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Diabetes Technology in Pregnant Women with Type 1 Diabetes—Distribution and Effects on Glycemic Regulation and Perinatal Outcomes 1 型糖尿病孕妇的糖尿病技术--分布情况及其对血糖调节和围产期结果的影响

Reproductive Medicine Pub Date : 2024-02-07 DOI: 10.3390/reprodmed5010002

Sara Yalda Ghaur, Pernille Bundgaard Grinderslev, Magnus Leth-Møller, P. G. Ovesen, J. Fuglsang, Sanne Fisker, H. D. McIntyre, Ulla Kampmann

{"title":"Diabetes Technology in Pregnant Women with Type 1 Diabetes—Distribution and Effects on Glycemic Regulation and Perinatal Outcomes","authors":"Sara Yalda Ghaur, Pernille Bundgaard Grinderslev, Magnus Leth-Møller, P. G. Ovesen, J. Fuglsang, Sanne Fisker, H. D. McIntyre, Ulla Kampmann","doi":"10.3390/reprodmed5010002","DOIUrl":"https://doi.org/10.3390/reprodmed5010002","url":null,"abstract":"Pregnancies complicated by type 1 diabetes (TID) are associated with an increased risk of obstetric and neonatal adverse outcomes. Optimal glycemic control prior to and through pregnancy is crucial to reduce complications. The use of diabetes technology is rapidly increasing. The aim of the study was to investigate the use and effects of diabetes technology in pregnant women with type 1 diabetes. A retrospective cohort study was conducted; 84 women were included in the analysis and were divided into subgroups according to their glucose monitoring method and insulin delivery method. HbA1c values declined during pregnancy in all subgroups with no significant difference between the subgroups. A difference was, however, found in birth weight z-scores. Women using a sensor and an insulin pump had larger babies compared to women without these treatment modalities. The results of the study indicate that diabetes technology, including insulin pumps and/or glucose sensors are not superior to self-monitoring blood glucose measurement and multiple daily injection insulin therapy, which is comforting in the light of the unequal access to health benefits.","PeriodicalId":516007,"journal":{"name":"Reproductive Medicine","volume":"25 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139855200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antenatal Secondhand Smoke (SHS) Exposure and the Receptor for Advanced Glycation End-Products (RAGE) 产前二手烟 (SHS) 暴露与高级糖化终产物受体 (RAGE)

Reproductive Medicine Pub Date : 2024-01-30 DOI: 10.3390/reprodmed5010001

K. Curtis, Kelsey M. Hirshi, K. Tsai, Evan T Clark, Brendan M Stapley, B. Bikman, P. Reynolds, J. Arroyo

{"title":"Antenatal Secondhand Smoke (SHS) Exposure and the Receptor for Advanced Glycation End-Products (RAGE)","authors":"K. Curtis, Kelsey M. Hirshi, K. Tsai, Evan T Clark, Brendan M Stapley, B. Bikman, P. Reynolds, J. Arroyo","doi":"10.3390/reprodmed5010001","DOIUrl":"https://doi.org/10.3390/reprodmed5010001","url":null,"abstract":"Exposure to secondhand smoke (SHS) during fetal development results in negative postnatal effects, including altered organ development, changes in metabolism, and increased risk of respiratory illness. Previously, we found the induction of intrauterine growth restriction (IUGR) dependent on the expression of the receptor for advanced glycation end-products (RAGE) in mice treated with SHS. Furthermore, antenatal SHS exposure increases RAGE expression in the fetal lung. Our objective was to determine the postnatal effects of antenatal SHS treatment in 4- and 12-week-old offspring. Pregnant animals were treated with SHS via a nose-only delivery system (Scireq Scientific, Montreal, Canada) for 4 days (embryonic day 14.5 through 18.5), and offspring were evaluated at 4 or 12 weeks of age. Animal and organ weights were measured, and lungs were histologically characterized. Blood pressure and heart rates were obtained, and RAGE protein expression was determined in the lungs of control and treated animals. We observed the following: (1) significant decreases in animal, liver, and heart weights at 4 weeks of age; (2) increased blood pressure in 4-week-old animals; and (3) increased RAGE expression in the lungs of the 4-week-old animals. Our results suggest an improvement in these metrics by 12 weeks postnatally such that measures were not different regardless of RA or SHS exposure. Increased RAGE expression in lungs from 4-week-old mice antenatally treated with SHS suggests a possible role for this important smoke-mediated receptor in establishing adult disease following IUGR pregnancies.","PeriodicalId":516007,"journal":{"name":"Reproductive Medicine","volume":"61 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140485637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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