Frontiers in dementia最新文献

{"title":"Discussing methodological gaps in psychosocial intervention research for dementia: an opinion article from the INTERDEM Methodology Taskforce guided by the MRC framework.","authors":"Sara Laureen Bartels, Nathan Stephens, Federica D'Andrea, Melanie Handley, Marine Markaryan, Andrea Nakakawa Bernal, Lieve Van den Block, Simone R de Bruin, Karen Windle, Martina Roes, Niels Janssen, Hannah Christie, Lesley Garcia, Gwen Teesing, Esme Moniz-Cook, Maud Graff","doi":"10.3389/frdem.2024.1458023","DOIUrl":"10.3389/frdem.2024.1458023","url":null,"abstract":"","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"3 ","pages":"1458023"},"PeriodicalIF":0.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interactions between muscle volume and body mass index on brain structure in the UK Biobank.","authors":"Alicia Lu, Stephanie Than, Richard Beare, Alexandra La Hood, Taya Annabelle Collyer, Velandai Srikanth, Chris Moran","doi":"10.3389/frdem.2024.1456716","DOIUrl":"https://doi.org/10.3389/frdem.2024.1456716","url":null,"abstract":"<p><strong>Background: </strong>Low skeletal muscle volume may increase dementia risk through mechanisms affecting brain structure. However, it is unclear whether this relationship exists outside of sarcopenia and/or varies by other factors. We aimed to study the interplay between skeletal muscle volume and factors, such as age, sex, and body mass index (BMI), in explaining brain structure at midlife in a cohort without sarcopenia.</p><p><strong>Methods: </strong>We used abdominal and brain magnetic resonance imaging (MRI) data from a population-based cohort enrolled in the UK Biobank. The following measures were derived: thigh fat-free muscle volume (FFMV), total brain volume (TBV), gray matter volume (GMV), white matter volume (WMV), total hippocampal volume (THV), and white matter hyperintensity volume (WMHV). Participants below sex-based grip strength thresholds suggesting probable sarcopenia were excluded. Linear regression analysis was used to study the interaction or mediation effects of age, sex, and BMI on the associations between FFMV and brain volumes.</p><p><strong>Results: </strong>Data were available for 20,353 participants (median age 64 years, 53% female). We found interactions between thigh FFMV, BMI, and age (all <i>p</i> < 0.05). Greater thigh FFMV was associated with better brain volumes in those aged <64 years with normal (TBV: β = 2.0 ml/L, <i>p</i> = 0.004; GMV: β = 0.8 ml/L, <i>p</i> = 0.04; WMV: β = 1.1 ml/L, <i>p</i> = 0.006; WMHV: β = -0.2 ml/L, <i>p</i> = 3.7 × 10^-5) or low BMI (TBV: β = 21.2 ml/L, <i>p</i> = 0.003; WMV: β = 13.3 ml/L, <i>p</i> = 0.002, WMHV: β = -1.1 ml/L, <i>p</i> = 0.04).</p><p><strong>Conclusion: </strong>Greater thigh muscle volume correlates with better brain volumes at midlife in people without sarcopenia, but this relationship weakens with greater age and BMI. Further study is required to investigate the underlying mechanisms to understand which components of body composition are potentially modifiable risk factors for dementia.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"3 ","pages":"1456716"},"PeriodicalIF":0.0,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: A critical reflection on using the Patient Engagement In Research Scale (PEIRS) to evaluate patient and family partners' engagement in dementia research.","authors":"Joey Wong, Lillian Hung, Cates Bayabay, Karen Lok Yi Wong, Annette Berndt, Jim Mann, Lily Wong, Lynn Jackson, Mario Gregorio","doi":"10.3389/frdem.2024.1490895","DOIUrl":"https://doi.org/10.3389/frdem.2024.1490895","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/frdem.2024.1422820.].</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"3 ","pages":"1490895"},"PeriodicalIF":0.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11445679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142368163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meaningful patient and public engagement in dissemination-embedding co-production in dementia research.","authors":"Susanne de Wolf-Linder, Iris Kramer, Martina Hersperger, Maria Schubert, Sonja Bächi, Monika Stolz, Emma Wolverson, Christina Ramsenthaler","doi":"10.3389/frdem.2024.1426019","DOIUrl":"10.3389/frdem.2024.1426019","url":null,"abstract":"<p><strong>Background: </strong>Patient and Public Involvement and Engagement (PPIE) is still underutilised in both dementia research and corresponding dissemination activities.</p><p><strong>Aim: </strong>To describe the methods, format, and lessons learned in co-creating and co-producing a dissemination strategy for a research project focused on establishing patient-centred outcome measures into routine palliative community care for persons living with dementia (PLWD) and their informal carers.</p><p><strong>Materials and methods: </strong>A participatory, hybrid-format workshop was conducted to co-create the dissemination strategy with a PPIE group. A video presentation of findings and a list of prompts shared prior to the workshop were used to elicit views on dissemination strategies and knowledge translation. The workshop was followed up with a survey to consolidate the dissemination strategy. Workshop minutes and survey responses were analysed using qualitative thematic analysis.</p><p><strong>Results: </strong>22 participants from our diverse PPIE group attended the workshop. Two major themes emerged: (a) Knowledge translation: building bridges between research and practise, and (b) Collaboration and dissemination: everyone's voice is needed. Participants suggested critical changes to dissemination methods and materials. Successful knowledge translation depends on a strong evidence base. For this, materials need to be tailored to specific audiences. Everyone's voice needs to be integrated through co-production in dissemination activities by PPIE members to influence societal change. Tailored dissemination activities within a dissemination strategy were co-created spanning all phases of the research cycle.</p><p><strong>Discussion: </strong>Informing and educating the public and policymakers about the needs of PLWD relies on disseminating and fostering knowledge translation throughout all phases of the research cycle.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"3 ","pages":"1426019"},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142336199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of audio-biographical cues in dementia care: a four-year evaluation in Swiss hospitals, care, and domestic homes.","authors":"Heather Edwards, Sandra Oppikofer, Damaris Aschwanden","doi":"10.3389/frdem.2024.1429290","DOIUrl":"https://doi.org/10.3389/frdem.2024.1429290","url":null,"abstract":"<p><strong>Introduction: </strong>In dementia care, the integration of innovative interventions is essential to enhancing the wellbeing and quality of life of people with dementia. Among these interventions, the Music Mirror intervention has emerged as a promising tool to provide personalized audio-biographical cues aimed at soothing, motivating, and engaging people with dementia. This study examined the effects of a Music Mirror intervention on the (a) wellbeing, emotions, and behavioral and psychological symptoms of 155 individuals with dementia, (b) perceived burden, relationship quality, and gains of their informal/formal caregivers, and (c) momentary closeness, wellbeing and stress of caregivers.</p><p><strong>Methods: </strong>This four-year study employed a quasi-experimental waiting-control group design, utilizing before-after measurements in Swiss hospitals, care homes, and domestic homes. For four 6-week intervention phases, Music Mirrors, i.e., brief written resources of acoustic material, associated with practical activities of daily life, were applied at least twice a week by the caregivers during critical moments such as staff handover. Repeated measures' analysis of variance and other tests were used to analyze the data.</p><p><strong>Results: </strong>Individuals with dementia had a higher wellbeing after the Music Mirror use across different care situations. While the Music Mirrors were played, individuals with dementia showed more positive than negative emotions at each measurement occasion, but emotion scores did not significantly change over time. After the MM use, caregivers felt better, closer to the person with dementia, and less stressed. Caregivers also reported significant gains at the end of the intervention. However, there were no significant changes in the frequency of the behavioral and psychological symptoms of dementia, care-related burden and relationship quality over time, regardless of the treatment condition.</p><p><strong>Discussion: </strong>By incorporating personalized audio-biographical cues into their care routines, the wellbeing of people with dementia was improved as well as it had positive momentary effects on their caregivers. The Music Mirror intervention addresses the preferences and needs of people with dementia and helps build bonds between care-recipients and caregivers. Therefore, Music Mirrors can be seen as a highly adaptive and individualized instrument to improve momentary wellbeing of people with dementia in various care situations during daily life.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"3 ","pages":"1429290"},"PeriodicalIF":0.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11401044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142306131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tyrosine kinases: multifaceted receptors at the intersection of several neurodegenerative disease-associated processes.","authors":"Max Stevenson, Norah K Algarzae, Charbel Moussa","doi":"10.3389/frdem.2024.1458038","DOIUrl":"10.3389/frdem.2024.1458038","url":null,"abstract":"<p><p>Tyrosine kinases (TKs) are catalytic enzymes activated by auto-phosphorylation that function by phosphorylating tyrosine residues on downstream substrates. Tyrosine kinase inhibitors (TKIs) have been heavily exploited as cancer therapeutics, primarily due to their role in autophagy, blood vessel remodeling and inflammation. This suggests tyrosine kinase inhibition as an appealing therapeutic target for exploiting convergent mechanisms across several neurodegenerative disease (NDD) pathologies. The overlapping mechanisms of action between neurodegeneration and cancer suggest that TKIs may play a pivotal role in attenuating neurodegenerative processes, including degradation of misfolded or toxic proteins, reduction of inflammation and prevention of fibrotic events of blood vessels in the brain. In this review, we will discuss the distinct roles that select TKs have been shown to play in various disease-associated processes, as well as identify TKs that have been explored as targets for therapeutic intervention and associated pharmacological agents being investigated as treatments for NDDs.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"3 ","pages":"1458038"},"PeriodicalIF":0.0,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11361951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The psychological effects of research participation on people with dementia: findings from a German exploratory interview study.","authors":"Katja Seidel, Claudia Winiarski, Jochen René Thyrian, Julia Haberstroh","doi":"10.3389/frdem.2024.1421541","DOIUrl":"10.3389/frdem.2024.1421541","url":null,"abstract":"<p><p>The German National Dementia Strategy aims to engage people with dementia in research projects. However, the effects of such research participation on experience and behavior have been insufficiently explored. This study aimed to investigate the psychological effect of research participation on people living with dementia. In a qualitative, exploratory approach, guideline-based interviews were conducted with four persons with dementia who had served as co-researchers on an advisory board in a health services research study for 8 months at that time. The analysis revealed predominantly positive effects of research participation at all levels of experience and behavior. Most effects were reported by the co-researchers on a cognitive level. Both the perception of being competent and of making a positive contribution to oneself and/or others are key effects of research participation. The main effects on an emotional level were joy and wellbeing and on a behavioral level were positive social contacts and social communication. Sadness and insecurity represent the sole negative effects. Nuanced focal points of effects among the individual interviews were found. The results align with existing research highlighting the positive effects of participation on people with dementia. Through advancing an interdisciplinary perspective on their research involvement, we advocate for heightened attention to this topic within the realm of psychology.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"3 ","pages":"1421541"},"PeriodicalIF":0.0,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11335729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142020004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Cognitive assessment in facilitating early detection of dementia.","authors":"Pai-Yi Chiu, Chi-Cheng Yang, Mohammad H Mahoor, Hsin-Te Chang","doi":"10.3389/frdem.2024.1441582","DOIUrl":"10.3389/frdem.2024.1441582","url":null,"abstract":"","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"3 ","pages":"1441582"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11325864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traffic-related air pollution and <i>APOE4</i> can synergistically affect hippocampal volume in older women: new findings from UK Biobank.","authors":"Vladimir A Popov, Svetlana V Ukraintseva, Hongzhe Duan, Anatoliy I Yashin, Konstantin G Arbeev","doi":"10.3389/frdem.2024.1402091","DOIUrl":"10.3389/frdem.2024.1402091","url":null,"abstract":"<p><p>A growing research body supports the connection between neurodegenerative disorders, including Alzheimer's disease (AD), and traffic-related air pollution (TRAP). However, the underlying mechanisms are not well understood. A deeper investigation of TRAP effects on hippocampal volume (HV), a major biomarker of neurodegeneration, may help clarify these mechanisms. Here, we explored TRAP associations with the HV in older participants of the UK Biobank (UKB), taking into account the presence of <i>APOE</i> e4 allele (<i>APOE4</i>), the strongest genetic risk factor for AD. Exposure to TRAP was approximated by the distance of the participant's main residence to the nearest major road (DNMR). The left/right HV was measured by magnetic resonance imaging (MRI) in cubic millimeters (mm³). Analysis of variance (ANOVA), Welch test, and regression were used to examine statistical significance. We found significant interactions between DNMR and <i>APOE4</i> that influenced HV. Specifically, DNMR <50m (equivalent of a chronically high exposure to TRAP), and carrying <i>APOE4</i> were synergistically associated with a significant (<i>P</i> = 0.01) reduction in the right HV by about 2.5% in women aged 60-75 years (results for men didn't reach a statistical significance). Results of our study suggest that TRAP and <i>APOE4</i> jointly promote neurodegeneration in women. Living farther from major roads may help reduce the risks of neurodegenerative disorders, including AD, in female <i>APOE4</i> carriers.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"3 ","pages":"1402091"},"PeriodicalIF":0.0,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11317402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A critical reflection on using the Patient Engagement In Research Scale (PEIRS) to evaluate patient and family partners' engagement in dementia research.","authors":"Joey Wong, Lillian Hung, Cates Bayabay, Karen Lok Yi Wong, Annette Berndt, Jim Mann, Lily Wong, Lynn Jackson, Mario Gregorio","doi":"10.3389/frdem.2024.1422820","DOIUrl":"10.3389/frdem.2024.1422820","url":null,"abstract":"<p><strong>Introduction: </strong>Research involvement of people with lived experiences is increasing. Few tools are designed to evaluate their engagement in research. The Patient Engagement In Research Scale (PEIRS) is one of the few validated tools. Our team employed the PEIRS with patient and family partners with lived experiences of dementia every 6 months in a two-year telepresence robot project. This reflection paper reports our self-study on key learnings and proposes practical tips on using the PEIRS to evaluate patient and family partners' engagement in dementia research. It is the first to document a case using the PEIRS multiple times in a dementia research project.</p><p><strong>Methods: </strong>Guided by Rolfe et al.'s reflective model, we conducted three team reflective sessions to examine the team's experiences using the PEIRS to improve and evaluate patient and family partners' engagement in the research. We also reviewed our meeting notes and fieldnotes documented in the research journal. A reflexive thematic analysis was performed.</p><p><strong>Results: </strong>The team identified three key learnings: the values of using the PEIRS survey, the adaptations, and the factors influencing its implementation as an evaluation tool. Using the PEIRS provided significant benefits to the project, although some patient and family partners felt it was burdensome. The evaluation tool was enhanced with emojis and comment boxes based on suggestions from patient partners. The emojis introduced an element of fun, while the comment boxes allowed for personalized responses. Several factors influenced the PEIRS tool's effectiveness: the interviewer's identity, the confidentiality of responses and follow-ups, the timing and frequency of using the tool, and the presentation of the evaluations. These learnings led to the development of six practical tips,-\"ENGAGE\": Enjoyable and fun process, Never impose, Get prepared early, Adapt to the team's needs, Give people options, and Engage and reflect.</p><p><strong>Conclusion: </strong>With the emerging trend of including people with lived experiences in dementia research, there is a need for ongoing assessment of engagement from both patient and family partners and the research team strategies. Future research can further explore survey logistics, co-development of evaluation tools, and the use of tools with people living with dementia.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"3 ","pages":"1422820"},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11285659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}