Monaldi Archives for Chest Disease最新文献_第3页

Prevalence and risk factors for chronic pulmonary aspergillosis in chronic obstructive pulmonary disease patients with acute exacerbations. 慢性阻塞性肺病急性加重期患者中慢性肺曲霉菌病的患病率和风险因素。

IF 1.1

Monaldi Archives for Chest Disease Pub Date : 2025-03-31 Epub Date: 2024-03-21 DOI: 10.4081/monaldi.2024.2927

Jayabharathi Palanivel, Madhusmita Mohanty Mohapatra, Manju Rajaram, Debasis Gochhait, Sunitha Vellathussery Chakkalakkoombil, Rakesh Singh

{"title":"Prevalence and risk factors for chronic pulmonary aspergillosis in chronic obstructive pulmonary disease patients with acute exacerbations.","authors":"Jayabharathi Palanivel, Madhusmita Mohanty Mohapatra, Manju Rajaram, Debasis Gochhait, Sunitha Vellathussery Chakkalakkoombil, Rakesh Singh","doi":"10.4081/monaldi.2024.2927","DOIUrl":"10.4081/monaldi.2024.2927","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) patients often experience acute exacerbations requiring hospitalization. Recently, attention has focused on Aspergillus sensitization in the airways of these COPD patients. This study aimed to assess the prevalence of chronic pulmonary aspergillosis (CPA) in COPD patients with acute exacerbations and identify associated risk factors. A cross-sectional descriptive study was conducted at the Jawaharlal Institute of Postgraduate Medical Education and Research from January 2021 to June 2022. Sixty-one COPD patients presenting with acute exacerbations were included. Demographic details, blood investigations, and sputum examinations were performed for all patients. A high-resolution computed tomography thorax was conducted for eligible patients. The prevalence of CPA among patients with an acute exacerbation of COPD was found to be 9.8%, with chronic cavitary pulmonary aspergillosis being the most common presentation (50%). Among post-tubercular COPD patients, the prevalence of CPA was significantly higher at 22.7%. Hemoptysis (p<0.001) and a previous history of tuberculosis (p=0.008) were associated with Aspergillus sensitization. This study highlights the substantial prevalence of CPA in COPD patients with acute exacerbations, particularly in those with a history of tuberculosis. Early recognition and targeted management of CPA in COPD patients may improve outcomes and reduce hospitalization rates. Further large-scale multicenter studies are needed to validate these findings and comprehensively address the impact of CPA on all COPD patients.","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the effectiveness of Tadalafil on improving pulmonary function and asthma severity in severe asthmatic patients: a randomized controlled trial study. 评估他达拉非改善严重哮喘患者肺功能和哮喘严重程度的效果：随机对照试验研究。

IF 1.1

Monaldi Archives for Chest Disease Pub Date : 2025-03-31 Epub Date: 2024-01-11 DOI: 10.4081/monaldi.2024.2685

Seyed Hamid Borsi, Seyed Ali Asghar Fakhr Mousavi, Mehrdad Dargahi Mal-Amir, Heshmatollah Tavakol, Hanieh Raji

{"title":"Evaluation of the effectiveness of Tadalafil on improving pulmonary function and asthma severity in severe asthmatic patients: a randomized controlled trial study.","authors":"Seyed Hamid Borsi, Seyed Ali Asghar Fakhr Mousavi, Mehrdad Dargahi Mal-Amir, Heshmatollah Tavakol, Hanieh Raji","doi":"10.4081/monaldi.2024.2685","DOIUrl":"10.4081/monaldi.2024.2685","url":null,"abstract":"Phosphodiesterase inhibitors elevate the levels of cyclic adenosine monophosphate and cyclic guanosine monophosphate, which have been associated with various anti-inflammatory effects that can help alleviate asthma symptoms. This study aims to assess the impact of Tadalafil, a selective phosphodiesterase inhibitor, on pulmonary function in patients with asthma. This study was a randomized, double-blind clinical trial conducted in 2021 at Imam Khomeini Hospital in Ahvaz, Iran. The study enrolled 44 patients with severe asthma, who were divided equally into a Tadalafil group and a placebo group. The Tadalafil group received 20 mg/day of Tadalafil, while the placebo group received a placebo at the same dose. The patients' spirometry tests, asthma quality of life questionnaire, 6-minute walking distance, and quality of life were measured at the beginning of the study and one month later. The study results indicated that there was no statistically significant difference between the Tadalafil group and the placebo group in terms of pulmonary parameters (p>0.05). Furthermore, the scores for patients' quality of life (p=0.167) and the 6-minute walking test (p=0.148) at the end of the study did not show any statistically significant improvement compared to the placebo group. Results showed that the use of Tadalafil (20 mg) once daily for one month in patients with severe asthma did not affect clinical and laboratory outcomes.","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139425982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative yield of transbronchial cryo-nodal biopsy, transbronchial intra-nodal forceps biopsy, and transbronchial needle aspiration for mediastinal lesions at a tertiary care center in India (COLD-FORCEPS study). 印度一家三级医疗中心经支气管低温结节活检、经支气管结节内镊子活检和经支气管针吸术治疗纵隔病变的比较结果（COLD-FORCEPS 研究）。

IF 1.1

Monaldi Archives for Chest Disease Pub Date : 2025-03-31 Epub Date: 2024-01-15 DOI: 10.4081/monaldi.2024.2813

Manu Madan, A J Mahendran, Rohit Kumar, Yash Kedia, Rajnish Kaushik, Pranav Ish, Shibdas Chakrabarti, Neeraj Kumar Gupta, Nitesh Gupta

{"title":"Comparative yield of transbronchial cryo-nodal biopsy, transbronchial intra-nodal forceps biopsy, and transbronchial needle aspiration for mediastinal lesions at a tertiary care center in India (COLD-FORCEPS study).","authors":"Manu Madan, A J Mahendran, Rohit Kumar, Yash Kedia, Rajnish Kaushik, Pranav Ish, Shibdas Chakrabarti, Neeraj Kumar Gupta, Nitesh Gupta","doi":"10.4081/monaldi.2024.2813","DOIUrl":"10.4081/monaldi.2024.2813","url":null,"abstract":"Endobronchial ultrasound (EBUS)-guided mediastinal cryobiopsy and intranodal forceps biopsy are newer modalities for sampling mediastinal lymph nodes. The data regarding the diagnostic yield of both modalities is scarce. Patients were recruited retrospectively from our existing database. Patients who had undergone both an EBUS-guided mediastinal cryobiopsy and an intranodal forceps biopsy were enrolled in the study. The final diagnosis was made with a clinical-pathological-radiological assessment and clinical-radiological follow-up after 1 month. A total of 34 patients were enrolled in the study who had undergone both EBUS-guided mediastinal cryobiopsy and intranodal forceps biopsy and had complete data available, including 1-month follow-up data. The sample adequacy rate of EBUS-transbronchial needle aspiration (EBUS-TBNA), EBUS-TBNA with mediastinal cryobiopsy, and EBUS-TBNA with intranodal forceps biopsy was 94.11%, 97.05%, and 94.11%, respectively (p=0.56). The diagnostic yield achieved in EBUS-TBNA, EBUS-TBNA with mediastinal cryobiopsy, and EBUS-TBNA with intranodal forceps biopsy was 73.52%, 82.35%, and 79.41%, respectively (p=0.38). No major complications were seen in any patient. To conclude, adding EBUS-guided mediastinal cryobiopsy and intranodal forceps biopsy to EBUS-TBNA may not be superior to routine EBUS-TBNA.","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139473079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary edema in a young male with severe uncontrolled cardiovascular risk factors and pan-vascular atherosclerosis: a case report. 病例报告：一名年轻男性肺水肿，心血管风险因素严重失控，并伴有泛血管动脉粥样硬化。

IF 1.1

Monaldi Archives for Chest Disease Pub Date : 2025-03-31 Epub Date: 2024-03-12 DOI: 10.4081/monaldi.2024.2862

Andrea Palomba, Francesco Pelizzo, Mattia Canevari, Olga Vriz

{"title":"Pulmonary edema in a young male with severe uncontrolled cardiovascular risk factors and pan-vascular atherosclerosis: a case report.","authors":"Andrea Palomba, Francesco Pelizzo, Mattia Canevari, Olga Vriz","doi":"10.4081/monaldi.2024.2862","DOIUrl":"10.4081/monaldi.2024.2862","url":null,"abstract":"Cardiovascular risk factors are the cause of atherosclerotic disease, which can involve all the elastic and muscolo-elastic arteries. The etiopathogenesis of atherosclerosis is multifactorial since genetics, lifestyle, and comorbidities can be simultaneously involved. Clinical manifestations can be heterogeneous and include myocardial infarction, stroke, aortic aneurysms, renal artery stenosis, renal insufficiency, peripheral artery disease, etc. Currently, 70% of clinical events cannot be prevented with available drug therapy, statins included, and at least 10% of coronary events occur in apparently healthy individuals in the absence of major traditional risk factors. The case of a young male with a history of coronary artery disease and multiple atherosclerotic risk factors not properly treated who was admitted to the emergency department for pulmonary edema and high blood pressure is presented. During the diagnostic workup, a dramatic atherosclerotic involvement of all arterial trees emerged. Moreover, the patient presented with thrombosis of the right subclavian artery, which was treated with a heparin infusion and later complicated by cerebral hemorrhage with residual hemiplegia.","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multidrug-resistant tuberculosis in Iran: a multicenter study. 伊朗的耐多药结核病：一项多中心研究。

IF 1.1

Monaldi Archives for Chest Disease Pub Date : 2025-03-31 Epub Date: 2024-01-12 DOI: 10.4081/monaldi.2024.2844

Fatemeh Khelghati, Fatemeh Nasirpour Seilakhori, Mehdi Goudarzi, Shima Malekloo, Amir Hashem Shahidi Bonjar, Hossein Goudarzi, Mohammad Javad Nasiri

{"title":"Multidrug-resistant tuberculosis in Iran: a multicenter study.","authors":"Fatemeh Khelghati, Fatemeh Nasirpour Seilakhori, Mehdi Goudarzi, Shima Malekloo, Amir Hashem Shahidi Bonjar, Hossein Goudarzi, Mohammad Javad Nasiri","doi":"10.4081/monaldi.2024.2844","DOIUrl":"10.4081/monaldi.2024.2844","url":null,"abstract":"The worldwide incidence of multidrug-resistant tuberculosis (MDR-TB) is rapidly increasing, and it has emerged as a pressing public health issue in Iran. Nevertheless, there is a scarcity of up-to-date research on the prevalence of MDR-TB in individuals with pulmonary TB in the country. In this cross-sectional study, we gathered a total of 1216 respiratory samples, each corresponding to a unique patient, from five distinct regional TB laboratories in Iran. We identified clinical isolates as Mycobacterium tuberculosis using the IS6110-based polymerase chain reaction assay and Xpert MTB/RIF. Drug susceptibility testing (DST) was conducted using the conventional proportion method. Out of the collected specimens, 448 tested positive for M. tuberculosis. Among these isolates, 445 (99.4%) exhibited susceptibility to the tested drugs, while 3 (0.6%) were found to be MDR. The findings from this recent study indicate that the prevalence of MDR in Iran stands at 0.6%. The absence of recently approved treatment protocols in various regions of Iran, along with inadequately equipped laboratories lacking DST capabilities, could contribute significantly to the rise in TB/MDR-TB prevalence in Iran. Therefore, the implementation of enhanced treatment management strategies and the adoption of innovative technologies are essential steps toward improving the current situation.","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139425983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transplantation of heterozygous familial hypercholesterolemia living donor liver resulting in early myocardial infarction: a possible dangerous link. 移植杂合子家族性高胆固醇血症活体肝脏导致早期心肌梗死：可能存在的危险联系。

IF 1.1

Monaldi Archives for Chest Disease Pub Date : 2025-03-31 Epub Date: 2024-01-16 DOI: 10.4081/monaldi.2024.2907

Naji Kholaif, Lin Batha, Isra Elmahi, Sulaiman Alnaser, Sultan Alzaher, Norah Almallohi, Mosaad Alhussein, Dana Alhalees, Ahmed Alshehri

{"title":"Transplantation of heterozygous familial hypercholesterolemia living donor liver resulting in early myocardial infarction: a possible dangerous link.","authors":"Naji Kholaif, Lin Batha, Isra Elmahi, Sulaiman Alnaser, Sultan Alzaher, Norah Almallohi, Mosaad Alhussein, Dana Alhalees, Ahmed Alshehri","doi":"10.4081/monaldi.2024.2907","DOIUrl":"10.4081/monaldi.2024.2907","url":null,"abstract":"Living donor liver transplantation (LDLT) is a lifesaving procedure that is often curative for several liver diseases. Familial hypercholesterolemia (FH) is a metabolic disease that results from an autosomal dominant mutation in the low-density lipoprotein receptor; yet, young patients with FH can live years without detection. Herein, we report a case of a patient who developed early myocardial infarction (MI) after having a transplant from a donor with undetected heterozygous FH. The patient was a 67-year-old female with non-alcoholic steatohepatitis-related liver cirrhosis, free from coronary artery disease, who underwent LDLT from her daughter, a 45-year-old female with no past medical history. One year post-transplantation, she presented with an acute MI with a large atherosclerotic burden. Genetic analysis confirmed heterozygous FH in the donor but not in the recipient. This case emphasizes the importance of incorporating a thorough clinical history and lipid profile into pre-transplant testing for both the recipient and donor, as well as aggressive lipid-lowering therapy post-transplantation to avoid cardiovascular complications.","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139473084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tailored treatment for tuberculosis in transgender individuals: a call for a patient-centered approach from a large Italian cohort. 变性人结核病的定制治疗：意大利大型队列呼吁采取以患者为中心的方法。

IF 1.1

Monaldi Archives for Chest Disease Pub Date : 2025-03-31 Epub Date: 2024-01-11 DOI: 10.4081/monaldi.2024.2852

Niccolò Riccardi, Roberta Maria Antonello, Maurizio Ferrarese, Alice Repossi, Laura Saderi, Giovanni Fumagalli, Giorgio Besozzi, Giovanni Sotgiu, Luigi Codecasa

{"title":"Tailored treatment for tuberculosis in transgender individuals: a call for a patient-centered approach from a large Italian cohort.","authors":"Niccolò Riccardi, Roberta Maria Antonello, Maurizio Ferrarese, Alice Repossi, Laura Saderi, Giovanni Fumagalli, Giorgio Besozzi, Giovanni Sotgiu, Luigi Codecasa","doi":"10.4081/monaldi.2024.2852","DOIUrl":"10.4081/monaldi.2024.2852","url":null,"abstract":"Tuberculosis (TB) diagnosis and management in special populations remain challenging. Data about TB and transgender individuals is scarce, and strategies aimed at reducing the TB burden in this at-risk group are needed. We conducted an observational monocentric study from a national reference center for TB, including transgender individuals with active TB in a low-TB burden country (Italy), over 34 years (1990-2023). A total of 66 transgender males and 2 transgender females (median age 30 years, interquartile range 26-38 years, 65 migrants) were included. Most patients (38/66, 57.6%) lived in poor social conditions. 65.2% (43/66) of patients were people living with HIV. Multidrug- and rifampicin-resistant TB and isoniazid-resistant TB were diagnosed in 5 (7.6%) and 3 (4.5%) patients, respectively. The overall treatment success rate was 72.7% (48/66 patients), with differences observed according to social conditions. Our study highlights the need for a tailored approach to increase treatment success in this at-risk population.","PeriodicalId":51593,"journal":{"name":"Monaldi Archives for Chest Disease","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139425984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Same-day discharge after elective percutaneous closure of patent foramen ovale. 纠正：择期经皮卵圆孔未闭闭锁术后同日出院。

IF 1.1

Monaldi Archives for Chest Disease Pub Date : 2025-03-31 Epub Date: 2025-04-08 DOI: 10.4081/monaldi.2025.3507

The Publisher

引用次数: 0

Comments on "Comparative yield of transbronchial cryo-nodal biopsy, transbronchial intra-nodal forceps biopsy, and transbronchial needle aspiration for mediastinal lesions at a tertiary care center in India (COLD-FORCEPS study)". 关于 "印度一家三级医疗中心经支气管低温结节活检、经支气管结节内镊子活检和经支气管针吸术治疗纵隔病变的比较结果（COLD-FORCEPS 研究）"的评论

IF 1.1

Monaldi Archives for Chest Disease Pub Date : 2025-03-31 Epub Date: 2024-02-19 DOI: 10.4081/monaldi.2024.2918

Vidushi Rathi

引用次数: 0

Authors' Response. 作者回复。

IF 1.1

Monaldi Archives for Chest Disease Pub Date : 2025-03-31 Epub Date: 2024-02-14 DOI: 10.4081/monaldi.2024.2934

Ana Isabel Pinho, Cátia Oliveira, Luís Daniel Santos, Catarina Marques, André Cabrita, Paula Dias, Gonçalo Pestana, Carla Sousa, Rui André Rodrigues

引用次数: 0