Korean Journal of Orthodontics最新文献

{"title":"Long-term structural and functional nasomaxillary evolution of children with mouth-breathing after rapid maxillary expansion: An 8-year follow-up study.","authors":"Raquel Harumi Uejima Satto, Emerson Taro Inoue Sakuma, José Dirceu Ribeiro, Eulalia Sakano","doi":"10.4041/kjod24.102","DOIUrl":"10.4041/kjod24.102","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effects of rapid maxillary expansion (RME) on nasal patency and nasomaxillary dimensions in children and adolescents with mouthbreathing through 8 years of clinical follow-up.</p><p><strong>Methods: </strong>RME was performed using a Hyrax orthodontic appliance in 28 mouth-breathers (6-13 years old). During follow-up, objective tests of nasal respiratory function were conducted, such as acoustic rhinometry, which provided the minimum cross-sectional areas of the nasal cavity, and active anterior computed rhinomanometry, which measured inspiratory nasal resistance. The tomographic widths of the coronal sections of the nose and maxilla were also measured. Fisher's exact test and the Mann-Whitney U test were used to compare categorical and numerical variables, respectively, in mouth-breathers with and without allergic rhinitis. Temporal evolution was assessed using generalized estimating equation models. Statistical significance was set at <i>P</i> < 0.05.</p><p><strong>Results: </strong>There was a reduction in inspiratory resistance after RME with a stable improvement in nasal patency during the 8-year follow-up period (<i>P</i> = 0.0179). All nasal and maxillary tomographic widths showed statistically significant increases in the short-term (<i>P</i> < 0.0001), and most of them showed significant increases in the long-term when compared with the pre-expansion period. Tomographic measurements were not influenced by allergic rhinitis.</p><p><strong>Conclusions: </strong>Our study showed that RME promoted and maintained the widening of the posterior maxillary structure in children and adolescents with mouth-breathing, with a decrease in inspiratory nasal resistance during the 8-year follow-up period. These findings highlight the importance of RME in mouth-breathers with maxillary atresia.</p>","PeriodicalId":51260,"journal":{"name":"Korean Journal of Orthodontics","volume":" ","pages":"95-104"},"PeriodicalIF":2.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of bisphosphonate vs. osteoprotegerin during orthodontic tooth movement: A systematic review and meta-analysis.","authors":"Kuri Tupak Sarango-Quishpe, María Isabel Cabrera-Padrón, José Esteban Torracchi-Carrasco, Gloria Andrade-Medina, Cesar Heriberto Juela-Moscoso","doi":"10.4041/kjod24.049","DOIUrl":"10.4041/kjod24.049","url":null,"abstract":"<p><strong>Objective: </strong>Orthodontic appliances are commonly used to achieve anchorage during orthodontic treatments; however, their use can contribute to oral diseases. Studies have shown that bisphosphonates and osteoprotegerin are highly effective in reducing orthodontic tooth movement. To determine the efficacy of bisphosphonates and osteoprotegerin in reducing orthodontic tooth movement.</p><p><strong>Methods: </strong>A comprehensive search was conducted across five databases-MEDLINE-PubMed, Scopus, Google Scholar, ScienceDirect, and Taylor & Francis-up to August 2, 2023. Clinical trials conducted in healthy animals, where bisphosphonates and osteoprotegerin were administered during tooth movement, were included. The search identified 3,099 articles, which underwent a two-phase screening process, resulting in twelve studies for the systematic review and seven for the meta-analysis. Risk of bias was assessed using the SYRCLE tool, and Egger's regression was used to evaluate publication bias.</p><p><strong>Results: </strong>The administration of bisphosphonates was more effective than osteoprotegerin in reducing mesiodistal orthodontic movement. However, osteoprotegerin did not significantly reduce orthodontic tooth movement.</p><p><strong>Conclusions: </strong>The findings align with previous studies, confirming the superior efficacy of bisphosphonates over osteoprotegerin. Further research is required to determine the optimal dosage and mechanism of action for these drugs in clinical practice, considering the specific objectives of orthodontic treatments.</p>","PeriodicalId":51260,"journal":{"name":"Korean Journal of Orthodontics","volume":"55 2","pages":"120-130"},"PeriodicalIF":2.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictability of maxillary dentoalveolar expansion with clear aligners in patients with mixed dentition.","authors":"Alessandro Bruni, Vittorio Gallo, Simone Parrini, Georgios Litsas, Giovanni Cugliari, Tommaso Castroflorio, Andrea Piero Deregibus","doi":"10.4041/kjod24.082","DOIUrl":"10.4041/kjod24.082","url":null,"abstract":"<p><strong>Objective: </strong>This prospective study evaluated the effectiveness of clear aligner treatment (CAT) in achieving dentoalveolar upper arch expansion in patients with mixed dentition and transverse maxillary deficiency.</p><p><strong>Methods: </strong>Forty patients with mixed dentition and a transverse discrepancy of ≤ 5 mm were treated using clear aligners. Pre- and post-treatment digital dental models were measured using specific landmarks and compared with the programmed expansion in the virtual treatment plan. Statistical analyses included the inter-class correlation coefficient to evaluate inter-rater reliability. A paired t test was employed to compare pre- and post-treatment values and to examine the significance of the changes. Multiple regression analysis was conducted to estimate the relationship between the prescribed and observed measurements, stratified by inter-dental measurements (deciduous canines, first deciduous molars, and permanent molars, at cusp and gingival levels).</p><p><strong>Results: </strong>Excellent measurement reproducibility was observed. The accuracy of dentoalveolar maxillary arch expansion varied among different tooth regions. The inter-canine accuracy was 87.7% at the cusp level and 82.7% at the gingival level. The inter-first deciduous molars exhibited accuracies of 84.9% (cusp level) and 80.5% (gingival level). The inter-first molars showed accuracies of 77.8% (cusp level) and 67.9% (gingival level). Significant differences were observed between the planned and obtained measurements for specific tooth regions.</p><p><strong>Conclusions: </strong>CAT demonstrated reliable predictability in achieving dentoalveolar expansion of the maxillary arch in patients with mixed dentition. A higher accuracy was observed in the anterior region than in the posterior region. These findings suggest that CAT could be an effective option for treating transverse maxillary deficiencies in patients with mixed dentition with moderate inter-arch transverse discrepancies, considering tooth-specific predictability differences.</p>","PeriodicalId":51260,"journal":{"name":"Korean Journal of Orthodontics","volume":"55 2","pages":"85-94"},"PeriodicalIF":2.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Key factors for successful eruption of the mandibular third molar after extraction of the mandibular second molar.","authors":"Jung Jin Park, Yoonjeong Noh, Yoon Jeong Choi, Jae Hyun Park, Ji Hyun Lee, Chooryung Judi Chung, Kyung-Ho Kim","doi":"10.4041/kjod24.210","DOIUrl":"10.4041/kjod24.210","url":null,"abstract":"<p><strong>Objective: </strong>Extraction of the mandibular second molar (L7) and substitution by the mandibular third molar (L8) is an effective treatment option. This study aimed to evaluate spontaneously erupted L8 occlusion after L7 extraction, and identify the influencing factors.</p><p><strong>Methods: </strong>This study assessed 46 L8 from 28 patients using dental study models, panoramic radiographs, and lateral cephalograms obtained during L7 extraction (T1) and completion of L8 eruption (T2). At T2, samples were categorized as acceptable (A-group) or unacceptable (U-group) based on the American Board of Orthodontics index. L8 angulation and position, retromolar space, distance between the Xi point and mandibular first molar (L6), and Nolla stage were compared between the groups to identify the predictive factors for successful eruption.</p><p><strong>Results: </strong>At T2, 58.7% of L8 exhibited acceptable occlusion. Age at T1 was significantly higher in the U-group than that in the A-group. Angles ∟6-MnP and ∟8-MnP differed significantly between the groups at T2. Xi-L6 distance was considerably longer in the A-group than that in the U-group at T1 and T2. Younger age at extraction and Xi-L6 distance at T1 affected the acceptable occlusion.</p><p><strong>Conclusions: </strong>Younger age at L7 extraction and adequate eruption space (Xi-L6 distance) appear to be the key factors for achieving acceptable L8 occlusion.</p>","PeriodicalId":51260,"journal":{"name":"Korean Journal of Orthodontics","volume":"55 2","pages":"154-163"},"PeriodicalIF":2.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finite element analysis of anterior maxillary segmental distraction osteogenesis using asymmetric distractors in patients with unilateral cleft lip and palate.","authors":"Zehua Jin, Ruomei Li, Jiajun Shi, Yuehua Zhang, Zhenqi Chen","doi":"10.4041/kjod24.184","DOIUrl":"10.4041/kjod24.184","url":null,"abstract":"<p><strong>Objective: </strong>The treatment of asymmetric maxillary hypoplasia and dental crowding secondary to unilateral cleft lip and palate (UCLP) is often challenging. This study introduced an asymmetric tooth-borne distractor in anterior maxillary segmental distraction osteogenesis and used three-dimensional finite element analysis to evaluate its potential for clinical application in cases of asymmetrical maxillary hypoplasia.</p><p><strong>Methods: </strong>A cone-beam computed tomography scan of a late adolescent with UCLP was used to construct a three-dimensional finite element model of the teeth and maxillary structures. An asymmetric distractor model was used to simulate conventional distraction osteogenesis and asymmetric distraction osteogenesis (ADO) to evaluate the resultant stress distribution and displacement.</p><p><strong>Results: </strong>Postoperatively, both distraction methods resulted in anterior maxillary segment advancement with a slight upward movement. ADO yielded a greater increase in the dental arch length on the cleft side and induced rotation of the anterior maxillary segment, potentially improving midline deviation. Both methods showed similar stress distributions, with higher stress concentrations on the cleft side.</p><p><strong>Conclusions: </strong>ADO may offer clinical advantages in correcting asymmetrical maxillary hypoplasia in patients with UCLP by facilitating asymmetrical expansion and rotation of the maxilla. Further research is needed to generalize these findings to other clinical presentations.</p>","PeriodicalId":51260,"journal":{"name":"Korean Journal of Orthodontics","volume":" ","pages":"142-153"},"PeriodicalIF":2.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence solutions for temporomandibular joint disorders: Contributions and future potential of ChatGPT.","authors":"Betul Kula, Ahmet Kula, Fatih Bagcier, Bulent Alyanak","doi":"10.4041/kjod24.106","DOIUrl":"10.4041/kjod24.106","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the reliability and usefulness of information generated by Chat Generative Pre-Trained Transformer (ChatGPT) on temporomandibular joint disorders (TMD).</p><p><strong>Methods: </strong>We asked ChatGPT about the diseases specified in the TMD classification and scored the responses using Likert reliability and usefulness scales, the modified DISCERN (mDISCERN) scale, and the Global Quality Scale (GQS).</p><p><strong>Results: </strong>The highest Likert scores for both reliability and usefulness were for masticatory muscle disorders (mean ± standard deviation [SD]: 6.0 ± 0), and the lowest scores were for inflammatory disorders of the temporomandibular joint (mean ± SD: 4.3 ± 0.6 for reliability, 4.0 ± 0 for usefulness). The median Likert reliability score indicates that the responses are highly reliable. The median Likert usefulness score was 5 (4-6), indicating that the responses were moderately useful. A comparative analysis was performed, and no statistically significant differences were found in any subject for either reliability or usefulness (<i>P</i> = 0.083-1.000). The median mDISCERN score was 4 (3-5) for the two raters. A statistically significant difference was observed in the mean mDISCERN scores between the two raters (<i>P</i> = 0.046). The GQS scores indicated a moderate to high quality (mean ± SD: 3.8 ± 0.8 for rater 1, 4.0 ± 0.5 for rater 2). No statistically significant correlation was found between mDISCERN and GQS scores (r = -0.006, <i>P</i> = 0.980).</p><p><strong>Conclusions: </strong>Although ChatGPT-4 has significant potential, it can be used as an additional source of information regarding TMD for patients and clinicians.</p>","PeriodicalId":51260,"journal":{"name":"Korean Journal of Orthodontics","volume":"55 2","pages":"131-141"},"PeriodicalIF":2.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary study on change in the upper airway dimension in growing patients with Pierre-Robin sequence.","authors":"Su-Ji Yoon, Il-Hyung Yang, Su-Jung Kim, Seung-Hak Baek","doi":"10.4041/kjod24.190","DOIUrl":"10.4041/kjod24.190","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the changes in upper airway (UA) dimensions in growing patients with Pierre-Robin sequence (PRS).</p><p><strong>Methods: </strong>The subjects were 23 PRS patients who had not undergone growth modification therapy or surgical intervention. Their lateral cephalograms were obtained longitudinally at mean ages of 8.81 (T0) and 14.05 (T1). Patients were categorized based on their SNB value at T0 (Criteria: -2 SD): Group-1 (very retrusive mandible, n = 13) and Group-2 (moderately retrusive mandible, n = 10). Skeletal and UA variables at T0 and T1, as well as ΔT0-T1, were statistically analyzed.</p><p><strong>Results: </strong>At T0, Group-1 exhibited more retrusive maxilla and mandible (SNA, <i>P</i> < 0.01; SNB, <i>P</i> < 0.001), a more hyperdivergent pattern (facial height ratio, <i>P</i> < 0.05), and a more posteriorly positioned hyoid bone (H-PTV, <i>P</i> < 0.05), while Group-1 showed larger UA spaces (superior pharyngeal airway space [SPAS] and inferior pharyngeal airway space, all <i>P</i> < 0.05) than Group 2, which might indicate the existence of a compensatory response to maintain the UA patency. At T1, Group-1 maintained significantly retrusive maxilla and mandible (SNA and SNB, all <i>P</i> < 0.01), exhibited a less anteriorly positioned tongue (TT-PTV, <i>P</i> < 0.05), and displayed a more obtuse soft palate angle (SPA, <i>P</i> < 0.05) than Group-2. Between T0 and T1, Group-1 demonstrated significant increases in the hyoid symphysis distance (ΔH-RGN, <i>P</i> < 0.001), tongue length (ΔTGL, <i>P</i> < 0.01), and pharyngeal UA spaces (ΔSPAS and ΔPNS-ad2, all <i>P</i> < 0.001).</p><p><strong>Conclusions: </strong>Even in growing PRS patients with severe mandibular retrusion, the UA dimensions increased due to forward growth of the mandible, repositioning of tongue and hyoid bone, and existence of compensatory mechanism.</p>","PeriodicalId":51260,"journal":{"name":"Korean Journal of Orthodontics","volume":"55 2","pages":"105-119"},"PeriodicalIF":2.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are different photogrammetry applications on smartphones sufficiently reliable?","authors":"Gülden Karabiber, Hanife Nuray Yılmaz, Gamze Yıldırım","doi":"10.4041/kjod24.134","DOIUrl":"10.4041/kjod24.134","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to compare the accuracy of Qlone, Magiscan, and 3dMD with that of direct anthropometry (DA).</p><p><strong>Methods: </strong>The study involved 41 patients. Sixteen facial landmarks, including six individual and five paired points, were marked on each participant's face. Subsequently, 18 linear measurements were assessed using a 3dMD device (multicamera photogrammetry), Qlone, Magiscan smartphone applications (single-camera photogrammetry), and DA. The Qlone and Magiscan images were calibrated using a reference point 10 mm from the nasion during DA to ensure a 1:1 correspondence.</p><p><strong>Results: </strong>Concerning the precision of the digital methods compared to DA, the mean intraclass correlation coefficient values of 3dMD, Qlone and Magiscan were 0.989, 0.980 and 0.982, respectively. Compared with DA, 3dMD achieved excellent trueness with the lowest average absolute differences in the measurements (highest value = 0.95 ± 0.62 mm). The highest values for Qlone and Magiscan were 1.51 ± 1.11 mm and 2.14 ± 1.69 mm, respectively. According to the number of parameters, the ranking of unreliable values (> 2 mm) was Magiscan (n = 46), Qlone (n = 35), and then, 3dMD (n = 4). Furthermore, reliability (less than 1 mm) was the highest for 3dMD (n = 517), followed by Magiscan (n = 457), and then, Qlone (n = 415).</p><p><strong>Conclusions: </strong>The 3dMD achieved excellent trueness with the lowest average absolute differences in the measurements. Based on statistical analysis, the trueness values of Magiscan and Qlone were close to that of 3dMD. To apply these smartphone applications clinically, more studies are necessary.</p>","PeriodicalId":51260,"journal":{"name":"Korean Journal of Orthodontics","volume":"55 1","pages":"37-47"},"PeriodicalIF":2.6,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"READER'S FORUM.","authors":"Soo Hyun Nam","doi":"10.4041/kjod55.0001RF","DOIUrl":"10.4041/kjod55.0001RF","url":null,"abstract":"","PeriodicalId":51260,"journal":{"name":"Korean Journal of Orthodontics","volume":"55 1","pages":"1-2"},"PeriodicalIF":2.6,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of maxillary incisor positions and chin prominences on the perception of lateral smiling profile attractiveness among orthodontists and laypersons.","authors":"Pareeya Yongwongsoontorn, Pimsiri Kanpittaya","doi":"10.4041/kjod24.152","DOIUrl":"10.4041/kjod24.152","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the ideal anteroposterior position of incisors in lateral smiling profiles with different chin prominences and to relate these positions to nose and chin landmarks based on the perceptions of orthodontists and laypersons.</p><p><strong>Methods: </strong>A lateral smiling profile image of a female subject was adjusted to create five levels of chin prominence (-6, -3, 0, +3, +6 mm). For each level, the anteroposterior positions of the maxillary incisors were adjusted across five positions (-4, -2, 0, +2, +4 mm). Thirty-six orthodontists and 36 laypersons rated the attractiveness of each profile using a visual analog scale. The maxillary incisor position (U1) was measured relative to the external nose and chin landmarks (E-lines). Differences in perceptions between orthodontists and laypersons were analyzed.</p><p><strong>Results: </strong>For profiles with 6 and 3 mm chin retrusion, the most favored incisor positions were the 2 mm retrusion and unaltered positions, respectively. For the unaltered chin prominence, orthodontists preferred unaltered incisors, while laypersons favored 2 mm protrusion. Conversely, for 3 and 6 mm chin protrusion, both groups preferred 4 and 2 mm protrusion, respectively. The distance between U1 and the E-line is the most attractive images ranged from 8.5 to 11.5 mm. Based on the regression model, an optimal U1-E-line distance of 8.95 mm was recommended.</p><p><strong>Conclusions: </strong>The preferred incisor position is influenced by chin prominence, with the incisor position shifting in the same direction as the chin. The U1 E-line can be a useful clinical tool for determining the proper incisor positioning. Esthetic perceptions were generally consistent between orthodontists and laypersons.</p>","PeriodicalId":51260,"journal":{"name":"Korean Journal of Orthodontics","volume":"55 1","pages":"48-57"},"PeriodicalIF":2.6,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}