Improvement of heart rate variability after metabolic bariatric surgery in Korean subjects with obesity

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation Pub Date : 2024-10-16 DOI:10.1111/jdi.14332

Han Na Jang, Young Suk Park, Joon Ho Moon, Sung Hee Choi, Hak Chul Jang, Tae Jung Oh

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引用次数: 0

Abstract

Introduction

Cardiovascular autonomic neuropathy (CAN) is a chronic complication of diabetes. As obesity is a major risk factor for CAN, we hypothesized that metabolic bariatric surgery (MBS) could improve CAN indices in Korean patients with obesity.

Materials and Methods

Patients who underwent bariatric surgery between February 2020 and June 2022 were prospectively recruited. CAN was conducted once before surgery and again after surgery, using the Ewing method and heart rate variability (HRV) analysis (standard deviation of the NN interval [SDNN], root mean square of successive RR interval difference [RMSSD], and spectral analysis).

Results

A total of 47 patients were included. The mean age was 39.8 ± 8.7 years, 15 (31.9%) were male, and 26 (55.3%) had diabetes. Resting HR before surgery was 81.0 ± 12.3 bpm, which decreased significantly to 68.0 ± 9.3 bpm after surgery (P < 0.001). Changes in HR and BP according to the Valsalva maneuver, postural changes, and handgrip were not significantly different before and after surgery. However, SDNN significantly increased from 25.2 [15.1, 33.5] to 38.0 [25.4, 45.0] ms (P < 0.001), and RMSSD also significantly increased from 17.0 [9.2, 31.8] to 28.2 [15.3, 45.6] ms (P = 0.001). Both low-frequency power (LF) and high-frequency power (HF) increased significantly, and the LF/HF ratio significantly decreased from 2.1 ± 1.6 to 1.3 ± 1.3 (P = 0.010). Loss of weight, fat mass, and lean body mass were independently associated with improving the HRV variables.

Conclusions

MBS improved HRV variables, and these changes were mainly associated with postoperative weight loss.

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韩国肥胖症患者接受代谢减肥手术后心率变异性的改善。

导言心血管自主神经病变（CAN）是糖尿病的一种慢性并发症。由于肥胖是心血管自主神经病变的主要风险因素，我们假设代谢减肥手术（MBS）可以改善韩国肥胖患者的心血管自主神经病变指数：前瞻性地招募了 2020 年 2 月至 2022 年 6 月期间接受减肥手术的患者。采用尤因法和心率变异性（HRV）分析（NN间期标准偏差[SDNN]、连续RR间期差的均方根[RMSSD]和频谱分析），在术前和术后各进行一次CAN分析：结果：共纳入 47 名患者。平均年龄（39.8±8.7）岁，男性 15 人（31.9%），糖尿病患者 26 人（55.3%）。手术前的静息心率为 81.0 ± 12.3 bpm，手术后明显降低至 68.0 ± 9.3 bpm（P 结论：MBS 改善了心率变异变量，并提高了心率变异性：MBS 改善了心率变异变量，这些变化主要与术后体重减轻有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Investigation ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

9.40%

发文量

218

审稿时长

6-12 weeks

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).