Narra J最新文献

{"title":"Biomarkers for predicting COVID-19 mortality: A study at Sulianti Saroso Infectious Disease Hospital, Indonesia.","authors":"Siti Maemun, Aninda D Widiantari, Farida Murtiani, Herlina Herlina, Dian W Tanjungsari, Kunti Wijiarti, Tiara Z Pratiwi, Faisal Matondang, Adria Rusli, Rivaldiansyah Rivaldiansyah, Maria L Tampubolon, Nina Mariana, Vivi Setiawaty, Tri B Purnama","doi":"10.52225/narra.v5i2.1936","DOIUrl":"10.52225/narra.v5i2.1936","url":null,"abstract":"<p><p>The high transmissibility and mortality rates of the COVID-19 pandemic pose significant challenges. Patients can deteriorate rapidly, making it crucial to identify laboratory biomarkers for high-risk individuals. The aim of this study was to evaluate the predictive value of various laboratory parameters, including C-reactive protein (CRP), D-dimer, ferritin, neutrophil-to-lymphocyte ratio (NLR), prothrombin time (PT), and procalcitonin (PCT), in predicting COVID-19 mortality. A retrospective cohort study was conducted at Sulianti Saroso Infectious Disease Hospital, where COVID-19 patients were categorized into survivors and non-survivors. The Mann-Whitney test was used to assess group differences, while receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive performance of each biomarker, with Youden's index (J) determining optimal cut-off values. Kaplan-Meier analysis was used to compare median survival times, and Cox regression assessed hazard rates and the relationship between biomarkers and mortality. A total of 1,598 patients were analyzed, the majority of whom were admitted with oxygen saturation levels >95% and classified as having mild to moderate disease severity. Among them, 216 patients died, resulting in a mortality rate of 13.52%. Significant variations in mortality rates were observed along the survival functions for NLR, ferritin, D-dimer, CRP, and PCT (<i>p</i><0.001). The survival curves for these biomarkers demonstrated distinct trends across tertiles over time. Among hematological markers, NLR was significantly associated with mortality (<i>p</i><0.001), with a 1.5-2.2% increased risk per unit increase. Biochemical markers (complete blood count) proved to be more effective than hematological parameters (NLR, ferritin, PT, D-dimer, CRP, PCT) when evaluating individual prognostic performance. Bivariate analysis of CRP, D-dimer, ferritin, NLR, PT, and PCT between survivors and non-survivors showed significant differences. Notably, NLR and PCT were highly relevant for predicting disease prognosis and mortality, with sensitivity and specificity values exceeding 80%.</p>","PeriodicalId":517416,"journal":{"name":"Narra J","volume":"5 2","pages":"e1936"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Helicobacter pylori sabA, hopQ</i> and <i>hom</i> genotypes as potential genetic biomarkers for gastric mucosal inflammation.","authors":"Ramdan Hunowu, Kartika A Fauzia, Ricky I Alfaray, Selva R Dewi, Juniastuti Juniastuti, Yoshio Yamaoka, Muhammad Miftahussurur","doi":"10.52225/narra.v5i2.1917","DOIUrl":"10.52225/narra.v5i2.1917","url":null,"abstract":"<p><p><i>Helicobacter pylori</i> infection drives heterogeneous gastric pathologies, yet genotype-phenotype correlations in diverse populations remain underexplored. The aim of this cross-sectional study was to investigate the associations between <i>H. pylori</i> virulence genotypes (<i>sabA, hopQ, hom</i> family) and histopathological severity in gastric mucosa among 113 Indonesian dyspepsia patients (mean age: 49.6 years; male predominance: 64.6%). Whole-genome sequencing characterized virulence genotypes, while histopathological grading system using the Updated Sydney System assessed inflammation, atrophy, and bacterial density in the antral and corporal gastric regions. Phylogenetic analysis elucidated strain relatedness. Key genotype frequencies included <i>sabA</i> \"on\" (40.6%, 43/106), <i>hopQ</i> type I (53.7%, 43/80), and <i>homC</i> ^<i>L</i> (82.4%, 75/91). Statistical analysis revealed <i>sabA</i> \"on\" status significantly associated with elevated antral bacterial density (odds ratio (OR) 2.70 and 95% confidence interval (95%CI) 1.10-6.60, <i>p</i>=0.027). The <i>homC</i> variants (<i>homC</i> ^<i>L</i> /<i>homC</i> ^<i>S</i> ) demonstrated robust associations with chronic inflammation severity (OR: 3.04; 95%CI: 0.99-9.36, <i>p</i>=0.046) and atrophy progression (OR: 4.78; 95%CI: 1.00-22.86, <i>p</i>=0.035), in contrast to the <i>hopQ</i> genotype, which showed no histopathological association. These findings indicated that <i>sabA</i> and <i>homC</i> as critical determinants of gastric microenvironment modulation, potentially through <i>sabA</i>-mediated colonization efficiency and <i>homC</i> ^<i>L</i> -<i>babA</i> synergistic interactions. While histological profiles predominantly indicated mild atrophy, widespread severe chronic inflammation signals latent progression risks.</p>","PeriodicalId":517416,"journal":{"name":"Narra J","volume":"5 2","pages":"e1917"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healing the healers: Unlocking psychological well-being through meaningful work and quality of work life.","authors":"Eka D Aprilia, Muhammad Adam, Zulkarnain Zulkarnain, Marty Mawarpury","doi":"10.52225/narra.v5i2.2152","DOIUrl":"10.52225/narra.v5i2.2152","url":null,"abstract":"<p><p>Healthcare workers in developing countries, such as Indonesia, experience significant psychological stress due to heavy workloads, limited resources, and systemic inefficiencies, all of which negatively impact their psychological well-being (PWB). The aim of this study was to investigate the direct and indirect effects of quality of work life (QWL) on PWB, with meaningful work (MW) as a mediating variable. A cross-sectional survey was conducted with 285 healthcare professionals from various healthcare facilities, including specialists, general practitioners, and nurses. Data were collected using validated scales to assess QWL, MW, and PWB. Pearson correlation analysis was employed to examine relationships among variables, while mediation analysis tested direct and indirect effects. The results indicate that QWL positively influences PWB both directly (β=0.22, <i>p</i><0.001) and indirectly through MW (β=0.13, <i>p</i><0.001). Furthermore, MW was found to be a strong mediator (β=0.61, <i>p</i><0.001), underscoring its critical role in enhancing purpose and resilience. Specialists reported the highest QWL and PWB, whereas nurses exhibited the lowest levels, highlighting occupational disparities. These findings suggest that enhancing the QWL and fostering MW can significantly improve healthcare professionals' PWB. Accordingly, organizations should prioritize strategies that promote MW and improve work-life conditions to support mental well-being and job satisfaction.</p>","PeriodicalId":517416,"journal":{"name":"Narra J","volume":"5 2","pages":"e2152"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of <i>LBX1</i> rs11190870 polymorphism in adolescent idiopathic scoliosis in the Acehnese population: A preliminary study.","authors":"Teuku N Aulia, Luthfi Gatam, Aman Yaman, Djufri Djufri","doi":"10.52225/narra.v5i2.2038","DOIUrl":"10.52225/narra.v5i2.2038","url":null,"abstract":"<p><p>Genome-wide association studies (GWAS) have identified the single nucleotide polymorphism (SNP) rs11190870 near the <i>ladybird homeobox 1</i> (<i>LBX1</i>) gene as being associated with the susceptibility and severity of adolescent idiopathic scoliosis (AIS). However, no such genetic studies have been conducted in the Indonesian population. The aim of this study was to investigate the genetic profile of AIS patients in the Acehnese population, with a focus on <i>LBX1</i> rs11190870, and to assess its association with disease severity. A total of 30 female AIS patients were included. Genetic analysis was performed to determine the rs11190870 genotype in each subject. The association between rs11190870 and curve progression, measured by Cobb angle, was analyzed using the Mann-Whitney U test. The T allele was found to be more prevalent (73.3%), with the TC genotype being the most common (53.3%). A significant association was observed between <i>LBX1</i> rs11190870 and curve progression, where patients with the TT genotype exhibited a larger Cobb angle compared to those with TC or CC genotypes (<i>p</i>=0.01). This is the first study to characterize the genetic profile of AIS and its association with curve severity in the Acehnese population. These findings suggest that <i>LBX1</i> rs11190870 may act as a disease modifier in AIS. Further studies with larger sample sizes are warranted to confirm the role of <i>LBX1</i> rs11190870 in AIS susceptibility and severity in the Indonesian population.</p>","PeriodicalId":517416,"journal":{"name":"Narra J","volume":"5 2","pages":"e2038"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in maritime evacuation during pre-hospital emergency anesthesia on a remote island in Indonesia: A case report.","authors":"Airi Mutiar, Kun A Abbas","doi":"10.52225/narra.v5i2.1643","DOIUrl":"10.52225/narra.v5i2.1643","url":null,"abstract":"<p><p>Preeclampsia and eclampsia remain significant contributors to maternal and perinatal mortality. Managing these conditions is particularly challenging in remote areas in many islands of Indonesia, where access to medical care is severely limited. The aim of this study was to analyze the pre-hospital anesthetic management of an eclampsia patient during maritime evacuation to a higher-level facility, highlighting the complexities of medical transport in resource-limited settings. A 38-year-old multiparous woman from a remote village on Pagerungan Island, Indonesia, at 37 weeks of gestation, presented with tonic-clonic seizures consistent with eclampsia. The absence of antenatal care necessitated urgent intervention. Upon presentation, the patient had a Glasgow Coma Scale (GCS) score of 5, tachycardia, and irregular breathing, requiring rapid-sequence intubation and magnesium sulfate administration. Given the geographic constraints, the patient was evacuated by sea under challenging conditions. Despite significant waves, a multidisciplinary team successfully performed an emergency cesarean section onboard, delivering a male infant who required neonatal resuscitation. Postoperatively, both mother and neonate were transferred to a higher-level facility. However, engine failure extended the journey to 18 hours, leading to depletion of oxygen and essential medications, necessitating critical decision-making. This case underscores the significant challenges of emergency eclampsia management in remote settings, particularly during maritime evacuation. Effective stabilization, anesthesia, monitoring, and timely transport are crucial. This case highlights the need for optimized evacuation protocols and increased healthcare resource allocation to enhance maternal and neonatal outcomes in maritime and other resource-limited settings.</p>","PeriodicalId":517416,"journal":{"name":"Narra J","volume":"5 2","pages":"e1643"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to iron supplementation and associated factors among pregnant women in Cambodia: Insights from the 2021-2022 Demographic and Health Survey.","authors":"Annas Buanasita, Sri Sumarmi, Trias Mahmudiono, Soenarnatalina Melaniani, Lutfi A Salim, Ma Sokvy, Nur Mw Sari","doi":"10.52225/narra.v5i2.1659","DOIUrl":"10.52225/narra.v5i2.1659","url":null,"abstract":"<p><p>Iron deficiency is the leading cause of anemia during pregnancy, a major public health concern in many developing countries. To mitigate anemia, iron supplementation for at least 90 days is recommended for pregnant women. The aim of this study was to evaluate adherence to iron supplementation during pregnancy and to identify its key determinants in Cambodia. A cross-sectional study was conducted using secondary data from the 2021- 2022 Cambodia National Demographic and Health Survey. Key variables assessed included maternal age, education level, ethnicity, wealth index, number of pregnancies, age at first pregnancy, prenatal care provider, timing of the first antenatal care (ANC) visit, and frequency of ANC visits. Multivariate logistic regression was employed to evaluate associations between adherence and independent variables. A total of 4,475 women aged 15-49 years who had been pregnant in the past five years were included in the analysis, with 91.2% adhering to iron supplementation for at least 90 days. Multivariate logistic regression showed that those with primary and higher education had greater odds of adherence (odds ratio (OR)=1.38; 95%CI: 1.00-1.90; OR=3.07; 95%CI: 1.39-6.79, respectively) compared to women with no education. There was a positive relationship between education level and adherence. Women who attended four or more ANC visits were more likely to adhere (OR=2.93; 95%CI: 2.27-3.77), and those who initiated ANC in the first trimester had higher adherence compared to those who started later (OR=1.78; 95%CI: 1.35-2.36). This study highlights that education level, frequency, and timing of ANC visits significantly influenced adherence to iron supplementation. Strengthening maternal education and promoting early and regular ANC follow-up should be prioritized to improve adherence and prevent anemia during pregnancy.</p>","PeriodicalId":517416,"journal":{"name":"Narra J","volume":"5 2","pages":"e1659"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between plasma beta amyloid and cognitive decline: A systematic review and meta-analysis.","authors":"Cynthia Cynthia, Jusak Nugraha, Muhammad Hamdan, Rahajuningsih Dharma, Silvia F Limempouw","doi":"10.52225/narra.v5i2.2268","DOIUrl":"10.52225/narra.v5i2.2268","url":null,"abstract":"<p><p>Alzheimer's disease is a leading neurodegenerative disorder characterized by progressive cognitive decline. Early prediction is crucial for enabling timely interventions. Plasma amyloid β-peptides (Aβ), particularly the Aβ-42/Aβ-40 ratio, have been proposed as potential non-invasive biomarkers for cognitive decline and Alzheimer's disease risk. However, conflicting findings and methodological variability have hindered consensus regarding their clinical utility. The aim of this study was to evaluate whether the plasma Aβ levels predict dementia, Alzheimer's disease, and cognitive decline. Studies were eligible for inclusion if they measured at least one plasma Aβ species (Aβ-40, Aβ-42, or the Aβ-42/Aβ-40 ratio) and reported outcomes related to dementia, Alzheimer's disease, or cognitive change. Only human studies published in peer-reviewed journals were included. A comprehensive search of six databases (PubMed, PMC, SSRN, Scopus, BioRxiv, and MedRxiv) was conducted up to December 1, 2024. Risk of bias was assessed using the ROBINS-E tool, and pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using a random-effects meta-analysis. A total of 25 studies were included in the systematic review, with four contributing to the meta-analysis. Lower plasma Aβ-42/Aβ-40 ratio was not significantly associated with Alzheimer's disease risk (pooled HR=0.8; 95%CI: 0.62-1.04), and substantial heterogeneity was observed (<i>I2</i>=70%, <i>p</i>=0.02). Individual studies varied in their findings: while some reported that lower Aβ-42/Aβ-40 ratio predicted increased Alzheimer's disease risk, others found no association or even opposing trends. Methodological heterogeneity-including differences in sample handling, measurement techniques, and study designs-likely contributed to these inconsistencies. Overall, this review suggests that plasma Aβ-42/Aβ-40 ratio is not reliable predictors for the onset of Alzheimer's disease or dementia. However, the substantial heterogeneity observed underscores the need for further research to clarify the potential of plasma Aβ as a preclinical biomarker.</p>","PeriodicalId":517416,"journal":{"name":"Narra J","volume":"5 2","pages":"e2268"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing a maturity-level model for interprofessional collaboration in elective surgery preparation.","authors":"Else Agustina, Respati S Dradjat, Viera Wardhani, Kuswantoro R Putra","doi":"10.52225/narra.v5i2.2213","DOIUrl":"10.52225/narra.v5i2.2213","url":null,"abstract":"<p><p>Interprofessional collaboration plays a crucial role in the preparation for elective surgeries to enhance the quality, safety, and efficiency of patient care. However, its implementation continues to encounter substantial obstacles, which require the creation of a customized maturity model to effectively resolve these concerns. The aim of this study was to develop an interprofessional collaboration maturity model that is specifically designed for the context of elective surgery preparation. This qualitative study employed a case study approach, conducted in 2024. This maturity model was developed through four stages: a literature study to identify key interprofessional collaboration indicators in surgery; in-depth interviews with ten healthcare professionals at Universitas Muhammadiyah General Hospital, Malang, Indonesia; (3) adaptation of existing maturity models (Fleming, Hudson, collaboration maturity model, and quality management system) as a framework for synthesizing data from the findings of stage 2 (in-depth interviews); and (4) expert panel review to evaluate the maturity model. We successfully developed an interprofessional collaboration maturity model specifically applied to elective surgery preparation, Preoperative Interprofessional Collaboration Maturity Model (P-ICMM), consisting of five maturity levels: emerging, developing, coordinated, integrated, and optimized. Each level's assessment criteria are based on indicators of interprofessional collaboration. This maturity model has been evaluated by the experts in elective surgery preparation to ensure its validity and applicability. This maturity model is expected to help hospitals identify the level of interprofessional collaboration, design strategies to enhance collaboration, and ultimately improve the quality of healthcare services and patient safety in the preparation for elective surgeries.</p>","PeriodicalId":517416,"journal":{"name":"Narra J","volume":"5 2","pages":"e2213"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of solifenacin and tamsulosin in alleviating stent-related symptoms: A systematic review and meta-analysis.","authors":"Dianita H Harahap, Kharisma P Adhyatma, Elbert Elbert, Felix Khosasi, Muhammad H Warli","doi":"10.52225/narra.v5i2.1683","DOIUrl":"10.52225/narra.v5i2.1683","url":null,"abstract":"<p><p>Ureteral stents, commonly used in urology, can cause side effects affecting patient quality of life. However, studies on managing lower urinary tract symptoms showed inconsistencies due to the use of various alpha-blockers and antimuscarinic drugs. The aim of this study was to evaluate the effectiveness of combining tamsulosin and solifenacin therapy compared to tamsulosin and solifenacin monotherapy for treating stent-related symptoms. Randomized controlled trials assessing tamsulosin, solifenacin, or their combination for stent-related symptoms treatment were identified through a comprehensive search of four databases (PubMed, Scopus, Web of Science, and Cochrane) from January 2018 to December 2023. Ureteral stent symptom questionnaire (USSQ), international prostate symptom score (IPSS), visual analog scale (VAS), and quality of life (QoL) were pooled for meta-analysis. Eleven studies with a total of 1,627 patients were included in the quantitative analysis. Solifenacin significantly improved urinary symptoms (MD: 15.31; 95%CI: 0.36-30.26; <i>p</i>=0.040) and reduced the IPSS (MD: -2.52; 95%CI: -3.68--1.36; <i>p</i><0.00001) compared to the control group. Tamsulosin reduced urinary symptoms on the USSQ (MD: 14.27; 95%CI: 8.68-19.86; <i>p</i><0.00001), general health problems (MD: 4.53; 95%CI: 2.13-6.94; <i>p</i>=0.0002), and IPSS (MD: -0.95; 95%CI:-1.86--0.03; <i>p</i><0.00001) compared to the control group. Solifenacin demonstrated a more significant reduction in the overall IPSS compared to tamsulosin (MD: -1.57; 95%CI: -2.85--0.29; <i>p</i>=0.020). The combination of solifenacin and tamsulosin resulted in a significantly superior reduction in IPSS compared to solifenacin monotherapies (MD: - 2.30; 95%CI: -3.23--1.37; <i>p</i><0.00001) and tamsulosin monotherapy (MD: -3.17; 95%CI: -5.07--1.27; <i>p</i>=0.00001). No significant differences were found between tamsulosin and solifenacin in terms of QoL (MD: 0.12; 95%CI: -0.01-0.26; <i>p</i>=0.070) and VAS (MD: 0.25; 95%CI: -0.95-1.44; <i>p</i>=0.690). In conclusion, solifenacin was more effective than tamsulosin in reducing stent-related symptoms, and the combination of tamsulosin and solifenacin was superior to either monotherapy in alleviating stent-related symptoms.</p>","PeriodicalId":517416,"journal":{"name":"Narra J","volume":"5 2","pages":"e1683"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of hemotoxic, myotoxic, and inflammatory profiles of <i>Calloselasma rhodostoma</i> and <i>Trimeresurus insularis</i> venoms in mice.","authors":"Adiva Aphrodita, Diva N Sentono, Donan S Yudha, Yekti A Purwestri, Tri R Nuringtyas, Slamet Raharjo, Isra Wahid, Sri N Rahmi, Setyanto T Wahyudi, Fajar Sofyantoro","doi":"10.52225/narra.v5i2.1874","DOIUrl":"10.52225/narra.v5i2.1874","url":null,"abstract":"<p><p>Snakebite envenomation remains a significant medical concern, particularly in tropical regions where venomous snakes such as <i>Calloselasma rhodostoma</i> and <i>Trimeresurus insularis</i> are prevalent. Both venoms are known for their potent hemotoxic, myotoxic, and inflammatory effects, yet their differential impacts on systemic physiological pathways remain unclear. The aim of this study was to characterize the hematological, myotoxic, and inflammatory effects of <i>C. rhodostoma</i> and <i>T. insularis</i> venoms in a murine model and to explore their influence on systemic factors such as insulin-like growth factor 1 (IGF-1), which is critical for muscle repair and inflammation regulation. Mice were exposed to varying doses (20-100 µg) of <i>C. rhodostoma</i> and <i>T. insularis</i> venoms. Hematological parameters, muscle degeneration, inflammatory cell infiltration, and plasma IGF-1 levels were assessed to evaluate the venoms' systemic and local effects. Our data indicated that <i>C. rhodostoma</i> venom induced significant changes in blood coagulation, muscle edema, and inflammatory infiltration, with pronounced effects even at lower doses. Conversely, <i>T. insularis</i> venom showed a dose-dependent suppression of IGF-1 levels, highlighting its unique systemic impact. Both venoms caused severe muscle damage, characterized by structural disintegration and increased leukocyte infiltration, with <i>C. rhodostoma</i> eliciting a stronger inflammatory response at lower doses.</p>","PeriodicalId":517416,"journal":{"name":"Narra J","volume":"5 2","pages":"e1874"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}