Frontiers in dementia最新文献

{"title":"Environmental audit scoring evaluation: evolution of an evidence-based environmental assessment tool to support person-centered care.","authors":"Robert A Wrublowsky, Migette L Kaup, Margaret P Calkins","doi":"10.3389/frdem.2024.1470036","DOIUrl":"https://doi.org/10.3389/frdem.2024.1470036","url":null,"abstract":"<p><p>Long-term care settings are at the center of strongly debated approaches to policies that shape the delivery of care and operational practices. There is advocacy for transformational change within these settings to support a person-centered approach to care delivery, but it is difficult and multifaceted involving everything from changing the level of staffing and care models to developing appropriate metrics to assess an individual's quality of life. The physical environment is a key component for accomplishing the organizational and operational goals related to person-centered care, but providers and their design teams need the appropriate tools to guide evidence-based decision-making. The Environmental Audit Scoring Evaluation (EASE) is a tool that helps lend structure to the process of developing the environment for our senior population-especially those living with dementia. This perspective article will discuss how EASE aims to align the design process to more fully support the myriad environmental elements that have a demonstrable impact on the individual, and the associated quality of life they experience. The article will also explore how EASE differs from previous planning strategies that did not prioritize residents' psychological wellbeing in conforming to current person-centered philosophies.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"3 ","pages":"1470036"},"PeriodicalIF":0.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The African American Dementia and Aging Project: an Oregon-based longitudinal study.","authors":"Allison Lindauer, Raina Croff, Kevin Duff, Nora Mattek, Patrice Fuller, Aimee Pierce, Kalisha Bonds Johnson, Jeffrey Kaye","doi":"10.3389/frdem.2024.1498835","DOIUrl":"10.3389/frdem.2024.1498835","url":null,"abstract":"<p><strong>Introduction: </strong>The vast majority of studies on aging, cognition, and dementia focus on non-Hispanic white subjects. This paper adds to the extant literature by providing insight into the African American aging experience. Here we describe the study design and baseline characteristics of the African American Dementia and Aging Project (AADAPt) study, which is exploring aging and cognition in African American older adults in Oregon.</p><p><strong>Methods: </strong>African American older adults (<i>n</i> = 177) participated in AADAPt, a longitudinal study that collected data on cognitive, physical, and social functioning in annual visits since 2000.</p><p><strong>Results: </strong>AADAPt participants had risk factors for developing dementia in future, such as hypertension and hyperlipidemia, but also reported protective factors such as high social engagement.</p><p><strong>Discussion: </strong>The AADAPt project offers new insights into aging in older African Americans that includes data on cognition, social engagement, and physical health, which are crucial for understanding the experience of under-represented groups and making future studies more inclusive.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"3 ","pages":"1498835"},"PeriodicalIF":0.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The staff perspectives of facilitators and barriers to implementing virtual reality for people living with dementia in long-term care.","authors":"Joey Wong, Karen Lok Yi Wong, Winnie Kan, Catherine Wu, Mona Upreti, Mary Van, Alisha Temirova, Hadil Alfares, Kayla Wen, Vaishali Sharma, Christine Wallsworth, Jim Mann, Lily Wong, Lillian Hung","doi":"10.3389/frdem.2024.1462946","DOIUrl":"https://doi.org/10.3389/frdem.2024.1462946","url":null,"abstract":"<p><strong>Introduction: </strong>One emerging technology in long-term care (LTC) is virtual reality (VR), an innovative tool that uses head-mounted devices to provide the viewer with an immersive experience. It has been shown that VR has a positive impact on the well-being of residents living with dementia, and staff are essential in the implementation and sustainable use of technology. Currently, there is a lack of inclusion and focus on direct staff perspectives on VR implementation in LTC. This paper aims to report staff perspectives on VR adoption in a 2-year study on a virtual reality program at three Canadian LTC homes.</p><p><strong>Methods: </strong>Our interdisciplinary team (clinicians, people living with dementia and family partners, trainees, and researchers) explored the facilitators and barriers to implementing VR in LTC, guided by the Consolidated Framework for Implementation Research (CFIR) and intersectionality supplemented CFIR. Twenty-one participants were recruited, including recreation staff, care aides, nurses, screeners, and leadership team members. The team collected data through staff interviews, focus groups, and ethnographic observation field notes. Reflexive thematic analysis was performed to identify themes reporting the facilitators and barriers for VR implementation in LTC from staff perspectives.</p><p><strong>Results: </strong>The data analysis resulted in three facilitators and four barriers. Facilitators are (1) perceived VR benefits, (2) integrate VR into workflow and routines, and (3) partner with skillful VR champions. Barriers include (1) staff concerns about VR use, (2) financial burden and competing priorities, (3) lack of infrastructure and physical spaces, and (4) staff workload and limited leadership support.</p><p><strong>Discussion: </strong>This study contributes to the field with staff perspectives on facilitators and barriers to VR implementation. It underscores the rarely discussed aspects of VR implementation, such as funding prioritization and implementation timing. We offer practical strategies to inform future practices and research. Future studies should further explore long-term VR implementation, the involvement of family members as VR facilitators, and the use of VR in LTC.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"3 ","pages":"1462946"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scoping review of magnetic resonance angiography and perfusion image synthesis.","authors":"Rémi Lamontagne-Caron, Simon Duchesne","doi":"10.3389/frdem.2024.1408782","DOIUrl":"10.3389/frdem.2024.1408782","url":null,"abstract":"<p><strong>Introduction: </strong>Deregulation of the cerebrovascular system has been linked to neurodegeneration, part of a putative causal pathway into etiologies such as Alzheimer's disease (AD). In medical imaging, time-of-flight magnetic resonance angiography (TOF-MRA) and perfusion MRI are the most common modalities used to study this system. However, due to lack of resources, many large-scale studies of AD are not acquiring these images; this creates a conundrum, as the lack of evidence limits our knowledge of the interaction between the cerebrovascular system and AD. Deep learning approaches have been used in recent developments to generate synthetic medical images from existing contrasts. In this review, we study the use of artificial intelligence in the generation of synthetic TOF-MRA and perfusion-related images from existing neuroanatomical and neurovascular acquisitions for the study of the cerebrovascular system.</p><p><strong>Method: </strong>Following the PRISMA reporting guidelines we conducted a scoping review of 729 studies relating to image synthesis of TOF-MRA or perfusion imaging, from which 13 met our criteria.</p><p><strong>Results: </strong>Studies showed that T1-w, T2-w, and FLAIR can be used to synthesize perfusion map and TOF-MRA. Other studies demonstrated that synthetic images could have a greater signal-to-noise ratio compared to real images and that some models trained on healthy subjects could generalize their outputs to an unseen population, such as stroke patients.</p><p><strong>Discussion: </strong>These findings suggest that generating TOF-MRA and perfusion MRI images holds significant potential for enhancing neurovascular studies, particularly in cases where direct acquisition is not feasible. This approach could provide valuable insights for retrospective studies of several cerebrovascular related diseases such as stroke and AD. While promising, further research is needed to assess their sensitivity and specificity, and ensure their applicability across diverse populations. The use of models to generate TOF-MRA and perfusion MRI using commonly acquired data could be the key for the retrospective study of the cerebrovascular system and elucidate its role in the development of dementia.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"3 ","pages":"1408782"},"PeriodicalIF":0.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Crosslinking neuropsychiatric symptoms across the continuum of Alzheimer's disease and related dementias.","authors":"Foteini Christidi, Christos Bakirtzis, Gita A Pathak, Carolyn Fredericks, Catherine Munro","doi":"10.3389/frdem.2024.1498924","DOIUrl":"10.3389/frdem.2024.1498924","url":null,"abstract":"","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"3 ","pages":"1498924"},"PeriodicalIF":0.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11576301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outdoor stays-A basic human need except for older adults in residential care facilities? Researcher-practitioner interaction crosses zones and shows the way out.","authors":"Susanna Nordin, Madeleine Liljegren, Martin Nilsson, Anna Bengtsson, Helle Wijk","doi":"10.3389/frdem.2024.1470691","DOIUrl":"https://doi.org/10.3389/frdem.2024.1470691","url":null,"abstract":"<p><p>The aim of this discussion paper is to show the way to the outdoors by shedding light on conditions in the physical environment enabling outdoor stays for older adults living in residential care facilities (RCFs). The origin was that outdoor stays is a basic human need and applies to everyone. However, despite extensive research on the health-promoting values of contact with the outdoors, it seems that for older adults in RCFs this is not met because they often have difficulty getting outdoors on their own. Therefore, the access to and the conditions of outdoor environments are discussed and exemplified through two cases based on evidence-based approaches, namely the principal model of four zones of contact with the outdoors, and the Swedish version of the Sheffield Care Environment Assessment Matrix (S-SCEAM). An interdisciplinary team, including both researchers and practitioners highlights future directions by showing the way to the outdoors on a national level with six suggested points. As a reader, you will gain increased knowledge about environmental qualities that support outdoor stays as well as initiatives that are needed to achieve equal conditions related to outdoor stays in RCFs.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"3 ","pages":"1470691"},"PeriodicalIF":0.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative proteomic analysis using a mouse model of Lewy body dementia induced by α-synuclein preformed fibrils injection.","authors":"Fatih Akkentli, In Kyu Jang, Yoonseop Choi, Young Min, Jinhee Park, Heejin Jo, Leoni Kim, Aashi Mendpara, Bikram Bains, Dongyoon Yoo, Jinchong Xu, Chan Hyun Na, Sung-Ung Kang","doi":"10.3389/frdem.2024.1477986","DOIUrl":"https://doi.org/10.3389/frdem.2024.1477986","url":null,"abstract":"<p><p>The aggregation of α-synuclein in the nervous system leads to a class of neurodegenerative disorders termed α-synucleinopathies. A form of primary degenerative dementia called Lewy body dementia (LBD) often develops when these aggregations develop into intracellular inclusions called Lewy bodies (LB) and Lewy neurites (LN). Although high frequency of LBD are the leading cause of dementia after Alzheimer's disease (AD), limited information has been discovered about its pathological pathway or diagnostic criteria. In this report, we attempt to address such shortcomings via utilizing a proteomic approach to identify the proteome changes following intrastriatal injection of α-synuclein pre-formed fibril (α-syn PFF). Using mass spectrometry, we have identified a total of 179 proteins that were either up- or down-regulated at different time points, with the four proteins-TPP3, RAB10, CAMK2A, and DYNLL1, displaying the most significant changes throughout the timeframe. Through further examining the modulated proteins with network-based enrichment analyses, we have found that (1) the most significantly associated neurodegenerative pathways were Parkinson's (<i>p</i>V = 3.0e-16) and Huntington's (<i>p</i>V = 1.9e-15) disease, and (2) the majority of molecular functions specific to the pathology only appeared at later time points. While these results do not expose a conclusive biomarker for LBD, they suggest a framework that is potentially applicable to diagnose and differentiate LBD pathology from other forms of dementia by focusing on the cortical proteome changes which occur in a later time span.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"3 ","pages":"1477986"},"PeriodicalIF":0.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142636176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The COM-B model: a cross-sectional survey assessing capability, opportunities, and motivation to follow the MIND diet among informal female caregivers of people with Alzheimer's disease and related dementias.","authors":"Jacqueline Guzman, Susan Aguiñaga","doi":"10.3389/frdem.2024.1451310","DOIUrl":"https://doi.org/10.3389/frdem.2024.1451310","url":null,"abstract":"<p><strong>Introduction: </strong>Caring for a person with Alzheimer's disease or dementia has been correlated with poor dietary patterns in caregivers. Dietary patterns like The Mediterranean-DASH diet intervention for neurodegenerative delay (MIND) diet have the potential to reduce the negative health outcomes associated with caregiving. Our objective was to assess capabilities, opportunities, and motivation of caregivers to follow the MIND diet using the COM-B model approach.</p><p><strong>Method: </strong>Female caregivers (<i>n</i> = 299, <i>m</i> _age = 37.7 ± 13.7) participated in an online survey. Majority were White (72%) and cared for someone with Alzheimer's disease (42.6%). The survey included at least one question for each of the 6 COM-B subcomponents: psychological capability, physical capability, social opportunity, physical opportunity, reflective motivation, and automatic motivation.</p><p><strong>Results: </strong>Most caregivers were not consuming the MIND diet as only 8.4% reported normally eating the MIND diet items. Caregivers (36.5%) were slightly confident or not confident at all in cooking and eating the MIND diet. Participants (67.1%) reported that consuming the MIND diet would somewhat to very much be supported by friends and family. Budget, time, and transportation were selected as the main barriers. Budget, cooking skills, access to food and stores, and family support were the main facilitators.</p><p><strong>Discussion: </strong>Strategies to increase capability, opportunities, and motivation for the MIND diet are needed to improve caregivers' health. Future MIND diet interventions should improve budget planning and cooking skills of caregivers (capabilities), make MIND diet food items accessible to them (opportunity) and incorporate social support from family and friends (motivation).</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"3 ","pages":"1451310"},"PeriodicalIF":0.0,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11484045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differentiation of Alzheimer's disease from other neurodegenerative disorders using chemiluminescence immunoassays measuring cerebrospinal fluid biomarkers.","authors":"Philipp Arendt, Katharina Römpler, Britta Brix, Viola Borchardt-Lohölter, Mandy Busse, Stefan Busse","doi":"10.3389/frdem.2024.1455619","DOIUrl":"10.3389/frdem.2024.1455619","url":null,"abstract":"<p><strong>Introduction: </strong>Prior research identified four neurochemical cerebrospinal fluid (CSF) biomarkers, Aβ1-42, Aβ1-40, tTau, and pTau(181), as core diagnostic markers for Alzheimer's disease (AD). Determination of AD biomarkers using immunoassays can support differential diagnosis of AD vs. several neuropsychiatric disorders, which is important because the respective treatment regimens differ. Results of biomarker determination can be classified according to the Amyloid/Tau/Neurodegeneration (ATN) system into profiles. Less is known about the clinical performance of chemiluminescence immunoassays (ChLIA) measuring specific biomarkers in CSF samples from patients suffering from neuropsychiatric impairments with various underlying causes.</p><p><strong>Methods: </strong>Chemiluminescence immunoassays (ChLIAs, EUROIMMUN) were used to determine Beta-Amyloid (1-40), Beta-Amyloid (1-42), Total-Tau, and pTau(181) concentrations in precharacterized cerebrospinal fluid (CSF) samples from 219 AD patients, 74 patients with mild cognitive impairment (MCI), and 220 disease control (DC) patients.</p><p><strong>Results: </strong>83.0% of AD patients had ATN profiles consistent with AD, whereas 85.5% of DC patients and 77.0% of MCI patients had profiles inconsistent with AD. AD patients showed significantly lower amyloid ratio Aβ1-42/Aβ1-40 (mean: 0.07) and significantly higher concentrations of tTau (mean: 901.6 pg/ml) and pTau(181) (mean: 129 pg/ml) compared to DC and MCI patients (all <i>p</i> values < 0.0071).</p><p><strong>Discussion: </strong>The ChLIAs effectively determined specific biomarkers and can support differential diagnostics of AD. Their quality was demonstrated in samples from 513 patients with cognitive impairments, representing a realistic mix of underlying causes for seeking treatment at a memory clinic.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"3 ","pages":"1455619"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11473414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modifying a multidisciplinary method to address challenging behavior in nursing home residents with dementia to involve family caregivers.","authors":"Petra E M Tasseron-Dries, Hanneke J A Smaling, Jenny T van der Steen, Wilco P Achterberg","doi":"10.3389/frdem.2024.1444815","DOIUrl":"https://doi.org/10.3389/frdem.2024.1444815","url":null,"abstract":"<p><strong>Introduction: </strong>Challenging behavior and pain are common in nursing home residents with dementia. Challenging behavior and pain can be related and are stressful for residents, family caregivers and healthcare professionals. The STA OP! method provides a step-by-step protocol to manage challenging behavior and pain in nursing home residents with dementia. However, this method does not include a prominent and active role for family caregivers.</p><p><strong>Methods: </strong>The STA OP! method was modified to include a role for family caregivers, in co-creation with family caregivers and healthcare professionals using elements of a realist approach. In separate meetings, two advisory groups comprised of family caregivers and professionals discussed ideas on how to involve family caregivers in STA OP!. Furthermore, barriers to involving family and possible solutions to overcome those barriers were discussed. Experts who had experience with the STA OP! method assessed the feasibility of the ideas in a nominal group technique meeting.</p><p><strong>Results: </strong>Thirty-eight ideas emerged in the advisory groups. The two ideas that generated the most discussion were Inviting family for a multidisciplinary meeting, and Assessment of pain in collaboration with family caregivers. Eventually, 21 ideas and suggestions to overcome possible barriers were included in a manual for the training of healthcare professionals in the adapted method, now called STA OP! <i>with family</i>.</p><p><strong>Conclusion: </strong>Healthcare professionals and family caregivers collaborated well to shape the involvement of family caregivers in this method for managing challenging behavior and pain. The collected ideas supported by all involved resulted in a modified method: STA OP! <i>with family</i> and can now be tested in daily practice.</p>","PeriodicalId":520000,"journal":{"name":"Frontiers in dementia","volume":"3 ","pages":"1444815"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11471609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}