Ega Widya Prayogo, I. Sholikhah, S. Suciati, Wiwied Ekasari, R. Widyowati
{"title":"Identification of Metabolite Compounds from A Ethanol Extract of Caulerpa racemosa using LC-MS/MS with Inhibitory Activity of Interleukin-1β and Expression Inhibitory Nitric Oxide Synthase Enzyme; In Silico Virtual Screening","authors":"Ega Widya Prayogo, I. Sholikhah, S. Suciati, Wiwied Ekasari, R. Widyowati","doi":"10.48048/tis.2024.8026","DOIUrl":"https://doi.org/10.48048/tis.2024.8026","url":null,"abstract":"Osteoarthritis (OA) is the prevailing kind of arthritis, impacting a substantial number of individuals globally. The incidence of OA is on the rise and is projected to further increase due to the aging population and escalating rates of obesity. This study aims to evaluate the anti-OA potential of Caulerpa racemosa. The Caulerpa racemosa 96 % ethanol extract of the plant was analysed using LC-MS/MS. The metabolite compositions were identified as polyunsaturated fatty acids, terpenes, bisindole alkaloids and diterpenoids. The 18 compounds analysed by LC-MS/MS, and the binding affinity of the compounds to the target proteins Interleukin-1 (PDB ID: 1ITB) was assessed by molecular docking fucosterol (∆G = –8.29 kcal/mol), variolin A (∆G = –8.02 kcal/mol), and clionasterol (∆G = –7.50 kcal/mol) and Nitric Oxide Synthase Inducible (3E7G) was assessed by molecular docking. Brassicasterol (∆G = –9.25 kcal/mol), fucosterol (∆G = –9.20 kcal/mol) and 24-methylenecholesterol (∆G = –9.04 kcal/mol) exhibited the highest docking scores, indicating their strong potential as inhibitors of IL1β and nitric oxide (NO). This knowledge is valuable for the future bioassay investigations about the possible applicability of these medicines as innovative solutions for OA.","PeriodicalId":513497,"journal":{"name":"Trends in Sciences","volume":"103 30","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141820756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Influences of Enterobacter Cloacae Strain Fg 5-2 and Its Vermicompost and Nitrogen Fertilizer Usage Efficiency on Groundnut Yield","authors":"N. Chuong","doi":"10.48048/tis.2024.8039","DOIUrl":"https://doi.org/10.48048/tis.2024.8039","url":null,"abstract":"Reducing production costs by replacing chemical nitrogen fertilizer (CNF) with natural nitrogen fertilizers from endophytic nitrogen-fixing bacteria is an optimally alternative solution to utilize natural nitrogen sources from biological nitrogen fixation to improve crop yields. Three levels of nitrogen (N) and vermicompost (VMC) application combined with Enterobacter cloacae strain Fg 5-2 (EC strain Fg 5-2) inoculation, which were carried out in 2 experiments, aimed to evaluate its impacts on the groundnut output. The 2 experiments consisted of 0, 20, 40 kg N ha–1 and 0, 5.0, 10 t VMC ha–1 application associated with EC strain Fg 5-2 inoculation and 4 replications. Results observed that 50 % CNF reduction, which increased up to 16.5 % of the groundnut yield compared to no CNF application, was no yield difference of the 100 % CNF application. Application of 10 t VMC ha–1 associated with EC strain Fg 5-2 inoculation increased up to 38.4 % compared to no VMC amendment. The groundnut yield of experiment 1 and 2 remarkably increased up to 19.6 and 12.9 %, respectively, with the EC strain Fg 5-2 inoculation compared to the non- EC strain Fg 5-2 inoculation. Application of VMC was the high efficiency on the nodulous number and weight of groundnut. Application of 20 kg N or 10 t VMC ha–1 combined with EC strain Fg 5-2 inoculation adequately reached highest groundnut yield. These selected results are the best associated rate to reduce CNF by applying EC strain Fg 5-2 inoculation to improve farmland nutrients and increase the groundnut yield.","PeriodicalId":513497,"journal":{"name":"Trends in Sciences","volume":" 841","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141823482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Mahanil, Dusit Athinuwat, Anthikan Klomchit, Kritsadaphon Phonwong
{"title":"Assessing the Impact of Yeast Fermentation in Dry Processing on Coffee Quality from Coffea arabica cv. Caltimor, C. arabica cv. Bourbon and C. canephora cv. Robusta","authors":"S. Mahanil, Dusit Athinuwat, Anthikan Klomchit, Kritsadaphon Phonwong","doi":"10.48048/tis.2024.8132","DOIUrl":"https://doi.org/10.48048/tis.2024.8132","url":null,"abstract":"This study aims to investigate the influence of yeast fermentation and inoculation methods on the quality of coffee across 3 different coffee cultivars. Fermenting Sacchoromyces cerevisiae SafAle s-33 on Coffea arabica cv. Caltimor via bucket inoculation outperforms spray inoculation across all aspects including microbial cell adhesion, the chemical profile, reducing sugar content and sensory analysis conducted by a Q-grader. The PCA analysis revealed distinct profiles of organic acids and volatile compounds in roasted beans in yeast fermentation and natural fermentation of all 3 coffee varieties. Particularly, volatile compounds such 1-(4-Methoxyphenyl)octan-1-one, 8-Oxabicyclo[3.2.1]oct-6-en-3-one and 5,6-Dimethoxy-2-(2-hydroxyethyl-1-thio)-3 trimethylsilyl methyl-1,4-benzoquinone and, furfuryl ethyl ether and 5-methyl furfural were detected only in yeast fermented bean. The malic acid also contained a higher amount in roasted coffee beans from the yeast fermentation of all 3 coffee varieties than the natural fermentation. Those compounds present a notably positive influence on the sensory aspects of the coffee i.e. sweet caramel, dry fruit, vanilla and hazelnut-like flavors. In addition, roasted beans from the yeast fermentation of C. arabica cv. Caltimor and C. canephora cv. Robusta displayed higher sensory scores when compared to those from natural fermentation, conversely in C. arabica cv. Bourbon, beans from both yeast fermentation and natural fermentation displayed similar quality levels. Our study concluded that the commercial yeast strain within the beer and wine industry proved to be an alternative source for coffee fermentation. Nevertheless, the selection of the coffee variety plays a crucial role when utilizing S. cerevisiae SafAle s-33 as a starter.","PeriodicalId":513497,"journal":{"name":"Trends in Sciences","volume":"111 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141821314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Revolutionizing Indigo-Dyed Fabric Identification: A Novel Sulfonation Approach for Authenticity and Quality Assurance","authors":"Pornkamon Sakong, Witchapol Thosaikham","doi":"10.48048/tis.2024.8043","DOIUrl":"https://doi.org/10.48048/tis.2024.8043","url":null,"abstract":"This study explores a novel sulfonation method for analyzing blue-dyed fabrics containing reactive, direct and indigo dyes. The proposed method accurately distinguishes indigo fabrics by converting indigo blue into indigo carmine using concentrated H2SO4, resulting in distinct spectral analysis through UV-Visible spectrophotometry. Generally, UV-Visible spectroscopy shows absorption peak characteristics influenced by analyte and environmental properties, leading to broadening and wavelength shifts. Therefore, statistical analysis of peak characteristics, including center, centroid, Full Width at Half Maximum (FWHM), height and L/R ratio, was performed on the obtained spectra to facilitate comprehensive quality evaluation of indigo-dyed fabrics. The proposed method demonstrated good precision and accuracy, with %RSD values indicating excellent repeatability and reproducibility, contingent on consistent sample preparation, narrow analyte peaks and minimized background signals. Furthermore, this method was applied to analyze the collected indigo-dyed fabrics from Sakon Nakhon Province, revealing the center value (611.79 nm) as a precise marker for indigo dye, with a narrow control range (607.02 - 616.56 nm) and a low coefficient of variation (CV) of 0.26 %. Moreover, centroid, L/R ratio and FWHM significantly contributed to fabric classification and quality assessment. This research offers valuable insights to improve indigo fabric production in Sakon Nakhon Province, leading to more reliable authentication and quality control of the natural indigo-dyed industry.","PeriodicalId":513497,"journal":{"name":"Trends in Sciences","volume":" 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141823048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sri Rahayu, Nurul Huda, Rizky Priambodo, Rusdi Rusdi, Elsa Lisanti
{"title":"Liquid Soap from Waste Cooking Oil Containing Betel and Aloe Vera Creates Low Risk to Allergic Contact Dermatitis in Rat Skin","authors":"Sri Rahayu, Nurul Huda, Rizky Priambodo, Rusdi Rusdi, Elsa Lisanti","doi":"10.48048/tis.2024.8127","DOIUrl":"https://doi.org/10.48048/tis.2024.8127","url":null,"abstract":"The quality of used cooking oil can be improved by purifying it using bagasse activated charcoal. Purified used cooking oil can be used as raw material for soap. Use of soap can cause allergic contact dermatitis (ACD). Skin suffering from ACD is characterized by inflammatory cell infiltration of the skin, the inflammatory cells involved are mast cells, macrophages and polymorphonuclear cells (PMN), namely basophils, eosinophils and neutrophils. Therefore, inflammatory cells were chosen as a parameter for the ACD response to the use of used cooking oil liquid soap containing betel and aloe vera. Liquid soap formed was use an extract concentration of 4.5, 9 and 15 %. Skin sensitivity testing was tested on male Wistar rats aged 2 - 3 months for 14 days. Quantitative data was obtained through histopathological examination of the number of inflammatory cells, which were analyzed statistically. The results showed that the use of liquid soap with an extract concentration of 9 % (4.24 ± 0.74) and 15 % (3.96 ± 0.25) had no effect on basophil infiltration. The use of liquid soap with an extract concentration of 4.5 % (2.96 ± 1.17, 6.42 ± 0.86, 5.96 ± 0.38), 9 % (3.12 ± 0.47, 4.62 ± 0.68, 6.42 ± 1.06) and 15 % (3.36 ± 0.41, 5.08 ± 0.30, 6.44 ± 0.55) had no effect on infiltration of neutrophils, eosinophils and macrophages. The use of liquid soap with an extract concentration of 9 % (4.60 ± 0.86) had no effect on mast cell infiltration. Therefore, it can be concluded that the best concentration of 9 % extract betel and aloe vera showed no infiltration of inflammatory cells in rats’ skin given soap from waste cooking oil. Thus, that the soap formed from waste cooking oil treated with bagasse activated charcoal and contain betel and aloe vera is predicted safe to used.","PeriodicalId":513497,"journal":{"name":"Trends in Sciences","volume":"103 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141821698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Electron beam induced mutation in Curcuma longa L. against bacterial wilt disease","authors":"Katarut Chutinanthakun","doi":"10.48048/tis.2024.8061","DOIUrl":"https://doi.org/10.48048/tis.2024.8061","url":null,"abstract":"Curcuma longa L. is a major bioactive constituent (curcumin) possessing various pharmacological properties. However, a major problem of turmeric crop production is bacteria wilt disease caused by Ralstonia solanacearum leading to a substantial reduction in yield and plant death. This research aims to induce mutation of turmeric cv. Trang2 by 8 MeV electron beam in vitro culture plantlets and to select the turmeric against bacterial wilt disease. Sixty-day-old in vitro culture plantlets were exposed to 0, 50, 100 and 150 Gy electron beams with a dose rate of 240 Gy/min, at the Thailand Institute of Nuclear Technology (Public Organization), Thailand. To explore the potential of electron beam-sensitivity on survival and growth rate, unirradiated plantlets were used to normalize the radiation treatments. Plantlet survival was recorded to calculate the lethal dose (LD), and the number of new shoots was recorded to estimate the growth reduction dose (GR) through regression analysis. \u0000The plantlets survival and growth rate were decreased over the accompanying cultured period together with increased radiation doses. At doses of 100 and 150 Gy, the turmeric plantlets were unable to produce new shoots. The median lethal dose was 58.6 Gy (LD50). A 50% growth reduction dose revealed at 45.3 Gy (GR50). Symptom severity ranged from 11.7% to 91.7%, demonstrating significantly lower levels in EBRTP-2 and EBRTP-4 M1V5 electron beam irradiated populations. Furthermore, the disease incidence was 33.3% in the EBRTP-6 population. This study, 3 irradiated M1V5 populations were isolated EBRTP-2, EBRTP-4 and EBRTP-6 from 50 Gy electron beam irradiation.","PeriodicalId":513497,"journal":{"name":"Trends in Sciences","volume":"7 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141822632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad Nurrizki Haitamy, Hariojono Kario Sentono, Adi Prayitno, S. Soetrisno, Made Setiamika, Ida Nurwati, Risya Cimiaty A.R
{"title":"Revealing the Therapeutic Potential of Nigella Sativa Extract in Aspergillus Niger-Induced Otitis Externa: Anti-Inflammatory and Antioxidant Properties","authors":"Mohammad Nurrizki Haitamy, Hariojono Kario Sentono, Adi Prayitno, S. Soetrisno, Made Setiamika, Ida Nurwati, Risya Cimiaty A.R","doi":"10.48048/tis.2024.8145","DOIUrl":"https://doi.org/10.48048/tis.2024.8145","url":null,"abstract":"Otitis externa (OE), a fungal infection of the external auditory canal, often involving Aspergillus niger, can lead to OE externa, posing severe health risks. Establishing an animal model of OE induced by Aspergillus niger, this study aimed to evaluate the therapeutic potential of Nigella sativa (NS) extract, specifically its effect on inflammation and antioxidant activity in this OE animal model. The detection of Aspergillus niger on the 3rd day post-induction confirmed its thriving presence within the ear canal. NS extract, containing thymoquinone, significantly reduced the expression of IL-1B and TNF-a proteins. Notably, NS extract at 5 and 10 % showed comparable effects, surpassing the efficacy of topical miconazole. Evaluation of MDA protein expression, indicative of oxidative damage, revealed a significant decrease with NS extract treatment, especially at 5 % dosage. NS extract exhibited a notable decrease in subunit p50 and p65 proteins expression, particularly at the 5 % concentration. In conclusion, NS extract displayed promising anti-inflammatory effects on Aspergillus niger-induced otitis externa by modulating various inflammatory markers and pathways. These findings highlight the potential therapeutic role of NS extract in addressing inflammation associated with OE.","PeriodicalId":513497,"journal":{"name":"Trends in Sciences","volume":" 827","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141823361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Warnasih, A. H. Mulyati, Diana Widiastuti, Alita Chasanah Zahra, P. Sugita, L. Ambarsari
{"title":"Anticancer Potency of Methanol Extract from Terminalia catappa Leaves Using In Vitro and In Silico Methods","authors":"S. Warnasih, A. H. Mulyati, Diana Widiastuti, Alita Chasanah Zahra, P. Sugita, L. Ambarsari","doi":"10.48048/tis.2024.8057","DOIUrl":"https://doi.org/10.48048/tis.2024.8057","url":null,"abstract":"Terminalia catappa is a plant with potential for application in various antioxidant, anti-inflammatory, antimetastatic and antitumor treatments. Therefore, this study aimed to investigate anticancer properties of methanol extract derived from T. catappa leaves, using both in vitro and in silico methods. The results showed that methanol extract had inhibition of HeLa and DU145 cell lines, with respective IC50 values of 352.50 and 954.99 μg/mL. LC-MS/MS analysis identified several active compounds within the extract, including catechin, quercetin, rutin, hirsutrin, loliolide, sesquiterpene, kaempferol, apigenin, cirsiliol, cirsimaritin and demethoxycurcumin, all of which had promising anticancer potential. These compounds performed well in the in silico test. According to computational predictions, rutin (−9.1 kcal/mol), catechin (−8.0 kcal/mol) and sesquiterpene (−8.2 kcal/mol) had higher binding affinity values than cisplatin and paclitaxel (−7.5 kcal/mol). Considering these results, the compounds were potentially anticancer agents through the inhibition of the Bcl-2 protein. Finally, T. catappa active compounds can be used as alternative candidates as a chemopreventive agent.","PeriodicalId":513497,"journal":{"name":"Trends in Sciences","volume":" 355","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141823704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wellington Bruno Silva de Jesus, Vinicius Lima da Silva, Héricles Ruiliman Oliveira de Souza, Thiago Antônio Paixão de Sousa Costa, Otavio Fernandes Lima Da Rocha, Luiz Gabriel da Silva Nascimento Nascimento, Maria Adrina Paixão De Souza Da Silva
{"title":"Thermal and Microstructural Characterization of the Multicomponent Alloy Al33wt%Cu1wt%Ni-1.2wt%Ta Solidified with Transient Heat Flow","authors":"Wellington Bruno Silva de Jesus, Vinicius Lima da Silva, Héricles Ruiliman Oliveira de Souza, Thiago Antônio Paixão de Sousa Costa, Otavio Fernandes Lima Da Rocha, Luiz Gabriel da Silva Nascimento Nascimento, Maria Adrina Paixão De Souza Da Silva","doi":"10.48048/tis.2024.8029","DOIUrl":"https://doi.org/10.48048/tis.2024.8029","url":null,"abstract":"The demand for materials with specific properties continues to grow in modern industry, necessitating a deeper understanding of metal solidification processes. This study investigates the thermal and microstructural characteristics of a novel multicomponent alloy, Al33wt%Cu1wt%Ni-1.2wt%Ta, which has not been previously reported in the literature. This alloy, comprising aluminum, copper, nickel and tantalum, exhibits superior mechanical strength, thermal stability and corrosion resistance compared to conventional alloys, making it suitable for various applications. Utilizing transient heat flow techniques, thermal characterization and microstructural analysis were performed on the alloy after solidification. Thermal mapping revealed variable growth and cooling rates along the ingot, influencing macrostructural transitions from columnar to equiaxed grains. Microstructural examination uncovered a complex evolution, with refined dendritic spacings initially, followed by the formation of intermetallic phases such as Al3Ta, α-Al and Al2Cu. The study also proposed a hypothesis on the formation of diamond-shaped intermetallics like Ni3Ta and Ta(Cu,Al)2, which were consumed to form Al7Cu4Ni at the edges. Secondary dendritic spacing analysis supported this hypothesis, showing correlation with growth laws. The findings provide valuable insights into solidification behavior and microstructural evolution, aiding in parameter optimization and enhancing the alloy’s properties for specific applications. However, limitations include the need for further research to explore mechanical and thermal properties and validate industrial potential.","PeriodicalId":513497,"journal":{"name":"Trends in Sciences","volume":"118 50","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141821348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laily N. Hofi, S. Maryanto, Adi Susilo, S. D. Wuryani
{"title":"Derivative Analysis of Gravity Data in Revealing the Subsurface Fault Structure Model in Semeru Volcano, East Java and Its Surrounding","authors":"Laily N. Hofi, S. Maryanto, Adi Susilo, S. D. Wuryani","doi":"10.48048/tis.2024.8050","DOIUrl":"https://doi.org/10.48048/tis.2024.8050","url":null,"abstract":"Research with gravity data in the area of Semeru volcano has been undertaken. The study aims to determine the subsurface fault structure of the Semeru volcano by utilizing derivative analysis of gravity data anomalies. A comprehensive dataset of 1,929 measurement points, spaced 500 m apart, was analyzed to identify variations in the Bouguer anomaly. Complete Bouguer anomaly values ranged from 37 to 111 mGal. The contrast of Bouguer anomaly variations effectively delineates the boundaries of different rock formations: Mandalika, Wuni, Quarter Volcanic Semeru and Quarter Volcanic Jembangan. These formations are instrumental in causing significant variations in gravity anomalies, indicating an underlying geological structure. The derivative analysis, encompassing horizontal (FHD) and vertical (SVD) anomalies, unveiled a pronounced fault structure southeast of the Semeru crater, characterized by a NE-SW orientation. Advanced modeling, informed by residual anomaly incision lines and depth estimates derived from the radial spectrum, revealed a complex subsurface stratigraphy consisting of 5 types: Volcanic clastics, tuff, breccia, basaltic lava and andesitic lava. This research advances our understanding of the Semeru volcano’s subsurface architecture. It introduces an enhanced methodology for fault detection and characterization in volcanic areas, showcasing the potential of gravity data in geological investigations.","PeriodicalId":513497,"journal":{"name":"Trends in Sciences","volume":" 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141823016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}