Journal of Allergy and Clinical Immunology-In Practice最新文献

{"title":"Pharmacokinetics and Pharmacodynamics of neffy, Epinephrine Nasal Spray, in Pediatric Allergy Patients","authors":"David M. Fleischer MD ,&nbsp;H. Henry Li MD, PhD ,&nbsp;Neetu Talreja MD ,&nbsp;Richard F. Lockey MD ,&nbsp;Michael A. Kaliner MD ,&nbsp;Richard D. Wainford PhD ,&nbsp;Matthew J. Greenhawt MD ,&nbsp;Thomas B. Casale MD ,&nbsp;Richard Lowenthal MSc ,&nbsp;Sarina Tanimoto MD, PhD","doi":"10.1016/j.jaip.2025.03.019","DOIUrl":"10.1016/j.jaip.2025.03.019","url":null,"abstract":"<div><h3>Background</h3><div>Epinephrine is the gold-standard treatment for severe allergic reactions, including anaphylaxis, and is typically administered via intramuscular injection. Despite epinephrine’s well-documented safety and efficacy, patients may be hesitant to administer/receive injections, thereby increasing the risk of complications. <em>neffy</em> epinephrine nasal spray was developed to provide an additional option that may reduce dosing hesitancy.</div></div><div><h3>Objective</h3><div>This study was conducted to characterize <em>neffy’s</em> pharmacokinetic and pharmacodynamic profiles in pediatric subjects, and to compare profiles between pediatric and adult subjects.</div></div><div><h3>Methods</h3><div>This was a phase 1, multicenter, single-dose, pharmacokinetic/pharmacodynamic study. Forty-two pediatric patients were dosed with 1 or 2 mg of <em>neffy</em>, based on weight. Pharmacokinetic and pharmacodynamic parameters were summarized with descriptive statistics and analyzed using a linear mixed effects model.</div></div><div><h3>Results</h3><div>In pediatric subjects, <em>neffy</em> 1 mg resulted in a slightly lower mean maximum concentrations relative to <em>neffy</em> 2 mg (651 vs 690 pg/mL), which were higher than the maximum concentrations in adult subjects (481 pg/mL). Although adult subjects demonstrated a marked postdose increase in systolic blood pressure, the systolic blood pressure increase observed in pediatric patients was significantly lower and was accompanied by minimal differences in diastolic blood pressure. The effect on heart rate was similar between both pediatric and adult subjects.</div></div><div><h3>Conclusions</h3><div>In pediatric subjects, both the 1 and 2 mg doses of <em>neffy</em> resulted in mean maximum concentration values that are expected to be both safe and efficacious. Age-related differences in pharmacodynamic responses were noted; however, these differences are likely attributable to expected age-based differences in physiology.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1335-1341.e1"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic cat and dog allergenic products contain galactose-α-1,3-galactose","authors":"Tina K. Merritt MD ,&nbsp;Max D. Bermingham BSc ,&nbsp;Sayeh Agah PhD ,&nbsp;Rhys T. Meredith MRes ,&nbsp;Bryan R.E. Smith BA ,&nbsp;Martin D. Chapman PhD","doi":"10.1016/j.jaip.2025.03.012","DOIUrl":"10.1016/j.jaip.2025.03.012","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1461-1463.e1"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood food allergy and participation in free or reduced-price meal programs at school","authors":"Roxanne Dupuis PhD ,&nbsp;Gabrielle D’Ambrosi MPH ,&nbsp;Linda J. Herbert PhD ,&nbsp;Michael C. Monuteaux ScD ,&nbsp;Michael C. Young MD ,&nbsp;Erica L. Kenney ScD ,&nbsp;Catherine C. Peterson PhD ,&nbsp;Wanda Phipatanakul MD, MS ,&nbsp;Lisa M. Bartnikas MD","doi":"10.1016/j.jaip.2025.03.024","DOIUrl":"10.1016/j.jaip.2025.03.024","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1481-1484.e2"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dominant-Negative Versus Gain-of-Function STAT3 Defects: A Systematic Review on Epidemiological, Clinical, Immunological, and Molecular Aspects","authors":"Amirhossein Hajialigol MD ,&nbsp;Gholamreza Azizi PhD ,&nbsp;Mahnaz Seifi Alan PhD ,&nbsp;Afsaneh Soltani MD ,&nbsp;Zahra Arabian MD ,&nbsp;Mehrdad Tamiji MSc ,&nbsp;Christo Tsilifis MBBS, PhD ,&nbsp;Andrew R. Gennery MD, FRCPCH, MRCP, DCH ,&nbsp;Mahnaz Jamee MD","doi":"10.1016/j.jaip.2025.04.014","DOIUrl":"10.1016/j.jaip.2025.04.014","url":null,"abstract":"<div><h3>Background</h3><div>Germline signal transducer and activator of transcription 3 (STAT3) mutations cause 2 distinct syndromes with predominant infectious or autoimmune phenotype.</div></div><div><h3>Objective</h3><div>The objective of this study is to compile literature reports on gain-of-function (GOF) and dominant-negative (DN) mutations in the <em>STAT3</em>.</div></div><div><h3>Methods</h3><div>We searched 3 main databases including PubMed, Scopus, and Web of Science from 1990 to 2023. All full-text articles and major reviews were manually searched for additional studies.</div></div><div><h3>Results</h3><div>A total of 490 patients were reported in 107 articles including 265 patients with DN-<em>STAT3</em> and 225 patients with GOF-<em>STAT3</em> mutations. Major clinical differences between STAT3-DN and STAT3-GOF patients were observed in rates of infectious complication (98.2% vs 85.4%, <em>P</em> &lt; .001), pneumonia (67.3% vs 52.1%, <em>P</em> = .006), sinusitis (17.5% vs 2.1%, <em>P</em> &lt; .001), otitis (27.7% vs 5.2%, <em>P</em> &lt; .001), abscess (52.7% vs 17.7%, <em>P</em> &lt; .001), dermatologic manifestation (88.3% vs 58.4%, <em>P</em> &lt; .001), atopic disorders (66.4% vs 40.2%, <em>P</em> &lt; .001), interstitial lung disease (0.7% vs 17.7%, <em>P</em> &lt; .001), dental/gingival disorders (38.5% vs 11.7%, <em>P</em> &lt; .001), and endocrinopathies (0.9% vs 16.5%, <em>P</em> &lt; .001), respectively. Most patients had normal counts of lymphocyte subsets, with the exceptions of higher CD3+ T cells and lower natural killer cells in STAT3-DN patients, and lower CD4+ T cells in STAT3-GOF patients. Most STAT3-DN patients had either normal or high serum concentrations of IgG, IgA, and IgM with almost universal raised serum IgE. Most STAT3-GOF patients had a low level of IgG, but normal levels of IgA, IgM, and IgE.</div></div><div><h3>Conclusions</h3><div>Patients with STAT3-DN had recurrent dermatological and pulmonary infections, eczema, elevated IgE, and eosinophilia, whereas patients with STAT3-GOF had early-onset polyautoimmunity and frequently require immunosuppressive therapy.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1440-1448.e4"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food protein–induced enterocolitis syndrome oral food challenge with a single dose is safe enough and fast","authors":"Stefano Miceli Sopo MD ,&nbsp;Angela Aurelio MD ,&nbsp;Francesco Mastellone MD ,&nbsp;Giulia Bersani MD ,&nbsp;Tecla Fontana MD","doi":"10.1016/j.jaip.2025.03.050","DOIUrl":"10.1016/j.jaip.2025.03.050","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1503-1504"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypereosinophilic Disorders","authors":"","doi":"10.1016/j.jaip.2025.05.009","DOIUrl":"10.1016/j.jaip.2025.05.009","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Page 1496"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuing Medical Education Calendar","authors":"","doi":"10.1016/S2213-2198(25)00446-5","DOIUrl":"10.1016/S2213-2198(25)00446-5","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages A21-A22"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144213150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life Stressors, Resilience Resources, and Asthma Among Adults in the Hispanic Community Health Study/Study of Latinos","authors":"Yueh-Ying Han PhD, MS ,&nbsp;Kristina Gaietto MD, MPH ,&nbsp;Wei Chen PhD ,&nbsp;Krista M. Perreira PhD ,&nbsp;Eyal Oren PhD, MS ,&nbsp;Amber Pirzada MD ,&nbsp;Olga Garcia-Bedoya MD ,&nbsp;Robert Kaplan PhD ,&nbsp;Carmen R. Isasi MD, PhD ,&nbsp;Juan C. Celedón MD, DrPH","doi":"10.1016/j.jaip.2025.02.031","DOIUrl":"10.1016/j.jaip.2025.02.031","url":null,"abstract":"<div><h3>Background</h3><div>Whether life stressors and resiliency interact on asthma risk in adults is largely unknown.</div></div><div><h3>Objective</h3><div>To examine life stressors, resiliency, and asthma in Hispanic/Latino adults.</div></div><div><h3>Methods</h3><div>This is a cross-sectional study of 4747 adults aged 18 to 74 years in the Sociocultural Ancillary Study of the Hispanic Community Health Study/Study of Latinos. Participants completed questionnaires on life stressors (adverse childhood experiences [ACE], traumatic stress exposure (TSE), and chronic stressors [for ≥6 months]) and resilience resources (family cohesion, perceived social support, and spiritual well-being). Logistic regression was used for the multivariable analyses of current asthma and current asthma symptoms.</div></div><div><h3>Results</h3><div>Any ACE and any chronic stressor were associated with 54% to 69% increased odds of asthma and asthma symptoms in all individuals, with stronger associations for ACE in men and for chronic stressors in women. In a separate analysis, high family cohesion and high spiritual well-being were each associated with 35% to 36% reduced odds of asthma symptoms. There was suggestive evidence of interactions: any TSE was associated with increased odds of asthma in adults with low family cohesion (adjusted odds ratio [aOR] = 2.40, 95% confidence interval [CI] = 1.01-5.73) but not in others, and any chronic stressor was associated with increased odds of asthma symptoms in adults with low spiritual well-being (aOR = 2.24, 95% CI = 1.20-4.20) but not in others.</div></div><div><h3>Conclusions</h3><div>In Hispanic/Latino adults, ACE and chronic stress were associated with higher odds of asthma or asthma symptoms, whereas family cohesion and spiritual well-being were linked to lower odds of asthma or asthma symptoms. Further, resiliency may interact with life stressors on asthma.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1375-1384.e7"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Climate Change and Allergens: Current and Future Impacts","authors":"Allison J. Burbank MD ,&nbsp;Alexander J. Penrice MD ,&nbsp;Andrew C. Rorie MD ,&nbsp;Jae-Won Oh MD, PhD","doi":"10.1016/j.jaip.2025.02.039","DOIUrl":"10.1016/j.jaip.2025.02.039","url":null,"abstract":"<div><div>Climate change will continue to impact allergic diseases in direct and indirect ways. Rising global temperatures are contributing to increased duration of pollen seasons, altered aeroallergen production and potency of allergens, and changes in the geographic distribution of allergenic plants that drive increased human exposure to aeroallergens and increased allergic disease morbidity. Climate change is inextricably linked with air pollution, the latter of which was shown to act as an adjuvant for allergic inflammatory processes promoting allergic sensitization. Pollutant exposure is also linked with higher prevalence of childhood asthma and exacerbation of existing asthma and allergic disease. Increased exposure, or co-exposure, to aeroallergens and air pollution as a result of climate change will result in higher rates of sensitization, and incident allergic disease remains uncertain. Vulnerable populations, including children, the elderly, and marginalized groups, are likely to be disproportionately affected. This review summarizes the current knowledge of the effects of climate change on aeroallergens, and by extension, allergic disease. Addressing these health challenges requires a comprehensive understanding of the interaction between climate change, allergens, pollution and public health, alongside proactive measures to mitigate these effects.</div></div>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1281-1288"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severity of almond allergy and diagnostic value of almond extract in adults","authors":"Emily J.J. Kallen MD ,&nbsp;Paco M.J. Welsing PhD ,&nbsp;Pedro Botelho Alves MD ,&nbsp;Juliëtte E. Kuiken BSc ,&nbsp;André C. Knulst MD, PhD ,&nbsp;Ronald van Ree PhD ,&nbsp;Thuy-My Le MD, PhD","doi":"10.1016/j.jaip.2025.03.031","DOIUrl":"10.1016/j.jaip.2025.03.031","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":"13 6","pages":"Pages 1485-1488"},"PeriodicalIF":8.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}