Substance use & addiction journal最新文献

{"title":"Development and Delivery of a Theory-Guided Prescription Stimulant Misuse and Diversion Curriculum for College Health Providers: Results From Validity, Delphi, and Pre-Post Testing.","authors":"Maysaa Chaalan, Sarah Iglesias, Shelby Samuelson, Liz Barnett, Alison Looby, Niloofar Bavarian","doi":"10.1177/29767342251355128","DOIUrl":"https://doi.org/10.1177/29767342251355128","url":null,"abstract":"<p><strong>Background: </strong>Past studies have shown a large percentage of college health providers (CHPs) feel responsible yet unprepared to address prescription stimulant misuse (PSM) and prescription stimulant diversion (PSD). As such, the authors developed a theory-guided, universal curriculum for CHPs to more confidently address PSM and PSD among their student populations. The purpose of the current study was to refine the curriculum using a multistep approach and assess the impact on providers' PSM and PSD knowledge, attitudes, norms, barriers, and self-efficacy.</p><p><strong>Methods: </strong>The initial version of the curriculum was reviewed for content validity by 2 content/curriculum experts. Next, 5 students reviewed a revised version of the curriculum for face validity. The authors further refined the curriculum using the Delphi technique; specifically, a geographically diverse sample of 28 CHPs rated the appropriateness and clarity of each topic within each objective of the curriculum. Next, staff (N = 27) at 1 student health center received the training and completed a pre-post assessment to evaluate impact on knowledge, attitudes, norms, barriers, and self-efficacy. Quantitative (eg, means, medians, paired <i>t</i>-tests) and qualitative feedback were reviewed to guide refinement. These activities were completed between August 2023 and August 2024.</p><p><strong>Results: </strong>The criteria for content and face validity were met based on the reviews by curriculum experts and students, respectively. The Delphi technique required 2 rounds. All discussion topics had median and mode scores that reflected appropriateness and clarity. Pre-post assessment of the training showed significant improvements in CHPs knowledge, norms, self-efficacy, implementation barriers, and confidence to overcome barriers related to addressing PSM and PSD.</p><p><strong>Conclusions: </strong>A multistep process produced a comprehensive and theory-guided curriculum. Curriculum receipt resulted in improvements in multiple domains. Next steps include using an experimental design to test the impact of an intervention based on this training on student behavior, as well as digitizing and disseminating the training.</p>","PeriodicalId":516535,"journal":{"name":"Substance use & addiction journal","volume":" ","pages":"29767342251355128"},"PeriodicalIF":0.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Characteristic Parameters to Inform Continued Recovery Among Parenting Women With Opioid Use Disorder in a Residential Facility.","authors":"Doris Titus-Glover, George J Unick, Shijun Zhu, Soyeon Shim, Yali Deng, Jocelyn Gainers, Fadia T Shaya","doi":"10.1177/29767342251357676","DOIUrl":"https://doi.org/10.1177/29767342251357676","url":null,"abstract":"<p><strong>Introduction: </strong>Relevant characteristics of women with opioid use disorder (OUD) can guide new treatment plans or improve old ones. Despite known challenges, understanding why some women remain engaged in treatment while others do not is unclear. Continued treatment improves recovery and reduces relapse risks. Integrating characteristic parameters such as attributes, behaviors, and patterns into treatment can potentially prevent relapse and overdose risks. Therefore, the purpose of this study is to assess characteristic parameters such as demographics, health behavior, health status, utilization, and drug use patterns to inform the continued recovery of parenting women.</p><p><strong>Method: </strong>This is a descriptive cross-sectional study to assess the characteristics of parenting women with OUD (n = 39) recruited from residential facilities in an original study to explore capital factors for sustained recovery. Data were collected through interviews from 2021 to 2022.</p><p><strong>Results: </strong>Women in the sample had a mean age of 35 years, were single, white, and had completed high school. Most women were unemployed, received public assistance, including Medicaid, smoked, and were not ready to quit. Approximately 50% reported good to excellent physical/mental health; 67% utilized primary care services compared to emergency departments/hospitals. Women reported drug use for 13.7 years; prescription opioid misuse at about 19 years, and marijuana as the first drug used, before opioids. On average, more women were on methadone than on buprenorphine medication.</p><p><strong>Conclusion: </strong>This study highlights the influence of key characteristic parameters, including age, smoking, health status, utilization, and drug use patterns, to inform gender-based treatment planning for continued recovery.</p>","PeriodicalId":516535,"journal":{"name":"Substance use & addiction journal","volume":" ","pages":"29767342251357676"},"PeriodicalIF":0.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a Medication for Opioid Use Disorder Initiation Program in the Emergency Department.","authors":"Jaclyn Volney, Sarah R MacEwan, Jennifer L Hefner, Julie Teater, Emily Kauffman, Alice A Gaughan, Ramona G Olvera, Ann Scheck McAlearney","doi":"10.1177/29767342251355372","DOIUrl":"https://doi.org/10.1177/29767342251355372","url":null,"abstract":"<p><strong>Background: </strong>Medication for opioid use disorder (MOUD) is the standard evidence-based treatment option for patients with opioid use disorder (OUD). Initiating MOUD in the emergency department (ED) may help patients start the treatment and lead to greater success in sustaining recovery from OUD. Programs have been introduced in EDs to support the initiation of MOUD, but little is known about the implementation facilitators and challenges that impact these programs. The objective of this study was to explore key partners' perspectives about the facilitators and challenges of implementing and operating an ED-based MOUD program in a large, Midwestern academic medical center.</p><p><strong>Methods: </strong>Interviews were conducted in April and May 2019 with physicians, nurses, social workers, pharmacists, and administrators who were involved in implementing the ED MOUD initiation program. Verbatim transcripts were analyzed both deductively and inductively to identify themes related to the facilitators and challenges of program implementation, and suggestions about factors that contributed to program success.</p><p><strong>Results: </strong>We found subthemes related to each of these 3 major themes. First, facilitators of program implementation included institutional buy-in, community support, involvement of an interdisciplinary team, availability of ongoing training, and public awareness of the opioid epidemic. Second, program implementation challenges included inadequate staffing and training, complications in treatment linkage, uncertainty in prescribing, unclear workflow, and culture change. Identified success factors for program implementation included provider, community, and patient education, data availability, and provider buy-in.</p><p><strong>Conclusion: </strong>Our study results suggest that attention to factors such as buy-in, the need for the right training and education, and establishing key relationships with community organizations can help ED-based MOUD programs fill a critical gap in care for patients with OUD.</p>","PeriodicalId":516535,"journal":{"name":"Substance use & addiction journal","volume":" ","pages":"29767342251355372"},"PeriodicalIF":0.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Perceptions Related to Driving After Use of Alcohol and Cannabis in a Cross-National Sample of University Students in 6 Countries.","authors":"Kianna Csölle, Michael Amlung, Adrian J Bravo, Jordi Ortet-Walker, Verónica Vidal Arenas, Yanina Michelini, Eduardo Romano","doi":"10.1177/29767342251356352","DOIUrl":"https://doi.org/10.1177/29767342251356352","url":null,"abstract":"<p><strong>Background: </strong>Cross-national comparisons of driving under the influence (DUI) of cannabis (DUIC) or DUI of alcohol (DUIA; ie, driving after consuming too much to drive safely) may inform policies and preventative measures, although research is currently limited. This cross-national study sought to compare the frequency of DUI, being a passenger with an impaired driver, and associated risk perceptions.</p><p><strong>Methods: </strong>Secondary analyses of students from 6 countries (Argentina, Canada, England, Spain, South Africa, United States). Participants (n = 5167; 70% women; mean age 20.1 [SD = 3.7]) completed an online survey assessing past-year frequency of alcohol or cannabis-impaired driving and being a passenger with an impaired driver. Risk perceptions included the perceived threat to personal safety of impaired driving, and perceived likelihood of negative consequences (eg, being in an accident, stopped by police). Differences across countries were tested using chi-square tests with Bonferroni-corrected adjusted residuals for pairwise comparisons.</p><p><strong>Results: </strong>Endorsement of impaired driving was generally low (<12%) across countries. Significant differences were found across countries in perceived threat to the safety of driving after using alcohol or cannabis. Compared to other countries, England and Spain rated DUIA as less of a threat, and Argentina rated DUIC as less of a threat. Perceived likelihood of consequences also differed across countries, potentially due to perceptions of reduced enforcement in some countries (eg, Argentina, South Africa). Finally, participants with a history of impaired driving and men in some countries were more likely to report more favorable risk perceptions (ie, lower threat and lower likelihood of consequences) than drivers who reported never driving impaired.</p><p><strong>Conclusions: </strong>These results offer preliminary evidence of cross-national differences in alcohol and cannabis impaired driving and associated risk perceptions, providing a foundation for future studies investigating causal factors such as legalization and enforcement of driving-related laws across countries.</p>","PeriodicalId":516535,"journal":{"name":"Substance use & addiction journal","volume":" ","pages":"29767342251356352"},"PeriodicalIF":0.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Mobile Health Application to Support Reductions in Overdose Risk Behaviors: A Pilot Study.","authors":"Caitlin J Conway, Sarah Uhm, Mikaela Becker, Katy Mijal, Ryan P Westergaard, Rachel E Gicquelais","doi":"10.1177/29767342251355154","DOIUrl":"https://doi.org/10.1177/29767342251355154","url":null,"abstract":"<p><strong>Background: </strong>Mobile health (mHealth) applications are positioned to provide information and support anywhere and anytime, though few focus on overdose-related harm reduction. We aimed to describe the use of an e-harm reduction smartphone application theoretically based on self-determination theory among people who inject drugs.</p><p><strong>Methods: </strong>We enrolled 60 clients from 3 syringe services programs in Wisconsin in a single-arm, pre-post pilot study between December 2022 and June 2023. Eligible participants used opioids and injected drugs within the past week. Participants received a smartphone, unlimited data plan, and e-harm reduction focused mHealth application based on the self-determination theory principles of autonomy, competence, and relatedness. The app was used to deliver a 12-week overdose risk reduction intervention. Every week, participants self-selected 1 of 11 available overdose-focused harm reduction goals and received tailored education, resources, and support from study staff through the smartphone application. We evaluated the use of app features, intervention adherence, and described the most commonly selected overdose risk reduction goals.</p><p><strong>Results: </strong>Of available app features, participants most often used private messaging (median, interquartile range [IQR] days used: 28 [18-53]), viewed a motivational \"thought of the day\" (median [IQR] days used: 24 [15-47]), and interacted with discussion boards (median [IQR] days used: 12 [5-24]). Of 12 available weekly goal-setting intervention activities, participants completed a median of 9 (IQR: 4-11). Of 448 completed goal-setting activities, reducing drug injection and reducing drug use were the most commonly selected goals (chosen N = 86 [19.2%] and N = 81 [18.1%] times, respectively) followed by quitting use (N = 69 times, 15.4%), and reducing solitary drug use (N = 54 times, 12.1%).</p><p><strong>Conclusion: </strong>An e-harm reduction mHealth application was used by participants for overdose risk reduction goal setting, messaging, and viewing motivational content. Future studies will evaluate benefits of engaging with e-harm reduction mHealth applications for overdose prevention intervention relative to a control group.</p>","PeriodicalId":516535,"journal":{"name":"Substance use & addiction journal","volume":" ","pages":"29767342251355154"},"PeriodicalIF":0.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engaging Affected Family Members in Substance Use Disorder Care: Knowledge, Attitudes, and Behaviors of Addiction Care Teams.","authors":"Jessica B Calihan, Alicia S Ventura, Jiayi Wang, Radhika Puppala, Moriah Wiggins, Cala Renehan, Brigid Garrity, Sarah M Bagley","doi":"10.1177/29767342251355135","DOIUrl":"https://doi.org/10.1177/29767342251355135","url":null,"abstract":"<p><strong>Background: </strong>Engaging affected family members (AFMs) of individuals with substance use disorder (SUD) has the potential to improve treatment outcomes across the continuum from identification of substance misuse to treatment initiation, harm reduction, and recovery. Although family and social support improves outcomes for people with SUD, current care models often do not include AFMs in care. This study aimed to understand SUD care team members' behaviors, attitudes, training, and knowledge regarding engaging AFMs, and evaluate whether attitudes and receipt of related training are associated with clinical practices.</p><p><strong>Methods: </strong>This is a cross-sectional study of interdisciplinary SUD care team members at a large, urban, safety-net hospital. Surveys assessed providers' current clinical practices around including AFMs, related attitudes, prior training and desired support about family engagement, and a knowledge assessment.</p><p><strong>Results: </strong>Few providers (30%) reported regularly including AFMs in SUD despite most feeling it is helpful for families to be frequently or very frequently involved (68%). Providers more frequently provided education to AFMs about SUD (72%) and treatment (70%) than overdose prevention and naloxone (38%). Only 26% of providers had received any training on strategies to include AFMs and other social supports in SUD care, and the knowledge assessment revealed prevalent inaccurate and potentially stigmatizing beliefs about the involvement of AFMs in care.</p><p><strong>Conclusions: </strong>Although most SUD care team members recognize the benefit of social support in recovery, a minority regularly involve AFMs in their clinical work with individuals with SUD. Addressing these barriers and improving provider access to training may create opportunities to improve engagement of AFMs and outcomes for individuals with SUD.</p>","PeriodicalId":516535,"journal":{"name":"Substance use & addiction journal","volume":" ","pages":"29767342251355135"},"PeriodicalIF":0.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Board-Certified Psychiatric Pharmacists in Substance Use Disorder Care.","authors":"Anuja Vallabh, Audrey Abelleira, Amber R Douglass, Cynthia A Gutierrez, Ashley Maister, Benjamin Miskle, Karen E Moeller, Aaron Salwan, Kristin Waters, David Dadiomov","doi":"10.1177/29767342251352994","DOIUrl":"https://doi.org/10.1177/29767342251352994","url":null,"abstract":"","PeriodicalId":516535,"journal":{"name":"Substance use & addiction journal","volume":" ","pages":"29767342251352994"},"PeriodicalIF":0.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Clinician Practices and Attitudes Toward Acute Pain Management for Patients With Opioid Use Disorder.","authors":"Megan Muller, Abid Khan, Nikita Thomas, Mim Ari","doi":"10.1177/29767342251351108","DOIUrl":"https://doi.org/10.1177/29767342251351108","url":null,"abstract":"<p><strong>Background: </strong>Patients with opioid use disorder (OUD) often face challenges when being treated for acute pain due to opioid tolerance, co-occurring withdrawal, and clinician stigma and knowledge deficits. Guidelines for pain management in this population remain unclear. This study aimed to explore clinician practice patterns and attitudes regarding emergency department and inpatient acute pain management in patients with OUD.</p><p><strong>Methods: </strong>A survey with 2 clinical vignettes (a patient without OUD, a patient with OUD), 1 knowledge question, and 5 attitude questions was disseminated to clinicians in emergency medicine, internal medicine, and trauma surgery (n = 423, response rate 24.3%) at a single academic medical center. Descriptive statistics were performed on completed surveys (n = 103). An ordinal logistic regression model (α = .05) was generated to evaluate attitude responses by demographic.</p><p><strong>Results: </strong>In the vignettes, 18 (17.5%) indicated that an OUD diagnosis would not change acute pain management. Four (3.9%) and 2 (1.9%) would avoid IV opioids and oral opioids. Fifty-four (52.4%) and 34 (33.0%) would use higher dose IV and oral opioids, while 18 (17.5%) would use long-acting oral opioids. About half (53, 51.5%) \"agreed\" or \"strongly agreed\" that they felt comfortable treating acute pain in patients with OUD. Ninety-eight respondents (95.2%) \"disagreed\" or \"strongly disagreed\" that patients with OUD should not receive opioid analgesia. Sixty-six respondents (64.1%) \"disagreed\" or \"strongly disagreed\" that the physical symptoms of patients with substance use disorders are treated as seriously as those without.</p><p><strong>Conclusions: </strong>While most respondents aligned changes in management with pharmacologic principles (ie, higher tolerance requiring more opioids), a sizable proportion reported that they would not make changes or would withhold opioids. Additionally, only half of respondents indicated comfort with treating acute pain in patients with OUD. Additional research and guidelines, development of clinical decision supports, and targeted educational initiatives are needed to improve comfort and clinical care.</p>","PeriodicalId":516535,"journal":{"name":"Substance use & addiction journal","volume":" ","pages":"29767342251351108"},"PeriodicalIF":0.0,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pomegranate Juice Consumption Improves Sleep Quality and Melatonin Concentration of Patients With Opioid Use Disorders Under Medication-Assisted Treatment With Methadone and Buprenorphine: A Randomized Controlled Trial.","authors":"Christonikos Leventelis, Petros T Barmpas, Antzouletta Kampitsi, Kalliopi Iliopoulou, Nikoletta Toutouktsi, Prodromos Malakopoulos, Sotiris Tasoulis, Aristidis S Veskoukis","doi":"10.1177/29767342251342666","DOIUrl":"https://doi.org/10.1177/29767342251342666","url":null,"abstract":"<p><strong>Background and aims: </strong>Patients under medication-assisted treatment (MAT) with methadone and buprenorphine experience sleep disturbances related to drug addiction, which are risk factors for craving and relapse to opioids. Plants such as pomegranate, due to their ingredients, appear to act therapeutically ameliorating symptoms of sleep disorders. Thus, the aim of the present study was to investigate the impact of pomegranate juice on sleep quality and melatonin concentration of patients under MAT.</p><p><strong>Methods: </strong>In total, 58 volunteers were included in the present investigation. They were divided into the experimental group (n = 40), comprising patients under MAT who were administered with pomegranate juice (dosage: 250 ml/day, 7 days/week, 120 days) and the control group (n = 18) with MAT patients without juice consumption. These groups were further stratified based on MAT, namely, methadone maintenance treatment (MMT) and buprenorphine maintenance treatment (BMT). Melatonin concentration was measured in saliva and sleep quality was assessed through the Pittsburgh Sleep Quality Index at the 1st, 60th, and 120th day.</p><p><strong>Results: </strong>Melatonin concentration was increased in both MMT and BMT patients at the 120th day due to pomegranate juice consumption compared with that in the control. Furthermore, the applied nutritional intervention improved sleep quality only in the MMT patients at the 120th day, whereas sleep quality of MMT patients was compromised compared with those under BMT in the control group.</p><p><strong>Conclusions: </strong>The obtained findings indicate that pomegranate could be considered as an auxiliary intervention, in parallel with medication, toward rehabilitation of patients under MAT.</p>","PeriodicalId":516535,"journal":{"name":"Substance use & addiction journal","volume":" ","pages":"29767342251342666"},"PeriodicalIF":0.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis and Derived Cannabis Use, Motives, and Consequences Among US Young Adults: Findings From a Cross-Sectional Mediation Study.","authors":"Cassidy R LoParco, Yuxian Cui, Matthew E Rossheim, Rishika Chakraborty, Morgan Speer, Julia Chen-Sankey, Patricia A Cavazos-Rehg, Carla J Berg","doi":"10.1177/29767342251355094","DOIUrl":"https://doi.org/10.1177/29767342251355094","url":null,"abstract":"<p><strong>Background: </strong>Since the 2018 Agricultural Improvement Act, derived intoxicating cannabis products (DICPs) emerged as largely unregulated products; meanwhile, traditional cannabis use has increased. To inform effective prevention, research is needed to assess differences in motives for using cannabis <i>only</i> versus <i>both</i> cannabis and DICPs, as well as use-related consequences.</p><p><strong>Methods: </strong>We analyzed survey data (June-November 2023) from 4031 US young adults aged 18 to 34 (average age = 26.9; 63.9% white; 59.0% female; aiming for ~50% past-month cannabis use). The analytic sample included participants reporting past-month cannabis use (n = 1968). Two cross-sectional mediation models were conducted to examine: (1) cannabis use motives (social/cognitive enhancement and coping) in relation to use-related consequences (psychophysiological and sociobehavioral) via use category (cannabis-only vs cannabis-DICP co-use) and (2) consequences in relation to use category via use motives.</p><p><strong>Results: </strong>Overall, 54.4% reported cannabis-only use and 45.6% reported cannabis-DICP co-use. Greater enhancement and coping motives were associated with cannabis-DICP co-use (vs cannabis-only use). Regarding Model No. 1, lower cannabis coping motives and cannabis-DICP use (vs cannabis-only use) were associated with greater psychophysiological and sociobehavioral consequences, and the associations between coping and enhancement motives and psychophysiological and sociobehavioral consequences were indirectly mediated via cannabis-DICP co-use. For Model No. 2, lower psychophysiological and greater sociobehavioral consequences were associated with greater coping and enhancement motives, greater sociobehavioral consequences was associated with higher odds of cannabis-DICP co-use (vs cannabis-only use), and psychophysiological and sociobehavioral consequences were indirectly associated with cannabis-DICP co-use through enhancement and coping motives.</p><p><strong>Conclusions: </strong>Considering the risks associated with cannabis and DICP use, future intervention and prevention efforts should focus on the observed associations to reduce risk.</p>","PeriodicalId":516535,"journal":{"name":"Substance use & addiction journal","volume":" ","pages":"29767342251355094"},"PeriodicalIF":0.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}