The Eurasian Journal of Medicine最新文献

{"title":"Four Quadrant-Embedded Purse-String Closure for Defects of Benign Skin Tumors Post Circular Excision.","authors":"Alper Ural,&nbsp;Fatma Bilgen,&nbsp;Mehmet Bekerecioglu","doi":"10.5152/eurasianjmed.2020.19203","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2020.19203","url":null,"abstract":"<p><strong>Objective: </strong>Skin wounds after elliptical removal of benign tumors, are conventially sutured linearly for closure and often result in longer and undesirable scars. We aimed to evaluate the efficiency of four quadrant embedded intradermal purse-string suture closure technique for round defects in order to obtain satisfactory cosmetic outcomes and limited scar.</p><p><strong>Materials and methods: </strong>We analysed the features of 143 patients for whom a total of 208 four quadrant embedded purse string sutures were used to completely close their postoperative surgical defects. The location and histopathological types of the tumors removed were noted. Tumors were located in the cervicofacial region, thoracic region, back, lower and upper extremities. The patient and observer scar assessment scale (POSAS) questionairre was utilized to evaluate objective results of the ultimate scar.</p><p><strong>Results: </strong>The defects of the lesions after excision were closed using intradermal four quadrant buried purse-string suture. The wounds showed good final healing without obvious adverse events postoperatively. Infection occurred only in three patients. The final cosmetic appearance of the healed wounds was satisfying as POSAS scores were 17.74 for patient scar assesment scale (PSAS) and 15.3 for observer scar assessment scale (OSAS).</p><p><strong>Conclusion: </strong>Four quadrant embedded purse string technique is a simple and useful method to close skin defects after circular resection of lesions. It provides minimal scarring and remarkable patient satisfaction.</p>","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":"52 3","pages":"232-236"},"PeriodicalIF":1.5,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7651757/pdf/eajm-52-3-232.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38618061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontal Status, Its Treatment Needs, and Its Relationship with Airflow Limitation and Quality of Life in COPD Patients.","authors":"Nazli Javaheri,&nbsp;Somaieh Matin,&nbsp;Abbas Naghizadeh-Baghi,&nbsp;Abolfazl Bagheri,&nbsp;Ani Andreasian,&nbsp;Hassan Ghobadi","doi":"10.5152/eurasianjmed.2020.20002","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2020.20002","url":null,"abstract":"<p><strong>Objective: </strong>Chronic obstructive pulmonary disease (COPD) is one of the most prevalent respiratory diseases in the world. There is an impressive relationship between periodontal status and airflow limitation in patients with COPD. Therefore, in this study, we aimed to investigate the periodontal status, its treatment needs, and its relationship with the severity of airway obstruction and quality of life in patients with COPD.</p><p><strong>Materials and methods: </strong>In this case-control study, 36 healthy men (control group) and 35 men afflicted with COPD (case group) were investigated. On the basis of spirometry results and Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria, patients with COPD were further divided into 4 groups. The participants' quality of life was evaluated using COPD Assessment Test (CAT) questionnaire. Thereafter, both groups of participants were referred to a dentistry clinic so that the related specialist could investigate their periodontal health status. The relationship between the periodontal indices and the variables under study including GOLD stage, CAT score, Forced Expiratory Volume in first second and Forced Vital Capacity (FEV1/FVC) ratio, Forced Expiratory Volume in first second (FEV1), and the exacerbation rate were statistically analyzed using independent t-test, one-way analysis of variance, Tukey's test, and Pearson correlation coefficient.</p><p><strong>Results: </strong>The results revealed that probing pocket depth (PDD), bleeding on probing (BOP), and loss of attachment (LOA) are negatively correlated with FEV1% (r=-0.53, p=0.001), (r=-0.62, p=0.001), and (r=-0.72, p=0.001) as well as FEV1/FVC ratio (r=-0.45, p=0.007), (r=-0.47, p=0.004), and (r=-0.61, p=0.001), respectively. The results showed that PDD, BOP, and LOA are positively correlated with CAT score (r=0.51, p=0.002), (r=0.47, p=0.004), and (r=0.71, p=0.001), respectively.</p><p><strong>Conclusion: </strong>Periodontal problems are positively associated with COPD severity as determined by GOLD criteria and negatively associated with quality of life of patients with COPD.</p>","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":"52 3","pages":"259-264"},"PeriodicalIF":1.5,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7651767/pdf/eajm-52-3-259.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38618066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Diagnosis of Ischemic Vertigo by Optical Coherence Tomography.","authors":"Mehmet Nuri Kocak,&nbsp;Orhan Ates,&nbsp;Osman Ondas,&nbsp;Zulkuf Kaya","doi":"10.5152/eurasianjmed.2020.20188","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2020.20188","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the differences in the mean retinal nerve fiber layer (RNFL) thickness using optical coherence tomography (OCT) in patients with early stage central vertigo with or without vertebrobasilar stenosis detected by Doppler ultrasound.</p><p><strong>Materials and methods: </strong>A total of 50 patients with ischemic vertigo and 50 healthy individuals were included in the study. The distinction between central and peripheral vertigo was determined by physical and neurological examinations and the Dix-Hallpike maneuver. For all patients, the mean RNFL thickness was determined using OCT performed by 2 independent ophthalmologists.</p><p><strong>Results: </strong>There were no significant differences between the groups in terms of age and sex distribution (p>0.05). On average, in superior, inferior, and temporal quadrants, there was a statistically significant difference between the control and patient groups (p<0.001).</p><p><strong>Conclusion: </strong>The retina may be affected in patients with ischemic vertigo because of atherosclerotic ischemic lesions in the carotid and vertebral arteries. Neuroimaging methods and OCT were evaluated together to develop a new diagnostic approach. With OCT, which is a non-invasive method, early and more objective differential diagnosis will be possible.</p>","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":"52 3","pages":"288-291"},"PeriodicalIF":1.5,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7651755/pdf/eajm-52-3-288.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38627581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Review of Histopathological Pulmonary Findings of COVID-19: What We Learned from Postmortem Biopsy and Autopsies; Beyond the Horizon.","authors":"Sevilay Akalp Ozmen,&nbsp;Onur Ceylan,&nbsp;Funda Demirag,&nbsp;Omer Araz","doi":"10.5152/eurasianjmed.2020.20170","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2020.20170","url":null,"abstract":"on COV-ID-19-positive and at of the first in the of the disease, days after the of a lymphocytic viral pneumonia, infiltration of the alveolar walls by numerous lymphocytes and edema, and type 2 pneumocyte hyperplasia with cytologic atypia. In 5 other patients who died nearly 20 days after the beginning of the found the his-tological pattern an acute, fibrinous, and organizing pneumonia (AFOP) characterized by an extensive intra-alveolar fibrin deposition called fibrin balls rather than hyaline membranes. is a cortico-sensitive in its subacute fibrin in both alveolar spaces bronchioles endothelial fulminant pre-The","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":"52 3","pages":"307-308"},"PeriodicalIF":1.5,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7651760/pdf/eajm-52-3-307.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38627585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nationwide Study on Practices Related to Screening Among Greek Paediatricians.","authors":"Christos Dresios,&nbsp;Georgios Rachiotis,&nbsp;Xanthi Rousou,&nbsp;Sotiria Panagakou,&nbsp;Varvara Mouchtouri,&nbsp;Christos Hadjichristodoulou","doi":"10.5152/eurasianjmed.2020.19192","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2020.19192","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to investigate pediatricians' practices toward screening in Greece.</p><p><strong>Materials and methods: </strong>The survey was conducted within a six month period in a stratified random sample of 371 pediatricians. A questionnaire with three sections was created and pilot tested. Socio-demographic characteristics associated with inappropriate screening were identified using multivariable logistic regression models and latent class analysis.</p><p><strong>Results: </strong>A total of 294 participants completed the telephone survey (response rate 78.6%). The median number of wrong answers to questions related to pediatricians' practice towards screening recommendations was 7±1.57 with minimum 2 and maximum 11 wrong answers. Pediatricians, with less than 15 years of experience, age >50 years old or view more than eighty patients per week, have had significantly higher odds of responding wrong to more than seven questions, hence be less compliant to USPSTF screening guidelines. Latent class analysis has shown that female gender, age <50 years old, and work in the private sector, were associated with a poor practice towards international screening guidelines.</p><p><strong>Conclusion: </strong>Our survey found gaps in screening practices among a nationwide sample of Greek pediatricians. Moreover considerable variability in reported practices of screening was noted. There is a need for the development of a national childhood screening program in Greece.</p>","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":"52 3","pages":"237-342"},"PeriodicalIF":1.5,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7651763/pdf/eajm-52-3-237.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38618062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Factors Affecting Mortality in Late-Onset Ventilator-Associated Pneumonia.","authors":"Aziz Ahmad Hamidi,&nbsp;Serhat Kescioglu","doi":"10.5152/eurasianjmed.2020.20005","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2020.20005","url":null,"abstract":"<p><strong>Objective: </strong>Pneumonia that develops 48 hours after intubation has been defined as ventilator-associated pneumonia (VAP) in patients hospitalized in the intensive care unit (ICU). Late-onset VAP (LO-VAP) is described as pneumonia that occurs within or after the 5th day of mechanical ventilation. We aimed to determine the factors that affect the mortality and survival in patients with LO-VAP.</p><p><strong>Materials and methods: </strong>We retrospectively reviewed the hospital records of adult patients (>18 years) who developed LO-VAP in the training and research hospital between January 2014 and June 2018. We compared the demographic findings and laboratory characteristics of the survivors and deaths on the 28-day mortality.</p><p><strong>Results: </strong>The mean age of 231 (90 female and 141 male) patients with LO-VAP was 73.43±14.06 years. As a result of multivariate logistic regression analysis, we determined that advanced age (p=0.023; 95% confidence interval [CI]: 1.003-1.047) and unconsciousness (p=0.001; 95% CI: 1.674-6.547) were the independent factors affecting mortality. However, parenteral nutrition (PN) (p=0.027; 95% CI: 0.263-0.923) and tracheostomy (p=0.001; 95% CI: 0.112-0.545) were the independent factors supporting survival. We found that acute physiology and chronic health evaluation II score, presence of bacteremia, and enteral nutrition did not have a significant effect on mortality.</p><p><strong>Conclusion: </strong>Use of tracheostomy and PN in patients with LO-VAP has a positive effect on survival. Our study also points out that mortality can be high in patients with advanced age and unconsciousness.</p>","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":"52 3","pages":"254-258"},"PeriodicalIF":1.5,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7651759/pdf/eajm-52-3-254.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38618065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Endothelin 1 on Proliferation and Migration of Human MCF-7 Cells.","authors":"Irfan Cinar,&nbsp;Muhammed Yayla,&nbsp;Muhammet Celik,&nbsp;Arzu Bilen,&nbsp;Zafer Bayraktutan","doi":"10.5152/eurasianjmed.2020.20033","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2020.20033","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to explore the role of endothelin 1 (ET-1) in human breast cancer proliferation and migration and antagonism of endothelin receptor A (ETAR) and endothelin receptor B (ETBR) by using the non-selective dual ETA/ETB receptor antagonist bosentan and determine its anti-proliferative, anti-metastatic, and apoptotic effects demonstrated by nuclear factor kappa B (NF-kB), vascular endothelial growth factor (VEGF), Caspase 3 and Caspase 9 expression on endothelin-induced proliferation of MCF-7 cell line in vitro.</p><p><strong>Materials and methods: </strong>A total of 8,000 cells were seeded into e-plates 24 hours after the cells were incubated with or without 10-4 M BOS (1 hour before ET-1 treatment); 10-7, 10-8, and 10-9 M ET-1 for 1-4 days.</p><p><strong>Results: </strong>Whether ET-1 is present or not in the tumor area, bosentan exerts anti-proliferative effect on breast cancer. However, ET-1 and bosentan group showed important inhibitory effect on tumor migration compared to bosentan alone, which can be attributed to increased activity of ET-1 axis in the presence of ET-1. The imbalance among the NF-kB, caspases, and VEGF, which are predictive factors of carcinogenesis significantly improved after bosentan administration.</p><p><strong>Conclusion: </strong>Our study definitely demonstrated ET-1 and its critical role in cancer progression with apoptotic and anti-apoptotic pathways (NF-κB) and VEGF expression, and migration analyses were also performed. The second major finding was that bosentan inhibited ET-1-mediated effects on tumor proliferation and migration.</p>","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":"52 3","pages":"277-282"},"PeriodicalIF":1.5,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7651758/pdf/eajm-52-3-277.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38627579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protection Against Ionizing Radiation-Induced Normal Tissue Damage by Resveratrol: A Systematic Review.","authors":"Alaba Tolulope Agbele,&nbsp;Olatunji Jimoh Fasoro,&nbsp;Olufemi Moses Fabamise,&nbsp;Oluwabusayo Odunola Oluyide,&nbsp;Omena Raphael Idolor,&nbsp;Esther Abosede Bamise","doi":"10.5152/eurasianjmed.2020.20143","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2020.20143","url":null,"abstract":"<p><p>The use of some agents as radioprotectors has been evaluated for protection against normal tissue toxicity following exposure to ionizing radiation. Resveratrol, a natural flavonoid, with antioxidant and anti-inflammatory properties has attracted research interests for its radioprotective potential. This study systematically evaluates existing studies to examine the radioprotective effectiveness of resveratrol. A literature search of the electronic databases, including PubMed, Scopus, and Embase was conducted to retrieve articles investigating the protective effect of resveratrol against ionizing radiation-induced damage to normal tissues. The search timeframe ranged from the inception of each database to January 2020. From an initial search of 231 articles, and after the removal of duplicates as well as applying the predetermined inclusion and exclusion criteria, 33 articles were finally included for this systematic review. Results showed promising protective effect of resveratrol against ionizing radiation-induced damage to normal tissues. Furthermore, no adverse effect was observed after administering resveratrol. Resveratrol showed the potential to protect against ionizing radiation-induced damage to normal tissue cells via notable mechanisms, including anti-apoptotic and anti-inflammatory effects. However, further studies on the efficacy of clinical translation of resveratrol would open up more insights, while other gray areas such as the optimal radioprotective dosage of resveratrol requires further investigation. Overall, resveratrol is a potential double-edged sword in cancer therapy while protecting healthy tissues.</p>","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":"52 3","pages":"298-303"},"PeriodicalIF":1.5,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7651762/pdf/eajm-52-3-298.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38627583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leucocytes and Th-associated Cytokine Profile of HIV-Leishmaniasis Co-Infected Persons Attending Abuja Teaching Hospital, Nigeria.","authors":"Idris Nasir Abdullahi,&nbsp;Anthony Uchenna Emeribe,&nbsp;Hafeez Aderinsayo Adekola,&nbsp;Habiba Yahaya Muhammad,&nbsp;Abdurrahman El-Fulaty Ahmad,&nbsp;Abubakar Umar Anka,&nbsp;Yusuf Mohammed,&nbsp;Shamsuddeen Haruna,&nbsp;Bamidele Soji Oderinde,&nbsp;Halima Ali Shuwa,&nbsp;Adamu Babayo","doi":"10.5152/eurasianjmed.2020.20008","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2020.20008","url":null,"abstract":"<p><strong>Objective: </strong>T-helper cells (Th)-1& -2 cytokines homeostasis control or predict clinical outcome of infected persons, especially those with HIV /AIDS. This case-control study evaluated the leucocytes differentials, TNF-alpha, interleukin (IL)-2 and -10 levels among HIV infected persons with serological evidence of leishmaniasis attending University of Abuja Teaching Hospital, Nigeria.</p><p><strong>Materials and methods: </strong>Blood samples from 28 HIV infected persons who had Leishmania donovani rK39 and Immunoglobulin-G (IgG) positive (group 1), 30 age- & -sex matched HIV infected persons without Leishmania antibodies (group 2) and 30 apparently healthy persons without HIV and Leishmania antibodies (group 3). Full blood counts, TNF alpha, IL-2 and -10 levels were analyzed using automated hematology analyzer and ELISA, respectively. Structured questionnaires were used to collate biodata and clinical presentations of participants.</p><p><strong>Results: </strong>Ten (35.7%) participants in group 1 were on ART, 15 (50%) in group 2 were on ART, while group 3 were ART naïve. There were significantly higher values in basophil (4.4±2.5%) and eosinophil counts (12.9±3.8%) in HIV/leishmania coinfected persons (p<0.005). However, other white cells subpopulation was significantly lower in HIV/leishmania co-infected participants (p<0.05). There was significantly reduced CD4+ T cell counts ([119±26 versus 348±63 versus 605±116 cells/mm3]), TNF-alpha ([36.82±8.21 versus 64.67±12.54 versus 254.98±65.59 pg/mL]) and IL-2 levels ([142.14±20.91 versus 507.6±84.42 versus 486.62±167.87 pg/mL]) among HIV/Leishmania co-infected participants compared to group 2 and group 3 participants, respectively. However, higher IL-10 level (80.35±14.57 pg/mL) was found in HIV/Leishmania co-infected participants as opposed to the HIV monoinfected (62.2±10.43 pg/mL) and apparently healthy persons (23.97±4.88 pg/mL) (p<0.001).</p><p><strong>Conclusion: </strong>Eosinophil, basophil counts and serum IL-10 level were high in HIV/Leishmania coinfected persons, demonstrating parasite-induced hypersensitivity and immunosuppression.</p>","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":"52 3","pages":"271-276"},"PeriodicalIF":1.5,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7651764/pdf/eajm-52-3-271.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38627578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histological Comparison of Nanocomposite Multilayer Biomimetic Scaffold, A Chondral Scaffold, and Microfracture Technique to Repair Experimental Osteochondral Defects in Rats.","authors":"Kazim Solak,&nbsp;Istemi Yucel,&nbsp;Z Okan Karaduman,&nbsp;Sena Arda,&nbsp;M Mufit Orak,&nbsp;Ahmet Midi","doi":"10.5152/eurasianjmed.2019.19077","DOIUrl":"https://doi.org/10.5152/eurasianjmed.2019.19077","url":null,"abstract":"<p><strong>Objective: </strong>We used biomimetic scaffolds, chondral scaffolds, and microfractures to repair experimentally created osteochondral defects in rat knees and then compared the results of each method.</p><p><strong>Materials and methods: </strong>We used a total of 56 female Wistar albino rats. The rats were grouped into 4 groups, with 14 rats each: biomimetic scaffold, chondral scaffold, microfracture, and control groups. Cylindrical full-thickness osteochondral defects 2.5 mm in diameter and 2 mm in depth were drilled into the right knees with the rats under general anesthesia. The knees of all rats were operated again after 4 weeks. Biomimetic and chondral scaffolds were classified into two groups. Microfractures 0.5 mm in diameter and 0.8 mm in depth were created in the rats of the microfracture group. The control group received no treatment. All the rats were observed for 6 weeks and then sacrificed, with samples subjected to macroscopic and histopathological examinations.</p><p><strong>Results: </strong>The macroscopic and histopathological results in the biomimetic scaffold group differed significantly from those of the other treatment groups (p<0.05). When we compared the 3 treatment groups, the results of the chondral scaffold group were better than those of the microfracture group. The results of the microfracture group were somewhat better than those of the control group, but the result was not statistically significant (p>0.05).</p><p><strong>Conclusions: </strong>Nanocomposite multilayer biomimetic scaffolds were better than chondral scaffolds and microfractures when used to treat osteochondral defects.</p>","PeriodicalId":517142,"journal":{"name":"The Eurasian Journal of Medicine","volume":"52 2","pages":"145-152"},"PeriodicalIF":1.5,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311144/pdf/eajm-52-2-145.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38107466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}