Frontiers in dementia最新文献

{"title":"Case report: Behavioral variant FTD confounding a language variant FTD in a case of PSP-CBS.","authors":"Alexandra V Jürs, Elisabeth Kasper, Manuela Neumann, Jens Kurth, Bernd J Krause, Daniel Cantré, Johannes Prudlo","doi":"10.3389/frdem.2025.1540519","DOIUrl":"10.3389/frdem.2025.1540519","url":null,"abstract":"<p><p>Frontotemporal dementia (FTD) occurs in two main clinical subtypes, which can transition into one another: the behavioral variant (bvFTD) and the language variant (primary progressive aphasia; PPA). It is common for the latter, as primary progressive aphasia (PPA), to transition into bvFTD; however, the opposite development, where bvFTD is followed by \"secondary progressive aphasia,\" has received little attention. This constellation is particularly challenging to recognize as frontal dysexecutive syndrome can confound subsequent progressive aphasia as impulsive behavior, a lack of inhibition, and apathy can lead to non-aphasic communication disturbances, including impoverished syntax, reduced cognitive flexibility, and insufficient error monitoring. A 78-year-old patient, with a disease duration of 10 years, was initially diagnosed in the 3rd year of the disease with corticobasal syndrome (CBS) with frontal behavioral-spatial syndrome (CBS-FBS) and subsequently with CBS with progressive non-fluent aphasia (CBS-PNFA) in the 4th year. Severe ophthalmoplegia was the reason for changing the diagnosis in the seventh year to progressive supranuclear palsy with CBS predominance type (PSP-CBS). The pathological diagnosis was FTLD-tau in the form of a PSP subtype. The MRI showed asymmetric atrophy, particularly of the left insular cortex and the left inferior frontal gyrus. The 2-[¹⁸F]FDG-PET revealed left-accentuated bifrontal glucose hypometabolism. This case report highlights how progressive neurodegenerative aphasia can occur in FTD not only as a primary language phenomenon (in the sense of PPA) but also as a secondary phenomenon (following a primary behavioral disorder with a non-aphasic communication disorder). Dysexecutive syndrome can mask aphasia. Therefore, incorporating spontaneous speech tasks into standard neuropsychological language tests, in addition to MRI and PET imaging techniques, could help better recognize such secondary aphasias, even in the presence of dysexecutive syndrome, and thus broaden our understanding of the natural history of FTD.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"4 ","pages":"1540519"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wayfinding behavioral patterns of seniors with dementia: two exploratory case studies.","authors":"Leonie van Buuren, Daantje Derks, Masi Mohammadi, Bernard Colenbrander","doi":"10.3389/frdem.2025.1524425","DOIUrl":"10.3389/frdem.2025.1524425","url":null,"abstract":"<p><strong>Introduction: </strong>While wayfinding is vital for quality of life, it is also a declining skill for people with dementia. Understanding wayfinding behavioral patterns of people with dementia helps to improve the nursing home corridor designs to facilitate autonomously conducting activities of daily life. However, a comprehensive image of these patterns is lacking.</p><p><strong>Methods: </strong>An empirical qualitative study was conducted, studying seven wayfinding behavioral patterns of people with advanced dementia (<i>n</i> = 8) in two nursing home corridors where they live, using fly-on-the-wall observation.</p><p><strong>Results: </strong>The data show that the most frequent wayfinding behavioral patterns observed were \"movements\" followed by \"looking at\", \"stops on the route\", and \"verbal navigational cues\".</p><p><strong>Discussion: </strong>These behaviors occurred often at crossroads; i.e., places in which participants should make a decision concerning continuing their route. Spatially, these places have high-visibility values and many things to see for people with dementia. Contradictory, these places might cause more confusion for people with dementia. Therefore, special attention should be paid to the design of these spaces.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"4 ","pages":"1524425"},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Differentiation of Alzheimer's disease from other neurodegenerative disorders using chemiluminescence immunoassays measuring cerebrospinal fluid biomarkers.","authors":"Philipp Arendt, Katharina Römpler, Britta Brix, Viola Borchardt-Lohölter, Mandy Busse, Stefan Busse","doi":"10.3389/frdem.2025.1568275","DOIUrl":"https://doi.org/10.3389/frdem.2025.1568275","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/frdem.2024.1455619.].</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"4 ","pages":"1568275"},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Informed consent in dementia research: how Public Involvement can contribute to addressing \"old\" and \"new\" challenges.","authors":"Ana Diaz, Cindy Birck, Angela Bradshaw, Jean Georges, Daphne Lamirel, Soraya Moradi-Bachiller, Dianne Gove","doi":"10.3389/frdem.2025.1536762","DOIUrl":"10.3389/frdem.2025.1536762","url":null,"abstract":"<p><p>Informed consent is a critical ethical requirement in research, ensuring the protection of participants' rights and promoting their wellbeing and autonomy. In dementia research, this process becomes particularly complex due to cognitive impairments and fluctuating capacity. While substantial work has been done to address these challenges, much of the literature on informed consent in dementia research has been shaped by the perspectives of researchers and healthcare professionals, with less focus on those with lived experience. This paper provides an overview of the perspectives of people with dementia and their carers resulting from Public Involvement activities organized by Alzheimer Europe. It builds on Alzheimer Europe's previous work with the European Working Group of People with Dementia and draws on discussions held during a face-to-face meeting about Participant Informed Consent forms and processes used in two specific European projects. We highlight views and key concerns raised by people with lived experience regarding the informed consent process, including barriers and facilitators. In addition to ensuring understandability, the discussions emphasized the importance of promoting respect and autonomy, ensuring that the values and interests of people with lived experience remain central throughout the research process. This paper contributes to the ongoing dialogue on improving informed consent practices in dementia research, highlighting the need for continuous involvement and the inclusion of people with lived experience in shaping consent practices to address both old and emerging challenges (i.e., new types of research such as artificial intelligence and data sharing/re-use) in dementia research.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"4 ","pages":"1536762"},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining familiarity in nursing homes providing care for residents with dementia: a scoping review.","authors":"Joanna Sun, Sumiyo Brennan, Therese Doan","doi":"10.3389/frdem.2025.1470066","DOIUrl":"10.3389/frdem.2025.1470066","url":null,"abstract":"<p><strong>Objective: </strong>This study explores the underpinning definitions associated with familiarity in the context of dementia inclusive design and nursing home environment.</p><p><strong>Background: </strong>Environmental design in nursing homes impacts the quality of life and care of residents with dementia. One of the key principles of design is the need for the environment to achieve a sense of familiarity. However, there are divergent perspectives regarding the term \"familiarity.\" Inconsistent definitions are challenging to understand, and they continue to impact the implementation of good design. To that end, this scoping review examines the definitions and associated with familiarity, dementia, and the design of nursing home environments.</p><p><strong>Methods: </strong>The Arksey and O'Malley methodological framework and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews ensure the rigor of the scoping review. Searches were conducted using six databases for peer-reviewed publications in English from 1991 to 2023. Search terms included \"dementia,\" \"nursing home,\" \"long-term care,\" \"familiar,\" \"familiarity,\" and \"environments.\"</p><p><strong>Results: </strong>The searches yielded 245 publications. Of those, 46 studies from 19 countries were included in this review. The review uncovered three central themes and compelling evidence citing the inclusion of homelike environments. Emphasis on design considerations includes the wellbeing of the designated population and the need to embrace multisensory integration in the design process.</p><p><strong>Conclusions: </strong>A strong link exists between familiarity and key design considerations, such as a homelike environment, wellbeing, and multisensory integration. These considerations can enhance the effectiveness of the design of familiar environments.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"4 ","pages":"1470066"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating neuropathological correlates of hyperactive and psychotic symptoms in dementia: a systematic review.","authors":"Giulia Negro, Michele Rossi, Camillo Imbimbo, Alberto Gatti, Andrea Magi, Ildebrando Marco Appollonio, Alfredo Costa, Tino Emanuele Poloni","doi":"10.3389/frdem.2025.1513644","DOIUrl":"10.3389/frdem.2025.1513644","url":null,"abstract":"<p><strong>Introduction: </strong>Behavioral and Psychological Symptoms of Dementia (BPSD) are common neuropsychiatric manifestations that complicate the clinical course of dementia and impact caregiving. Among these, the Hyperactivity-Impulsivity-Irritiability-Disinhibition-Aggression-Agitation (HIDA) and Psychosis (P) domains are particularly challenging to manage. Despite their prevalence, their underlying mechanisms and neuropathological correlates, remain poorly understood. This systematic review aims to elucidate the neuropathological basis of the HIDA and psychosis domains, exploring whether distinct proteinopathies and neural circuit dysfunctions are associated with these symptoms.</p><p><strong>Methods: </strong>The review follows PRISMA guidelines, with a systematic search conducted across MEDLINE, CENTRAL, and EMBASE databases. Inclusion criteria involved studies exploring the neuropathology of the HIDA and psychosis domains in individuals with dementia. Records were screened using PICO software, and data quality was assessed using the Newcastle-Ottawa Scale (NOS) and CARE guidelines. A narrative synthesis was conducted due to heterogeneity in the data.</p><p><strong>Results: </strong>From 846 records identified, 37 studies met inclusion criteria. Of the 18,823 cases analyzed, the most common diagnoses were Alzheimer's Disease (83.44%), Dementia with Lewy Bodies (5.37%), and Frontotemporal Dementia (13.40%). HIDA-P symptoms were distributed across all clinical diagnoses, with agitation (14.00%), delusions (11.60%), disinhibition (7.61%), and hallucinations (6.83%) being the most frequently reported behaviors. The primary neuropathological diagnosis was Alzheimer's Disease Neuropathologic Change (ADNC), present predominantly in intermediate to severe forms. The neuropathological analysis revealed the co-occurrence of multiple proteinopathies, particularly TAUopathy, TDP-43 pathology, and Lewy-related pathology (LRP), with the latter, in association with ADNC, reported in 15 studies.</p><p><strong>Discussion: </strong>HIDA-P symptoms were linked with overlapping involvement of different neural circuits, particularly the amygdala and the broader limbic system. Evidence suggests that TAUopathy and multiple proteinopathies in key brain regions, such as amygdala, are central to the development of these symptoms. In contrast, the contribution of beta-amyloid and vascular damage appears marginal in the genesis of HIDA and psychotic symptoms. No behavioral symptom is pathognomonic of a specific proteinopathy; rather, the topography and severity of lesions plays a more decisive role than their single molecular composition.</p><p><strong>Systematic review registration: </strong>INPLASY2024100082.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"4 ","pages":"1513644"},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11814221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hormone replacement therapy, menopausal age and lifestyle variables are associated with better cognitive performance at follow-up but not cognition over time in older-adult women irrespective of APOE4 carrier status and co-morbidities.","authors":"Tamlyn J Watermeyer, Sarah Gregory, Emmi Leetham, Chinedu T Udeh-Momoh, Graciela Muniz-Terrera","doi":"10.3389/frdem.2024.1496051","DOIUrl":"10.3389/frdem.2024.1496051","url":null,"abstract":"<p><strong>Introduction: </strong>The impact of Hormone Replacement Therapy (HRT) on cognitive function in postmenopausal women remains a topic of considerable debate. Although estrogen's neuroprotective effects suggest potential cognitive benefits, empirical findings are mixed.</p><p><strong>Methods: </strong>This study uses data from the Cognitive Function and Ageing Study Wales (CFAS Wales) cohort to explore the relationships between HRT use, age at menopause, APOE4 carrier status, lifestyle factors, comorbidities, and cognitive outcomes in older adult women. Two regression models were employed: one analyzing cognitive performance at follow-up and another examining changes in cognitive scores over time.</p><p><strong>Results: </strong>Results indicate that while age, education, HRT use, age at menopause, alcohol consumption, and diet were associated with cognitive function at a single later time point, only age remained a significant predictor when modeling cognition over time.</p><p><strong>Discussion: </strong>These findings suggest that while HRT, menopausal age and lifestyle factors may support cognitive stability, they do not necessarily predict cognitive decline in post-menopausal older women. A major limitation of the current work is the lack of detail regarding HRT use, such as formulation, timing and duration; caveats that future studies should address. The study underscores the need for longer follow-up periods, consideration of other female-specific risk factors, and more comprehensive lifestyle and health assessments to clarify the complex interplay between HRT use, reproductive history, lifestyle, comorbidities and cognitive aging in women.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"3 ","pages":"1496051"},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"A torch, a rope, a belly laugh\": engaging with the multiple voices of support groups for people living with rare dementia.","authors":"Paul M Camic, Emma Harding, Sam Rossi-Harries, Oliver S Hayes, Mary Pat Sullivan, Lawrence Wilson, Nikki Zimmermann, Roberta McKee-Jackson, Joshua Stott, Nick C Fox, Catherine J Mummery, Jonathan D Rohrer, Jason D Warren, Rimona S Weil, Sebastian James Crutch","doi":"10.3389/frdem.2024.1488025","DOIUrl":"10.3389/frdem.2024.1488025","url":null,"abstract":"<p><strong>Purpose: </strong>Rare forms of dementia bring unique difficulties related to age of onset, impact on family commitments, employment and finances, and also bring distinctive needs for support and care. The aim of the present study was to explore and better understand what the concept of support means for people living with different rare dementia (PLwRD) and their care-partners who attend ongoing support groups.</p><p><strong>Methods: </strong>Representing seven types of rare dementia, source material was collected from 177 PLwRD and care-partners attending in-person support groups, with the goal of developing research-informed group poems, co-constructed by a facilitating poet. Data were analyzed through a three-step process involving linguistic analysis followed by structured-tabular thematic analysis, relational analysis, and concluded with an online survey about participation in the study.</p><p><strong>Results: </strong>Linguistic analysis found that co-constructed poems remained faithful to the original source material offered by participants. These results provided confidence to subsequently conduct a thematic analysis of eight completed poems, identifying 15 initial themes. A further relational analysis between themes drew on six relational forms and identified an overarching theme \"A Community, Not an Intervention\" that describes the process of support for this population. Survey results revealed a varied but generally positive response to writing whilst reactions to the completed poems reflected strong emotional connections that resonated with personal experience.</p><p><strong>Conclusion: </strong>This is the first study that we are aware of to explore the use of co-constructed research poetry to better understand how in-person support groups provide support for people impacted by different rare dementias. The poems portray the complex, dynamic and relational aspects of how support groups provide a necessary form of connection for this population. An overarching theme characterized the support groups as a community rather than an intervention. Findings are discussed within the theoretical context of positive social identity, social health and biosocial groups. The results also demonstrate that solicited words from participants can be faithfully portrayed in poems co-created by an experienced poet. This novel finding expands methodological options for the use of research poetry in healthcare and also offers support group members further creative choices for engagement, connection and communication.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"3 ","pages":"1488025"},"PeriodicalIF":0.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dementia incidence among a cohort of lebanese older adults: first incidence estimates from the Middle East and North Africa region.","authors":"Monique Chaaya, Sarah Assaad, Hala Darwish, Marc Haber, Rosemary Khoury, Dahlia Saab, Khalil El Asmar, Ramzi Hajjar","doi":"10.3389/frdem.2024.1494719","DOIUrl":"10.3389/frdem.2024.1494719","url":null,"abstract":"<p><strong>Objective: </strong>To provide the first estimates of dementia incidence rates among elderly in Lebanon.</p><p><strong>Methods: </strong>The cohort established in 2013 consisted of 470 elderly from Beirut and Mount Lebanon, who consented to be followed-up. In 2017, we reached 341 participants/informants, achieving a response rate of 72.6%. The validated Arabic version of the 10/66 Dementia Research Group diagnostic tool was administered through face-to-face interviews. Direct age standardization was applied to the data using the Western European population distribution. Age-, sex- and location-specific incidence rates were estimated.</p><p><strong>Results: </strong>After 3.5 years of follow up, 19 new cases of dementia were identified among 229 surviving participants. The crude incidence rate was 16.8 per 1,000 p-y, and the age standardized rate was 20.5 per 1,000 p-y. The incidence rate increased with age, going from 6.5 for those aged 65-74 years to 54.0 for those aged 85-89 years. Incidence rate was higher among females than males (20.7 vs.12.0), and higher in Mount Lebanon, as compared to the capital city Beirut (19.5 vs.14.9).</p><p><strong>Conclusion: </strong>Dementia incidence rate was close to European and North American countries' estimates. The use of validated tools increased the internal validity of our results. A large cohort study is warranted to confirm these results.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"3 ","pages":"1494719"},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the prevention approach in National Dementia Plans from European and North American countries.","authors":"Mattia Andreoletti, Alessandro Blasimme","doi":"10.3389/frdem.2024.1463837","DOIUrl":"10.3389/frdem.2024.1463837","url":null,"abstract":"<p><strong>Objectives: </strong>This paper aims to provide a comprehensive review of National Dementia Plans (NDPs) from selected European and North American countries, focusing on the distinct prevention strategies outlined and the approaches employed for reducing dementia risk.</p><p><strong>Method: </strong>The sample consisted of 16 NDPs from Austria, Canada, Finland, France, Germany, Greece, Ireland, Italy, Liechtenstein, Luxembourg, Malta, the Netherlands, Spain, Switzerland, the UK, and the USA. These NDPs were retrieved from the Alzheimer's Disease International (ADI) database, with regular updates checked on official governmental websites. A qualitative analysis was conducted to identify common themes related to the vision, goals, and corresponding actions and measures within these strategies.</p><p><strong>Results: </strong>Our analysis revealed that dementia prevention is a strategic goal for most of the countries studied. Common actions identified include the identification of risk factors, advancing research, promoting healthy aging, increasing public awareness, and encouraging lifestyle interventions.</p><p><strong>Conclusion: </strong>We discuss the limitations and challenges of these actions, and more broadly, of the NDPs in relation to the recent literature on the most effective approaches to preventing dementia. We suggest adopting a more \"horizontal\" approach to dementia prevention, which current NDPs overlook in favor of \"vertical\" paradigms.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"3 ","pages":"1463837"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11738615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}