Angewandte Chemie (International ed. in English)最新文献_第5页

Intramolecular Nickel-Catalyzed Reductive Coupling: Enantioselective Synthesis of Tetrahydroisoquinolines and Related Heterocycles. 分子内镍催化的还原偶联：四氢异喹啉及相关杂环的对映选择性合成。

IF 16.9

Angewandte Chemie (International ed. in English) Pub Date : 2026-10-19 Epub Date: 2026-09-02 DOI: 10.1002/anie.6219487

Thilo Bender, Markus Leutzsch, Yannik Sell, Alois Fürstner

{"title":"Intramolecular Nickel-Catalyzed Reductive Coupling: Enantioselective Synthesis of Tetrahydroisoquinolines and Related Heterocycles.","authors":"Thilo Bender, Markus Leutzsch, Yannik Sell, Alois Fürstner","doi":"10.1002/anie.6219487","DOIUrl":"10.1002/anie.6219487","url":null,"abstract":"The P-chiral phosphine AntPhos was found to be the ligand of choice for nickel-catalyzed intramolecular reductive coupling reactions of 5-amino substituted 2,4-dienoates bearing a tethered aldehyde. This approach to heterocyclic compounds has little precedent in the literature; it provides, inter alia, ready access to hydroxylated tetrahydroisoquinoline derivatives comprising an anti-configured amino alcohol motif, which are difficult to make in optically active form otherwise. These compounds qualify for diverse downstream functionalization as exemplified by the swift elaboration of a representative member of the series into a fluorinated heterocyclic building block as well as into the core region of potently cytotoxic phenanthroquinolizidine alkaloids in two differently substituted formats. Detailed NMR studies in combination with crystallographic data allowed the reactive oxanickelacycle intermediates primarily formed to be characterized with regard to the bonding mode of the allylnickel subunit that they comprise. Moreover, insights into conformational aspects pertinent to the understanding of the stereochemical course of this metal-catalyzed C─C-bond formation were gained, which leads to the generation of two stereogenic centers at the vic-amino alcohol subunit.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e6219487"},"PeriodicalIF":16.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148877087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solvent-Directed Modulation of Stacking Isomers in Single-Crystal One-Dimensional Covalent Organic Frameworks. 单晶一维共价有机骨架中堆叠异构体的溶剂定向调制。

IF 16.9

Angewandte Chemie (International ed. in English) Pub Date : 2026-10-19 Epub Date: 2026-08-26 DOI: 10.1002/anie.7177046

Tonghai Wang, Baoqiu Yu, Liqin Hao, Wenbo Zhou, Yujie Liu, Peng Cheng, Yao Chen, Zhenjie Zhang

{"title":"Solvent-Directed Modulation of Stacking Isomers in Single-Crystal One-Dimensional Covalent Organic Frameworks.","authors":"Tonghai Wang, Baoqiu Yu, Liqin Hao, Wenbo Zhou, Yujie Liu, Peng Cheng, Yao Chen, Zhenjie Zhang","doi":"10.1002/anie.7177046","DOIUrl":"10.1002/anie.7177046","url":null,"abstract":"Stacking isomerism in covalent organic frameworks (COFs) has long remained elusive, with no unambiguous single-crystal structure confirmation to date. Herein, we present the first definitive structural resolution of stacking isomers in one-dimensional COFs, enabled by a solvent-directed modulation strategy. Two distinct stacking isomers were obtained: one exhibiting AA'-stacking (synthesized in mesitylene) and the other featuring an ABCD quadruple stacking mode (synthesized in anisole/n-butanol). Their atomic structures were determined by continuous rotation electron diffraction (cRED) at resolutions of 0.98 and 1.02 Å, respectively, with all non-hydrogen atoms directly located. Compared to the AA'-stacked isomer, the ABCD-stacked counterpart displays broader optical absorption, a narrower bandgap, and approximately twofold higher charge-separation efficiency, resulting in significantly enhanced visible-light photocatalytic activity for H2O2 production and N-benzylbenzaldimine synthesis. Mechanistic studies reveal that the ABCD stacking configuration narrows the bandgap, weakens electron localization, and substantially increases the dipole moment, thereby inducing strong interlayer charge transfer and polarization effects.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e7177046"},"PeriodicalIF":16.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148820921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Active Learning-Accelerated Discovery of Antifungal Polymers With Self-Assembly Capacity for Tackling Invasive Fungal Diseases. 主动学习加速发现具有自组装能力的抗真菌聚合物，用于治疗侵袭性真菌疾病。

IF 16.9

Angewandte Chemie (International ed. in English) Pub Date : 2026-10-19 Epub Date: 2026-08-28 DOI: 10.1002/anie.3008697

Tianyi Zhang, Zhizhao Zhang, Haojie Chen, Yuhui Wu, Ye Tian, Qiannuan Shi, Qun Fang, Jianzhang Pan, Jian Ji, Youxiang Wang, Qiao Jin

{"title":"Active Learning-Accelerated Discovery of Antifungal Polymers With Self-Assembly Capacity for Tackling Invasive Fungal Diseases.","authors":"Tianyi Zhang, Zhizhao Zhang, Haojie Chen, Yuhui Wu, Ye Tian, Qiannuan Shi, Qun Fang, Jianzhang Pan, Jian Ji, Youxiang Wang, Qiao Jin","doi":"10.1002/anie.3008697","DOIUrl":"10.1002/anie.3008697","url":null,"abstract":"Invasive fungal diseases (IFD) are life-threatening infections with limited clinical management. Antifungal peptide (AFP)-mimicking polymers are promising candidates for tackling IFD. However, due to the structural diversity of polymers, it remains a great challenge to discover new polymers with potent antifungal activity and biocompatibility. Herein, we propose a novel active learning-guided framework PolyCAML for accelerated discovery of antifungal polymers. Inspired by AFPs, we construct a quaternary copolymer library comprising 516,114 combinations with different side chains. By integrating automated synthesis platform, Graph Transformer machine learning model, and greedy algorithm, 11 top-performing candidates are screened via the Design-Build-Test-Learn (DBTL) intelligent iterative workflow within merely 18 days. Through further data mining, key factors that influence antifungal potency and biocompatibility of polymers are identified. By more rigorous biological evaluation, four target polymers are screened, exhibiting a minimum fungicidal concentration ≤ 8 µg/mL and a 50% inhibitory concentration of L929 cells ≥ 512 µg/mL. These polymers are self-assembled into positively charged nanoparticles for delivering fluconazole, which exhibit synergistic anti-biofilm activity by enhanced biofilm penetration. The in vivo therapeutic efficacy is confirmed by a fungemia model and a fungal keratitis model. Overall, we establish a multi-task intelligent prediction platform PolyCAML to discover antifungal polymers for tackling IFD.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e3008697"},"PeriodicalIF":16.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148852188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Isoquinolines Through Isochromenylium Intermediates Captured by Nitriles and a CO-to-CN Switch. 利用腈捕获的等色胺中间体和CO-to-CN开关合成异喹啉。

IF 16.9

Angewandte Chemie (International ed. in English) Pub Date : 2026-10-19 Epub Date: 2026-08-28 DOI: 10.1002/anie.5898322

Xu-Dong Hu, Gui-Feng Ding, Yu-Qing Zheng, Wen-Bo Liu

{"title":"Synthesis of Isoquinolines Through Isochromenylium Intermediates Captured by Nitriles and a CO-to-CN Switch.","authors":"Xu-Dong Hu, Gui-Feng Ding, Yu-Qing Zheng, Wen-Bo Liu","doi":"10.1002/anie.5898322","DOIUrl":"10.1002/anie.5898322","url":null,"abstract":"Isochromenylium ions have emerged as versatile intermediates for the rapid construction of molecular complexity through cascade reactions. However, their application in catalytic annulation processes with nitriles to form isoquinolines remains largely unexplored, despite the prevalence of nitrile motifs and isoquinoline frameworks in bioactive molecules and functional materials. Here we report a catalytic cascade strategy for the efficient synthesis of isoquinolines, including enantioenriched variants, from readily available substrates. The reaction includes palladium-catalyzed cyclization of ortho-alkynylaryl aldehydes to generate an isochromenylium palladium species, which is captured by indium-promoted 1,2-addition of nitriles. Subsequent water-assisted ring opening furnishes a Zincke-type intermediate, followed by intramolecular condensation to deliver the isoquinoline products. This cascade process achieves a net conversion of a carbonyl (CO) unit into a nitrile-derived carbon-nitrogen (CN) linkage at an intermediate-stage in a single operation. Notably, the use of malononitrile-tethered substrates enables the synthesis of enantioenriched isoquinolines with high enantioselectivity. Mechanistic studies indicate a cooperative role of palladium and indium in promoting the 1,2-addition of isochromenylium palladium species to the nitrile. The method exhibits excellent atom economy, good functional group tolerance, and scalability, highlighting its potential application for heterocycle synthesis.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e5898322"},"PeriodicalIF":16.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148852317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light-Gated Chirality in a Supramolecular Cavitand. 超分子空腔中的光门控手性。

IF 16.9

Angewandte Chemie (International ed. in English) Pub Date : 2026-10-19 Epub Date: 2026-09-04 DOI: 10.1002/anie.9254918

Hang Yu, Aiyou Hao, Pengyao Xing

{"title":"Light-Gated Chirality in a Supramolecular Cavitand.","authors":"Hang Yu, Aiyou Hao, Pengyao Xing","doi":"10.1002/anie.9254918","DOIUrl":"10.1002/anie.9254918","url":null,"abstract":"Achieving precise and modulable chiral expression on molecular platforms is of great significance for the design and synthesis of chiroptical materials. Herein, we construct a supramolecular cavitand platform that enables programmable locking, switching, and rewriting of chiral information gated by light. A resorcin[4]arene-based cavitand integrates multiple photoisomeriable stilbenes and alternating imidazole segments. By employing an outer-wall binding strategy to bind multiple chiral carboxylic acids, it achieves efficient chirality transfer and enables the construction of a supramolecular chiral cavitand. Photoisomerization of embedded stilbene units, drives pathway-dependent conformational transformations that govern chirality induction, retention, and erasure. Notably, different light channels (365/254 nm) enable distinct outcomes, including preservation of chiral host-guest complexes, disruption of propeller chirality, and complete guest release. Furthermore, chirality can be locked and retained in a propeller form after removing the chiral acids, demonstrating a light-regulated chiral construction. The system further functions as a read-write chiral information platform, allowing visualization, encryption, decryption, and erasure of chiroptical signals through programmable photochemical inputs. This work establishes a strategy for coupling photochemical control with supramolecular confinement, providing a proof-of-concept study of significant importance in chiral informatics.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e9254918"},"PeriodicalIF":16.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148893276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Host-Directed Discovery of Dynamic-Covalent Guests From Dynamic Combinatorial Libraries. 动态组合库中动态共价来宾的主定向发现。

IF 16.9

Angewandte Chemie (International ed. in English) Pub Date : 2026-10-19 Epub Date: 2026-09-04 DOI: 10.1002/anie.7195803

Zhenye Qiu, Ruirui Gu, He Tian, Jean-Marie Lehn, Da-Hui Qu

{"title":"Host-Directed Discovery of Dynamic-Covalent Guests From Dynamic Combinatorial Libraries.","authors":"Zhenye Qiu, Ruirui Gu, He Tian, Jean-Marie Lehn, Da-Hui Qu","doi":"10.1002/anie.7195803","DOIUrl":"10.1002/anie.7195803","url":null,"abstract":"Dynamic covalent chemistry and host-guest recognition are complementary tools for constructing adaptive molecular systems and functional materials, yet their integration has been hindered by the lack of general strategies for efficiently discovering host-compatible dynamic-covalent guests. Here we report a host-directed screening strategy that directly identifies optimal imine guests from dynamic combinatorial libraries. Upon addition of the macrocyclic host, selective host-guest binding drives thermodynamically controlled library redistribution, leading to significant constitutional amplification of the preferred guests. A one-pot workflow involving activation, complexation, deactivation, displacement, and readout enables precise quantification of this redistribution by simple one-dimensional NMR spectroscopy. While 1H NMR readout is well suited to smaller libraries, 19F NMR offers clear advantages for more complex libraries, as demonstrated with a [5× 5] library. [2×n] library architecture further improves screening robustness by directing the major antagonistic response toward a channel excluded from candidate ranking. Although pillararene-imine complexes have rarely been reported because of their weak binding, stepwise screening of three library sets identified imine guests for ethyl pillar[5]arene with association constants of up to (2.2 ± 0.1) × 103 M-1. These findings establish host-directed selection as a practical strategy for coupling molecular recognition with constitutional dynamics in adaptive systems and materials.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e7195803"},"PeriodicalIF":16.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148893322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Plasmonic S-Scheme Heterojunction Achieves Broadband Response and Ultralow Overpotential of Photo-Assisted Li─O₂ Batteries. 等离子体s型异质结实现光辅助锂氧电池的宽带响应和超低过电位。

IF 16.9

Angewandte Chemie (International ed. in English) Pub Date : 2026-10-19 Epub Date: 2026-08-28 DOI: 10.1002/anie.2006350

Xingyu Yu, Yunyun Xu, Hao Gong, Zhixin Liu, Xingxu Gao, Kun Chang, Tao Wang, Jianping He, Zhong-Shuai Wu

{"title":"A Plasmonic S-Scheme Heterojunction Achieves Broadband Response and Ultralow Overpotential of Photo-Assisted Li─O2 Batteries.","authors":"Xingyu Yu, Yunyun Xu, Hao Gong, Zhixin Liu, Xingxu Gao, Kun Chang, Tao Wang, Jianping He, Zhong-Shuai Wu","doi":"10.1002/anie.2006350","DOIUrl":"10.1002/anie.2006350","url":null,"abstract":"Li─O2 batteries (LOBs) offer an ultrahigh theoretical energy density but suffer from a large overpotential. Photocathodes can lower this overpotential, but most of them cannot achieve efficient charge separation, sufficient redox capability, and broadband photoresponse at the same time. Here, a plasmonic S-scheme heterojunction photocathode (W18O49/g-C3N4, WOCN) is constructed. W18O49 serves as the oxidation semiconductor of the heterojunction and a noble-metal-free plasmonic absorber, forming a continuous plasmonic heterointerface with g-C3N4. The intrinsic localized surface plasmon resonance (LSPR) of W18O49 originates from periodically arranged lattice-localized electrons in W5+ clusters. Photogenerated carriers with strong redox capability and LSPR-generated hot electrons are separated by the S-scheme carrier transfer pathway. Under AM 1.5G illumination, the WOCN-based LOBs exhibit an ultralow overpotential of 0.04 V and a round-trip efficiency of 98.75%. Even under NIR illumination, an overpotential of 0.34 V and a round-trip efficiency of 90.12% are achieved, demonstrating an effective NIR response in photo-assisted LOBs for the first time. This work opens a new avenue for designing plasmonic S-scheme heterojunctions toward next-generation energy storage systems with full solar spectrum utilization.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e2006350"},"PeriodicalIF":16.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148852129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Senescence-Associated β-Galactosidase With Single-Molecule Resolution. 衰老相关β-半乳糖苷酶的单分子分辨鉴定。

IF 16.9

Angewandte Chemie (International ed. in English) Pub Date : 2026-10-19 Epub Date: 2026-08-28 DOI: 10.1002/anie.5443283

Guangwei Wang, Xi Chen, Yihao Ge, Kaixuan Duan, Shaowei Wu, Qinglong Qiao, Donglei Shi, Ji-Wei Shen, Jianjian Zhang, Tony D James, Zhaochao Xu, Yuan Guo

{"title":"Identification of Senescence-Associated β-Galactosidase With Single-Molecule Resolution.","authors":"Guangwei Wang, Xi Chen, Yihao Ge, Kaixuan Duan, Shaowei Wu, Qinglong Qiao, Donglei Shi, Ji-Wei Shen, Jianjian Zhang, Tony D James, Zhaochao Xu, Yuan Guo","doi":"10.1002/anie.5443283","DOIUrl":"10.1002/anie.5443283","url":null,"abstract":"The majority of human senescent cells exhibit overexpression of senescence-associated β-galactosidase (SA-β-gal), rendering this enzyme the most extensively utilized biomarker of senescence and a key prodrug target for intervening in aging. However, strategies for the authentic in situ identification of SA-β-gal with single-molecule resolution have not been established, limiting the accuracy of senescence targeting. Here we present an unprecedented molecular approach to identify SA-β-gal in a manner that avoids dissociation from the target enzyme, which integrates the atomic hybridization of SA-β-gal substrates with protein-environment-sensitive fluorescence technology. Using this design principle, we created nine fluorescent probes with distinct working modes for the single-molecule (target enzyme)-resolved identification of SA-β-gal. Five of them formed crystal complexes with the wild-type β-galactosidase by binding at the active site, clearly evidencing their single-molecule resolution capability. Our strategy, capable of both identifying and locating SA-β-gal, facilitated its application in dynamic single-molecule localization microscopic imaging, achieving the in situ tracking of SA-β-gal in living cells at the nanoscale. Significantly, the probing of SA-β-gal with high fidelity enabled the precise evaluation of the aging degree in mice. As such, our research provides a promising method for the authentic in situ identification of this senescence-associated protein with single-molecule resolution.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e5443283"},"PeriodicalIF":16.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148852273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Created Ex Nihilo: A Near-Infrared Afterglow Luminescent Framework of Imidazole Derivatives for Bioimaging. 创建的无氧：用于生物成像的咪唑衍生物的近红外余辉发光框架。

IF 16.9

Angewandte Chemie (International ed. in English) Pub Date : 2026-10-19 Epub Date: 2026-09-02 DOI: 10.1002/anie.9929915

Zihan Wu, Liping Zhang, Ziwei Wang, Yachao Wang, Gelin Xu, Feng Chi, Dongxia Zhu, Martin R Bryce, Ben Zhong Tang, Lijie Ren

{"title":"Created Ex Nihilo: A Near-Infrared Afterglow Luminescent Framework of Imidazole Derivatives for Bioimaging.","authors":"Zihan Wu, Liping Zhang, Ziwei Wang, Yachao Wang, Gelin Xu, Feng Chi, Dongxia Zhu, Martin R Bryce, Ben Zhong Tang, Lijie Ren","doi":"10.1002/anie.9929915","DOIUrl":"10.1002/anie.9929915","url":null,"abstract":"Afterglow luminescence probes are limited by (i) a lack of new afterglow scaffolds; (ii) a dependence on initial external light activation, and (iii) aggregation-caused quenching. Herein, we demonstrate for the first time that Ir(III) complexes of general formula Ir(C^N)2(N^N)+ PF6 - with an imidazole-based N^N ligand exhibit bright afterglow luminescence in the presence of reactive oxygen and nitrogen species (RONS) or under ultrasound (US) irradiation. A series of Ir(III) complexes (Ir-1-Ir-4) establish a new afterglow luminescence mechanism based on experimental data and theoretical calculations. The key feature of the present mechanism is the reaction of the ─N═C─N─H unit of the imidazole ligands with various RONS. After modification of the luminescent framework by quinolyl-triphenylamine C^N ligands, Ir-4 is endowed with aggregation induced emission (AIE) properties and with enhanced near-infrared afterglow luminescence. When assembled into water-soluble nanoparticles (NPs) with the aid of an amphiphilic polymer, Ir-4@R NPs demonstrated excellent afterglow luminescence imaging and effective sonodynamic therapy in vitro and in vivo. These Ir(III) complexes represent the first examples of an afterglow luminescent molecular framework based on readily available and versatile imidazole ligands, breaking through the existing limitation of molecular structures with afterglow luminescence.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e9929915"},"PeriodicalIF":16.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148877072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unconventional Dendrite-Free Deposition of Mg Metal Anodes at Low Temperatures. 低温下非常规无枝晶沉积Mg金属阳极。

IF 16.9

Angewandte Chemie (International ed. in English) Pub Date : 2026-10-19 Epub Date: 2026-08-26 DOI: 10.1002/anie.2311794

Yuan Wang, Shiyang Wang, Junbo Cui, Kangyu Yi, Kewei Wang, Ke Wang, Zixu He, Yijiang Bao, Junpeng Yan, Yulin Jie, Dongsheng Xu, Xuefeng Wang, Ruiguo Cao, Shuhong Jiao

{"title":"Unconventional Dendrite-Free Deposition of Mg Metal Anodes at Low Temperatures.","authors":"Yuan Wang, Shiyang Wang, Junbo Cui, Kangyu Yi, Kewei Wang, Ke Wang, Zixu He, Yijiang Bao, Junpeng Yan, Yulin Jie, Dongsheng Xu, Xuefeng Wang, Ruiguo Cao, Shuhong Jiao","doi":"10.1002/anie.2311794","DOIUrl":"10.1002/anie.2311794","url":null,"abstract":"Temperature plays a critical role in governing the plating behavior of metallic anodes by regulating ionic conductivity of the electrolyte, desolvation energy, and charge transfer processes in the solid-electrolyte interphase (SEI). While low temperature commonly triggers dendritic growth on metallic anodes (e.g., Li, Na, and Zn), the temperature effect on Mg plating/stripping behaviors remains unknown thus far. Herein, we report an unconventional temperature-dependent deposition behavior of Mg anodes that tends to form dendrite-free deposits at low temperatures. Integration of cryo-transmission electron microscopy, atomic force microscopy, and x-ray photoelectron spectroscopy reveals that the SEI layer formed at low temperatures has an ultrathin thickness (∼2-3 nm) and is enriched in high-modulus inorganic compounds, which facilitates the uniform deposition of Mg anodes. As a result, the Mg metal anode realizes an exceptional average Coulombic efficiency up to 99.92% over 2000 cycles at -20°C. This study demonstrates the unconventional deposition behavior of Mg metal anodes at low temperatures, underpinning their potential for low-temperature applications and advancing the fundamental understanding of metal deposition.","PeriodicalId":520556,"journal":{"name":"Angewandte Chemie (International ed. in English)","volume":" ","pages":"e2311794"},"PeriodicalIF":16.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148820893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0