Journal of the American Veterinary Medical Association最新文献_第2页

Acute death, myocarditis, and myositis in a 7-month-old Angus heifer (Bos taurus). 一头 7 个月大的安格斯（Bos taurus）小母牛急性死亡、心肌炎和肌炎。

Journal of the American Veterinary Medical Association Pub Date : 2024-04-19 DOI: 10.2460/javma.24.02.0129

Emily Caflisch, Lorelei Clarke

引用次数: 0

Immunotherapy with genetically engineered T cells holds promise for the treatment of nonmalignant diseases in the dog. 基因工程 T 细胞免疫疗法有望治疗狗的非恶性疾病。

Journal of the American Veterinary Medical Association Pub Date : 2024-04-16 DOI: 10.2460/javma.24.02.0113

Nicola J. Mason

{"title":"Immunotherapy with genetically engineered T cells holds promise for the treatment of nonmalignant diseases in the dog.","authors":"Nicola J. Mason","doi":"10.2460/javma.24.02.0113","DOIUrl":"https://doi.org/10.2460/javma.24.02.0113","url":null,"abstract":"The ability to genetically redirect the antigenic specificity of T cells using chimeric antigen receptors (CAR) has led to unprecedented durable clinical remissions in human patients with relapsed/refractory hematological malignancies. This remarkable advance in successful immune cell engineering has now led to investigations into the application of CAR-T-cell technology to treat nonmalignant diseases. The use of CAR-T cells to target and eliminate specific cell subsets involved in the pathogenesis of autoimmunity, fibrosis, senescence, and infectious disease represents a new direction for adoptive cell therapies. While the use of CAR-T cells for nonmalignant disease is still in its infancy, early reports of dramatic clinical responses to CAR-T cells targeting CD19+ B cells in patients with severe autoimmune disease raise the possibility that this approach could lead to durable remissions, eliminating the need for ongoing conventional immunosuppressive therapies. Excitingly, nonmalignant disease processes that may be addressed by CAR-T-cell therapy in humans also occur in our canine populations. Given that technologies for developing canine CAR constructs are now available, robust protocols have been described for generating canine CAR-T cells, and experience is being gathered with their clinical use in oncology, it is anticipated that CAR-T cells will soon enter the veterinary clinics for the treatment of debilitating nonmalignant diseases. Here, we provide a broad overview of CAR-T-cell therapies for nonmalignant diseases and extrapolate these advances into the veterinary space, highlighting areas in which canine CAR-T cells are poised to enter the clinics for the treatment of nonmalignant disease.","PeriodicalId":514111,"journal":{"name":"Journal of the American Veterinary Medical Association","volume":"62 s284","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140694569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improved predictability is needed for calculators used to preoperatively determine the etiology of splenic masses in dogs: an external validation study of the HeLP score and T-STAT. 用于术前确定犬脾脏肿块病因的计算器需要提高可预测性：HeLP 评分和 T-STAT 的外部验证研究。

Journal of the American Veterinary Medical Association Pub Date : 2024-04-16 DOI: 10.2460/javma.24.01.0016

Townes N Hillier, Janet A Grimes, M. Wallace, Brian J Sutherland, C. Schmiedt

{"title":"Improved predictability is needed for calculators used to preoperatively determine the etiology of splenic masses in dogs: an external validation study of the HeLP score and T-STAT.","authors":"Townes N Hillier, Janet A Grimes, M. Wallace, Brian J Sutherland, C. Schmiedt","doi":"10.2460/javma.24.01.0016","DOIUrl":"https://doi.org/10.2460/javma.24.01.0016","url":null,"abstract":"OBJECTIVE\u0000To assess the predictability of the hemangiosarcoma likelihood prediction (HeLP) score and the Tufts Splenic Tumor Assessment Tool (T-STAT) for hemangiosarcoma and malignancy, respectively.\u0000\u0000\u0000ANIMALS\u0000261 dogs undergoing splenectomy for a splenic mass.\u0000\u0000\u0000METHODS\u0000Medical records were retrospectively reviewed; variables for the HeLP score and T-STAT were collected, and scores were assigned. Area under the curve (AUC) was calculated for each score.\u0000\u0000\u0000RESULTS\u0000The HeLP score included 141 dogs; hemangiosarcoma was diagnosed in 87 (61.7%) dogs. The median cumulative HeLP score was 51 (range, 17 to 82; IQR, 39 to 58) for dogs with hemangiosarcoma and 28 (range, 0 to 70; IQR, 17 to 41) for dogs without hemangiosarcoma. The categorical HeLP score was low (28; 32.2%), medium (31; 35.6%), and high (28; 32.2%) for dogs with hemangiosarcoma and was low (41; 75.9%), medium (9; 16.7%), and high (4; 7.4%) for dogs without hemangiosarcoma. The AUC of the cumulative and categorical HeLP scores for diagnosis of hemangiosarcoma were 0.79 (95% CI, 0.71 to 0.86) and 0.73 (95% CI, 0.65 to 0.82), respectively. The T-STAT included 181 dogs. Lesions were benign in 95 (52.5%) and malignant in 86 (47.5%) dogs. The median T-STAT score was 62% (range, 5% to 98%; IQR, 36% to 77%) for dogs with malignant lesions and 38% (range, 5% to 91%; IQR, 24% to 59%) for dogs with benign lesions. The T-STAT had an AUC of 0.68 (0.60 to 0.76) for diagnosis of malignancy.\u0000\u0000\u0000CLINICAL RELEVANCE\u0000The HeLP score had acceptable performance, and the T-STAT had poor performance for diagnosis prediction. A tool with excellent or outstanding discrimination is needed to more reliably predict the presence of hemangiosarcoma or a malignant lesion preoperatively.","PeriodicalId":514111,"journal":{"name":"Journal of the American Veterinary Medical Association","volume":"3 11","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140696003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma and synovial fluid extracellular vesicles display altered microRNA profiles in horses with naturally occurring post-traumatic osteoarthritis: an exploratory study. 血浆和滑膜液细胞外囊泡显示患有自然发生的创伤后骨关节炎的马匹的微RNA谱发生了变化：一项探索性研究。

Journal of the American Veterinary Medical Association Pub Date : 2024-04-13 DOI: 10.2460/javma.24.02.0102

Shannon S. Connard, A. Gaesser, Emily J Clarke, R. Linardi, Kayla M. Even, J. Engiles, Drew W Koch, Mandy J Peffers, K. Ortved

{"title":"Plasma and synovial fluid extracellular vesicles display altered microRNA profiles in horses with naturally occurring post-traumatic osteoarthritis: an exploratory study.","authors":"Shannon S. Connard, A. Gaesser, Emily J Clarke, R. Linardi, Kayla M. Even, J. Engiles, Drew W Koch, Mandy J Peffers, K. Ortved","doi":"10.2460/javma.24.02.0102","DOIUrl":"https://doi.org/10.2460/javma.24.02.0102","url":null,"abstract":"OBJECTIVE\u0000The objective of this study was to characterize extracellular vesicles (EVs) in plasma and synovial fluid obtained from horses with and without naturally occurring post-traumatic osteoarthritis (PTOA).\u0000\u0000\u0000ANIMALS\u0000EVs were isolated from plasma and synovial fluid from horses with (n = 6) and without (n = 6) PTOA.\u0000\u0000\u0000METHODS\u0000Plasma and synovial fluid EVs were characterized with respect to quantity, size, and surface markers. Small RNA sequencing was performed, and differentially expressed microRNAs (miRNAs) underwent bioinformatic analysis to identify putative targets and to explore potential associations with specific biological processes.\u0000\u0000\u0000RESULTS\u0000Plasma and synovial fluid samples from horses with PTOA had a significantly higher proportion of exosomes and a lower proportion of microvesicles compared to horses without PTOA. Small RNA sequencing revealed several differentially expressed miRNAs, including miR-144, miR-219-3p, and miR-199a-3l in plasma and miR-199a-3p, miR-214, and miR-9094 in synovial fluid EVs. Bioinformatics analysis of the differentially expressed miRNAs highlighted their potential role in fibrosis, differentiation of chondrocytes, apoptosis, and inflammation pathways in PTOA.\u0000\u0000\u0000CLINICAL RELEVANCE\u0000We have identified dynamic molecular changes in the small noncoding signatures of plasma and synovial fluid EVs in horses with naturally occurring PTOA. These findings could serve to identify promising biomarkers in the pathogenesis of PTOA, to facilitate the development of targeted therapies, and to aid in establishing appropriate translational models of PTOA.","PeriodicalId":514111,"journal":{"name":"Journal of the American Veterinary Medical Association","volume":"33 5","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140708792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zoonoses-specific resources, collaborative networks, and enhanced communication can help US veterinarians tackle zoonotic diseases: results from a national survey. 人畜共患病专用资源、协作网络和强化交流可帮助美国兽医应对人畜共患病：一项全国性调查的结果。

Journal of the American Veterinary Medical Association Pub Date : 2024-04-12 DOI: 10.2460/javma.24.02.0105

Sulagna Chakraborty, Annalisa Fama, William E. Sander

{"title":"Zoonoses-specific resources, collaborative networks, and enhanced communication can help US veterinarians tackle zoonotic diseases: results from a national survey.","authors":"Sulagna Chakraborty, Annalisa Fama, William E. Sander","doi":"10.2460/javma.24.02.0105","DOIUrl":"https://doi.org/10.2460/javma.24.02.0105","url":null,"abstract":"Increased incidence of zoonoses, coupled with veterinarians' occupational exposure, led to this study examining the knowledge of licensed US veterinarians on zoonoses and their disease prevention practices. This online survey supported by the National Association of State Public Health Veterinarians received 466 responses from 36 US states; 67% of the respondents were female, and 72.5% were small animal medicine practitioners. The One Health concept was familiar among 82% of respondents, 51.3% knew of continuing education training on zoonoses, and 68% had attended such a training in the last 5 years. Respondents were unaware of which zoonoses to report to public health departments. For 3 out of 8 questions on standard operating procedures, statistically significant differences in protocols followed among small, large, and mixed animal medicine practitioners were observed. Most respondents believed they play a critical role in zoonoses prevention but would like more information on zoonotic diseases. Results indicate that assisting veterinarians with regularly updated information on zoonoses, providing targeted education and training to adhere to standardized infection control measures, and increasing communication with public health agencies and physicians may help prevent and reduce incidence of zoonoses.","PeriodicalId":514111,"journal":{"name":"Journal of the American Veterinary Medical Association","volume":"89 6","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140710970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical examination findings and electrolyte abnormalities of dogs with marijuana/tetrahydrocannabinol toxicity: 223 cases (January 2017-July 2021). 大麻/四氢大麻酚中毒犬的临床检查结果和电解质异常：223例（2017年1月至2021年7月）。

Journal of the American Veterinary Medical Association Pub Date : 2024-04-12 DOI: 10.2460/javma.24.02.0092

Erin M Binagia, Elizabeth A Gregory, Igor Yankin

{"title":"Clinical examination findings and electrolyte abnormalities of dogs with marijuana/tetrahydrocannabinol toxicity: 223 cases (January 2017-July 2021).","authors":"Erin M Binagia, Elizabeth A Gregory, Igor Yankin","doi":"10.2460/javma.24.02.0092","DOIUrl":"https://doi.org/10.2460/javma.24.02.0092","url":null,"abstract":"OBJECTIVE\u0000The goal of this study was to describe the historical, physical, neurologic, and clinicopathologic findings in dogs with a definitive diagnosis of marijuana/tetrahydrocannabinol toxicity.\u0000\u0000\u0000ANIMALS\u0000A total of 223 dogs with known ingestion of marijuana or a positive tetrahydrocannabinol result on human urine multidrug test.\u0000\u0000\u0000METHODS\u0000Retrospective study from January 2017 to July 2021.\u0000\u0000\u0000RESULTS\u0000Median age was 1 year (1 month to 12 years). A common history was becoming acutely neurologic after going outside or to a public place (62/223 [27.8%]). Most owners denied possibility of exposure (152/223 [68%]). Median vitals were normal, but hyperthermia (38/212 [22.6%]), tachycardia (82/222 [37%]), and systemic hypertension (37/61 [60.7%]) were common abnormalities. The most common clinical signs included ataxia (197/223 [88.3%]), hyperesthesia (168/223 [75.3%]), urinary incontinence (102/223 [45.7%]), lethargy (140/223 [62.5%]), and vomiting (58/223 [26%]). The most common combinations of neurologic signs included ataxia and hyperesthesia (157/223 [70.4%]) and ataxia, hyperesthesia, and urinary incontinence (81/223 [36.3%]). Mild hyperkalemia (39/76 [51.3%]) and mild hypercalcemia (53/67 [79.1%]) were common. Twenty-two dogs were hospitalized. Survival was 100%.\u0000\u0000\u0000CLINICAL RELEVANCE\u0000A common presentation for marijuana toxicosis included young dogs with acute ataxia and hyperesthesia, with and without urinary incontinence, after going outside or to a public place. Vitals were often normal, but hyperthermia, tachycardia, and hypertension were common. Bloodwork was mostly normal, but mild hyperkalemia and mild ionized hypercalcemia were common. Marijuana should be high on the differential list with these history, physical examination, neurologic, and electrolyte abnormalities, regardless of owner denial or negative human urine multidrug test.","PeriodicalId":514111,"journal":{"name":"Journal of the American Veterinary Medical Association","volume":"52 5","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140711192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of abdominal thrusts is associated with improved rates of successful emesis induction in dogs. 使用腹推法可提高犬诱导催吐的成功率。

Journal of the American Veterinary Medical Association Pub Date : 2024-04-12 DOI: 10.2460/javma.23.12.0681

Trevor T Chan, Anthony L Gonzalez, Bridget M Lyons

{"title":"Use of abdominal thrusts is associated with improved rates of successful emesis induction in dogs.","authors":"Trevor T Chan, Anthony L Gonzalez, Bridget M Lyons","doi":"10.2460/javma.23.12.0681","DOIUrl":"https://doi.org/10.2460/javma.23.12.0681","url":null,"abstract":"OBJECTIVE\u0000To evaluate the effect of abdominal thrusts as a synergistic procedure to IV apomorphine administration on the occurrence and rate of onset of successful induction of emesis in dogs.\u0000\u0000\u0000ANIMALS\u000031 client-owned dogs.\u0000\u0000\u0000METHODS\u0000Dogs in which induction of emesis via IV apomorphine was prescribed by the attending clinician were prospectively randomized to either receive abdominal thrusts performed by a nurse or clinician or to have no physical interventions performed following IV apomorphine administration. Data collected included signalment, weight, reason for emesis, time from suspected ingestion to presentation, time from the dog's last meal to presentation, dose of apomorphine administered in milligrams, and time from apomorphine administration to emesis.\u0000\u0000\u0000RESULTS\u0000Emesis induction was successful in 14 of 14 (100%) of the dogs in the abdominal thrust group and 13 of 17 (76.5%) in the control group (P = .02). In dogs with successful emesis, median time to emesis was 90.5 seconds (range, 36 to 348 seconds) in the abdominal thrust group and 106 seconds (range, 37 to 360 seconds) in the control group (P = .29).\u0000\u0000\u0000CLINICAL RELEVANCE\u0000Abdominal thrusts were associated with an increased frequency of successful emesis in dogs following IV apomorphine, but did not shorten the rate of onset of emesis in dogs that vomited. Application of abdominal thrusts may be beneficial in dogs in which emesis is indicated and that do not have a clear contraindication.","PeriodicalId":514111,"journal":{"name":"Journal of the American Veterinary Medical Association","volume":"7 21","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140711944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leflunomide with prednisone or nonsteroidal anti-inflammatory drug therapy is safe and tolerated for long-term treatment of immune-mediated polyarthritis in 27 dogs. 来氟米特联合泼尼松或非类固醇抗炎药物治疗 27 只狗的免疫介导性多关节炎的长期治疗是安全和可耐受的。

Journal of the American Veterinary Medical Association Pub Date : 2024-04-12 DOI: 10.2460/javma.24.01.0032

Rebecca B Chesne, Michael T Doornink, L. Sri-Jayantha, Bridget K. Urie

{"title":"Leflunomide with prednisone or nonsteroidal anti-inflammatory drug therapy is safe and tolerated for long-term treatment of immune-mediated polyarthritis in 27 dogs.","authors":"Rebecca B Chesne, Michael T Doornink, L. Sri-Jayantha, Bridget K. Urie","doi":"10.2460/javma.24.01.0032","DOIUrl":"https://doi.org/10.2460/javma.24.01.0032","url":null,"abstract":"OBJECTIVE\u0000To retrospectively evaluate safety and tolerance of leflunomide for long-term treatment of canine idiopathic immune-mediated polyarthritis (IMPA).\u0000\u0000\u0000ANIMALS\u000027 dogs with clinical signs and synovial fluid cytology supportive of IMPA with ≥ 6 months' follow-up after starting leflunomide.\u0000\u0000\u0000METHODS\u0000Medical records were reviewed to identify dogs prescribed leflunomide for treatment of IMPA from February 2012 to May 2022. Initial leflunomide doses of 2 to 4 mg/kg once daily were prescribed and were titrated to the lowest effective dose with concurrent anti-inflammatory therapy. Complete blood count, serum chemistry, and clinical signs were monitored throughout the course of treatment.\u0000\u0000\u0000RESULTS\u0000Adverse effects potentially attributable to leflunomide noted in 9 of 27 dogs (33%) included vomiting, diarrhea, lethargy, decreased or absent appetite, polyuria and polydipsia, and secondary antibiotic responsive infection and were self-limiting or resolved with outpatient therapy. Alkaline phosphatase (ALP) and alanine aminotransferase (ALT) elevation were documented in all dogs prescribed leflunomide plus prednisone, with persistent liver enzyme elevation in 6 of 9 dogs (67%) and normalization after antibiotic therapy in 3 of 9 dogs (33%). The majority of dogs prescribed leflunomide plus NSAID (11/17 [65%] dogs) did not experience liver enzyme elevation; 2 of 17 (12%) dogs developed transient antibiotic-responsive liver enzyme elevations, and 4 of 17 (23%) dogs had persistent liver enzyme elevation.\u0000\u0000\u0000CLINICAL RELEVANCE\u0000Leflunomide was well tolerated for long-term management of IMPA. A significant difference in liver enzyme elevation was identified between dogs prescribed prednisone versus NSAID in combination with leflunomide. Leflunomide with NSAID therapy resulted in less hepatotoxicity compared with leflunomide with prednisone.","PeriodicalId":514111,"journal":{"name":"Journal of the American Veterinary Medical Association","volume":"31 5","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140710936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypercoagulability based on thromboelastography is common in dogs undergoing adrenalectomy. 在接受肾上腺切除术的狗中，根据血栓弹力图显示的高凝状态很常见。

Journal of the American Veterinary Medical Association Pub Date : 2024-04-12 DOI: 10.2460/javma.23.08.0456

Akiko Mitsui, Sydney Rosen, P. Yaxley, Janis M. Lapsley, G. Tremolada, L. Selmic

{"title":"Hypercoagulability based on thromboelastography is common in dogs undergoing adrenalectomy.","authors":"Akiko Mitsui, Sydney Rosen, P. Yaxley, Janis M. Lapsley, G. Tremolada, L. Selmic","doi":"10.2460/javma.23.08.0456","DOIUrl":"https://doi.org/10.2460/javma.23.08.0456","url":null,"abstract":"OBJECTIVE\u0000Thromboelastography (TEG) is a whole blood assay that yields global assessment of hemostasis, as it evaluates clot time, strength, and kinematics of clot formation and lysis. The main objective was to describe preoperative TEG findings in dogs that had an adrenalectomy performed and, secondarily, to describe TEG findings in the dogs with or without hyperadrenocorticism (HAC).\u0000\u0000\u0000ANIMALS\u000030 dogs that had preoperative TEG and adrenalectomy performed.\u0000\u0000\u0000METHODS\u0000Medical records between 2018 and 2022 were reviewed. Signalment, diagnostic data, and perioperative treatment were abstracted.\u0000\u0000\u0000RESULTS\u000053% (16/30) of the dogs were hypercoagulable, and none were hypocoagulable. Based on histopathology, 6 of 9 dogs with adenocarcinoma were hypercoagulable, 4 of 8 with pheochromocytoma were hypercoagulable, and 6 of 10 with adenoma were hypercoagulable. None of the 3 dogs with other histopathologic diagnoses or combinations of diagnoses (adrenocortical hyperplasia, poorly differentiated sarcoma, and both adrenocortical adenocarcinoma and pheochromocytoma) were hypercoagulable. Of the 14 dogs tested preoperatively for HAC, 4 of 8 HAC dogs were hypercoagulable and 2 of 6 non-HAC dogs were hypercoagulable.\u0000\u0000\u0000CLINICAL RELEVANCE\u0000The present report describes for the first time TEG findings for dogs undergoing adrenalectomy and suggests that the majority of dogs with adrenal neoplasia are hypercoagulable based on TEG results.","PeriodicalId":514111,"journal":{"name":"Journal of the American Veterinary Medical Association","volume":"8 8","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140710081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical approach and presence of preoperative pleural effusion impact thoracostomy tube usage in dogs and cats following thoracic surgery for suspected neoplasia. 手术方法和术前胸腔积液对因疑似肿瘤而进行胸腔手术的狗和猫使用胸腔造口管的影响。

Journal of the American Veterinary Medical Association Pub Date : 2024-04-12 DOI: 10.2460/javma.23.12.0725

Carley Johnson, Janis M. Lapsley, H. Piegols, L. Selmic

{"title":"Surgical approach and presence of preoperative pleural effusion impact thoracostomy tube usage in dogs and cats following thoracic surgery for suspected neoplasia.","authors":"Carley Johnson, Janis M. Lapsley, H. Piegols, L. Selmic","doi":"10.2460/javma.23.12.0725","DOIUrl":"https://doi.org/10.2460/javma.23.12.0725","url":null,"abstract":"OBJECTIVE\u0000To assess factors associated with increased pleural fluid and air evacuation, longer duration of thoracostomy tube usage, and longer hospitalization in dogs and cats following surgery for thoracic neoplasms.\u0000\u0000\u0000ANIMALS\u000062 dogs and 10 cats.\u0000\u0000\u0000METHODS\u0000Medical records were reviewed for dogs and cats undergoing thoracic surgeries between August 1, 2019, and June 30, 2023, for resection of suspected neoplasia in which a thoracostomy tube was placed. Data collected included patient signalment, type of procedure performed, histologic diagnosis of the primary mass removed, volume of fluid and air evacuated from the thoracostomy tube, and time in hospital.\u0000\u0000\u0000RESULTS\u0000Median sternotomy was associated with increased total fluid evacuation (median, 12.1 mL/kg; IQR, 15.4 mL/kg; P = .012), whereas rib resection was associated with increased total air evacuation (median, 2.1 mL/kg; IQR, 13.6 mL/kg; P = .06). The presence of preoperative pleural effusion was associated with higher total fluid evacuation (20.6 mL/kg; IQR, 32.1 mL/kg; P = .009), longer duration with a thoracostomy tube in place (42.5 hours; IQR, 41.9 hours; P = .027), and longer hospitalization period (61 hours; IQR, 52.8 hours; P = .025). Cats had a thoracostomy tube in place for a longer time compared to dogs (median, 42.6 hours; IQR, 23.5 hours; P = .043).\u0000\u0000\u0000CLINICAL RELEVANCE\u0000Animals undergoing median sternotomy and rib resection may be expected to have higher fluid and air volumes, respectively, evacuated postoperatively. This often leads to an increased duration of thoracostomy tube usage and a longer period of hospitalization.","PeriodicalId":514111,"journal":{"name":"Journal of the American Veterinary Medical Association","volume":"116 6","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140709417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0