Frontiers in dementia最新文献

{"title":"Multimorbidity research in dementia: it's time to shift to a person-centred approach.","authors":"Subhashisa Swain, Kumud Kantilal, Vidyani Suryadevara, Lucy E Stirland","doi":"10.3389/frdem.2026.1791795","DOIUrl":"https://doi.org/10.3389/frdem.2026.1791795","url":null,"abstract":"<p><p>People with dementia often live with several long-term conditions (known as multimorbidity). These conditions interact with dementia in complex ways and influence symptoms, care needs, and quality of life. Current researches are primarily divided into quantitative or qualitative methods without complementing each other. Most data driven research usually counts diagnoses or groups diseases. Qualitative evidence shows the need, and how daily routines, family roles, and personal goals affect care. These methods do not explain how people manage other long-term conditions alongside dementia. As a result, research findings do not always support care that centres on what matters to individuals. This paper proposes a shift in research on multimorbidity in people with dementia. Unlike other conditions, dementia is often diagnosed in later stage of life, with high burden of multimorbidity. We argue that data base research should focus on symptoms, function, treatment workload, and social context, which could shape how people live with dementia and multimorbidity. It can also inform the transitions between home, hospital, community services, and long-term care. These insights can guide the design of interventions that fit real situations. For evidence generation on symptom-based measures, functional assessments, and patient-reported outcomes, mixed methods studies can show how context, mechanisms, and outcomes interact. We offer a research agenda that places the person at the centre and what works for the patient going beyond the simple disease burden. This agenda supports the development of care that is feasible, acceptable, and meaningful. Without this shift, multimorbidity research may not improve everyday dementia care.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"5 ","pages":"1791795"},"PeriodicalIF":0.0,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147848864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Louise Snowball, room #237: exhibiting a multisensory mixed-media installation at a scientific dementia conference.","authors":"Ellen Snowball, Zoe Dempster, Inbal Itzhak, Jennifer Bethell","doi":"10.3389/frdem.2026.1845196","DOIUrl":"https://doi.org/10.3389/frdem.2026.1845196","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/frdem.2026.1758361.].</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"5 ","pages":"1845196"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147848938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating a co-developed pet robot intervention and implementation for residents with dementia in long-term care.","authors":"Wei Qi Koh, Tracy Carroll, Letetia Gimblett, Ellen Murphy, Nicole Gavin","doi":"10.3389/frdem.2026.1791588","DOIUrl":"https://doi.org/10.3389/frdem.2026.1791588","url":null,"abstract":"<p><strong>Background: </strong>Pet robots have the potential to improve the wellbeing of people living with dementia, particularly in residential care contexts. Despite increasing interest in their use and a body of research investigating their impact and effectiveness, more research is needed to support their translation into dementia care practice. This paper reports on the co-development and evaluation of a pet robot intervention and its implementation in a residential aged care facility to support the psychosocial wellbeing of residents living with dementia.</p><p><strong>Methods: </strong>A pet robot intervention protocol and implementation strategies were co-developed in consultation with key stakeholders from a residential aged care facility. Purposive sampling was used to recruit participants (residents) living with dementia. The pet robot intervention was delivered up to three times a week, for up to 30 min each time over a 6-week period. Following the intervention, residents with dementia, their family members and staff involved in delivering the intervention were invited to participate in a semi-structured interview to understand their experiences and perceptions of the impact of the intervention and its implementation. Interviews were audio-recorded, transcribed and analysed using content analysis.</p><p><strong>Results: </strong>Eight residents with dementia had consented to participate, however one had passed away before the intervention commenced. At the end of the intervention period, eight participants including five residents, one family member and two staff consented to participate in the semi-structured interviews. Four key themes were generated: (1) perceptions of the attributes of pet robots, (2) opening doors: facilitating connections and participation, (3) integrating pet robots into routine care, and (4) moving forward: maximising impact and sustainability.</p><p><strong>Conclusion: </strong>This study demonstrates the feasibility and potential impact of a 6-week pet robot intervention and implementation in a RACF facility to support residents living with dementia. Findings provide insights into strategies that might increase the routinisation of pet robots in dementia care; future studies could consider further refining, enhancing and formally evaluating these strategies.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"5 ","pages":"1791588"},"PeriodicalIF":0.0,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13133679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147825866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reimagining U.S. social care policy: a commentary on Medicaid strategies to better support individuals with dementia.","authors":"Alice Boughrum, Amy Lastuka, Nicole Batsch, Victoria Helmly, Mary Manchester, Lillian Morgado, Romil R Parikh, Mary Louise Pomeroy, Audrey Price, Michael Splaine, Raven H Weaver, William Zagorski, Regina A Shih","doi":"10.3389/frdem.2026.1820253","DOIUrl":"https://doi.org/10.3389/frdem.2026.1820253","url":null,"abstract":"","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"5 ","pages":"1820253"},"PeriodicalIF":0.0,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13128397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147825911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palliative care conversations with people with dementia who live alone: untapped dimensions from a lived experience.","authors":"Lesley E Williamson, Dawn Horne, Rasa Mikelyte, Elisabeth B Grey, Pippa Collins, Christopher Poyner, Annabel Farnood, Tomasina M Oh","doi":"10.3389/frdem.2026.1791608","DOIUrl":"https://doi.org/10.3389/frdem.2026.1791608","url":null,"abstract":"<p><p>Dementia is a life-limiting condition, and a palliative care approach can improve both quality of life and quality of care for people living-and dying-with dementia. Research has consistently shown that, compared with other terminal conditions such as cancer, dementia is under-recognised and under-treated within palliative care systems. Considerable attention has been paid to this overall under-representation; however, further inequities exist within palliative dementia care research and practice itself. This position paper draws on an in-depth conversation with a person living alone with Alzheimer's disease and vascular dementia, alongside a critical engagement with existing literature. Using lived experience as a starting point, we identify two untapped dimensions of palliative dementia care: (1) barriers in palliative care conversations when a person with dementia attends clinical appointments unaccompanied; and (2) intersectional disadvantage arising from dementia, living alone, and health and social care systems that overly rely on informal carers or supporters. These contribute to exclusionary research practices that marginalise people living with dementia without close care partners. While the involvement of carers and supporters in shared decision-making should be encouraged when they are present, high-quality palliative care and research must not depend on their presence and should be equally accessible to people living with dementia who attend services alone. We argue that addressing this neglected area requires the meaningful involvement of people with lived experience in shaping both research agendas and clinical practice.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"5 ","pages":"1791608"},"PeriodicalIF":0.0,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147825896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraordinary abilities, creativity, and love, in the path of dementia: a perspective article on the Walking the Talk for Dementia 2025 initiative.","authors":"Madalena P Liougas, Prabha Shrestha, Belen Custodio, Lenisa Brandao, Kevin Cullen, Therese Maher, Karen Young, Alan Young","doi":"10.3389/frdem.2026.1797005","DOIUrl":"https://doi.org/10.3389/frdem.2026.1797005","url":null,"abstract":"<p><p>This manuscript, co-created by researchers and people living with dementia and their care partners, explores how engagement with lived experience can transform conventional, deficit-based understandings of dementia-often defined by what is lost. While clinically useful, this framing can obscure the richness, resilience, and relational depth present in the lives of people living with dementia. Drawing on a collaborative and reflective process inspired by participation in Walking the Talk for Dementia 2025-a global immersive event that brought together people with lived experience of dementia, researchers, advocates, clinicians, and artists-the paper challenges traditional narratives of dementia. Through in-person and virtual discussions and documented reflections, the team conducted a qualitative thematic analysis to identify key insights. Three themes emerged: (1) 'Dementia Reimagined', highlighting personal and professional transformation and new identities; (2) 'Flourishing through Creativity and Resilience', illustrating humor, creativity, leadership, and authentic connection; and (3) 'Dementia as a Catalyst for Love and Understanding', emphasizing enduring love and deepened empathy within families and communities. These findings demonstrate that living with dementia can foster resilience, creativity, and meaningful human connection. This experiential, co-produced approach reframes dementia beyond deficit-based models, offering transformative insights that can inform person-centered care practices, policy development, and increase awareness.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"5 ","pages":"1797005"},"PeriodicalIF":0.0,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13111030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147794677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amyotrophic lateral sclerosis and chronic inflammatory demyelinating polyneuropathy coexistence in a patient with a C9orf72 variant: case report.","authors":"Christopher File, Anthony M Price, Rowaid Ahmad, Elena Shanina, Ruiqing L Sun","doi":"10.3389/frdem.2026.1785124","DOIUrl":"https://doi.org/10.3389/frdem.2026.1785124","url":null,"abstract":"<p><strong>Background: </strong>The <i>C9orf72</i> variation has been strongly implicated in the inheritance of familial ALS, frontotemporal dementia (FTD), and combined ALS-FTD cases. Increasing evidence implicates immune changes and inflammation in some ALS patients. Several studies demonstrated that ALS coexists with CIDP or polyneuropathy. Mouse models of C9orf72 loss-of-function mutations exhibit fatal immune dysregulation.</p><p><strong>Case summary: </strong>A 62-year-old Caucasian man developed right foot drop, and he underwent fibular nerve release without significant improvement. At the same time, he developed progressive weakness and numbness in his bilateral hands. MRI revealed cervical canal stenosis and neuroforaminal narrowing that prompted neurosurgical decompression without clinical improvement. Subsequently, he developed left foot drop. At the clinic presentation, he exhibited dysarthria, tongue fasciculations, weakness in all extremities, muscle atrophy, widespread fasciculations, and upper extremity hyperreflexia, meeting clinical criteria for ALS. Genetic testing identified a pathogenic variant in the C9orf72 gene, confirming a C9orf72 variant, commonly linked to familial ALS. Brain MRI demonstrated the motor band sign. Although EMG/NCS findings were consistent with lower motor neuron disease, he also had signs of demyelinating polyneuropathy based on conduction parameters. Neuromuscular ultrasound showed significant multifocal nerve enlargement typical of immune-mediated neuropathy. CSF studies revealed albuminocytologic dissociation (protein: 112 mg/dL, with normal cell count) and high albumin quotient and index. He fulfilled the 2021 EAN/PNS criteria for possible typical CIDP. He was treated with intravenous immunoglobulin in addition to riluzole with temporary improvement.</p><p><strong>Conclusion: </strong>This is the first case of the co-existence of CIDP and ALS in the setting of a pathogenic C9orf72 variant.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"5 ","pages":"1785124"},"PeriodicalIF":0.0,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147794720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A qualitative study to create a framework of Métis understandings of brain health promotion and dementia prevention in Alberta, Canada.","authors":"Shanaya Fischer, Meagan Ody, Lisa Zaretsky, Jennifer D Walker, Pamela Roach","doi":"10.3389/frdem.2026.1799514","DOIUrl":"https://doi.org/10.3389/frdem.2026.1799514","url":null,"abstract":"<p><strong>Background: </strong>Indigenous populations experience a higher prevalence of dementia compared to non-Indigenous populations. <i>Brain Health PRO</i> is a web-based educational program designed to increase knowledge around dementia risk factors and help create lifestyle changes. The purpose of this study is to understand whether <i>Brain Health PRO</i> is relevant to Métis communities in Alberta, Canada.</p><p><strong>Methods: </strong>Métis participants were recruited across Alberta and interviews were completed using the Métis visiting methodology (Keeoukaywin). Data were co-analysed using Indigenous approaches to reflexive thematic analysis.</p><p><strong>Results: </strong>Sixty-three interviews with 20 participants were completed between April and November 2024. The analysis generated two main themes which suggest the overall design and delivery of <i>Brain Health PRO</i> are not culturally relevant for Métis people in Alberta. The first theme, \"Promoting Métis knowledge systems\" was demonstrated through discussions of the seven components of <i>Brain Health PRO</i> (physical health, cognitive engagement, nutrition, sleep, social and psychological health, vascular health, and vision and hearing), and how these components excluded traditional Métis knowledge. The second theme, \"Holistic approaches to risk reduction\" described the how Métis knowledge could influence the way each component is presented and understood together in a Métis worldview. The subthemes were: importance of interaction and balance of multiple components; benefits of in-person program delivery; brain health promotion across the lifespan; accessing resources; and the legacy of colonization.</p><p><strong>Discussion: </strong>Though the seven components of <i>Brain Health PRO</i> may be useful for Métis people, the content and delivery of these components lacked Métis knowledge and worldviews. In-person engagement with Métis communities is a crucial next step to co-develop resources that are culturally appropriate.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"5 ","pages":"1799514"},"PeriodicalIF":0.0,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13111041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147794667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the cognitive impact of exergames on community-dwelling older adults beyond laboratory settings: a systematic review and meta-analysis.","authors":"Yijun Qian, Anna M Schwartz, Yichi Zhang, Arthur F Kramer, Alexandre Dias Lopes, Leanne Chukoskie","doi":"10.3389/frdem.2026.1768487","DOIUrl":"https://doi.org/10.3389/frdem.2026.1768487","url":null,"abstract":"<p><p>Cognitive decline in older adults is a growing global concern, with over 55 million people living with dementia worldwide. Exercise games, which combine physical exercise with cognitive training in an interactive digital environment, represent a promising approach for mitigating this decline in community settings. Here we present a systematic review and meta-analysis examining the cognitive effects of exercise games on community-dwelling older adults, including those with mild cognitive impairment and dementia. Across 10 randomized controlled trials with 690 participants (mean age 74 years), exercise games produced a small but statistically significant overall cognitive benefit compared to control conditions (Hedges' g = 0.135, 95% CI [0.037, 0.229], <i>p</i> = 0.012). Domain-specific analyses revealed memory showing a trend toward improvement (g = 0.179, <i>p</i> = 0.060), while global cognition, executive function, and attention did not reach statistical significance. A single study examining processing speed showed a positive effect, though this finding requires replication. Multicomponent exercise programs incorporating aerobic elements demonstrated numerically larger, though non-significant, effects (g = 0.291, <i>p</i> = 0.138) compared to aerobic-only interventions (g = 0.119, <i>p</i> = 0.142). The evidence base for clinical populations remains limited and inconclusive, with only two studies examining MCI (g = 0.256, <i>p</i> = 0.168) and three studies examining dementia (g = 0.005, <i>p</i> = 0.975), neither showing statistically significant effects. These findings provide preliminary evidence supporting exercise games as a modest, accessible supplementary intervention for cognitive health in community settings, though the small effect sizes and limited evidence in clinical populations indicate that substantially more research with larger samples and standardized protocols is needed to establish efficacy and optimize implementation.</p><p><strong>Systematic review registration: </strong>https://doi.org/10.17605/OSF.IO/AM8QT.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"5 ","pages":"1768487"},"PeriodicalIF":0.0,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13105986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147794736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in dementia care: challenges, controversies, and policy implications.","authors":"Natalia Vilor-Tejedor, Robert van Vorstenbosch, Tavia E Evans","doi":"10.3389/frdem.2026.1791195","DOIUrl":"https://doi.org/10.3389/frdem.2026.1791195","url":null,"abstract":"<p><p>Artificial intelligence (AI) is rapidly expanding into dementia-related health and social care, with proposed applications ranging from early risk detection and monitoring to care coordination and service planning. While these technologies may support independence, reduce caregiver burden, and improve efficiency in overstretched systems, dementia care is a uniquely high-stakes context for digital innovation. Cognitive decline can affect consent and agency, care often occurs in private domestic settings, and individuals may become increasingly dependent on others to interpret and act on algorithmic outputs. This Perspective examines the opportunities and challenges of AI in dementia policies and services, focusing on equity, privacy, accountability, and the risk that technologies displace human care. We argue that AI tools are only as reliable and fair as the data and infrastructures on which they depend, and that uneven access to digital resources may widen disparities in diagnosis, monitoring, and support. We also highlight often-overlooked considerations, including environmental sustainability and the broader role of AI in shaping exposures relevant to brain health across the life course. Whether AI improves dementia care will ultimately depend on policy and governance choices, including investment in equitable digital infrastructure, robust real-world validation, and safeguards that prevent technology from substituting for human care. Finally, we propose governance priorities to ensure that AI-enabled dementia innovations are implemented as a public-interest matter, grounded in meaningful engagement of people living with dementia and care partners, real-world validation, and safeguards that protect dignity, autonomy, and social legitimacy.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"5 ","pages":"1791195"},"PeriodicalIF":0.0,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13105861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147794690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}