Journal of Diabetes Investigation最新文献

{"title":"Use of technology in prediabetes and precision prevention","authors":"Jie He,&nbsp;Natural Chu,&nbsp;Heng Wan,&nbsp;James Ling,&nbsp;Yincong Xue,&nbsp;Kathy Leung,&nbsp;Aimin Yang,&nbsp;Jie Shen,&nbsp;Elaine Chow","doi":"10.1111/jdi.70057","DOIUrl":"10.1111/jdi.70057","url":null,"abstract":"<p>Controlling the epidemic of diabetes is an urgent global healthcare challenge. The low uptake of diabetes prevention programs highlights difficulties in scalability, partly due to the need for intensive face-to-face contact and its impact on healthcare resource utilization. In this narrative review, we will summarize the latest evidence in technology-assisted lifestyle interventions. We will appraise evidence of digital diabetes prevention programs that use internet platforms or text messaging tools to support information delivery, lifestyle coaching, or peer support. We will also discuss the use of wearables, including physical activity trackers and continuous glucose monitoring (CGM) as part of lifestyle intervention. Experience from diabetes highlights the potential for CGM as a motivational tool to promote lifestyle change. The integration of digital data may facilitate earlier detection of prediabetes, sub-phenotyping, and personalized nutritional predictions. We will highlight major gaps in research and the need for rigorous clinical trials to evaluate the acceptability and cost-effectiveness of integrating technologies as part of a multicomponent strategy in diabetes prevention.</p>","PeriodicalId":51250,"journal":{"name":"Journal of Diabetes Investigation","volume":"16 7","pages":"1217-1231"},"PeriodicalIF":3.1,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdi.70057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Mendelian randomization study on the causal association of circulating cytokines with diabetic nephropathy","authors":"Yiming Xu,&nbsp;Tian Xiao,&nbsp;Junqing Yang,&nbsp;Jiali Wang,&nbsp;Bingting Wang,&nbsp;Chen Qiao","doi":"10.1111/jdi.70051","DOIUrl":"10.1111/jdi.70051","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Circulating cytokines were reported to be related to diabetic nephropathy (DN) in observational studies. However, the causal relationship between them remains unknown. This study aimed to investigate the causal relationship between DN and circulating cytokines with genetic data in the frame of Mendelian Randomization (MR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We performed a two-sample MR analysis to investigate the causal relationship in individuals of European ancestry, utilizing publicly available genome-wide association study (GWAS) statistics. We selected eligible instrumental SNPs that were significantly related to the circulating cytokines. Multiple MR analysis approaches were employed, including inverse variance weighted (IVW), Weighted Median, MR-Egger, Weighted Mode, Simple Mode, and MR pleiotropy residual sum and outlier (MR-PRESSO) methods.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We found evidence supporting the causal role of genetically predicted circulating levels in the increased risk of DN. Specifically, we observed associations for interferon-gamma [OR = 1.352, 95% CI: 1.089–1.678, <i>P</i> = 0.006], stem cell factor [OR = 1.252, 95% CI: 1.028–1.525, <i>P</i> = 0.025], and stromal-cell-derived factor 1 alpha [OR = 1.326, 95% CI: 1.017–1.727, <i>P</i> = 0.037]. Additionally, MR analysis revealed a negative causal association between macrophage inflammatory protein 1b and DN [OR = 0.921, 95% CI: 0.858–0.988, <i>P</i> = 0.022]. The results obtained from MR-Egger, Weighted Median, Weighted Mode, and Simple Mode methods were consistent with the Inverse Variance Weighted (IVW) estimates. Sensitivity analyses showed no evidence of horizontal pleiotropy, suggesting that the causal estimates were not biased.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings offer promising leads for developing novel therapeutic targets for DN. By identifying the role of inflammatory cytokines in this debilitating condition through a genetic epidemiological approach, our study made contributions to a better understanding of the underlying disease mechanisms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":51250,"journal":{"name":"Journal of Diabetes Investigation","volume":"16 7","pages":"1274-1283"},"PeriodicalIF":3.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdi.70051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal relationship between body mass index and insulin resistance: Linear and nonlinear Mendelian randomization study in a Japanese population","authors":"Noriyuki Ishida,&nbsp;Sei Harada,&nbsp;Ryota Toki,&nbsp;Aya Hirata,&nbsp;Minako Matsumoto,&nbsp;Naoko Miyagawa,&nbsp;Miho Iida,&nbsp;Shun Edagawa,&nbsp;Atsuko Miyake,&nbsp;Kazuyo Kuwabara,&nbsp;Takuma Shibuki,&nbsp;Suzuka Kato,&nbsp;Kazuharu Arakawa,&nbsp;Kengo Kinoshita,&nbsp;Mika Sakurai-Yageta,&nbsp;Gen Tamiya,&nbsp;Kengo Nagashima,&nbsp;Hirokazu Muraoka,&nbsp;Yasunori Sato,&nbsp;Toru Takebayashi","doi":"10.1111/jdi.14377","DOIUrl":"10.1111/jdi.14377","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims/Introduction</h3>\u0000 \u0000 <p>Obesity is a known risk factor for several chronic diseases, including type 2 diabetes mellitus, which results from increased insulin resistance and impaired insulin secretion. However, the association between obesity and insulin resistance in Asian populations has not yet been fully elucidated. Therefore, we aimed to investigate the causal relationship between body mass index (BMI) and glycemic traits using Mendelian randomization (MR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>We performed individual-level MR analyses using genetic risk scores based on BMI-related variants in 3,745 individuals without diabetes mellitus from a Japanese cohort. We examined heterogeneity through subgroup analyses based on potential modifiers and determined the shape of the causal relationship using nonlinear MR analyses to further assess the impact of BMI on the homeostasis model assessment of insulin resistance (HOMA-IR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>MR analyses revealed a significant positive association between BMI and HOMA-IR (β = 0.077; 95% confidence interval, 0.014–0.141; <i>P</i> = 0.016; outcome variable was log-transformed and standardized). Additional analyses revealed heterogeneity among subgroups differentiated by age, sex, lifestyle habits, and cardiometabolic traits. Nonlinear MR analyses suggested a potential J-shaped causal relationship between BMI and HOMA-IR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings demonstrated that obesity and low BMI may contribute to increased insulin resistance. Furthermore, the impact of BMI on insulin resistance could vary owing to effect modification. Managing BMI is crucial in individuals at high risk of increased insulin resistance and may have important implications for preventing type 2 diabetes, especially given the low insulin secretory capacity observed in East Asian populations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":51250,"journal":{"name":"Journal of Diabetes Investigation","volume":"16 7","pages":"1305-1314"},"PeriodicalIF":3.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdi.14377","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Questioning the pros and cons of metformin treatment in diabetic peripheral neuropathy","authors":"Hiroki Mizukami","doi":"10.1111/jdi.70055","DOIUrl":"10.1111/jdi.70055","url":null,"abstract":"<p>Diabetic peripheral neuropathy (DPN) is the most common complication among diabetic patients. Its symptoms include pain, hyperalgesia, hypoalgesia, and paralysis, all of which can significantly reduce patients' quality of life. In DPN, peripheral nerve fibers are affected as early as the prediabetic stage. Currently, no curative treatment has been established. As demonstrated in large clinical trials like the Diabetes Control and Complication Trial, strict glycemic control remains the only proven method to slow the progression of DPN. Consequently, it is crucial to identify which diabetes medications are more effective against neuropathy or, at the very least, do not exacerbate it.</p><p>Experimentally, various antidiabetic drugs—including dipeptidyl peptidase-4 (DPP-4) inhibitors, α-glucosidase inhibitors, sodium-glucose cotransporter-2 (SGLT2) inhibitors, and incretin agonists—have shown therapeutic effects on DPN that are independent of blood glucose improvement<span>¹</span>. Among oral antidiabetic agents, metformin is one of the most widely used drugs for diabetes. However, its effects on DPN remain controversial. Several studies have reported that metformin use decreases cobalamin (Vitamin B12) levels while increasing its related metabolite homocysteine and methylmalonic acid. Deficiency in cobalamin and elevated homocysteine and methylmalonic acid levels are known to induce peripheral neuropathy; hence, metformin has been suggested to worsen DPN<span>²</span>. On the other hand, some studies indicate that metformin has no apparent effect on DPN<span>³</span>. Furthermore, other research suggests that while metformin reduces cobalamin levels, it does not influence DPN progression<span>⁴</span>. As such, the therapeutic effects of metformin on DPN remain contentious.</p><p>In this context, Dhanapalaratnam <i>et al</i>.<span>⁵</span> recently published a cross-sectional clinical study in <i>Diabetes</i> journal, examining the effect of metformin on DPN outcomes in patients with type 2 diabetes (Figure 1). The study involved 69 participants with type 2 diabetes receiving metformin therapy and 69 clinically matched participants who were not on metformin as part of standard clinical care. Participants not receiving metformin were prescribed other oral antihyperglycemic agents, such as SGLT2 inhibitors, DPP-4 inhibitors, and sulfonylureas. All participants underwent peripheral nerve ultrasonography of the median and tibial nerves to measure nerve cross-sectional area (CSA). Neurological assessments, including the modified Toronto Clinical Neuropathy Scale (mTCNS) and Total Neuropathy Score (TNS), were used to evaluate DPN severity, alongside nerve conduction studies performed on the tibial motor and sural sensory nerves. Peripheral nerve ultrasonography was indeed utilized in the study to assess the cross-sectional areas (CSA) of the tibial and median nerves.</p><p>In the metformin group,","PeriodicalId":51250,"journal":{"name":"Journal of Diabetes Investigation","volume":"16 7","pages":"1151-1153"},"PeriodicalIF":3.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdi.70055","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on “Serum vitamin D is substantially reduced and predicts flares in diabetic retinopathy patients”","authors":"Mostafa Javanian,&nbsp;Mohammad Barary,&nbsp;Danial Hosseinzadeh,&nbsp;Ali Zahedian,&nbsp;Soheil Ebrahimpour","doi":"10.1111/jdi.70052","DOIUrl":"10.1111/jdi.70052","url":null,"abstract":"&lt;p&gt;Dear Editor,&lt;/p&gt;&lt;p&gt;We read with great interest the article “Serum Vitamin D is Substantially Reduced and Predicts Flares in Diabetic Retinopathy Patients,” published in your esteemed journal&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt;. The study aimed to clarify whether vitamin D deficiency predisposes patients to diabetic retinopathy or if the disease leads to reduced vitamin D levels. The findings, namely, significantly lower serum vitamin D in patients with diabetic retinopathy and the suggestion that deficiency may accelerate disease onset, are intriguing and hold significant clinical relevance. We appreciate the authors' efforts in conducting this study and their commitment to advancing our understanding of this vital issue. However, we believe that addressing several limitations could enhance the clarity and impact of the study's conclusions.&lt;/p&gt;&lt;p&gt;The study's conclusions might be strengthened by incorporating additional laboratory parameters. The absence of data on markers such as serum albumin, zinc, vitamin B12, platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and the systemic immune-inflammatory index (SII) is a significant limitation that hinders the comprehensive validation of the findings. The inclusion of these parameters, as suggested by previous studies&lt;span&gt;&lt;sup&gt;2, 3&lt;/sup&gt;&lt;/span&gt;, is crucial to better delineate the relationship between vitamin D deficiency and adverse outcomes.&lt;/p&gt;&lt;p&gt;Secondly, the study lacks detailed information regarding the pharmacological interventions administered to the participants. Data on medications such as corticosteroids and phosphodiesterase inhibitors, which can significantly influence patient outcomes, would provide important context for interpreting the results&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt;.&lt;/p&gt;&lt;p&gt;Thirdly, the analysis is not adequately adjusted for potential confounding factors, including comorbid conditions like cerebrovascular disease, cardiovascular disorders, peripheral arterial disease, psychological disorders, immune deficiencies, and autoimmune disorders. Given their potential impact on patient outcomes, their inclusion is crucial to strengthen the study's conclusions.&lt;/p&gt;&lt;p&gt;Furthermore, key demographic variables, such as socioeconomic status, educational background, detailed smoking history (including current, former, and heavy smokers), and opium use, were not reported. This omission restricted both the analysis depth and the findings' generalizability. For instance, socioeconomic status and educational background could influence access to healthcare and adherence to treatment, while smoking history and opium use could affect the progression of diabetic retinopathy. Additionally, the explanation of methods used to assess insulin resistance and nutritional status was insufficient and warranted further clarification.&lt;/p&gt;&lt;p&gt;Lastly, there appeared to be a discrepancy between the introduction and discussion regarding the role of vitamin D in modulating vascular endothelial growth factor (","PeriodicalId":51250,"journal":{"name":"Journal of Diabetes Investigation","volume":"16 7","pages":"1350-1351"},"PeriodicalIF":3.1,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdi.70052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor in response to the article “Effect of luseogliflozin on liver fibrosis differs depending on alcohol consumption in patients with type 2 diabetes”","authors":"Akash Suthar,&nbsp;Deepa Lachhman Das","doi":"10.1111/jdi.70049","DOIUrl":"10.1111/jdi.70049","url":null,"abstract":"<p>Dear Editor,</p><p>To the best of our knowledge, the first study on “Effect of luseogliflozin on liver fibrosis differs depending on alcohol consumption in patients with type 2 diabetes”, penned by Mr. Ito <i>et al</i>.<span>¹</span>, was published in your honored journal. It highlighted the favorable changes in FIB-4, HbAlc, weight loss, and serum albumin concentrations in drinkers and non-drinkers with type-2 diabetes and liver fibrosis. This retrospective study covered not only the facts respective to a topic but also the depth and diversity of the study beamed so many perspectives which enhanced our concepts. Still, there is always a margin of uncertainties and addressing those limitations will enhance the validity of further studies.</p><p>Primarily, the authors mentioned that SGLT2 therapy contributes to the prevention of cardiovascular diseases. However, the results based on drinkers and non-drinkers with or without cardiovascular diseases are lacking. Along with this.</p><p>Mr. Hajika <i>et al</i>.<span>²</span> also highlighted the suppression of cardiovascular diseases with luseogliflozin, such as arteriosclerosis. This restricted investigation was not able to unfold a broad aspect of this study.</p><p>Secondly, the authors highlighted the effects of luseogliflozin and its association with diabetes and liver fibrosis and its results based on FIB-4 levels. It also led to the authenticity of this study in the right direction but took the study to low accuracy, false-positive, and false-negative results, which diminishes the chance to enhance the effect of results<span>³</span>.</p><p>Thirdly, the study also confuses the readers with differences in FIB-4 levels in the low-risk group and intermediate-/high-risk group concerning drinkers and non-drinkers, which can be due to the hidden impact of diet on individual groups. Mr. Soleimani <i>et al</i>.<span>⁴</span> also mentioned a healthy diet pattern plays a role against hepatic fibrosis. This clarity of diet could intensify its validity and strengthen this study.</p><p>The authors declare no conflict of interest.</p><p>Approval of the research protocol: None.</p><p>Informed consent: None.</p><p>Registry and the registration no. of the study/trial: None.</p><p>Animal studies: None.</p>","PeriodicalId":51250,"journal":{"name":"Journal of Diabetes Investigation","volume":"16 6","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdi.70049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Induction of proximal tubular proliferation and lengthening in response to sodium glucose linked cotransporter-2 inhibition in experimental rats","authors":"Ellen Wu,&nbsp;Sarah Macklin,&nbsp;Yanling Zhang,&nbsp;Kerri Thai,&nbsp;Linda Nghiem,&nbsp;Caterina Di Ciano-Oliveira,&nbsp;Nuno Coelho,&nbsp;Hai Wang,&nbsp;Suzanne L. Advani,&nbsp;Jean-François Desjardins,&nbsp;Darren A Yuen,&nbsp;Paraish Misra,&nbsp;Kim A. Connelly,&nbsp;Jens R. Nyengaard,&nbsp;Richard E. Gilbert","doi":"10.1111/jdi.70043","DOIUrl":"10.1111/jdi.70043","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims/Introduction</h3>\u0000 \u0000 <p>While SGLT2 accounts for &gt;90% of kidney glucose reabsorption, its pharmacological inhibition or genetic knockdown reduces glucose reabsorption by only 50%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>We postulated that the less than expected glucosuric response to SGLT2 inhibition might result from a compensatory increase in the length of the proximal tubule as seen in experimental diabetes where early tubular proliferation is followed by tubular lengthening. Taking advantage of their differing anatomical locations, stereological techniques were used to differentiate the SGLT1 expressing straight proximal tubule that lies within the outer stripe of the outer medulla (S3 segment) and that of the predominantly SGLT2 expressing early proximal convoluted tubule located within the kidney cortex (S1, S2 segments).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The SGLT2 inhibitor, dapagliflozin, induced an early, transient hyperplastic response (3-fold increase of Ki67 labelling, <i>P</i> &lt; 0.0001) in S3 proximal tubular cells followed by a 32% increase in its length (<i>P</i> &lt; 0.0001). In contrast, the length of the SGLT2 expressing S1, S2 segments of the proximal tubule was unaffected.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The finding that SGLT2 inhibition leads to expansion of the S3 segment of the proximal tubule, the site of SGLT1, is suggestive of a physiological response to diminish urinary glucose loss akin to that occurring in experimental diabetes. These findings provide a cogent explanation for the less-thanthan-expected effect of this drug class on glucose reabsorption.</p>\u0000 </section>\u0000 </div>","PeriodicalId":51250,"journal":{"name":"Journal of Diabetes Investigation","volume":"16 7","pages":"1232-1242"},"PeriodicalIF":3.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdi.70043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"β-Cell dysfunction in diabetes: The role of neuroplastin","authors":"Moon-Kyu Lee","doi":"10.1111/jdi.70036","DOIUrl":"10.1111/jdi.70036","url":null,"abstract":"<p>\u0000 \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":51250,"journal":{"name":"Journal of Diabetes Investigation","volume":"16 6","pages":"986-988"},"PeriodicalIF":3.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdi.70036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of body mass index on the association between kidney function and insulin resistance in diabetic and nondiabetic populations","authors":"Ruo Zhang,&nbsp;Malgorzata A Garstka,&nbsp;Chunhong Zhang,&nbsp;Shimei Ding,&nbsp;Jing Xu","doi":"10.1111/jdi.70048","DOIUrl":"10.1111/jdi.70048","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims/Introduction</h3>\u0000 \u0000 <p>The kidneys play a role in regulating insulin metabolism, and kidney function may indicate the progression to insulin resistance (IR) in individuals with obesity and diabetes. We evaluated the relationship between kidney function biomarkers and IR in diabetic and nondiabetic adults categorized by body mass index (BMI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 8,272 adults from the China Health and Nutrition Survey 2009 were categorized into four groups based on BMI (overweight/obesity vs underweight/normal weight) and diabetes status (diabetes vs non-diabetes). Univariable and multivariable linear regression, along with restricted cubic spline regression, were used to determine the relationship between estimated glomerular filtration rate (eGFR), creatinine, urea nitrogen, uric acid (UA), and homeostasis model assessment for insulin resistance (HOMA-IR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The relationship between kidney function biomarkers and IR only existed in the overweight/obese populations and varied by diabetic status. In diabetic patients, linear associations were observed: eGFR was negatively associated with HOMA-IR, and creatinine was positively associated. In nondiabetic individuals, nonlinear associations were found. The relationship between eGFR and HOMA-IR followed an L-shaped curve: HOMA-IR decreased as eGFR increased up to 100 mL/min/1.73 m², then slightly increased. The UA-HOMA-IR association showed an inverted L-shape: HOMA-IR increased with higher UA levels, plateauing after UA exceeded 360 μmol/L.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Kidney function biomarkers are associated with IR in overweight/obese populations, with and without diabetes. eGFR and creatinine can be indicators of IR in overweight/obese subjects with diabetes, while eGFR and UA may be used in those without diabetes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":51250,"journal":{"name":"Journal of Diabetes Investigation","volume":"16 7","pages":"1292-1304"},"PeriodicalIF":3.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdi.70048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of tele-guidance for physiotherapy in older patients with type 2 diabetes: A randomized controlled trial","authors":"Hiroaki Kataoka,&nbsp;Takuo Nomura,&nbsp;Hiroyuki Oka,&nbsp;Yukio Ikeda","doi":"10.1111/jdi.70047","DOIUrl":"10.1111/jdi.70047","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims/Introduction</h3>\u0000 \u0000 <p>Whether regular intervention via modern communication tools is effective in older patients with type 2 diabetes is unclear. We aimed to determine the effects of tele-guidance for physiotherapy on muscle strength in such patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This randomized controlled trial was conducted at seven hospitals across Japan. The study participants were 74 older patients with type 2 diabetes randomly assigned to either the tele-guidance for physiotherapy group, which received weekly telephone interventions, or the non-intervention group. Both groups performed a combined aerobic and resistance exercise program. The intervention period was 6 months, during which the tele-guidance for physiotherapy and non-intervention groups received remote physiotherapy instruction once weekly and at the 3-month mark, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Knee extension force was significantly increased in the tele-guidance for physiotherapy group (from 1.25 ± 0.52 to 1.34 ± 0.54 Nm/kg) but significantly decreased in the non-intervention group (from 1.28 ± 0.46 to 1.22 ± 0.43 Nm/kg). Hemoglobin A1c levels improved significantly in the tele-guidance for physiotherapy and non-intervention groups (from 9.5 ± 2.6 to 7.4 ± 1.6% and from 10.2 ± 2.5 to 7.6 ± 2.0%, respectively). Adherence to the physiotherapy program was significantly higher in the tele-guidance for physiotherapy group than in the non-intervention group (71.8% vs 48.6%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Weekly tele-guidance for physiotherapy proved effective in improving knee extension force and increasing physiotherapy adherence in older patients with type 2 diabetes. Tele-guidance may be a valuable intervention to improve muscle strength in such patients, offering a cost-effective, accessible solution for healthcare management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":51250,"journal":{"name":"Journal of Diabetes Investigation","volume":"16 7","pages":"1284-1291"},"PeriodicalIF":3.1,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdi.70047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}