Journal of Allergy and Clinical Immunology-In Practice最新文献

{"title":"Biological Sex Differences in Rhinitis Prevalence Among Adults in the United States: An \"All of Us\" Research Program Database Analysis.","authors":"Victoria S Lee, Richard G Chiu, Anthony I Dick, Sharmilee M Nyenhuis, Thasarat Sutabutr Vajaranant, Rachel Caskey, Kamal Eldeirawi","doi":"10.1016/j.jaip.2024.12.032","DOIUrl":"https://doi.org/10.1016/j.jaip.2024.12.032","url":null,"abstract":"<p><strong>Clinical implications: </strong>Female sex is associated with allergic rhinitis among adults, but not with nonallergic rhinitis. These findings could support a role of sex hormones in the pathogenesis of allergic rhinitis and nasal inflammation, but more research is needed to establish causation.</p>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Food Challenge Protocols in Food Protein-Induced Enterocolitis Syndrome: A Systematic Review.","authors":"Tayseer Ibrahim, Laura Argiz, Sonsoles Infante, Stefania Arasi, Ulugbek Nurmatov, Marta Vazquez-Ortiz","doi":"10.1016/j.jaip.2024.12.033","DOIUrl":"https://doi.org/10.1016/j.jaip.2024.12.033","url":null,"abstract":"<p><strong>Background: </strong>Oral Food Challenges (OFC) are essential for the diagnosis and follow-up of acute Food Protein-Induced Enterocolitis Syndrome (FPIES) because no diagnostic or prognostic biomarkers are available. However, the optimal OFC procedure remains unclear.</p><p><strong>Objectives: </strong>This systematic review aimed to assess OFC procedures' design and clinical outcomes in patients with FPIES.</p><p><strong>Methods: </strong>Ten databases were searched for studies published in English between 1978 and February 2024 involving children or adults undergoing OFC for FPIES. Critical appraisal followed Effective Public Health Practice Project parameters.</p><p><strong>Results: </strong>Fifty-two studies met the inclusion criteria, all observational studies. Of these, 35 were judged to have strong methodological quality. There was great heterogeneity in OFC procedures, particularly in cumulative dose, number, size, and timing between doses. OFC outcome reporting was often inadequate, especially regarding reaction symptoms and severity grading. In single-dose OFC protocols, most children reacted after at least two hours. Four small studies showed that a single dose of 25% of an age-appropriate portion was sufficient to trigger reactions in 80-100% of cases, and this was associated with less severe reactions. Due to methodological heterogeneity and insufficient outcome reporting, further assessment of the OFC protocol characteristics associated with safer outcomes was not possible.</p><p><strong>Conclusion: </strong>There is significant heterogeneity in FPIES OFC practices. Current recommendations on OFC procedures and outcome assessments have limitations and should be revisited, as this may impact patient safety and diagnostic accuracy. Future studies should focus on standardizing clinical outcomes and generating evidence to support safer, more accurate OFC protocols in FPIES.</p>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifetime Disability-adjusted Life Year assessment of indolent systemic mastocytosis.","authors":"M Mounié, H Derumeaux Burel, L Molinier, N Costa, C Bulai Livideanu","doi":"10.1016/j.jaip.2024.12.034","DOIUrl":"https://doi.org/10.1016/j.jaip.2024.12.034","url":null,"abstract":"<p><strong>Background: </strong>Indolent Systemic Mastocytosis (ISM) is a rare disease associated with numerous and diverse symptoms that significantly impact patients' overall health, psychological, emotional, and professional well-being, ultimately affecting their quality of life.</p><p><strong>Objective: </strong>We aim to estimate the Disability-adjusted Life Year (DALY) of ISM to assess the burden for patients and society.</p><p><strong>Methods: </strong>We used prospective and retrospective data on symptoms and quality of life from an ISM population recruited at the French expert center CEREMAST, to estimate Disability Weight allowing DALY calculation. An agent-based model was developed to more accurately assess the DALY of ISM over lifetime.</p><p><strong>Results: </strong>Prospective data were available for 168 ISM patients. A wide variety of symptoms were assessed, with 12.7 (±5.9) symptoms per patient and huge impact on the quality of life. However, the emotional dimension and the impact on social life were also affected. Finally, we estimated the DALY per patient to be between 4.56 and 8.79, representing 89 to 168 per 100,000 inhabitants. The DALY of ISM is comparable to that of lymphoma, leukemia, and psoriasis.</p><p><strong>Conclusion: </strong>This is the first study to focus on the DALY of ISM. Despite the differences in disease characteristics (such as prevalence, mortality, and age at diagnosis), DALY allows for the ranking of conditions and provides a better understanding of the disease burden. These data may help research prioritization by offering valuable information to healthcare policymakers.</p>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical monitoring of eosinophilic esophagitis using the esophageal string test.","authors":"Morgan Chang, Adelyn D Dao, Ashley Worner, Julia Loegering, Melissa Pecak, Alfred D Doyle, Benjamin L Wright, Shauna Schroeder","doi":"10.1016/j.jaip.2024.12.030","DOIUrl":"10.1016/j.jaip.2024.12.030","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total Serum Immunoglobulin E in a Cohort of Children with Food Allergy.","authors":"Amal H Assa'ad, Lili Ding, Qing Duan, Tesfaye B Mersha, Christopher Warren, Lucy Bilaver, Megan Ulrich, Mark Wlodarski, Jialing Jiang, Johnathan J Choi, Susan S Xie, Ashwin Kulkarni, Susan Fox, Sai Nimmagadda, Mary C Tobin, Mahboobeh Mahdavinia, Hemant Sharma, Ruchi S Gupta","doi":"10.1016/j.jaip.2024.12.029","DOIUrl":"10.1016/j.jaip.2024.12.029","url":null,"abstract":"<p><strong>Background: </strong>Total serum immunoglobulin E (TsIgE) has not been examined in children with food allergy.</p><p><strong>Objective: </strong>Evaluate associations of TsIgE with patient, household, environmental and community-level characteristics among children with food allergy.</p><p><strong>Method: </strong>Linear mixed effect models of data from 398 Black and/or African American (B/AA) and White and/or European American (W/EA) children with allergist-diagnosed food allergy from the multi-center, observational cohort FORWARD; TsIgE in kU/L was the primary outcome measure.</p><p><strong>Results: </strong>In univariable analyses of data from all study sites, children's TsIgE was positively associated with older age (p < .001), B/AA race (p < .001), male sex (p = .014), lower household income (p = .005), lower caregiver education (p = .005), higher area deprivation index (p< .001), presence of allergic rhinitis (p < .001), asthma (p < .001), and eczema (p = .024), and a higher number of food allergies (p< .001), but not with tobacco smoke exposure. With covariable adjustment in multivariable analysis, total serum IgE was higher in older vs. younger children (p < .001), male vs. female children, B/AA vs. W/EA children (p < .001), and in children with allergic rhinitis (p = .010), asthma (p < .001), eczema (p = .007), or a higher number of food allergies (p < .001), but not with tobacco smoke exposure or area deprivation index.</p><p><strong>Conclusions: </strong>In children with food allergy, age, sex, race, atopic diagnosis, allergic rhinitis, asthma and eczema are associated with TsIgE. These findings are important when TsIgE values are utilized in diagnosis and therapies.</p>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistence, severity and reactivity thresholds in fish allergic patients sensitized to parvalbumin.","authors":"Rosialzira Natasha Vera-Berrios, Sonia Vázquez-Cortés, Alejandro Gonzalo-Fernández, Carsten Bindslev-Jensen, Michael Clausen, Rosa Ferrara, Maria Gunnbjornsdottir, Laurian Jongejan, Anna Lewandowska-Polak, Adriano Mari, Nikolaos Papadopoulos, Lars K Poulsen, Náyade Del Prado, Sara Santos Magadán, Heidi Schnoor, George Stavroulakis, Serge A Versteeg, Marianne Witten, Ronald van Ree, Montserrat Fernández-Rivas","doi":"10.1016/j.jaip.2024.12.026","DOIUrl":"https://doi.org/10.1016/j.jaip.2024.12.026","url":null,"abstract":"<p><strong>Background: </strong>Fish allergy affects children and adults worldwide and there are transient and persistent phenotypes.</p><p><strong>Objective: </strong>We aimed to analyze persistence, severity and reactivity thresholds in challenge-confirmed fish allergic patients sensitized to parvalbumin.</p><p><strong>Methods: </strong>Patients 12-65 years-old reporting immediate reactions to fish, with fish skin prick test ≥5 mm and IgE to cod and carp β-parvalbumins ≥0.70 kU_A/L were recruited in 6 European centers. Except if recent severe anaphylaxis, patients were eligible for a double-blind placebo-controlled food challenge with cod, followed, if negative, by an open food challenge. Severity of reported and elicited reactions was graded with FASS, eliciting dose (ED) was calculated using interval-censoring survival analysis and probabilistic models, and factors associated with a positive challenge and severe reactions were analyzed by logistic regression.</p><p><strong>Results: </strong>Out of 42 patients fulfilling inclusion criteria, fish allergy was confirmed in 30 (71.4%). The median fish allergy duration was 23 yr. Although 70% of cases reported anaphylaxis with respiratory or cardiovascular involvement, food challenges resulted in oropharyngeal symptoms (34.7%) or mild systemic reactions (73.9%), with only 1 anaphylaxis with bronchospasm (4.3%). Male sex was associated with severe reactions (OR 5.44, 95%CI 1.04-28.53). ED₁₀ for objective symptoms range was 0.99-2.54 mg protein. No correlation was found between severity and ED.</p><p><strong>Conclusion: </strong>Adolescents and adults with persistent fish allergy linked to parvalbumin sensitization have experienced severe allergic reactions in real life and have a low threshold of reactivity. Our findings support the need for large-scale studies and new therapeutic options for these fish allergic patients.</p>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preimplantation genetic testing for hereditary angioedema as a potential dominant cost-effective intervention.","authors":"Willem Roosens, Lore Lannoo, Ellen Denayer, Liesbeth Gilissen, Karen Peeraer, Eftychia Dimitriadou, Jeroen Luyten, Kristel Van Calsteren, Rik Schrijvers","doi":"10.1016/j.jaip.2024.12.023","DOIUrl":"10.1016/j.jaip.2024.12.023","url":null,"abstract":"","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors of Hypersensitivity Reactions to Carboplatin: A Systematic Review and Meta-analysis.","authors":"Ha Young Jang, Boyoon Choi, In-Wha Kim, Hye Ryun Kang, Jung Mi Oh","doi":"10.1016/j.jaip.2024.12.021","DOIUrl":"https://doi.org/10.1016/j.jaip.2024.12.021","url":null,"abstract":"<p><strong>Background: </strong>The development of hypersensitivity reactions (HSRs) to carboplatin can interrupt anticancer treatment and may shorten patient survival. Several studies have evaluated the risk factors for carboplatin HSRs, but the results have been inconclusive.</p><p><strong>Objective: </strong>This systematic review and meta-analysis aim to establish a consensus on the risk factors of HSRs to carboplatin in cancer patients.</p><p><strong>Methods: </strong>Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, relevant studies were searched across MEDLINE, EMBASE, and Korean Medical Database. Inclusion criteria focused on original articles of case-control or cohort studies that evaluated risk factors for carboplatin HSRs in cancer patients. Exclusion criteria targeted articles with incomplete or overlapping data. The latest search and quality assessment of the included studies, using the Newcastle-Ottawa scale, was performed on February 1, 2023.</p><p><strong>Results: </strong>Among 1,182 articles identified, 19 studies were included in the final systematic review and meta-analysis. The identified risk factors for carboplatin hypersensitivity included a history of allergy to medicines, food, or environmental factors (OR of 1.76, 95% CI 1.46 - 2.12), BRCA mutation (OR of 4.03, 95% CI 2.00 - 8.13), carboplatin free interval of 12 months or more (OR of 4.93, 95% CI 2.89 - 8.40), increased cumulative dose (SMD of 0.58, 95% CI 0.41 - 0.75), relapse (OR of 2.26, 95% CI 1.58 - 3.25), and younger age (SMD of -0.15, 95% CI: -0.26 - -0.03).</p><p><strong>Conclusion: </strong>This meta-analysis provides the first comprehensive quantitative evaluation of risk factors for carboplatin HSRs in cancer patients. These findings can guide the development of personalized risk assessment tools and preventive strategies, potentially improving patient safety and treatment outcomes in carboplatin-based chemotherapy.</p>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An overview of climate changes and its effects on health - from mechanisms to One Health.","authors":"Ioana Agache, Michelle L Hernandez, Jared M Radbel, Harald Renz, Cezmi A Akdis","doi":"10.1016/j.jaip.2024.12.025","DOIUrl":"https://doi.org/10.1016/j.jaip.2024.12.025","url":null,"abstract":"<p><p>Human activities, primarily the burning of fossil fuels, widespread deforestation, soil erosion or machine-intensive farming methods, manufacturing, food processing, mining, and construction iron, cement, steel, and chemicals industry, have been the main drivers of the observed increase in Earth's average surface temperature and climate change. Rising global temperatures, extreme weather events, ecosystems disruption, agricultural impacts, water scarcity, problems in access to good quality water, food and housing, and profound environmental disruptions such as biodiversity loss and extreme pollution are expected to steeply increase the prevalence and severity of acute and chronic diseases. Its long-term effects cannot be adequately predicted or mitigated without a comprehensive understanding of the adaptive ecosystems. Studying the complex interaction between environmental aggressors and the resilient adaptive responses requires the exposomic and the One Health approaches. The problem is broad and affects the whole ecosystem, plants, pets and animals in addition to humans. The central role of the epithelial barrier, microbiome, and diet as key pillars for an adaptive tolerogenic immune response should be explored for increasing resilience at the individual level. A radical change in mindset worldwide, with sustainable solutions and adaptive strategies and climate-resilience and health equity policies at their center, should be achieved quickly through increased awareness based on solid scientific data.</p>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controversies in Allergy: If and When to Consider Prophylactic Immunoglobulin Replacement Therapy in Secondary Hypogammaglobulinemia.","authors":"Iris M Otani, Mark Ballow","doi":"10.1016/j.jaip.2024.12.024","DOIUrl":"https://doi.org/10.1016/j.jaip.2024.12.024","url":null,"abstract":"<p><p>Secondary hypogammaglobulinemia, or decreased IgG levels due to reduced production or increased loss caused by medications or underlying conditions, can be associated with increased infection risk. While immunoglobulin replacement therapy (IgRT) is generally accepted as a strategy to help prevent recurrent bacterial infections in SHG, controversy exists as to whether it should be initiated to prevent the first occurrence of infection. This question has been raised particularly in the setting of anti-CD20 therapy, solid organ transplant, and B-cell malignancies and their treatments once IgG levels fall below 300-400 mg/dL. This article reviews the evidence for and against initiating IgRT in these settings, as well as associated considerations for evaluation and monitoring. While it is relatively clear that infection risk increases with decreasing IgG levels, the exact contribution of SHG to overall infection risk, and the protective benefit of IgRT in the absence of infections remains unclear. In the absence of clear consensus, shared decision-making is often needed to determine if and when to initiate IgRT.</p>","PeriodicalId":51323,"journal":{"name":"Journal of Allergy and Clinical Immunology-In Practice","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}