Frontiers in dementia最新文献

{"title":"MRI evaluation of cerebral perivascular spaces predicts amyloid-related imaging abnormalities risk in preclinical Alzheimer's disease.","authors":"Bavrina Bigjahan, Michele Cavallari, Giuseppe Barisano","doi":"10.3389/frdem.2026.1719740","DOIUrl":"https://doi.org/10.3389/frdem.2026.1719740","url":null,"abstract":"<p><strong>Background and purpose: </strong>Amyloid-related imaging abnormalities (ARIA) are radiographic findings observed in the natural course of Alzheimer's disease and have been reported at higher rates in patients receiving anti-amyloid monoclonal antibody therapy. Identifying novel radiographic factors predicting ARIA risk may help prevent its occurrence, improve patient stratification, and provide insight on the underlying biological mechanisms. It remains unclear whether cerebral perivascular spaces (PVS) along with other quantitative radiographic markers of cerebral small vessel disease may help predict the risk of incident ARIA in patients diagnosed with preclinical Alzheimer's disease.</p><p><strong>Methods: </strong>Participants from the A4 study were included. PVS and white matter hyperintensities (WMH) were segmented with robust fully-automated methods on T1-weighted and FLAIR images, respectively. Number of microhemorrhages and subcortical infarcts were previously recorded by expert radiologists. Baseline measurements of these markers were used in Cox proportional-hazards models to predict ARIA risk controlling for relevant demographic, clinical, and radiographic factors.</p><p><strong>Results: </strong>Among 6,028 brain MRI from 1,088 participants (median age: 71-y.o.; 59.4% women), 356 ARIA were diagnosed (median study follow-up: 5.4 years). The volume fraction of PVS and WMH, and the number of microhemorrhages at baseline predicted higher ARIA risk (adjusted hazard ratio ranges: 1.32-1.55; adjusted <i>p</i>-values all <0.05). Importantly, the effect of PVS on ARIA with microhemorrhages risk was observed in individuals considered at low risk of ARIA according to current guidelines, i.e., APOE-ε4 non-carriers, low WMH burden, or no microhemorrhages.</p><p><strong>Conclusions: </strong>These results support the use of quantitative measurements of PVS in addition to WMH and microhemorrhages to assist clinicians in estimating an individual's risk of ARIA.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"5 ","pages":"1719740"},"PeriodicalIF":0.0,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147794701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-driven magnetoencephalography biomarkers in dementia risk prediction: current evidence, challenges and future perspectives.","authors":"Electra Chatzidimitriou, Charis Styliadis, Katherine P Rankin, Despina Moraitou, Panagiotis Ioannidis, Panagiotis D Bamidis","doi":"10.3389/frdem.2026.1743627","DOIUrl":"https://doi.org/10.3389/frdem.2026.1743627","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Dementia imposes a substantial global healthcare burden, with rising prevalence and limited disease-modifying treatments. Early identification of at-risk individuals is critical for timely intervention and care planning. Magnetoencephalography (MEG) provides high-temporal-resolution measurements of neuronal activity, capturing subtle functional alterations that precede clinical symptoms. Artificial intelligence (AI), particularly machine learning (ML), can leverage MEG's rich spatiotemporal information to enhance diagnostic accuracy and dementia risk prediction. This scoping review synthesizes current evidence on AI-driven MEG analysis for the classification, prediction, and prognosis of MCI and dementia, focusing on methodological approaches, predictive performance, and translational potential.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A systematic PubMed-MEDLINE search identified studies published between January 2015 and October 2025, capturing the last decade's rapid evolution of AI methodologies and their integration with neurophysiological research. Search terms combined MEG, AI, and ML with cognitive impairment and dementia. Eligible studies were peer-reviewed original research, involved human participants, employed MEG, and applied AI algorithms for classification or prediction. Extracted data included study population characteristics, MEG features, ML models, predictive biomarkers, and performance metrics.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Fourteen studies met eligibility criteria, covering populations from healthy controls to individuals with subjective cognitive decline, MCI, AD, and other dementias. MEG systems varied, with most studies employing 306-channel whole-head systems. ML algorithms ranged from traditional approaches, such as support vector machines and random forests, to deep learning architectures, including convolutional neural networks. Reported classification accuracies ranged from moderate (~60%) to high, with several studies achieving over 80% in distinguishing diagnostic categories or predicting MCI-to-AD progression. Key biomarkers included alterations in frequency-specific oscillatory activity, functional connectivity patterns, and large-scale network dynamics. Multimodal approaches integrating MEG with structural neuroimaging further improved predictive performance.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion/conclusions: &lt;/strong&gt;Despite heterogeneity across study designs, AI-driven MEG analyses hold significant translational potential for early, non-invasive dementia prediction, enhancing diagnostic and prognostic accuracy. Advancing clinical translation will require standardized preprocessing pipelines, larger multicenter cohorts, and explainable AI frameworks. Future research should leverage next-generation MEG technologies, such as optically pumped magnetometers, to capture brain dynamics in ecologically valid, real-world scenarios. Integrating these data with AI-driven multimodal biomarkers will improve in","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"5 ","pages":"1743627"},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13095543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147794728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment priorities from the perspectives of people with dementia with Lewy bodies: a reflexive thematic analysis.","authors":"Paula Sinead Donnelly, Kathryn Mitchell, Noleen K McCorry, Marco Boeri, Anthony Peter Passmore, Joseph P M Kane","doi":"10.3389/frdem.2026.1721320","DOIUrl":"https://doi.org/10.3389/frdem.2026.1721320","url":null,"abstract":"<p><strong>Introduction: </strong>Treatment priorities in dementia with Lewy bodies (DLB) have important implications for outcome selection and measurement in clinical trials and for person-centered care. The reasons underlying these priorities remain unclear. This study explored these reasons from the perspectives of people with DLB.</p><p><strong>Methods: </strong>A qualitative component was embedded within a larger stated-preference study. As part of orally administered surveys, eight people with DLB answered an open-ended question regarding which symptoms they considered most important to treat and why. Responses were analyzed using reflexive thematic analysis.</p><p><strong>Results: </strong>Six themes were identified: (1) Cognitive and functional decline as a threat to autonomy, safety, and self, (2) Motor symptoms and pain as barriers to identity, activity, and wellbeing, (3) Autonomic symptoms as sources of stigma, shame, and disruption, (4) Sleep as a foundation for functioning in daily life, (5) Neuropsychiatric and psychological symptoms and the erosion of connection, motivation, and self, and (6) Navigating symptom complexity and uncertainty.</p><p><strong>Discussion: </strong>Symptoms were prioritized for their frequency and severity, and for the ways in which they threatened valued aspects of life, such as autonomy, safety, intimacy, and sense of self. Participants' reasoning therefore drew attention to relatively understudied dimensions of living with DLB. Although the sample was modest, participants' accounts provided rich insights into the lived experience of DLB and its consequences for this under-researched population. The findings provide evidence to guide outcome selection in trials and highlight the need for outcome measures that capture multidimensional domains reflecting fundamental human needs, ideally through DLB-specific instruments.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"5 ","pages":"1721320"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13079032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147701787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain and Nutrition in Dementia and Alzheimer's Phase 1: a cross-sectional, observational study design.","authors":"Taylor C Judkins, Hailey J Andrews, Qianqian Song, Edward I Clark, Camesha Tate, Joshua I Wais, Roger Fillingim, Zhiguang Huo, Steven T DeKosky, Barabara Gower, Ronald A Cohen, Natalie C Ebner, Yenisel Cruz-Almeida, Larissa J Strath","doi":"10.3389/frdem.2026.1789761","DOIUrl":"https://doi.org/10.3389/frdem.2026.1789761","url":null,"abstract":"<p><strong>Background: </strong>Neurodegenerative diseases such as Alzheimer's Disease and related dementias (ADRDs) as well as chronic pain have increased in prevalence as the population ages. In fact, recent epidemiological research suggests that having chronic pain may increase one's risk of all-cause dementia. There are mechanistic factors that overlap in both ADRD and chronic pain progression, including epigenetic dysregulation that could lead to increased inflammation. Previously, our group presented evidence that dietary patterns impact inflammatory potential and epigenetic modifications, and accelerate epigenetic aging. Here, we hypothesize that diet- induced inflammation and epigenetic alterations may be underexplored mechanistic pathways connecting chronic pain and ADRD risk.</p><p><strong>Methods: </strong>The Pain and Nutrition in Dementia and Alzheimer's Phase 1 (PANDA-1) study is a cross-sectional, observational study, which will recruit 90 individuals ≥55 years of age with and without painful knee osteoarthritis (OA). Biological samples will be collected to assess study eligibility, blood-based inflammatory markers, and epigenetic age using the epigenetic clock DNAmGrimAge. A 24-h dietary recall will be completed to determine nutrition status via the Dietary Inflammation Index (DII). Pain and psychosocial questionnaires will be employed to determine pain phenotypes. Quantitative Sensory Testing will be conducted to determine responses to noxious mechanical and thermal stimuli. Lower-extremity function and mobility measures will also be obtained. Finally, height, weight, pain history, medical history, medication use, and demographic variables will be collected as covariates. Hierarchical regression, mediation and moderation analyses, as well as ANOVAs will be conducted to evaluate relationships among the DII, epigenetic aging, cognition status, and pain.</p><p><strong>Conclusion: </strong>This study will integrate dietary, epigenetic, and cognitive assessments in a chronic pain population, to lay the groundwork of a possible associations linking chronic pain and ADRDs. PANDA-1 aims to determine potential relationships of dietary patterns on interindividual variability of cognitive status and pain outcomes in older adults deemed cognitively intact. Subsequent phases of this study will include individuals with mild cognitive impairment and ADRDs. Findings from this work will inform future studies targeting dietary intervention approaches to mitigate overlapping neurodegenerative and pain-related aging processes.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"5 ","pages":"1789761"},"PeriodicalIF":0.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Louise Snowball, room #237: exhibiting a multisensory mixed-media installation at a scientific dementia conference.","authors":"Ellen Snowball, Zoe Dempster, Inbal Itzhak, Jennifer Bethell","doi":"10.3389/frdem.2026.1758361","DOIUrl":"10.3389/frdem.2026.1758361","url":null,"abstract":"<p><p>This article describes exhibiting an interactive art installation about dementia and long-term care at the Canadian Consortium on Neurodegeneration in Aging (CCNA) Partners Forum and Science Days (PFSD), authored from the perspectives of the artist, people with lived experience of dementia and event organizers. We outline examples of collaborating with the Engagement of People with Lived Experience of Dementia (EPLED) Advisory Group to organize the exhibit. We also report evaluation data from diverse audiences, including researchers, trainees and others, demonstrating that the artwork was a highly valued part of the scientific conference, impacting perceptions of dementia and increasing awareness of lived experience engagement in research.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"5 ","pages":"1758361"},"PeriodicalIF":0.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herpes simplex virus 2 and dementia risk: a systematic review and meta-analysis.","authors":"C J Hunt, Brinley N Zabriskie, Ethan J Coulter, Morgan Chase McClellan, Grace Templeton, Reagan Erbstoesser, Scott MacLean, Chris H Miller, Jarod Moss, Caitlyn Carter, Shawn D Gale, Jonathan D Moore, Thomas J Farrer, Dawson W Hedges","doi":"10.3389/frdem.2026.1737068","DOIUrl":"https://doi.org/10.3389/frdem.2026.1737068","url":null,"abstract":"<p><strong>Introduction: </strong>Several potentially modifiable risk factors for dementia have been identified, including infectious diseases. Among the infectious diseases potentially associated with dementia is herpes simplex virus type-2 (HSV-2).</p><p><strong>Methods: </strong>To better characterize the association between HSV-2 and dementia, we conducted a meta-analysis of published peer-reviewed studies reporting HSV-2 exposure and dementia outcomes.</p><p><strong>Results: </strong>Of 626 identified primary studies, eight met our inclusion criteria, with one of these excluded due to overlapping data with another study, yielding seven independent studies (total <i>N</i> = 751,156). Meta-analyses found no significant association between HSV-2 infection and Alzheimer's disease (pooled odds ratios ≈ 1.1, 95% confidence intervals included the null across all methods). Similarly, when pooling odds ratios across studies examining all-cause dementia, results were non-significant (pooled odds ratios ≈ 1.2, 95% confidence intervals included 1). In contrast, pooled hazard ratios from three studies for all-cause dementia suggested a possible increased risk among individuals with HSV-2 (DerSimonian and Laird pooled hazard ratio = 1.37, 95% CI: 1.00-1.89; Hartung-Knapp-Sidik-Jonkman pooled hazard ratio = 1.35, 95% CI: 0.58-3.14), driven primarily by two significant studies.</p><p><strong>Discussion: </strong>Overall, the available evidence indicates no clear association between HSV-2 and Alzheimer's disease and only one of the two meta-analytic methods shows evidence of a potential relationship with all-cause dementia. These findings support continued investigation into the association between HSV-2 and dementia.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"5 ","pages":"1737068"},"PeriodicalIF":0.0,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147641172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Farm-based therapeutic horticulture for people living with dementia: the Vicenza Farm Project.","authors":"Leonardo Dalla Costa, Francesca Meneghello, Costantina Righetto, Giulio Senes","doi":"10.3389/frdem.2026.1772835","DOIUrl":"https://doi.org/10.3389/frdem.2026.1772835","url":null,"abstract":"<p><p>Dementia is a major global health challenge, with wide-ranging psychosocial and relational impacts that call for supportive, everyday interventions alongside clinical care. While advances in Alzheimer's disease are promising, dementia includes multiple conditions, including young-onset forms, and existing pharmacological and non-pharmacological interventions still offer valuable but incomplete support, often leaving everyday psychosocial needs unmet for most people living with dementia. This Perspective describes the Vicenza Farm Project, a farm-based therapeutic horticulture program developed on social and educational farms of Northern Italy. The program offers weekly 3-h group sessions from March to October for around 8-10 participants, including people with young-onset dementia, facilitated by a multidisciplinary team of farmers, psychologists and trained volunteers. Activities follow a structured, replicable protocol that combines cognitive stimulation, seasonal gardening and farm tasks, shared breaks and closing reflection, with an emphasis on supported participation, personal agency and safe freedom. Drawing on qualitative and quantitative data from international literature on nature-based and care farming interventions, we outline how a farm-based therapeutic horticulture can help restore purpose, social connection and embodied identity while also animating rural spaces and reinforcing environmentally sensitive farming practices. We contrast the Italian policy framework of social agriculture, in which therapeutic horticulture is not yet recognized as a health intervention, with the more institutionalized Dutch model of green care farms, and we propose priorities for evaluation, integration into dementia pathways and long-term funding.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"5 ","pages":"1772835"},"PeriodicalIF":0.0,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13035757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating dementia care: a qualitative study of family care partners' experiences in managing behavioural and psychological symptoms in Lima, Peru.","authors":"Belen Custodio, Åsa Dorell","doi":"10.3389/frdem.2026.1774816","DOIUrl":"10.3389/frdem.2026.1774816","url":null,"abstract":"<p><strong>Introduction: </strong>Supporting a person living with dementia involves multiple challenges, particularly when responding to changes in behaviour and psychological symptoms, which can be emotionally demanding for care partners. Despite this, limited research has examined how care partners in Latin America experience and respond to these symptoms. Therefore, this study aims to gain an understanding of how family care partners of persons living with dementia experience and cope with behavioural and psychological dementia symptoms (BPSD).</p><p><strong>Methods: </strong>A qualitative study was carried out using semi-structured interviews with 17 family care partners of individuals with clinically confirmed dementia and BPSD, recruited from a private neurology clinic in Lima, Peru. Data were analysed using reflexive thematic analysis.</p><p><strong>Results: </strong>Three main themes were identified: (1) caregiving as an emotional and behavioural challenge, (2) the role of adaptation and flexibility when managing BPSD, and (3) building the care partner's emotional well-being to support care. Care partners reflected on the challenges that arose from changes in behaviour in the people living with dementia, noting how these shifts sometimes influenced relationships and emotional well-being. In response, they employed adaptive strategies including modified communication, environmental adjustments, avoiding confrontation, and self-care.</p><p><strong>Discussion: </strong>Managing BPSD places a substantial emotional challenge on family care partners in Lima, Peru. Nonetheless, care partners actively develop strategies to respond to these situations. These findings contribute novel insights into dementia caregiving in underrepresented populations in Latin America and highlight the importance of understanding caregiving experiences in diverse cultural contexts.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"5 ","pages":"1774816"},"PeriodicalIF":0.0,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13033498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amyloid-β acute exposition affects the CA1 hippocampal network activity and its topological organization, evaluated with multielectrode arrays.","authors":"David Alcantara-Gonzalez, Elizabeth Santiago, Fernando Peña-Ortega","doi":"10.3389/frdem.2026.1738954","DOIUrl":"https://doi.org/10.3389/frdem.2026.1738954","url":null,"abstract":"<p><strong>Introduction: </strong>Neuronal networks enable brain's information processing through a well-coordinated activity. Disruptions in this activity can impair key brain functions such as synaptic plasticity and long-term memory. Such dysfunctions are relevant to the cognitive deterioration in Alzheimer's disease (AD). Neuronal circuit alterations in AD are associated with amyloid-β (Aβ) extracellular accumulation across multiple brain regions involved in cognitive regulation. Although several studies have analyzed network topology and examined anatomical, functional, and effective connectivity to understand their role in AD, the direct contribution of Aβ to local neuronal network disturbances has not been investigated.</p><p><strong>Methods: </strong>We assessed the CA1 hippocampal network structure after acute exposure to Aβ1-42 (30 nM) using an <i>in vitro</i> multielectrode array approach. We analyzed neuronal spiking activity recordings, evaluated the frequency of spontaneous synchronized events, and assessed functional connectivity to elucidate the functional alterations in the network. We also elucidated the statistical features of network topology using Graph Theoretical analysis, small-world network properties, and network classification using the Estrada index approach.</p><p><strong>Results: </strong>CA1 hippocampal neurons showed an average reduced firing frequency. However, some putative pyramidal neurons and interneurons increased their activity. These differences in activity are cell-type-specific, being the interneurons the cells that mainly reduce their firing in presence of Aβ. The number and magnitude of their functional links within the network were not different, but a synchronized firing pattern of different neurons was observed. These changes were associated with alterations to the network's topological structure, indicating the generation of highly connected nodes in the presence of Aβ.</p><p><strong>Conclusion: </strong>The main change in the reconfiguration of the CA1 hippocampal network induced by acute exposure to Aβ involved the differential change in firing of different neurons, where the average reduction in firing was found, but some neurons increased their firing. This may constitute an adaptive mechanisms that compensate for neuronal connectivity and help maintain the level of activity. This is the first time the Estrada index has been used to elucidate alterations in the topological neuronal network in an <i>ex vivo</i> brain preparation, highlighting its greater sensitivity for detecting changes compared to other topological network analysis approaches.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"5 ","pages":"1738954"},"PeriodicalIF":0.0,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13002378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147501576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From mild behavioral impairment-checklist (MBI-C) to MBI-distress (MBI-D): a paired assessment and clinical correlates of domain-specific caregiver distress in MCI due to AD.","authors":"Efthalia Angelopoulou, Niki Tsinia, Maria Hatzopoulou, Akylina Despoti, Vasiliki Kamtsadeli, Marina Papadogiani, Evangelia Stanitsa, Vasilis Kyriakidis, Sokratis Papageorgiou, John D Papatriantafyllou","doi":"10.3389/frdem.2026.1736570","DOIUrl":"https://doi.org/10.3389/frdem.2026.1736570","url":null,"abstract":"<p><strong>Background: </strong>Mild behavioral impairment (MBI) captures later-life onset neuropsychiatric symptoms (NPS) that may herald neurodegeneration. The emotional impact of these early behavioral changes on caregivers is under-measured in pre-dementia care.</p><p><strong>Objective: </strong>To develop a brief, domain-aligned caregiver distress scale for MBI (MBI-D) and examine clinical correlates of MBI-related caregiver distress in mild cognitive impairment due to AD (MCI-AD).</p><p><strong>Methods: </strong>One hundred and four participant-informant dyads with MCI-AD at a Greek memory clinic were included. Caregivers completed the Greek MBI-C and the new five-item MBI-D (one item per ISTAART-AA MBI domain). Internal consistency (Cronbach's <i>α</i>), non-parametric tests, and Spearman correlations assessed bivariate associations. Multiple linear regression identified independent correlates of MBI-D total. Prespecified covariates were age, education, sex, global cognition (MMSE or ACE-R), disease duration, and MBI-C (total or domains).</p><p><strong>Results: </strong>Internal consistency of the MBI-D was moderate (<i>α</i> = 0.617; standardized <i>α</i> = 0.627; mean inter-item <i>r</i> = 0.25). MBI-D total correlated strongly with MBI-C total (<i>ρ</i> = 0.789, <i>p</i> < 0.001), and each MBI-D domain correlated with its corresponding MBI-C domain (<i>ρ</i> = 0.478-0.850, all <i>p</i> < 0.001). Disease duration was associated with MBI-D total and with apathy-related distress (<i>ρ</i> = 0.302, <i>p</i> = 0.002 and <i>ρ</i> = 0.392, <i>p</i> < 0.001, respectively). In multivariable regression, MBI-C total and education were independent predictors of MBI caregiver distress (<i>β</i> = 0.804, <i>p</i> < 0.001, and <i>β</i> = 0.135, <i>p</i> = 0.017, respectively). In the MBI-C domains model, impulse dyscontrol, apathy and emotional dysregulation independently related to higher distress (<i>B</i> = 0.513, <i>β</i> = 0.482, <i>p</i> < 0.001, <i>B</i> = 0.315, <i>β</i> = 0.278, <i>p</i> < 0.001, and <i>B</i> = 0.289, <i>β</i> = 0.227, <i>p</i> = 0.001 respectively), while cognitive performance (MMSE and ACE-R) did not have a significant impact.</p><p><strong>Conclusion: </strong>The MBI-D, strongly coupled with MBI-C, is a concise, clinically practical and scalable measure of MBI-related caregiver distress in MCI-AD, capturing both symptom burden and domain-specific distress in a single administration. Impulsivity, apathy, and affective dysregulation are highlighted as priority targets for early, caregiver-focused interventions advancing innovative, prevention-oriented dementia care delivery.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"5 ","pages":"1736570"},"PeriodicalIF":0.0,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147439047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}