Journal of the American Veterinary Medical Association最新文献

AVMA News 美国兽医协会新闻

Journal of the American Veterinary Medical Association Pub Date : 2024-07-01 DOI: 10.2460/javma.262.7.889

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AVMA News 美国兽医协会新闻

Journal of the American Veterinary Medical Association Pub Date : 2024-06-01 DOI: 10.2460/javma.262.6.755

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AVMA News 美国兽医协会新闻

Journal of the American Veterinary Medical Association Pub Date : 2024-05-01 DOI: 10.2460/javma.262.5.611

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Progressive cervical swelling in a 6-year-old Belgian gelding. 一匹 6 岁的比利时骟马颈部进行性肿胀。

Journal of the American Veterinary Medical Association Pub Date : 2024-04-24 DOI: 10.2460/javma.24.03.0201

Emmy Y. Luo, Christopher Tollefson

引用次数: 0

Paraneoplastic hypercalcemia in a canine patient with a mandibular salivary carcinoma. 下颌涎腺癌犬类患者的副肿瘤性高钙血症。

Journal of the American Veterinary Medical Association Pub Date : 2024-04-24 DOI: 10.2460/javma.24.01.0058

Pablo Delgado-Bonet, Richard Coe, Gawain J. C. Hammond, Laura A. Wennerdahl, Katie A. McNaught

{"title":"Paraneoplastic hypercalcemia in a canine patient with a mandibular salivary carcinoma.","authors":"Pablo Delgado-Bonet, Richard Coe, Gawain J. C. Hammond, Laura A. Wennerdahl, Katie A. McNaught","doi":"10.2460/javma.24.01.0058","DOIUrl":"https://doi.org/10.2460/javma.24.01.0058","url":null,"abstract":"OBJECTIVE\u0000To describe a novel presentation of paraneoplastic hypercalcemia caused by a canine salivary carcinoma.\u0000\u0000\u0000ANIMAL\u0000A 6-year-old intact male Husky with hypercalcemia and a spontaneous salivary carcinoma, stage III.\u0000\u0000\u0000CLINICAL PRESENTATION, PROGRESSION, AND PROCEDURES\u0000The dog presented with polyuria, polydipsia, and hypercalcemia. Physical examination revealed a 37 X 43-mm firm mass in the ventrolateral aspect of the right-hand side of the neck, caudal to the temporomandibular joint. Incisional biopsy was suspicious of metastatic carcinoma to the mandibular lymph node. A full-body CT scan found a large, heterogenous, contrast-enhancing mass on the right ventrolateral neck that appeared to be originating from either the mandibular lymph node or right mandibular salivary gland. Parathyroid hormone-related protein was considered within normal reference intervals, and both parathyroid glands appeared ultrasonographically normal.\u0000\u0000\u0000TREATMENT AND OUTCOME\u0000The patient was treated with a marginal surgical excision of the mass, without immediate complications. Histopathology confirmed the presence of a salivary carcinoma with narrow margins of excision and invasion of the mandibular lymph node. Twenty-four hours after surgery, ionized calcium returned to normal reference values and clinical signs completely resolved.\u0000\u0000\u0000CLINICAL RELEVANCE\u0000Hypercalcemia is an urgent pathology with important systemic implications requiring prompt diagnosis and intervention. In this case report, we identify the first salivary carcinoma associated with a paraneoplastic hypercalcemia, including this pathology as a new differential diagnosis. The hypercalcemia resolved with marginal surgical excision, but interestingly the parathyroid hormone-related protein was not overexpressed, meaning that this neoplasia could mediate hypercalcemia by another pathophysiological mechanism.","PeriodicalId":514111,"journal":{"name":"Journal of the American Veterinary Medical Association","volume":"66 36","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140663799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping the future of antimicrobial use data collection in US animal agriculture: insights from FDA-funded pilot studies. 绘制美国畜牧业抗菌药使用数据收集的未来蓝图：从 FDA 资助的试点研究中获得的启示。

Journal of the American Veterinary Medical Association Pub Date : 2024-04-24 DOI: 10.2460/javma.24.03.0180

Katherine L. Huebner, Anna Nevius, Julia Chamberlain, S. Bright-Ponte

{"title":"Mapping the future of antimicrobial use data collection in US animal agriculture: insights from FDA-funded pilot studies.","authors":"Katherine L. Huebner, Anna Nevius, Julia Chamberlain, S. Bright-Ponte","doi":"10.2460/javma.24.03.0180","DOIUrl":"https://doi.org/10.2460/javma.24.03.0180","url":null,"abstract":"Antimicrobial use (AMU) contributes to the emergence of antimicrobial resistance, necessitating antimicrobial stewardship actions across all sectors using a One Health approach to preserve antimicrobial effectiveness. This overview delves into 2 FDA-funded projects focused on collecting and analyzing AMU data in major food-producing animal species (cattle, swine, turkeys, and chickens). Initiated in 2016, the projects aimed to establish baseline AMU information and pilot methodologies. This article describes the methodologies used by grantees for data collected from 2016 to 2021, emphasizing the diverse data sources and metrics utilized. Instead of summarizing the trends, it provides a list of publications generated from the grants. Factors contributing to successful data collection included early interaction and trust building between the producers/data holders and researchers. Shared challenges include limitations stemming from convenience sampling, variable industry participation, and lack of data covering all segments of a particular commodity (eg, data on breeding or young animals were lacking). Future collaborative efforts are needed to enhance data standardization, contextualization, representativeness, and reporting of national-scale AMU data going forward. Addressing these challenges and data gaps is essential for effective monitoring of AMU in veterinary settings and animal agriculture, in alignment with national strategies to combat antimicrobial resistance.","PeriodicalId":514111,"journal":{"name":"Journal of the American Veterinary Medical Association","volume":"75 2","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140659409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IL-1ra gene therapy in equine osteoarthritis improves physiological, anatomical, and biological outcomes of joint degeneration. IL-1ra 基因疗法在马骨关节炎中的应用可改善关节退化的生理、解剖和生物学结果。

Journal of the American Veterinary Medical Association Pub Date : 2024-04-22 DOI: 10.2460/javma.24.02.0078

Laurie R. Goodrich, C. Mcilwraith, Josh Grieger, Virginia Byers Kraus, Thomas Stabler, Natasha Werpy, J. Phillips, R. Samulski, D. Frisbie

{"title":"IL-1ra gene therapy in equine osteoarthritis improves physiological, anatomical, and biological outcomes of joint degeneration.","authors":"Laurie R. Goodrich, C. Mcilwraith, Josh Grieger, Virginia Byers Kraus, Thomas Stabler, Natasha Werpy, J. Phillips, R. Samulski, D. Frisbie","doi":"10.2460/javma.24.02.0078","DOIUrl":"https://doi.org/10.2460/javma.24.02.0078","url":null,"abstract":"OBJECTIVE\u0000To evaluate the effects of a gene transfer approach to IL-1β inhibition in an equine osteochondral chip fragment model of joint injury using a self-complementary adeno-associated virus with interleukin receptor antagonist transgene cassette (scAAVIL-1ra), as posttraumatic osteoarthritis in horses, similar to people, is a significant clinical problem.\u0000\u0000\u0000ANIMALS\u000016 horses were utilized for the study.\u0000\u0000\u0000METHODS\u0000All horses had an osteochondral chip fragment induced arthroscopically in one middle carpal joint while the contralateral joint was sham operated. Eight horses received either scAAVIL-1ra or saline in the osteoarthritis joint. Horses were evaluated over 70 days clinically (lameness, imaging, and biomarker analysis) and euthanized at 70 days and evaluated grossly, with imaging and histopathology.\u0000\u0000\u0000RESULTS\u0000The following findings were statistically significant. Injection of scAAVIL-1ra resulted in high synovial fluid levels of IL-1ra (0.5 to 9 μg/mL) throughout the duration of the experiment (70 days). Over the duration, we observed scAAVIL-1ra to improve lameness (lameness score relative improvement of 1.2 on a scale of 0 to 5), cause suppression of prostaglandin E2 (a relative decline of 30 pg/mL), and result in histological improvement in articular cartilage (decreased chondrocyte loss and chondrone formation) and subchondral bone (less osteochondral splitting and osteochondral lesions). Within the synovial membrane of scAAVIL-1ra-treated joints, we also observed perivascular infiltration with CD3-positive WBCs, suggesting lymphocytic T-cell perivascular infiltration commonly observed with viral transduction.\u0000\u0000\u0000CLINICAL RELEVANCE\u0000These data provide support for further evaluation and optimization of scAAVIL-1ra gene therapy to treat equine osteoarthritis.","PeriodicalId":514111,"journal":{"name":"Journal of the American Veterinary Medical Association","volume":"44 9","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140675967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infertility and periocular swelling in a female zebra finch (Taeniopygia guttata). 一只雌性斑马雀（Taeniopygia guttata）的不育症和眼周肿胀。

Journal of the American Veterinary Medical Association Pub Date : 2024-04-19 DOI: 10.2460/javma.24.03.0151

Yao Lee, Emily G Franklin, Magalie Boucher, Nathan M Pate, Niora J Fabian

引用次数: 0

SARS-CoV-2 morbidity, treatment interventions, and vaccination practices in tigers (Panthera tigris ssp) in North American zoos. 北美动物园老虎（Panthera tigris ssp）的 SARS-CoV-2 发病率、治疗干预措施和疫苗接种方法。

Journal of the American Veterinary Medical Association Pub Date : 2024-04-19 DOI: 10.2460/javma.24.01.0030

Ashlyn C. Heniff, Denise McAloose, Erika Crook, Tara M Harrison

{"title":"SARS-CoV-2 morbidity, treatment interventions, and vaccination practices in tigers (Panthera tigris ssp) in North American zoos.","authors":"Ashlyn C. Heniff, Denise McAloose, Erika Crook, Tara M Harrison","doi":"10.2460/javma.24.01.0030","DOIUrl":"https://doi.org/10.2460/javma.24.01.0030","url":null,"abstract":"OBJECTIVE\u0000Evaluate SARS-CoV-2 morbidity, mortality, clinical signs, treatment interventions, and vaccination practices in tigers under professional care.\u0000\u0000\u0000ANIMALS\u0000Amur (Panthera tigris altaica), Sumatran (Panthera tigris sumatrae), and Malayan (Panthera tigris jacksoni) tigers managed under the Tiger Species Survival Plan (SSP).\u0000\u0000\u0000METHODS\u0000A retrospective, voluntary online survey was sent to all North American zoos holding SSP tigers between January 2020 and June 2023.\u0000\u0000\u0000RESULTS\u0000Responses were received from 55 of 108 institutions (51%) housing 162 tigers in total, and SARS-CoV-2 infection was diagnosed in 39 tigers from 15 institutions (20 Amur, 8 Sumatran, and 11 Malayan [1 to 18 years old; 17 males and 22 females]). This corresponds to a minimum study group infection incidence of 24% over 42 months. Clinical signs included dry cough (82%), inappetence (64%), lethargy (62%), nasal discharge (46%), wheezing (31%), wet cough (18%), and ocular discharge (15%). Most cases were characterized as mild (n = 22) or moderate (14). A single case was characterized as severe. Two cases were asymptomatic. Seventeen positive tigers had been vaccinated once (n = 8) or twice (9) for SARS-CoV-2 prior to infection. No deaths due to SARS-CoV-2 were reported in the study group. Treatment interventions included antibiotics (49%), NSAIDs (18%), antiemetics (15%), and fluids (13%). No treatments were administered in 19 of 39 cases (49%). Amongst participating institutions, 69% reported fully vaccinating tigers for SARS-CoV-2 (≥ 2 doses).\u0000\u0000\u0000CLINICAL RELEVANCE\u0000Most SARS-CoV-2-infected tigers presented with mild to moderate clinical signs and recovered with limited to no treatment interventions. Asymptomatic SARS-CoV-2 infections can occur in tigers and may be underreported. Tigers vaccinated for SARS-CoV-2 remain susceptible to infection.","PeriodicalId":514111,"journal":{"name":"Journal of the American Veterinary Medical Association","volume":" 6","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140684358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nasolacrimal duct obstruction prevalence is 0.3% among alpacas evaluated with ophthalmic disease at a veterinary teaching hospital between 2000 and 2023. 2000 年至 2023 年期间，在一家兽医教学医院接受眼科疾病评估的羊驼中，鼻泪管阻塞的发病率为 0.3%。

Journal of the American Veterinary Medical Association Pub Date : 2024-04-19 DOI: 10.2460/javma.23.10.0579

Madison R Baker, A. Niehaus, M. Miesner, Joseph W. Lozier, Brianna A. Jordan, Michelle K Carman, Jennifer Clark, David E Anderson

{"title":"Nasolacrimal duct obstruction prevalence is 0.3% among alpacas evaluated with ophthalmic disease at a veterinary teaching hospital between 2000 and 2023.","authors":"Madison R Baker, A. Niehaus, M. Miesner, Joseph W. Lozier, Brianna A. Jordan, Michelle K Carman, Jennifer Clark, David E Anderson","doi":"10.2460/javma.23.10.0579","DOIUrl":"https://doi.org/10.2460/javma.23.10.0579","url":null,"abstract":"OBJECTIVE\u0000To examine the prevalence of nasolacrimal duct (NLD) obstruction in hospital populations and assess signalment, diagnostics, and clinical approaches for alpacas and llamas diagnosed with NLD atresia or obstruction.\u0000\u0000\u0000ANIMALS\u000029 alpacas and 2 llamas.\u0000\u0000\u0000CLINICAL PRESENTATION\u0000Medical records were reviewed to identify camelids with NLD evaluated between 2000 and 2023. Signalment, history, physical examination data, diagnosis, and treatments were recorded. Follow-up information was gathered via phone and email questionnaire. Data were evaluated to determine prevalence and describe signalment and treatments for NLD disease.\u0000\u0000\u0000RESULTS\u000031 camelids met the inclusion criteria. A total of 8,027 alpacas and 1,998 llamas were seen within the study period at 1 teaching institution. The prevalence of NLD obstruction for this population of alpacas was 0.3% (26/8,027). Nineteen of 31 (61%) camelids presented at 1 year of age or younger. The most common physical exam finding was ocular discharge (68%). The most common diagnosis was NLD atresia (16/31 [51%]). Patency was established by surgical opening or lavage of the NLD. Long-term follow-up was available for 13 alpacas and 2 llamas, of which 11 (73%) had successful outcomes.\u0000\u0000\u0000CLINICAL RELEVANCE\u0000Results indicate that NLD obstruction is a condition that most commonly affects alpacas < 1 year of age and is associated with a good prognosis for treatment success.","PeriodicalId":514111,"journal":{"name":"Journal of the American Veterinary Medical Association","volume":" 100","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140683695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0