Reproductive Medicine最新文献

Fetal Gestational Age Prediction in Brain Magnetic Resonance Imaging Using Artificial Intelligence: A Comparative Study of Three Biometric Techniques 利用人工智能预测脑磁共振成像中的胎儿妊娠年龄：三种生物识别技术的比较研究

Reproductive Medicine Pub Date : 2024-07-15 DOI: 10.3390/reprodmed5030012

Farzan Vahedifard, Xuchu Liu, Kranthi K. Marathu, H. Ai, M. Supanich, Mehmet Kocak, Seth Adler, Shehbaz M. Ansari, Melih Akyuz, Jubril O. Adepoju, Sharon Byrd

{"title":"Fetal Gestational Age Prediction in Brain Magnetic Resonance Imaging Using Artificial Intelligence: A Comparative Study of Three Biometric Techniques","authors":"Farzan Vahedifard, Xuchu Liu, Kranthi K. Marathu, H. Ai, M. Supanich, Mehmet Kocak, Seth Adler, Shehbaz M. Ansari, Melih Akyuz, Jubril O. Adepoju, Sharon Byrd","doi":"10.3390/reprodmed5030012","DOIUrl":"https://doi.org/10.3390/reprodmed5030012","url":null,"abstract":"Accurately predicting a fetus’s gestational age (GA) is crucial in prenatal care. This study aimed to develop an artificial intelligence (AI) model to predict GA using biometric measurements from fetal brain magnetic resonance imaging (MRI). We assessed the significance of using different reference standards for interpreting GA predictions. Measurements of biparietal diameter (BPD), fronto-occipital diameter (FOD), and head circumference (HC) were obtained from 52 normal fetal MRI cases from Rush University. Both manual and AI-based methods were utilized, and comparisons were made using three reference standards (Garel, Freq, and Bio). The AI model showed a strong correlation with manual measurements, particularly for HC, which exhibited the highest correlation with actual values. Differences between GA predictions and picture archiving and communication system (PACS) records varied by reference, ranging from 0.47 to 2.17 weeks for BPD, 0.46 to 2.26 weeks for FOD, and 0.75 to 1.74 weeks for HC. Pearson correlation coefficients between PACS records and GA predictions exceeded 0.97 across all references. In conclusion, the AI model demonstrated high accuracy in predicting GA from fetal brain MRI measurements. This approach offers improved accuracy and convenience over manual methods, highlighting the potential of AI in enhancing prenatal care through precise GA estimation.","PeriodicalId":516007,"journal":{"name":"Reproductive Medicine","volume":"11 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141646634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal Evaluation of a Minimally Invasive Method of Preimplantation Genetic Testing for Aneuploidy (mi-PGT-A) in Human Embryos 人类胚胎非整倍体植入前遗传检测微创方法（mi-PGT-A）的时间评估

Reproductive Medicine Pub Date : 2024-07-08 DOI: 10.3390/reprodmed5030011

Katharine R. B. Phillips, Alexander G. Kuzma-Hunt, Michael S. Neal, Connie Lisle, Hariharan Sribalachandran, Ronald F. Carter, Shilpa Amin, M. Karnis, Mehrnoosh Faghih

{"title":"Temporal Evaluation of a Minimally Invasive Method of Preimplantation Genetic Testing for Aneuploidy (mi-PGT-A) in Human Embryos","authors":"Katharine R. B. Phillips, Alexander G. Kuzma-Hunt, Michael S. Neal, Connie Lisle, Hariharan Sribalachandran, Ronald F. Carter, Shilpa Amin, M. Karnis, Mehrnoosh Faghih","doi":"10.3390/reprodmed5030011","DOIUrl":"https://doi.org/10.3390/reprodmed5030011","url":null,"abstract":"Preimplantation genetic testing for aneuploidy (PGT-A) has become a useful approach for embryo selection following IVF and ICSI. However, the biopsy process associated with PGT-A is expensive, prone to errors in embryo ploidy determination, and potentially damaging, impacting competence and implantation potential. Therefore, a less invasive method of PGT-A would be desirable and more cost-effective. Noninvasive methods for PGT-A (ni-PGT-A) have been well-studied but present limitations in terms of cf-DNA origin and diagnostic accuracy. Minimally invasive pre-implantation genetic testing (mi-PGT-A) for frozen-thawed embryo transfer is a promising, less studied approach that utilizes a combination of spent culture media (SCM) and blastocoelic fluid (BF)-derived cell-free (CF)-DNA for genetic testing. This study aimed to optimize the effectiveness of mi-PGT-A for aneuploidy diagnosis by investigating the optimal temporal sequence for this protocol. SCM+BF was collected at either 48 or 72 h of culture after thawing day 3 preimplantation embryos. cf-DNA in the SCM+BF was amplified, analyzed by next-generation sequencing (NGS) and compared with results from the corresponding whole embryos (WEs) obtained from human embryos donated for research. Fifty-three (42 expanded blastocysts, 9 early blastocysts, and 2 morula) WE and SCM+BF samples were analyzed and compared. The overall concordance rate between SCM+BF and WE was 60%. Gender and ploidy concordance improved with extended culture time from 48 h (73% and 45%) to 72 h (100% and 64%), respectively. These results demonstrate that SCM+BF-derived cf-DNA can be successfully used for mi-PGT-A. Our findings indicate that longer embryo culture time prior to SCM+BF-derived cf-DNA analysis improves DNA detection rate and concordance with WEs and decreases the proportion of false positive results.","PeriodicalId":516007,"journal":{"name":"Reproductive Medicine","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141670120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Pathogenic Microbes within the Endometrium in Normal Weight vs. Obese Women with Infertility 不孕症正常体重妇女与肥胖妇女子宫内膜病原微生物的流行情况

Reproductive Medicine Pub Date : 2024-06-06 DOI: 10.3390/reprodmed5020010

Sarah King, Florence Osei, Courtney Marsh

{"title":"Prevalence of Pathogenic Microbes within the Endometrium in Normal Weight vs. Obese Women with Infertility","authors":"Sarah King, Florence Osei, Courtney Marsh","doi":"10.3390/reprodmed5020010","DOIUrl":"https://doi.org/10.3390/reprodmed5020010","url":null,"abstract":"This study investigates the association between body mass index (BMI) and the composition of the endometrial microbiota in infertile women of childbearing age. This is a retrospective clinical study comparing the endometrial microbiota across body weight in 132 patients presenting for care at an infertility clinic. The reason for infertility was recurrent pregnancy loss (RPL) or implantation failure with a prior IVF cycle. Microbe analysis was completed by Igenomix Laboratory (Valencia, Spain) using two comprehensive panels. Patients were separated into three groups based on their results: normal, dysbiotic, and pathogenic. Prevalence of these groups was compared across BMI categories and statistical analysis was used to determine significance. Of the 132 endometrial samples collected, 80 (60.6%) were normal, 16 (12.1%) were dysbiotic, and 36 (27.3%) were pathogenic. Patients with a BMI ≥ 30 showed a statistically significant increase in pathogenic endometrium compared to normal weight controls (p = 0.029). Our conclusion is that the prevalence of pathogenic endometrium was significantly higher in the obese group compared with normal weight controls. There is a possible association between obesity and the endometrial microbiome.","PeriodicalId":516007,"journal":{"name":"Reproductive Medicine","volume":"4 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141379619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of Obstetric Anal Sphincter Injury by Delivering Provider 接生人员造成产科肛门括约肌损伤的风险

Reproductive Medicine Pub Date : 2024-05-08 DOI: 10.3390/reprodmed5020007

Taniya Walker, Ciara Bryson, Sara Rahman, C. Carter-Brooks

{"title":"Risk of Obstetric Anal Sphincter Injury by Delivering Provider","authors":"Taniya Walker, Ciara Bryson, Sara Rahman, C. Carter-Brooks","doi":"10.3390/reprodmed5020007","DOIUrl":"https://doi.org/10.3390/reprodmed5020007","url":null,"abstract":"Introduction and Hypothesis: Obstetric anal sphincter injuries (OASIs) complicate 5.8% of vaginal deliveries. Our objective was to assess if the primary delivery provider, a nurse-midwife versus physician obstetrician, is associated with OASIs. Methods: We performed a secondary analysis of the Consortium of Safe Labor, a multicenter, retrospective cohort study. Included were nulliparous women with singleton, vaginal delivery at ≥37 weeks from 2002 to 2008. Women were excluded if delivery was complicated by shoulder dystocia or from sites without midwife deliveries. Student’s t-tests, chi-squared analysis, and Fisher’s exact test were used as appropriate. Multivariable logistic regression and propensity score-matching analyses were performed. Results: Of 228,668 births at 19 sites, 2735 births from 3 sites met the inclusion criteria: 1551 physician and 1184 midwife births. Of all births, 4.2% (n = 116) were complicated by OASIs. Physician patients were older, more often White, privately insured, with higher BMI, more medical co-morbidities, and labor inductions/augmentations. Midwife patients had higher fetal gestational age and infant birth weights (all p < 0.05). OASIs were more common in physician compared to midwife births (5.9% vs. 2.0%, p < 0.0001). This difference persisted in multivariable logistic regression. OASIs were 2.4 (95%CI 1.5–3.9) times more likely with physician delivery when controlling for maternal heart disease, episiotomy, increasing maternal age, decreasing maternal BMI, non-White race, and increasing birthweight. The AUC was 0.78. With propensity score matching, OASI rates remained higher amongst physician births (6.6% vs. 1.8%, p < 0.0001; aOR 3.8 (95%CI 2.0–7.1)). Conclusion: OASIs were more common in physician compared to midwife deliveries even when controlling for other associated factors.","PeriodicalId":516007,"journal":{"name":"Reproductive Medicine","volume":" 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141001007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Rose et al. The Effect of In Vitro Maturation (IVM) Protocol Changes on Measures of Oocyte/Embryo Competence. Reprod. Med. 2023, 4, 65–73 更正：罗斯等人，体外成熟（IVM）方案变化对卵母细胞/胚胎能力测量的影响。Reprod.Med.2023, 4, 65-73

Reproductive Medicine Pub Date : 2024-04-12 DOI: 10.3390/reprodmed5020004

Bruce I. Rose, Kevin Nguyen, Samuel E. Brown

引用次数: 0

Pre-Operative Anxiety Related to Major Urogynecologic Surgery: Insights from Perioperative Survey Data in Maine 与泌尿妇科大手术相关的术前焦虑：缅因州围手术期调查数据的启示

Reproductive Medicine Pub Date : 2024-03-07 DOI: 10.3390/reprodmed5010003

N. Kaonga, Yanghee Courbron, Emmy Holmgren, Eliot Konzal, Whitney Williams, Mary Brandes, Caroline Foust-Wright

{"title":"Pre-Operative Anxiety Related to Major Urogynecologic Surgery: Insights from Perioperative Survey Data in Maine","authors":"N. Kaonga, Yanghee Courbron, Emmy Holmgren, Eliot Konzal, Whitney Williams, Mary Brandes, Caroline Foust-Wright","doi":"10.3390/reprodmed5010003","DOIUrl":"https://doi.org/10.3390/reprodmed5010003","url":null,"abstract":"Background: Higher levels of pre-operative anxiety are associated with adverse outcomes according to the cardiothoracic and orthopedic literature on emergent surgeries. There are limited data on pre-operative anxiety levels in the gynecologic setting. This study sought to identify predictive variables for high pre-operative anxiety levels in patients undergoing major urogynecologic surgery. Methods: Pre- and post-operative surveys that included demographic data, a modification of the Amsterdam Pre-Operative Anxiety and Information Scale, and open-ended questions regarding anxiety were administered. Descriptive, univariate and multivariate analyses were used to analyze the quantitative elements of the survey data. The qualitative components of the survey data were coded and analyzed using thematic analyses. Results: A total of 54 participants completed the pre-operative survey. The median age was 62 years old, and the majority were employed (n = 34, 60.7%). Roughly 1/3 had been diagnosed with a mental health condition (n = 19, 33.9%) and nearly all had other health conditions (n = 51, 91%). The baseline APAIS score ranged from 9 to 40, with higher scores reflecting higher levels of pre-operative anxiety. The median APAIS score was 24, with a score equal to or greater than 30 being in the highest tertile. Conclusion: No associations were made between the variables and pre-operative anxiety levels. However, useful insights into our patient population were made.","PeriodicalId":516007,"journal":{"name":"Reproductive Medicine","volume":"27 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140260623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetes Technology in Pregnant Women with Type 1 Diabetes—Distribution and Effects on Glycemic Regulation and Perinatal Outcomes 1 型糖尿病孕妇的糖尿病技术--分布情况及其对血糖调节和围产期结果的影响

Reproductive Medicine Pub Date : 2024-02-07 DOI: 10.3390/reprodmed5010002

Sara Yalda Ghaur, Pernille Bundgaard Grinderslev, Magnus Leth-Møller, P. G. Ovesen, J. Fuglsang, Sanne Fisker, H. D. McIntyre, Ulla Kampmann

{"title":"Diabetes Technology in Pregnant Women with Type 1 Diabetes—Distribution and Effects on Glycemic Regulation and Perinatal Outcomes","authors":"Sara Yalda Ghaur, Pernille Bundgaard Grinderslev, Magnus Leth-Møller, P. G. Ovesen, J. Fuglsang, Sanne Fisker, H. D. McIntyre, Ulla Kampmann","doi":"10.3390/reprodmed5010002","DOIUrl":"https://doi.org/10.3390/reprodmed5010002","url":null,"abstract":"Pregnancies complicated by type 1 diabetes (TID) are associated with an increased risk of obstetric and neonatal adverse outcomes. Optimal glycemic control prior to and through pregnancy is crucial to reduce complications. The use of diabetes technology is rapidly increasing. The aim of the study was to investigate the use and effects of diabetes technology in pregnant women with type 1 diabetes. A retrospective cohort study was conducted; 84 women were included in the analysis and were divided into subgroups according to their glucose monitoring method and insulin delivery method. HbA1c values declined during pregnancy in all subgroups with no significant difference between the subgroups. A difference was, however, found in birth weight z-scores. Women using a sensor and an insulin pump had larger babies compared to women without these treatment modalities. The results of the study indicate that diabetes technology, including insulin pumps and/or glucose sensors are not superior to self-monitoring blood glucose measurement and multiple daily injection insulin therapy, which is comforting in the light of the unequal access to health benefits.","PeriodicalId":516007,"journal":{"name":"Reproductive Medicine","volume":"31 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139795238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetes Technology in Pregnant Women with Type 1 Diabetes—Distribution and Effects on Glycemic Regulation and Perinatal Outcomes 1 型糖尿病孕妇的糖尿病技术--分布情况及其对血糖调节和围产期结果的影响

Reproductive Medicine Pub Date : 2024-02-07 DOI: 10.3390/reprodmed5010002

Sara Yalda Ghaur, Pernille Bundgaard Grinderslev, Magnus Leth-Møller, P. G. Ovesen, J. Fuglsang, Sanne Fisker, H. D. McIntyre, Ulla Kampmann

{"title":"Diabetes Technology in Pregnant Women with Type 1 Diabetes—Distribution and Effects on Glycemic Regulation and Perinatal Outcomes","authors":"Sara Yalda Ghaur, Pernille Bundgaard Grinderslev, Magnus Leth-Møller, P. G. Ovesen, J. Fuglsang, Sanne Fisker, H. D. McIntyre, Ulla Kampmann","doi":"10.3390/reprodmed5010002","DOIUrl":"https://doi.org/10.3390/reprodmed5010002","url":null,"abstract":"Pregnancies complicated by type 1 diabetes (TID) are associated with an increased risk of obstetric and neonatal adverse outcomes. Optimal glycemic control prior to and through pregnancy is crucial to reduce complications. The use of diabetes technology is rapidly increasing. The aim of the study was to investigate the use and effects of diabetes technology in pregnant women with type 1 diabetes. A retrospective cohort study was conducted; 84 women were included in the analysis and were divided into subgroups according to their glucose monitoring method and insulin delivery method. HbA1c values declined during pregnancy in all subgroups with no significant difference between the subgroups. A difference was, however, found in birth weight z-scores. Women using a sensor and an insulin pump had larger babies compared to women without these treatment modalities. The results of the study indicate that diabetes technology, including insulin pumps and/or glucose sensors are not superior to self-monitoring blood glucose measurement and multiple daily injection insulin therapy, which is comforting in the light of the unequal access to health benefits.","PeriodicalId":516007,"journal":{"name":"Reproductive Medicine","volume":"25 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139855200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antenatal Secondhand Smoke (SHS) Exposure and the Receptor for Advanced Glycation End-Products (RAGE) 产前二手烟 (SHS) 暴露与高级糖化终产物受体 (RAGE)

Reproductive Medicine Pub Date : 2024-01-30 DOI: 10.3390/reprodmed5010001

K. Curtis, Kelsey M. Hirshi, K. Tsai, Evan T Clark, Brendan M Stapley, B. Bikman, P. Reynolds, J. Arroyo

{"title":"Antenatal Secondhand Smoke (SHS) Exposure and the Receptor for Advanced Glycation End-Products (RAGE)","authors":"K. Curtis, Kelsey M. Hirshi, K. Tsai, Evan T Clark, Brendan M Stapley, B. Bikman, P. Reynolds, J. Arroyo","doi":"10.3390/reprodmed5010001","DOIUrl":"https://doi.org/10.3390/reprodmed5010001","url":null,"abstract":"Exposure to secondhand smoke (SHS) during fetal development results in negative postnatal effects, including altered organ development, changes in metabolism, and increased risk of respiratory illness. Previously, we found the induction of intrauterine growth restriction (IUGR) dependent on the expression of the receptor for advanced glycation end-products (RAGE) in mice treated with SHS. Furthermore, antenatal SHS exposure increases RAGE expression in the fetal lung. Our objective was to determine the postnatal effects of antenatal SHS treatment in 4- and 12-week-old offspring. Pregnant animals were treated with SHS via a nose-only delivery system (Scireq Scientific, Montreal, Canada) for 4 days (embryonic day 14.5 through 18.5), and offspring were evaluated at 4 or 12 weeks of age. Animal and organ weights were measured, and lungs were histologically characterized. Blood pressure and heart rates were obtained, and RAGE protein expression was determined in the lungs of control and treated animals. We observed the following: (1) significant decreases in animal, liver, and heart weights at 4 weeks of age; (2) increased blood pressure in 4-week-old animals; and (3) increased RAGE expression in the lungs of the 4-week-old animals. Our results suggest an improvement in these metrics by 12 weeks postnatally such that measures were not different regardless of RA or SHS exposure. Increased RAGE expression in lungs from 4-week-old mice antenatally treated with SHS suggests a possible role for this important smoke-mediated receptor in establishing adult disease following IUGR pregnancies.","PeriodicalId":516007,"journal":{"name":"Reproductive Medicine","volume":"61 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140485637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0