting Zheng, Jun Lu

{"title":"Dual-Affinity Host Engineering for Highly Reversible Zinc-Iodine Batteries.","authors":"Meijia Chen, Chuang Sun, Yuxuan Zhu, Mengting Zheng, Jun Lu","doi":"10.1002/anie.5243975","DOIUrl":"10.1002/anie.5243975","url":null,"abstract":"Aqueous zinc-iodine (Zn-I2) batteries are promising for large-scale energy storage, yet their practical development is impeded by the coupled degradation of both electrodes, including instability Zn anode and sluggish iodine kinetics of cathode. Existing approaches typically focus on individual optimization of each electrode, limiting full cell to achieve synergistic enhancement and inevitably increases system complexity. Herein, a dual-affinity three-dimensional host is constructed by integrating one-dimensional carbon nanotubes with two-dimensional vermiculite nanosheets. The incorporation of vermiculite overcomes the intrinsically low polarity and weak adsorption capability with active material of the conventional 3D carbon frameworks. Benefiting from the densely stacked hybrid architecture with high mechanical strength, excellent electrical conductivity and dual affinity toward Zn and polyiodides, the 3D host concurrent regulate Zn deposition and iodine conversion chemistry. The zincophilic vermiculite regulate Zn2+ flux, lower the nucleation barrier and promote uniform deposition, while the porous structure effectively suppress polyiodide shuttling through synergistic physical confinement and chemical anchoring. Consequently, the Zn composite anode exhibits remarkable cycling stability over 3000 cycles at 20 mA cm-2 at 60% depth-of-discharge, whereas the integrated Zn-I2 full cell maintains 90.0% capacity retention after 2000 cycles. This work offers a route for designing durable, highly efficient Zn-I2 batteries.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e5243975"},"PeriodicalIF":16.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148877092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical Cobalt/Vanadium Relay Catalysis: Enantioselective Markovnikov Hydrooxygenation of Alkenes. 电化学钴/钒接力催化：烯烃的对映选择性马尔可夫尼科夫氢氧反应。

IF 16.9

Angewandte Chemie (International ed. in English) Pub Date : 2026-10-19 Epub Date: 2026-09-02 DOI: 10.1002/anie.1324586

Pan Peng, Cong Zhou, Zongang Liu, Xuezheng Yi, Yongsheng Tao, Weipeng Zheng, Fabao Li, Qingquan Lu

{"title":"Electrochemical Cobalt/Vanadium Relay Catalysis: Enantioselective Markovnikov Hydrooxygenation of Alkenes.","authors":"Pan Peng, Cong Zhou, Zongang Liu, Xuezheng Yi, Yongsheng Tao, Weipeng Zheng, Fabao Li, Qingquan Lu","doi":"10.1002/anie.1324586","DOIUrl":"10.1002/anie.1324586","url":null,"abstract":"The direct enantioselective intermolecular Markovnikov hydrooxygenation of alkenes remains a fundamental challenge, as it requires simultaneous control over regioselectivity, stereochemistry, and reactivity. Here we report an electrochemical cobalt/vanadium relay catalytic strategy that overcomes these constraints by decoupling regio- and stereochemical control across two distinct catalytic events. A cobalt hydride selectively engages alkenes through metal-hydride hydrogen atom transfer to generate a Markovnikov alkyl radical, while a vanadium catalyst mediates a subsequent stereodetermining bimolecular homolytic substitution (SH2) to form the C─O bond with high enantioselectivity. Electrochemical modulation of the cobalt and vanadium redox states enables efficient catalytic relay under mild conditions, suppressing overoxidation pathways and eliminating the need for stoichiometric chemical oxidants. This approach provides access to a broad range of enantioenriched alcohols and derivatives with high functional group tolerance and scalability, offering streamlined access to pharmaceutically relevant scaffolds. More broadly, the demonstrated compatibility of vanadium-catalyzed asymmetric bond formation with electrochemical control establishes a general framework for stereoselective C─O bond construction via radical intermediates.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e1324586"},"PeriodicalIF":16.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148877095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-Derived Tetrahydropyrazines for Late-Stage α- and β-Functionalization of Piperazine-Based Pharmaceuticals. 哌嗪类药物α-和β-功能化后期的药物衍生四氢吡嗪。

IF 16.9

Angewandte Chemie (International ed. in English) Pub Date : 2026-10-19 Epub Date: 2026-09-02 DOI: 10.1002/anie.6711809

Soichiro Mori, Cunyuan Zhao, Tenghui Wang, Yuankai Wang, Yu Nishio, Matthew D Disney, Masayuki Wasa

{"title":"Drug-Derived Tetrahydropyrazines for Late-Stage α- and β-Functionalization of Piperazine-Based Pharmaceuticals.","authors":"Soichiro Mori, Cunyuan Zhao, Tenghui Wang, Yuankai Wang, Yu Nishio, Matthew D Disney, Masayuki Wasa","doi":"10.1002/anie.6711809","DOIUrl":"10.1002/anie.6711809","url":null,"abstract":"Piperazine is one of the most prevalent saturated nitrogen heterocycles in pharmaceuticals, yet late-stage access to α- and β-substituted piperazine analogues remains challenging. Here, we report a flavin-photocatalyzed platform that converts complex piperazine-containing drugs into persistent tetrahydropyrazine intermediates that serve as versatile branch points for downstream functionalization. Under blue-light irradiation, riboflavin tetraacetate (RFTA) promotes sequential α- and β-C─H bond cleavage of N-alkyl, N-aryl, and N-heteroaryl piperazines under mild conditions and with tolerance of diverse functional groups. The resulting drug-derived tetrahydropyrazines can be isolated or directly telescoped into reactions with electrophiles and nucleophiles, enabling late-stage access to cyclopropyl-, trifluoromethyl-, carbonyl-, amide-, and cyano-substituted piperazine analogues. By decoupling C─H oxidation from subsequent bond construction, this two-stage strategy enables transformations that would otherwise be incompatible with flavin-mediated oxidation. The utility of this approach is demonstrated through the rapid preparation of diverse analogues of piperazine-based pharmaceuticals and a preliminary structure-activity relationship (SAR) study of erastin, which reveals that piperazine-core substitution and stereochemistry can substantially influence cellular activity. Stern-Volmer quenching experiments, cyclic voltammetry, and characterization of intermediates formed under photoirradiation provide insight into the reaction mechanism. This work establishes drug-derived tetrahydropyrazines as practical late-stage intermediates for expanding medicinally relevant chemical space around piperazine-containing drug leads.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e6711809"},"PeriodicalIF":16.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148877113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modular and Stereoselective Synthesis of Cyclobutane β-Amino Alcohols. 环丁烷β-氨基醇的模块化和立体选择性合成。

IF 16.9

Angewandte Chemie (International ed. in English) Pub Date : 2026-10-19 Epub Date: 2026-08-28 DOI: 10.1002/anie.1530338

Xinyu Yang, Tomoya Ozaki, Bo Li, Shih-Yuan Liu

引用次数: 0

Iron-Photocatalyzed Alkene Chloroaminoxylation: A Platform for Orthogonally Activatable Building Blocks. 铁光催化烯烃氯胺氧化：一个正交活化构建块的平台。

IF 16.9

Angewandte Chemie (International ed. in English) Pub Date : 2026-10-19 Epub Date: 2026-08-29 DOI: 10.1002/anie.5509453

Amrita Chaudhuri, Meghana Aladahalli Shekar, Mohammad Zafar, Marianne Engeser, Gregor Schnakenburg, Ala Bunescu

{"title":"Iron-Photocatalyzed Alkene Chloroaminoxylation: A Platform for Orthogonally Activatable Building Blocks.","authors":"Amrita Chaudhuri, Meghana Aladahalli Shekar, Mohammad Zafar, Marianne Engeser, Gregor Schnakenburg, Ala Bunescu","doi":"10.1002/anie.5509453","DOIUrl":"10.1002/anie.5509453","url":null,"abstract":"We report the development of an iron-photocatalyzed 1,2-chloroaminoxylation of alkenes that installs two orthogonal and independently activatable synthetic handles, a chlorine atom and an alkoxyamino group, across a diverse range of alkene substrates. The reaction is driven by iron's ability to generate chlorine radicals via photoinduced chloride-to-iron charge transfer, followed by addition across the carbon-carbon double bond and subsequent trapping by TEMPO derivatives. This operationally simple protocol exhibits broad functional group tolerance, exquisite chemo- and regioselectivity and efficiently converts a wide range of C═C bonds, such as styrene derivatives, unactivated alkenes, and Michael acceptors, into synthetically valuable chlorooxygenated scaffolds. The resulting products can be engaged with various nucleophiles through distinct modes of reactivity: the TEMPO-derived alkoxyamino moiety undergoes photoredox activation, while the C-Cl bond participates in nucleophilic substitution. This dual-reactivity platform enables a programmable incorporation of two different nucleophiles under complementary activation conditions, providing streamlined access to structurally diverse architectures. Comprehensive mechanistic studies, integrating reaction kinetics, UV-vis spectroscopy, high-resolution mass spectrometry (HRMS), x-ray crystallographic characterization of key catalytic intermediates, cyclic voltammetry (CV), and chronoamperometry, elucidate the underlying reaction pathway and reveal key features of the iron catalytic cycle.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e5509453"},"PeriodicalIF":16.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148852326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cascaded Energy Transfer in Supramolecular Assemblies Enables Amplified and Photoswitchable Circularly Polarized Luminescence. 超分子组件中的级联能量传递实现了放大和可光切换的圆偏振发光。

IF 16.9

Angewandte Chemie (International ed. in English) Pub Date : 2026-10-19 Epub Date: 2026-09-02 DOI: 10.1002/anie.1803367

Yanshan Sheng, Xin Wang, Minzan Zuo, Xiao-Yu Hu

{"title":"Cascaded Energy Transfer in Supramolecular Assemblies Enables Amplified and Photoswitchable Circularly Polarized Luminescence.","authors":"Yanshan Sheng, Xin Wang, Minzan Zuo, Xiao-Yu Hu","doi":"10.1002/anie.1803367","DOIUrl":"10.1002/anie.1803367","url":null,"abstract":"Photoresponsive circularly polarized luminescence (CPL) materials are promising for optical information processing and anti-counterfeiting. However, integrating high luminescence dissymmetry factor (glum) with high-contrast reversible switching within a single system remains a significant challenge. In this study, we present a supramolecular CPL nanoplatform that combines hierarchical chirality amplification with light-gated cascaded Förster resonance energy transfer (FRET). Selective host-guest recognition between a TPE-functionalized chiral pillar[5]arene (TPEP5) and a polymeric guest forms emissive supramolecular polymers with amplified chirality. Confined co-assembly with the achiral relay dye 4,7-di(2-thienyl)-benzo[2,1,3]thiadiazole (DBT) enables efficient FRET from TPEP5 to DBT, accompanied by concomitant chirality transfer, generating red-shifted CPL with enhanced |glum| values of 10- 2. Eventually, diarylethene (DAE) is incorporated as a final photoresponsive \"gatekeeper\": UV irradiation induces DAE ring closure, activating FRET pathway and quenching CPL; subsequent visible-light irradiation reverses the process, fully restoring emission and CPL activity. This orthogonal design preserves the structural integrity of the chiral scaffold over repeated switching cycles, achieving robust, fatigue-resistant, and architecture-preserving CPL on/off control. Therefore, our strategy provides a generalizable blueprint for intelligent chiral photonic materials with built-in security functionality.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e1803367"},"PeriodicalIF":16.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148877118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lysine Oxidation by LOXL2 in Single Strands Versus Triple Helices: Implications for Collagen-Related Diseases. 单链与三螺旋中LOXL2的赖氨酸氧化：对胶原蛋白相关疾病的影响

IF 16.9

Angewandte Chemie (International ed. in English) Pub Date : 2026-10-19 Epub Date: 2026-08-28 DOI: 10.1002/anie.1329257

Laura M Poller, Tomas Fiala, Helma Wennemers

{"title":"Lysine Oxidation by LOXL2 in Single Strands Versus Triple Helices: Implications for Collagen-Related Diseases.","authors":"Laura M Poller, Tomas Fiala, Helma Wennemers","doi":"10.1002/anie.1329257","DOIUrl":"10.1002/anie.1329257","url":null,"abstract":"Collagen cross-linking is essential for the structural integrity of the extracellular matrix. In several pathological conditions, the triple-helical core of collagen is disrupted, and proline-rich single strands occur. Lysyl oxidases (LOXs), enzymes that initiate cross-linking by catalyzing the oxidative deamination of lysine to allysine residues, are upregulated in disease. Surprisingly little is known about the selectivity of LOXs. LOX-initiated cross-linking is believed to occur exclusively in the unstructured terminal domains of collagen, the telopeptides. But is this really the case? Herein, we show, with a combination of tailored chemical probes, enzymatic assays, CD and NMR spectroscopic analyses, that LOXL2 oxidizes Lys in proline-rich single strands but not in triple helices. A comparison of Lys-containing collagen model peptides (CMPs) with Lys-containing telopeptides revealed comparable or higher oxidation rates in proline-rich segments. The data suggest that LOXL2-initiated cross-linking occurs in pathologically disrupted triple-helical domains, offering insights into aberrant extracellular matrix stiffening.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e1329257"},"PeriodicalIF":16.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148852318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intramolecular Nickel-Catalyzed Reductive Coupling: Enantioselective Synthesis of Tetrahydroisoquinolines and Related Heterocycles. 分子内镍催化的还原偶联：四氢异喹啉及相关杂环的对映选择性合成。

IF 16.9

Angewandte Chemie (International ed. in English) Pub Date : 2026-10-19 Epub Date: 2026-09-02 DOI: 10.1002/anie.6219487

Thilo Bender, Markus Leutzsch, Yannik Sell, Alois Fürstner

{"title":"Intramolecular Nickel-Catalyzed Reductive Coupling: Enantioselective Synthesis of Tetrahydroisoquinolines and Related Heterocycles.","authors":"Thilo Bender, Markus Leutzsch, Yannik Sell, Alois Fürstner","doi":"10.1002/anie.6219487","DOIUrl":"10.1002/anie.6219487","url":null,"abstract":"The P-chiral phosphine AntPhos was found to be the ligand of choice for nickel-catalyzed intramolecular reductive coupling reactions of 5-amino substituted 2,4-dienoates bearing a tethered aldehyde. This approach to heterocyclic compounds has little precedent in the literature; it provides, inter alia, ready access to hydroxylated tetrahydroisoquinoline derivatives comprising an anti-configured amino alcohol motif, which are difficult to make in optically active form otherwise. These compounds qualify for diverse downstream functionalization as exemplified by the swift elaboration of a representative member of the series into a fluorinated heterocyclic building block as well as into the core region of potently cytotoxic phenanthroquinolizidine alkaloids in two differently substituted formats. Detailed NMR studies in combination with crystallographic data allowed the reactive oxanickelacycle intermediates primarily formed to be characterized with regard to the bonding mode of the allylnickel subunit that they comprise. Moreover, insights into conformational aspects pertinent to the understanding of the stereochemical course of this metal-catalyzed C─C-bond formation were gained, which leads to the generation of two stereogenic centers at the vic-amino alcohol subunit.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e6219487"},"PeriodicalIF":16.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148877087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solvent-Directed Modulation of Stacking Isomers in Single-Crystal One-Dimensional Covalent Organic Frameworks. 单晶一维共价有机骨架中堆叠异构体的溶剂定向调制。

IF 16.9

Angewandte Chemie (International ed. in English) Pub Date : 2026-10-19 Epub Date: 2026-08-26 DOI: 10.1002/anie.7177046

Tonghai Wang, Baoqiu Yu, Liqin Hao, Wenbo Zhou, Yujie Liu, Peng Cheng, Yao Chen, Zhenjie Zhang

{"title":"Solvent-Directed Modulation of Stacking Isomers in Single-Crystal One-Dimensional Covalent Organic Frameworks.","authors":"Tonghai Wang, Baoqiu Yu, Liqin Hao, Wenbo Zhou, Yujie Liu, Peng Cheng, Yao Chen, Zhenjie Zhang","doi":"10.1002/anie.7177046","DOIUrl":"10.1002/anie.7177046","url":null,"abstract":"Stacking isomerism in covalent organic frameworks (COFs) has long remained elusive, with no unambiguous single-crystal structure confirmation to date. Herein, we present the first definitive structural resolution of stacking isomers in one-dimensional COFs, enabled by a solvent-directed modulation strategy. Two distinct stacking isomers were obtained: one exhibiting AA'-stacking (synthesized in mesitylene) and the other featuring an ABCD quadruple stacking mode (synthesized in anisole/n-butanol). Their atomic structures were determined by continuous rotation electron diffraction (cRED) at resolutions of 0.98 and 1.02 Å, respectively, with all non-hydrogen atoms directly located. Compared to the AA'-stacked isomer, the ABCD-stacked counterpart displays broader optical absorption, a narrower bandgap, and approximately twofold higher charge-separation efficiency, resulting in significantly enhanced visible-light photocatalytic activity for H2O2 production and N-benzylbenzaldimine synthesis. Mechanistic studies reveal that the ABCD stacking configuration narrows the bandgap, weakens electron localization, and substantially increases the dipole moment, thereby inducing strong interlayer charge transfer and polarization effects.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e7177046"},"PeriodicalIF":16.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148820921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Active Learning-Accelerated Discovery of Antifungal Polymers With Self-Assembly Capacity for Tackling Invasive Fungal Diseases. 主动学习加速发现具有自组装能力的抗真菌聚合物，用于治疗侵袭性真菌疾病。

IF 16.9

Angewandte Chemie (International ed. in English) Pub Date : 2026-10-19 Epub Date: 2026-08-28 DOI: 10.1002/anie.3008697

Tianyi Zhang, Zhizhao Zhang, Haojie Chen, Yuhui Wu, Ye Tian, Qiannuan Shi, Qun Fang, Jianzhang Pan, Jian Ji, Youxiang Wang, Qiao Jin

{"title":"Active Learning-Accelerated Discovery of Antifungal Polymers With Self-Assembly Capacity for Tackling Invasive Fungal Diseases.","authors":"Tianyi Zhang, Zhizhao Zhang, Haojie Chen, Yuhui Wu, Ye Tian, Qiannuan Shi, Qun Fang, Jianzhang Pan, Jian Ji, Youxiang Wang, Qiao Jin","doi":"10.1002/anie.3008697","DOIUrl":"10.1002/anie.3008697","url":null,"abstract":"Invasive fungal diseases (IFD) are life-threatening infections with limited clinical management. Antifungal peptide (AFP)-mimicking polymers are promising candidates for tackling IFD. However, due to the structural diversity of polymers, it remains a great challenge to discover new polymers with potent antifungal activity and biocompatibility. Herein, we propose a novel active learning-guided framework PolyCAML for accelerated discovery of antifungal polymers. Inspired by AFPs, we construct a quaternary copolymer library comprising 516,114 combinations with different side chains. By integrating automated synthesis platform, Graph Transformer machine learning model, and greedy algorithm, 11 top-performing candidates are screened via the Design-Build-Test-Learn (DBTL) intelligent iterative workflow within merely 18 days. Through further data mining, key factors that influence antifungal potency and biocompatibility of polymers are identified. By more rigorous biological evaluation, four target polymers are screened, exhibiting a minimum fungicidal concentration ≤ 8 µg/mL and a 50% inhibitory concentration of L929 cells ≥ 512 µg/mL. These polymers are self-assembled into positively charged nanoparticles for delivering fluconazole, which exhibit synergistic anti-biofilm activity by enhanced biofilm penetration. The in vivo therapeutic efficacy is confirmed by a fungemia model and a fungal keratitis model. Overall, we establish a multi-task intelligent prediction platform PolyCAML to discover antifungal polymers for tackling IFD.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e3008697"},"PeriodicalIF":16.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148852188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0